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At least 1,081 records · Page 60

TPSAS-NF1676L-32493-DND

The Committee on Earth Observation Satellites (CEOS) System Engineering Office (SEO) has supported the Open Data Cube (ODC) initiative to provide a data architecture solution that has value to its global users and increases the impact of EO satellite data. ODC is an open-source platform for processing satellite data. We have developed software products and tools around the core ODC that would help users perform machine learning on EO satellite data. The recent United Nations (UN) Sustainable Development Agenda provides a shared blueprint for peace and prosperity for people and for the planet, considering our current situation and helping to create a plan. The core of this agenda is a set of seventeen Sustainable Development Goals (SDGs), which represent an urgent call for action by all countries - both developed and developing - in a global partnership. The CEOS SEO team has recently developed and released a set of innovative Jupyter notebooks addressing UN SDGs 6.6.1 (spatial extents of water-related ecosystems), 11.3.1 (ratio of land consumption rate to population growth rate), and 15.3.1 (proportion of land that is degraded over total land area). These notebooks empower users by providing features that will assist with streamlining analysis ready data retrieval, processing, and visualization. We have recently incorporated several machine learning techniques in these notebooks. In this paper, we present the lessons learned from our experience on classifying land using supervised and unsupervised machine learning techniques using ODC framework for UN SDGs. We identify the current limitations of ODC to seamlessly support machine learning techniques. We propose features that would help machine learning, specifically within the ODC framework. We propose a thematic indexing/loading of data for both unsupervised learning as well as data annotation/labeling pipeline. Currently, ODC supports machine learning by separating data-management from the analysis process. It works as a mechanism to load cubes of data. ODC does not natively support features that are vital in machine learning such as validation splits, fair/balanced sampling, establishing load size constraints, etc. We believe that our proposed features will empower users by providing features that bring machine learning techniques closed to ODC. Enhancements to ODC to better accommodate machine learning techniques can assist in fulfilling UN SDGs such as 6.3.2, 6.4.2, 6.6.1, 11.3.1, 14.1.1, 15.1.1, 15.3.1, and 15.4.2.

Syed R Rizvi↗

Cric searchable image database as a public platform for conventional pap smear cytology data

Amidst the current health crisis and social distancing, telemedicine has become an important part of mainstream of healthcare, and building and deploying computational tools to support screening more efficiently is an increasing medical priority. The early identification of cervical cancer precursor lesions by Pap smear test can identify candidates for subsequent treatment. However, one of the main challenges is the accuracy of the conventional method, often subject to high rates of false negative. While machine learning has been highlighted to reduce the limitations of the test, the absence of high-quality curated datasets has prevented strategies development to improve cervical cancer screening. The Center for Recognition and Inspection of Cells (CRIC) platform enables the creation of CRIC Cervix collection, currently with 400 images (1,376 × 1,020 pixels) curated from conventional Pap smears, with manual classification of 11,534 cells. This collection has the potential to advance current efforts in training and testing machine learning algorithms for the automation of tasks as part of the cytopathological analysis in the routine work of laboratories.

59 BASIC BIOLOGICAL SCIENCES↗

Data Analysis and Model Validation (2013 CEF Run - Phase 1)

Phase 1 of the 2013 Cold cap Evaluation Furnace (CEF) test was completed on June 3, 2013 after a 5-day round-the-clock feeding and pouring operation. The main goal of the test was to characterize the CEF offgas produced from a nitric-formic acid flowsheet feed and confirm whether the CEF platform is capable of producing scalable off-gas data necessary for the revision of the DWPF melter off-gas flammability model; the revised model will be used to define new safety controls on the key operating parameters for the nitric-glycolic acid flowsheet feeds including total organic carbon (TOC). Whether the CEF off-gas data were scalable for the purpose of predicting the potential flammability of the DWPF melter exhaust was determined by comparing the predicted H 2 and CO concentrations using the current DWPF melter off-gas flammability model to those measured during Phase 1; data were deemed scalable if the calculated fractional conversions of TOC-to-H 2 and TOC-to-CO at varying melter vapor space temperatures were found to trend and further bound the respective measured data with some margin of safety. Being scalable thus means that for a given feed chemistry the instantaneous flow rates of H 2 and CO in the DWPF melter exhaust can be estimated with some degree of conservatism by multiplying those of the respective gases from a pilot-scale melter by the feed rate ratio. This report documents the results of the Phase 1 data analysis and the necessary calculations performed to determine the scalability of the CEF off-gas data.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

First evaluation of the feasibility of MLC tracking using ultrasound motion estimation

Purpose: To quantify the performance of the Clarity ultrasound (US) imaging system (Elekta AB, Stockholm, Sweden) for real-time dynamic multileaf collimator (MLC) tracking. Methods: The Clarity calibration and quality assurance phantom was mounted on a motion platform moving with a periodic sine wave trajectory. The detected position of a 30 mm hypoechogenic sphere within the phantom was continuously reported via Clarity’s real-time streaming interface to an in-house tracking and delivery software and subsequently used to adapt the MLC aperture. A portal imager measured MV treatment field/MLC apertures and motion platform positions throughout each experiment to independently quantify system latency and geometric error. Based on the measured range of latency values, a prostate stereotactic body radiation therapy (SBRT) delivery was performed with three realistic motion trajectories. The dosimetric impact of system latency on MLC tracking was directly measured using a 3D dosimeter mounted on the motion platform. Results: For 2D US imaging, the overall system latency, including all delay times from the imaging and delivery chain, ranged from 392 to 424 ms depending on the lateral sector size. For 3D US imaging, the latency ranged from 566 to 1031 ms depending on the elevational sweep. The latency-corrected geometric root-mean squared error was below 0.75 mm (2D US) and below 1.75 mm (3D US). For the prostate SBRT delivery, the impact of a range of system latencies (400–1000 ms) on the MLC tracking performance was minimal in terms of gamma failure rate. Conclusions: Real-time MLC tracking based on a noninvasive US input is technologically feasible. Current system latencies are higher than those for x-ray imaging systems, but US can provide full volumetric image data and the impact of system latency was measured to be small for a prostate SBRT case when using a US-like motion input.

60 APPLIED LIFE SCIENCES↗

The Pathway to a Safe and Effective Medication Formulary for Exploration Spaceflight

PURPOSE: Exploration space missions pose several challenges to providing a comprehensive medication formulary designed to accommodate the size and space limitations of the spacecraft; while addressing the individual medications needs and preferences of the Crew; the negative outcome of a degrading inventory over time, the inability to resupply before expiration dates; and the need to properly forecast the best possible medication candidates to treat conditions that will occur in the future. METHODS: The Pharmacotherapeutics Discipline has partnered with the Exploration Medical Capabilities (ExMC) Element to develop and propose a research pathway that is comprehensively focused on evidence-based models and theories, as well as on new diagnostic tools and treatments or preventive measures aimed at closure of the Med02 “Pharmacy” Gap; defined in the Human Research Program’s (HRP) risk-based research strategy. The Med02 Gap promotes the challenge to identify a strategy to ensure that medications used to treat medical conditions during exploration space missions are available, safe, and effective. It is abundantly clear that pharmaceutical intervention is an essential component of risk management planning for astronaut healthcare during exploration space. However, the quandary still remains of how to assemble a formulary that is comprehensive enough to prevent or treat anticipated medical events; and is also chemically stable, safe, and robust enough to have sufficient potency to last for the duration of an exploration space mission. In cases where that is not possible, addressing this Gap requires exploration of novel drug development techniques, dosage forms, and dosage delivery platforms that enhance chemical stability as well as therapeutic effectiveness. RESULTS: The proposed research pathway outlines the steps, processes, procedures, and a research portfolio aimed at identifying a capability that will provide a safe and effective pharmacy for any specific exploration Design Reference Mission (DRM). The proposed approach to building this research portfolio is to seek research projects that concentrate on four major focus areas; (1) Formulary selection, (2) Formulary potency and shelf life, (3) Formulary safety and toxicity, and (4) Novel technology and innovation such as portable real-time chemical analysis innovative drug therapies and dosage and delivery platforms. CONCLUSION: The research pathway has been completed and presented to the HRP. In spring 2017, it is scheduled to be reviewed by a panel of pharmaceutical and clinical experts that will evaluate the scientific merit and operational feasibility of the research pathway, as well as make suggestions for any warranted additions or improvements. Once finalized, the ExMC Element will proceed with the execution of this research pathway with the goal of gathering as much data, and learning as much as possible, to provide a safe and effective pharmaceutical formulary for use during exploration missions.

Daniels, V. R.↗

Cleanroom Microbes Survive Drying, Vacuum, and Proton Irradiation

Introduction : The goal of planetary protection at NASA is to mitigate the risk of contaminating sensitive target bodies with biological life. While many cleaning procedures have been put in place to reduce bioburden on spacecraft, microbes are experts at evolving to survive harsh conditions. Specifically, the dry, low-nutrient environment of a cleanroom (commonly used for assembly of spacecraft) can represent an environment where extremophiles can survive. Methods : Scientists at NASA MSFC wished to gather a snapshot of the microbial population within a variety of cleanrooms on site. A study was undertaken to collect air, surface, and floor samples from clean-rooms and isolate unique morphologies. From this study, 95 isolates were collected and saved in a microbial library. About 86% of these were identified at least to a genus level. Following identification, 24 microbes were selected, based on a literature review, as potential extremophiles. These were grown in liquid cultures, diluted to a set optical density, washed with water, and then applied to a sterilized Kapton coupon. Droplets were allowed to dry overnight in a biosafety cabinet. Coupons were then installed in a pelletron and pumped down to high vacuum (~1E-6 Torr). Samples were then subjected 100 keV protons at a fluence of 2x10 15 p+/cm 2 up to 4x10 15 p+/cm 2 . Following exposure, samples were returned to the microbiology lab where they were pro-cessed by submerging in water, vortexing, and then plating either droplets or spread plates. Recovery data collected was qualitative with a ranking or +, minor, or – for growth. Some selected radiotolerant strains were sequenced using the Illumina sequencing platform. The resulting genomes were annotated with the Rapid Annotations using Subsystems Technology (RAST) server and analyzed for conserved and unique stress response relevant genomic signatures to identify clues related to specific tolerances. Results and Discussion : After five rounds of proton radiation, we narrowed our isolates to five, non-spore forming bacteria that demonstrated survival: Arthrobacter koreensis, Paenarthrobacter nitroguajacolicus, Mycetocola manganoxydans , and an Erwinia sp. Furthermore, we exposed these four microbes to 254 nm wavelength light at an intensity of 80 W/m 2 at a distance of ~18 cm for 10 minutes. Only A. koreensis demonstrated survival following UV exposure. Finally, we performed whole genome sequencing on the four strains to look for genetic markers of stress resistance. When we compared the genomes of the four strains, we found that genes coding for GGDEF and EAL domains with PAS/PAC sensors were only found in A. koreensis . These domains, modulated by PAS/PAC sensors, are hypothesized to facilitate survival under drying, desiccation, and proton irradiation. Drying and Desiccation : PAS domains sense hydration changes and modulate GGDEF and EAL domain activity to adjust c-di-GMP levels, enhancing resistance to desiccation. For instance, in Pseudomonas aeruginosa , the PAS domain of RbdA modulates activity under varying hydration conditions, affecting stress responses [1]. Proton Irradiation : Proton irradiation causes oxidative stress, leading to ROS generation. PAS domains detect this stress and modulate GGDEF and EAL domains to manage oxidative stress responses. In Shewanella , EAL domain proteins modulated by PAS sensors help bacteria adapt to extreme conditions [2]. These genes upregulate other stress response genes, protecting membrane function, protein stability, DNA repair, and antioxidant defenses. The modulation of c-di-GMP by PAS domains is crucial for bacterial adaptation to stress conditions, enabling dynamic physio-logical adjustments [3]. Understanding these mechanisms provides insights into bacterial stress responses and strategies for controlling bacterial growth [4]. Conclusions : These findings indicate that clean-rooms harbor extremophile microbes that may be able to survive conditions in deep space. Furthermore, while we identified certain stress-response genes that may be at least partly responsible for the phenotypes observed in this study, there are likely unidentified genes or characteristics about A. koreensis , and other bacteria, that may allow them to survive in harsh environments. Future studies will focus on identifying these unknown genes and characteristics, further elucidating the mechanisms of extremophile survival and potentially informing the development of new biotechnologies for space exploration and other extreme environments.

Chelsi Cassilly↗

Defining a Use Case for the ADMS Test Bed: Fault Location, Isolation, and Service Restoration with Distributed Energy Resources: Preprint

Advanced distribution management systems (ADMS) integrate multiple enterprise-level functions into a single platform and offer advanced applications such as fault location, isolation, and service restoration (FLISR), to utilities to meet their operational needs for a modernized grid. These applications need to operate reliably even as distributed energy resource (DER) penetration increases on distribution systems. The ADMS test bed at the National Renewable Energy Laboratory offers utilities and vendors the opportunity to evaluate the performance of such advanced applications on distribution feeders of the future and to understand their potential benefits for a specific utility. This is done through defining use cases that address specific questions. This paper presents the definition of a use case on the performance of a commercially-available FLISR application on a feeder of an electric cooperative with DERs. Results from this use case will be disseminated to the electric utility and research community to improve understanding of the challenges and benefits that DERs present to ADMS applications and the operation of a modernized grid.

61 RADIATION PROTECTION AND DOSIMETRY↗

Vulcan Test Platform: Demonstrating the Data Center as a Flexible Grid Asset

Explosive data center demand is outpacing grid infrastructure development. AI workloads and hyperscale cloud growth are creating unprecedented power requirements, while traditional grid expansion faces multi-year development timelines, regulatory hurdles, and decarbonization challenges. Sidewalk Infrastructure Partners recognized this impending crisis years ago and founded Verrus to develop an innovative solution: data centers that function as grid assets rather than passive loads. The Verrus approach integrates proprietary grid-aware controls with battery energy storage systems (BESS) in a medium-voltage architecture that delivers three critical capabilities: Fast-responding demand flexibility that can service requests from the utility within 10 seconds, Uninterrupted transition to islanded operation during grid disturbances, Continuous uptime assurance while maintaining all customer service level commitments Through Verrus' strategic partnership with the National Renewable Energy Laboratory (NREL), we validated these capabilities on Vulcan, a 70 MW utility-scale test platform powered by NREL's ARIES Virtual Emulation Environment. This deployment-ready technology has successfully demonstrated that Verrus data centers can deliver meaningful grid services while maintaining mission-critical reliability. This technical report outlines the design, methodology, and results of this emulated deployment, demonstrating that data centers can play a pivotal role in enhancing grid flexibility and reliability, without sacrificing service level guarantees.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Automation of Vulnerability and Patch Management: Information Extraction, Association, and Optimization

Vulnerability and patch management is an integral part of a robust cybersecurity program, yet it grows increasingly complex due to the sheer amount of data that must be analyzed. Particularly in Operational Technology (OT) environments, analysis must be done manually because of the lack of automated solutions. Additionally, there are many steps in this process, from the initial discovery of the vulnerability to the implementation of its remediation, and each step in the process requires different data in order to be performed effectively. In this work, we provide approaches and strategies to assist operators in industrial or OT environments throughout the vulnerability management cycle. Security advisories provide key information about mitigation strategies, or actions that can be taken when a patch is unavailable or cannot be installed. Details of these strategies are not shared in public vulnerability databases and must be found manually. We approach this problem by designing a solution to automatically identify that information within vendor security advisories and retrieve it for operator use. We start with an approach that requires domain-specific knowledge of certain frequently-seen reference websites. Next, an approach that can work on an arbitrary website but relies on certain keywords. Finally, an approach that uses Natural Language Processing (NLP) methods and does not require specific knowledge or keywords. Each of these approaches is more general than its predecessor; we demonstrate high accuracy for all approaches Advisories also often contain details of affected products in non-standard or natural language formats. While this information can be easily understood when read by an operator, the non-standard format acts as a barrier to effective automation. We provide an approach for the first step in this process: identifying vendors in security advisories and mapping them to a standard framework for representing digital assets and software products. We evaluate five established string similarity algorithms, plus one of our own design that combines string similarity and information theory, on the task of mapping vendors to their corresponding entries in the Common Platform Enumeration (CPE) repository. Our results show that our proposed metric outperforms all others. Due to the constraints on time, finances, and personnel for organizations, Large Language Models (LLMs) may seem like attractive opportunities for security operators to speed up information gathering; however, it is still not clear whether LLMs can handle vulnerability management tasks well. To answer this question, we perform an empirical study of LLMs’ ability to provide consistent, accurate information about vulnerabilities in order to guide organizations in their adoption of LLMs. We observe poor performance for all models tested, suggesting that these models are not well-suited to the consistent retrieval of accurate vulnerability information. Finally, once vulnerabilities have been identified and any additional information has been obtained, operators must decide which remediation actions to implement based on their available resources. This already-complex problem becomes even more so when we consider that a vulnerability may have multiple avenues for remediation. We formulate this scenario as two knapsack problems and provide solutions, which we then compare against several existing strategies for vulnerability prioritization seen in real operational environments.

McClanahan, Kylie↗

Defining a Use Case for the ADMS Test Bed: Fault Location, Isolation, and Service Restoration with Distributed Energy Resources

Advanced distribution management systems (ADMS) integrate multiple enterprise-level functions into a single platform and offer advanced applications such as fault location, isolation, and service restoration (FLISR), to utilities to meet their operational needs for a modernized grid. These applications need to operate reliably even as distributed energy resource (DER) penetration increases on distribution systems. The ADMS test bed at the National Renewable Energy Laboratory offers utilities and vendors the opportunity to evaluate the performance of such advanced applications on distribution feeders of the future and to understand their potential benefits for a specific utility. This is done through defining use cases that address specific questions. This paper presents the definition of a use case on the performance of a commercially-available FLISR application on a feeder of an electric cooperative with DERs. After experiments are completed, results from this use case will be disseminated to the electric utility and research community to improve understanding of the challenges and benefits that DERs present to ADMS applications and the operation of a modernized grid.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Scaling Relationships Based on Scaled Tank Mixing and Transfer Test Results

This report documents the statistical analyses performed (by Pacific Northwest National Laboratory for Washington River Protection Solutions) on data from 26 tests conducted using two scaled tanks (43 and 120 inches) in the Small Scale Mixing Demonstration platform. The 26 tests varied several test parameters, including mixer-jet nozzle velocity, base simulant, supernatant viscosity, and capture velocity. For each test, samples were taken pre-transfer and during five batch transfers. The samples were analyzed for the concentrations (lbs/gal slurry) of four primary components in the base simulants (gibbsite, stainless steel, sand, and ZrO2). The statistical analyses including modeling the component concentrations as functions of test parameters using stepwise regression with two different model forms. The resulting models were used in an equivalent performance approach to calculate values of scaling exponents (for a simple geometric scaling relationship) as functions of the parameters in the component concentration models. The resulting models and scaling exponents are displayed in tables and graphically. The sensitivities of component concentrations and scaling exponents to the test parameters are presented graphically. These results will serve as inputs to subsequent work by other researchers to develop scaling relationships that are applicable to full-scale tanks.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Null Space Monte Carlo Evaluation of the Plateau to River Model

The Plateau to River Groundwater Model (P2R Model) is a groundwater flow and contaminant fate and transport (F&T) simulation model used to support remedial activities conducted by CH2M HILL Plateau Remediation Company at the Hanford Site in Washington State. Figure 1-1 illustrates the P2R Model extents, discretization, and boundary conditions. The P2R Model provides a computational framework to simulate the F&T of contaminants in groundwater associated with the 200-PO-1, 200-UP-1, 200-BP-5, and 200-ZP-1 Groundwater Operable Units (OUs) in the Hanford Site Central Plateau. In addition, the model includes adjacent areas and facilities (e.g., the State Approved Land Disposal Site). Intended and anticipated uses of the model include calculating water levels, hydraulic gradients, and groundwater flows throughout the model domain (encompassing the 200 West and 200 East Areas) for use in subsequent F&T calculations for contaminants of concern and developing scale-appropriate, telescopic-mesh refinement models for detailed evaluation of areas within the model domain where required. The overall objective of the modeling effort is to provide a basis for making informed remedial action decisions based on descriptions of current and expected future contaminant concentrations in groundwater at decision points within the OU boundaries. The objective for the model development phase is to create a common modeling platform that can be used for investigations of the Central Plateau groundwater OUs and areas downgradient toward the Columbia River. The P2R Model calibration to historical data observed at the Hanford Site is documented in CP-57037, Model Package Report for the Plateau to River Model Version 8.3. The purpose of this environmental calculation is to describe a null space Monte Carlo (NSMC) evaluation was conducted with the historic calibration of the P2R model. Use of numerical groundwater models is always accompanied with uncertainty in the results produced by a model because models are approximations of reality. Thus, by definition, lack the detail to fully represent observed behavior. Use of numerical techniques, such as a NSMC analysis, can help in identifying and quantifying the potential uncertainties associated with a numerical model such as the P2R Model. Use of the NSMC approach results in 100 groundwater flow models that are variants of the calibrated P2R Model. These variant models can be used to evaluate uncertainty in model predictions made by the calibrated P2R Model for other analyses. A secondary purpose of the environmental calculation is to establish these variant models for use with other applications.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Bioinspired design of redox-active ligands for multielectron catalysis: Effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water

Here, mononuclear metalloenzymes in nature can function in cooperation with precisely positioned redox-active organic cofactors in order to carry out multielectron catalysis. Inspired by the finely tuned redox management of these bioinorganic systems, we present the design, synthesis, and experimental and theoretical characterization of a homologous series of cobalt complexes bearing redox-active pyrazines. These donor moieties are locked into key positions within a pentadentate ligand scaffold in order to evaluate the effects of positioning redox non-innocent ligands on hydrogen evolution catalysis. Both metal- and ligand-centered redox features are observed in organic as well as aqueous solutions over a range of pH values, and comparison with analogs bearing redox-inactive zinc(II) allows for assignments of ligand-based redox events. Varying the geometric placement of redox non-innocent pyrazine donors on isostructural pentadentate ligand platforms results in marked effects on observed cobalt-catalyzed proton reduction activity. Electrocatalytic hydrogen evolution from weak acids in acetonitrile solution, under diffusion-limited conditions, reveals that the pyrazine donor of axial isomer 1-Co behaves as an unproductive electron sink, resulting in high overpotentials for proton reduction, whereas the equatorial pyrazine isomer complex 2-Co is significantly more active for hydrogen generation at lower voltages. Addition of a second equatorial pyrazine in complex 3-Co further minimizes overpotentials required for catalysis. The equatorial derivative 2-Co is also superior to its axial 1-Co congener for electrocatalytic and visible-light photocatalytic hydrogen generation in biologically relevant, neutral pH aqueous media. Density functional theory calculations (B3LYP-D2) indicate that the first reduction of catalyst isomers 1-Co, 2-Co, and 3-Co is largely metal-centered while the second reduction occurs at pyrazine. Taken together, the data establish that proper positioning of non-innocent pyrazine ligands on a single cobalt center is indeed critical for promoting efficient hydrogen catalysis in aqueous media, akin to optimally positioned redox-active cofactors in metalloenzymes. In a broader sense, these findings highlight the significance of electronic structure considerations in the design of effective electron–hole reservoirs for multielectron transformations.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

NUM-DAT File Format Specification: Used in M-9 Gun Experiment Data Archiving

The M-9 Shock and Detonation Physics group executes experiments on gun and explosive platforms with large numbers of oscilloscopes used for data acquisition. The data acquisition from these oscilloscopes was automated many years ago using a custom piece of software called RunDig . The default save format from this software is a custom structure referred to as "NUM-DAT" format. This file format includes a text ".DAT" file which is a header file used to interpret the binary ".NUM" file which contains the oscilloscope data. The data save format was originally developed by John Vorthman and has been in use by M-9 personnel for over 20 years. This data format has been used for archiving data from experiments performed by M-9 personnel at TA-40, TA-39, and the TA-55 Impact Test Facility. Numerous custom analysis and visualization programs have also been developed, and continue to be used, that utilize this data format. This document describes the NUM-DAT format and provides code examples for reading the format and converting it to other formats.

47 OTHER INSTRUMENTATION↗

Residual waste detection in HLW tanks - 15701

This research uses commercial sonar technology to monitor residual waste in the U.S. Department of Energy's (DOE) Hanford Site high-level-waste staging tanks, with primary focus on the detection and imaging of the settled solids at specified areas of interest along the tank surface within a limited amount of time. High-level waste (HLW) is generated at the US-DOE Hanford Site as a by-product from the processing of nuclear materials. Waste is currently stored in 177 underground carbon-steel waste tanks. Pulse jet mixers (PJM) are often used to break loose and suspend the solids that have settled at the bottom of the tanks. A typical tank can have 6-8 pulse tubes. The Solid Liquid Interface Monitor (SLIM) must be capable of measuring dynamic movements in Region 1 zone between each PJM cycle. SLIM was originally developed to map the sludge/supernate interface within the U.S. DOE Hanford Site's HLW tanks. SLIM is a dual-axis mechanically rotating sonar and consists of an acoustic transducer, rotation motor with gearbox, tilt motor, position reference sensor, and pressure balancing mechanisms and its associated deployment platform. The sonar gathers a swath of data in the horizontal plane and rotates the transducer through a programmed angle around the vertical axis. Oil-filled device. No user serviceable parts. No semiconductors. Hard anodized aluminum and polyurethane delrin. May be deployed in areas of significant radioactivity. Kaolin will be used during mixing operations in order to simulate the physical properties of the expected slurry. In order to reduce the amount of time needed to image and object, all settings were decreased to their minimal state. The low resolution settings provide insufficient data for the manufacturer's 3D profiler to compile a visible point cloud and much less to allow the meshing algorithm to work properly. Several filtering algorithms have been applied to each scan in order to remove erroneous spikes and ghosting effects. Data has been collected for the mixing process of kaolin. This data consists of scans executed while the pump was active and inactive. The imaging algorithm has also been used with data derived from scans of 3% or less of kaolin. Future work: Mixing of kaolin within an experimental tank will be conducted in order to simulate the settling time of the HLW within the tank. The same filtering algorithms will be applied to each of these scans to evaluate the SLIM's efficiency to image solids at the bottom of a tank through increasing volume of kaolin.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Use of the Manuela 3D/Radiation Scanning Tool at Nuclear Facilities - 20437

Licensees, facility operators and decommissioning contractors have a need for comprehensive, accurate and precise radiological and topographical data to plan and execute safe and efficient Decontamination and Decommissioning (D and D) projects. Traditional approaches rely greatly upon labor and administratively intensive data collection methods that require considerable time and effort to glean the relevant data to plan and perform work in a radiological work area. Orano Decommissioning Services has developed and utilized at French nuclear facilities a lightweight portable scanning instrument called MANUELA (Mobile Apparatus for Nuclear Expertise Localization Assistance). Recently Orano conducted demonstrations at two United States nuclear facilities using MANUELA that may prove useful in areas of the fuel cycle including: - ALARA (As Low As Reasonably Achievable) planning during facility operations; - Scoping and site characterization during the D and D planning phase; - Remedial action support during active decommissioning work; - Radiation and modeling planning for plant modifications; - Support Final Status Survey and demonstration of 'end state' compliance for license termination. MANUELA is currently being evaluated for use during decommissioning of nuclear facilities and could aide in demonstrating compliance with end state criteria after decommissioning. Of particular interest are decommissioning projects planned for various sites across the United States. Most of these sites present unique challenges and opportunities to safely and efficiently decommission in a regulatory compliant manner. The two demonstration site's current conditions of relatively low radiation levels inside containment proved to be ideal platforms to deploy the MANUELA instrument for evaluation of the complex geometries typically found in a nuclear facility. The MANUELA instrument was able to precisely identify local hot spots of the reactor system's primary equipment and was able to simultaneously overlay the dose information onto the scanned 3D images. Using data like this, a licensee would be able to make informed technical and personnel decisions on methods to remediate, shield or properly dispose of the radioactive source term. MANUELA can be used throughout the decommissioning process to validate progress and continue to refine the work activities to optimize the efforts of the crew which reduces downtime waiting for survey results, whereas traditional survey methodology relies on a physical survey to be performed and the data transcribed onto survey maps that are only two dimensional. The traditional format tends to be inaccurate and difficult to interpret the precise location(s) of hot spots or generalized dose rates. The resultant scan also allows the user to know the exact extent of the survey versus transposing information onto a map with only a portion of the map area scanned. MANUELA also compiles all of the relevant survey data into a downloadable table format which includes the measurement identification number, time stamp, point space location on the XYZ plane, and the dose rate value. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Landsat at 45: How it Changed the Way We See the Earth

On October 24, 1946, more than 10 years before the launch of the first artificial satellite Sputnik, scientists at the White Sands Missile Range in New Mexico placed a camera on top of a captured German V-2 ballistic missile. As the rocket flew to an altitude of about 65 miles - just above the generally recognized border of outer space - the 35-millimeter motion picture camera snapped a frame every one and a half seconds. Minutes later, the missile came crashing back down and slammed into the ground at more than 340 mph, but the film survived and gave us our first glimpse of Earth from space. Earth Resources Technology Satellite aka Landsat It was images like those first grainy black and white pictures and later those taken by America's first astronauts in the 1960's that inspired the development of the Earth Resources Technology Satellite (ERTS). From the unique vantage point of space, we could now observe Earth using a variety of different instruments to monitor changes over time. The ERTS-1 satellite, wisely renamed Landsat-1, was launched aboard a Delta rocket on July 23, 1972, into a Sun-synchronous polar orbit at an altitude of about 560 miles. In this unique orbit, Landsat could observe the same point on the Earth every 18 days, always with the same solar illumination, allowing for precise monitoring of changes on the ground over time. Landsat-1, derived from the highly successful Nimbus weather satellites, carried two instruments that allowed it to take images not only in visible light but also in infrared, well-suited to track changes in vegetation over time. Designed to last only one year, Landsat-1 actually operated for nearly three years, by which time it had been joined in space by Landsat-2, a near identical copy of the original. Since then, ever more sophisticated instruments were flown aboard Landsat-3 through -8, with Landsat-9 planned for launch in 2020, acquiring millions of images of Earth over more than four decades. At first, images from Landsat were processed by NASA and hardcopies sold to users for a fee, a somewhat tedious process. Since 2008, images have been made available to all interested users by the US Geological Survey (USGS) at no cost via the Internet in near real time. So, how can Landsat help? In short, Landsat looks. And looks. And proves Yogi right. Space-based images from Landsat and other similar satellites offer a unique and critical capability to observe land use over time by providing repetitive observations of the Earth otherwise unavailable. The data provided by the images can be used by scientists and politicians to inform wise decisions in areas such as agriculture, climate, ecosystems and biodiversity, energy, forest management, human health, fire, natural disasters, urban growth and water management. This overview article doesn't allow for examples from each of these disciplines, but details can be found at the following website: https://landsat.gsfc.nasa.gov/how_landsat_helps/. One third of the US economy is influenced by climate, weather and natural hazards, providing strong economic incentives to sustain a healthy space-based Earth observation program. One example, however, may be illustrative of how Landsat and other space-based observations can be helpful in monitoring and documenting some effects of global climate change. It had been noted since the 1970's that permafrost in subarctic areas like Siberia was melting at an accelerating rate. It also became apparent that this led to the formation of hundreds of melt lakes and the liberation of large quantities of methane, a gas that in the short-term has more potent greenhouse effects than carbon dioxide. The methane turned the water in these lakes blue, making them easy to track over time by satellite. Additionally, the newly released methane has been carbon dated to tens of thousands of years ago, meaning that it had remained frozen since the last Ice Age and therefore hadn't been accounted for in models of the Earth's overall carbon balance. Release of sufficient methane by an increasingly warming climate could actually cause a positive feedback loop in global warming, melting more permafrost and releasing yet more methane. Further monitoring by Landsat and other platforms will reveal whether this process is reversible or whether we've passed the tipping point. In addition to the highly successful Landsat series of satellites, NASA and other agencies such as the National Oceanic and Atmospheric Administration (NOAA) operate a fleet of other Earth observing platforms, many with more specific research goals such as monitoring sea ice levels or atmospheric carbon content. Several instruments aboard the International Space Station also contribute to this overall effort to better understand short- and long-term changes to the Earth. Many of these missions are guided by the 2009 Decadal Survey published by the National Research Council of the National Academy of Sciences. Europe, Russia and China all see the value of space-based Earth observation by deploying their own fleet of satellites.

Uri, John↗

Spaceflight Biospecimen and Data Sharing in Support of Science Discovery and Exploration

For decades, NASA and international partners have conducted biological experiments in space to understand effects of spaceflight and address potential hazards. To enable spaceflight back to the Moon, and then to Mars and beyond, it is imperative to further understand basic science and health risks associated with spaceflight, along with developing countermeasures. The sending of experiments and organisms into space is a costly endeavor. To maximize scientific return, sharing with the scientific community both space-flown biospecimens and data from completed experiments is essential. New fundamental, applied, and bioinformatic science insights can be gained from specimen and data sharing efforts. Data reuse enables spaceflight health risk modeling, analyzing adverse outcomes across spaceflight hazards, and deep space autonomous support for the flight medical officer. Space-flown biospecimens not required by mission Principal Investigators are regularly archived and made available for scientific request. The largest biorepository of these samples are found within NASA’s Institutional Scientific Collection at Ames Research Center (ISC-ARC), which stores over 32,000 specimens mostly from Shuttle and International Space Station (ISS) missions, but also some ground-based analog samples. The Ames Life Sciences Data Archive manages the ISC-ARC. Tissues are predominantly from mice and rats, though samples are also available from bacteria and quail. Only a handful of other similar collections exist worldwide. Rodent biospecimens exposed to simulated space radiation at Brookhaven National Laboratory are archived under the purview of NASA HRP Space Radiation Element. Microbial collection and analyses from 20 years of routine environmental monitoring of air, surfaces, and water systems of the ISS were performed to ensure a safe environment for astronauts. Samples from the ISC-ARC, space radiation and microbial collections are searchable and requestable through the NASA Life Sciences Data Archive (LSDA). Decades of planetary protection microbial isolates derived from spacecraft bioburden are archived in JPL’s microbial collection. Rodent biospecimens from spaceflight investigations conducted by the Japan Aerospace Exploration Agency (JAXA) are archived and available at the JAXA Biorepository at Tsukuba Space Center. The Russian Institute of Biomedical Problems also has a collection of animal, microbial, cellular, and fungi available for research from ground analog experiments. Several data repositories exist for scientists to utilize. The LSDA is the primary NASA source of life sciences research data and information. It contains decades of spaceflight and ground-analog research involving human, microbial, cellular, plant, and animal subjects. Data is collected from NASA-funded investigations through the Human Research Program and the Space Biology Program. The NASA Lifetime Surveillance of Astronaut Health collects and grants access to clinical and occupational health monitoring data from astronauts, with a list and description of data collected available for request through the LSDA. NASA GeneLab at ARC collects genomic, transcriptomic, proteomic, and metabolomic data from any species. It is a repository and platform for collaborative open-science bioinformatic approaches. JAXA is establishing an ‘omics-based repository in collaboration with the Tohoku Medical Megabank (ToMMo), called the JAXA-ToMMo Integrated Biobank for Space Life Science. Overall, the sharing of these biospecimen and data resources can assist researchers worldwide in understanding spaceflight effects on biology, along with enabling next generation data science applications for space exploration platforms. Websites: https://lsda.jsc.nasa.gov/ ; https://www.nasa.gov/ames/research/space-biosciences/isc-bsp ; https://www.nasa.gov/ames/research/space-biosciences/alsda

Ryan T. Scott↗