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Overview of an Exploratory, Real-Time, Multi-Pilot Simulation Study of Early eVTOL Operations at Non-Towered Vertiports

This paper provides a report out on an exploratory, multi-aircraft/multi-pilot, real-time simulation study conducted by NASA of early commercial powered-lift, Urban Air Mobility (UAM) operations at a non-towered vertiport. As used in this paper, vertiport refers to the primary ground and airspace elements facilitating the takeoff and landing of electric vertical takeoff and landing (eVTOL) aircraft with central emphasis on a vertipad, i.e. the physical touch-down and lift-off area and surrounding approach , departure, local pattern procedures. The study, known as the Piloted UML-2 ConOps Study (PUCS), had two high-level goals. The first goal was providing preliminary insights and observations relevant to the piloting and flight operations of early, commercial UAM operations aligned with the initial stage of the FAA’s Advanced Air Mobility (AAM) Implementation Plan and the second level NASA’s UAM Maturity Level (UML) scale. The second goal was evaluating a novel, medium-fidelity, extensible, many-pilot, real-time simulation capability known as the UAM Flyers developed by NASA. The Flyers are intended to allow rapid development, screening, evaluation, and demonstrations of potential Concepts of Operation (ConOps) for UAM flight operations and airspace management in a modular and low-cost, real-time, human-in-the-loop rapid simulation prototyping environment. For this study, ten Flyer cockpits were configured to evaluate flight operations through a non-towered vertiport with pilot interfaces and displays (external and in-cockpit) appropriate for operations under visual flight rules (VFR) and employing flight and communication procedures representative of current operations at non-towered airports. The presented results include an achieved operational tempo; durations of individual flight tasks for approaches and departures; off-nominal events and triggers; and pilot comments regarding potential procedural and technology improvements.

Urban Air Mobility↗

Overview of an Exploratory, Multi-Pilot Simulation Study of Early eVTOL Operations at Non-Towered Vertiports

This paper provides a report out on an exploratory, multi-aircraft/multi-pilot, real-time simulation study conducted by NASA of early commercial powered-lift, Urban Air Mobility (UAM) operations at a non-towered vertiport. As used in this paper, vertiport refers to the primary ground and airspace elements facilitating the takeoff and landing of electric vertical takeoff and landing (eVTOL) aircraft with central emphasis on a vertipad, i.e. the physical touch-down and lift-off area and surrounding approach , departure, local pattern procedures. The study, known as the Piloted UML-2 ConOps Study (PUCS), had two high-level goals. The first goal was providing preliminary insights and observations relevant to the piloting and flight operations of early, commercial UAM operations aligned with the initial stage of the FAA’s Advanced Air Mobility (AAM) Implementation Plan and the second level NASA’s UAM Maturity Level (UML) scale. The second goal was evaluating a novel, medium-fidelity, extensible, many-pilot, real-time simulation capability known as the UAM Flyers developed by NASA. The Flyers are intended to allow rapid development, screening, evaluation, and demonstrations of potential Concepts of Operation (ConOps) for UAM flight operations and airspace management in a modular and low-cost, real-time, human-in-the-loop rapid simulation prototyping environment. For this study, ten Flyer cockpits were configured to evaluate flight operations through a non-towered vertiport with pilot interfaces and displays (external and in-cockpit) appropriate for operations under visual flight rules (VFR) and employing flight and communication procedures representative of current operations at non-towered airports. The presented results include an achieved operational tempo; durations of individual flight tasks for approaches and departures; off-nominal events and triggers; and pilot comments regarding potential procedural and technology improvements.

Urban Air Mobility↗

Development of a Broad High-Energy Gamma-Ray Telescope using Silicon Strip Detectors

The research effort has led to the development and demonstration of technology to enable the design and construction of a next-generation high-energy gamma-ray telescope that operates in the pair-production regime (E greater than 10 MeV). In particular, the technology approach developed is based on silicon-strip detector technology. A complete instrument concept based on this technology for the pair-conversion tracker and the use of CsI(T1) crystals for the calorimeter is now the baseline instrument concept for the Gamma-ray Large Area Space Telescope (GLAST) mission. GLAST is NASA's proposed high-energy gamma-ray mission designed to operate in the energy range from 10 MeV to approximately 300 GeV. GLAST, with nearly 100 times the sensitivity of EGRET, operates through pair conversion of gamma-rays and measurement of the direction and energy of the resulting e (+) - e (-) shower. The baseline design, developed with support from NASA includes a charged particle anticoincidence shield, a tracker/converter made of thin sheets of high-Z material interspersed with Si strip detectors, a CsI calorimeter and a programmable data trigger and acquisition system. The telescope is assembled as an array of modules or towers. Each tower contains elements of the tracker, calorimeter, and anticoincidence system. As originally proposed, the telescope design had 49 modules. In the more optimized design that emerged at the end of the grant period the individual modules are larger and the total number in the GLAST array is 25. Also the calorimeter design was advanced substantially to the point that it has a self-contained imaging capability, albeit much cruder than the tracker.

Michelson, Peter F.↗

Evolution of the Martian hydrosphere

The concept of the hydrological cycle is one of the greatest achievements in the understanding of nature. Leonardo da Vinci seems to have held two concurrent views of the cycle: an external process in which evaporation from ponded areas leads to precipitation and runoff from the land; and an internal process in which subsurface pressures from within the Earth force water upward. Endogenetic hypotheses for valley genesis on Mars maintain the necessary prolonged ground water flows by hydrothermal circulation associated with impact cratering or with volcanism. Ocean formation on Mars was episodic, mostly evidenced by the latest episodes. Coincident cataclysmic flood discharges to the northern plains, probably triggered by Tharsis volcanism, would lead to immense consequences. Potential volumes of ponded water are summarized. The outflow channels have a complex history of flooding events over a prolonged period of planetary history. It is hypothesized that episodic outbursts of concurrent discharge was triggered by planetary scale volcanism. The consequences of such episodes are summarized.

Baker, V.↗

Hidden Statistics Approach to Quantum Simulations

Recent advances in quantum information theory have inspired an explosion of interest in new quantum algorithms for solving hard computational (quantum and non-quantum) problems. The basic principle of quantum computation is that the quantum properties can be used to represent structure data, and that quantum mechanisms can be devised and built to perform operations with this data. Three basic non-classical properties of quantum mechanics superposition, entanglement, and direct-product decomposability were main reasons for optimism about capabilities of quantum computers that promised simultaneous processing of large massifs of highly correlated data. Unfortunately, these advantages of quantum mechanics came with a high price. One major problem is keeping the components of the computer in a coherent state, as the slightest interaction with the external world would cause the system to decohere. That is why the hardware implementation of a quantum computer is still unsolved. The basic idea of this work is to create a new kind of dynamical system that would preserve the main three properties of quantum physics superposition, entanglement, and direct-product decomposability while allowing one to measure its state variables using classical methods. In other words, such a system would reinforce the advantages and minimize limitations of both quantum and classical aspects. Based upon a concept of hidden statistics, a new kind of dynamical system for simulation of Schroedinger equation is proposed. The system represents a modified Madelung version of Schroedinger equation. It preserves superposition, entanglement, and direct-product decomposability while allowing one to measure its state variables using classical methods. Such an optimal combination of characteristics is a perfect match for simulating quantum systems. The model includes a transitional component of quantum potential (that has been overlooked in previous treatment of the Madelung equation). The role of the transitional potential is to provide a jump from a deterministic state to a random state with prescribed probability density. This jump is triggered by blowup instability due to violation of Lipschitz condition generated by the quantum potential. As a result, the dynamics attains quantum properties on a classical scale. The model can be implemented physically as an analog VLSI-based (very-large-scale integration-based) computer, or numerically on a digital computer. This work opens a way of developing fundamentally new algorithms for quantum simulations of exponentially complex problems that expand NASA capabilities in conducting space activities. It has been illustrated that the complexity of simulations of particle interaction can be reduced from an exponential one to a polynomial one.

Zak, Michail↗

A Safe Haven Concept for the Common Habitat in Moon, Mars, and Transit Environments

The safe haven for the Common Habitat architectures, both the Deep Space Exploration Vehicle and the Moon/Mars surface basecamps, consists of the airlock, logistics modules, and in-space or surface pressurized rovers. These elements are repositioned to dock together and form a secondary habitable environment. The multiple elements that compose the safe haven and its ability to share utilities across docking ports give it multiple subsystem options to sustain the crew. In the safe haven configuration, the two logistics modules dock to the side hatches of the airlock outer chamber, one pressurized rover docks to the outermost airlock hatch, and the second pressurized rover docks to the first. This configuration provides no less than thirty days of habitation for the eight-person crew. It also allows the airlock inner chamber to be used for EVAs to both the exterior surface and the Common Habitat interior, which may have lost pressure during the event that triggered the need for a safe haven. These EVAs enable the crew to work to repair the habitat and restore habitation capability.

Base camp↗

Technology Transfer: Marketing Tomorrow's Technology

The globalization of the economy and the end of the Cold War have triggered many changes in the traditional practices of U.S. industry. To effectively apply the resources available to the United States, the federal government has firmly advocated a policy of technology transfer between private industry and government labs, in this case the National Aeronautics and Space Administration (NASA). NASA Administrator Daniel Goldin is a strong proponent of this policy and has organized technology transfer or commercialization programs at each of the NASA field centers. Here at Langley Research Center, the Technology Applications Group (TAG) is responsible for facilitating the transfer of Langley developed research and technology to U.S. industry. Entering the program, I had many objectives for my summer research with TAG. Certainly, I wanted to gain a more thorough understanding of the concept of technology transfer and Langley's implementation of a system to promote it to both the Langley community and the community at large. Also, I hoped to become more familiar with Langley's research capabilities and technology inventory available to the public. More specifically, I wanted to learn about the technology transfer process at Langley. Because my mentor is a member of Materials and Manufacturing marketing sector of the Technology Transfer Team, another overriding objective for my research was to take advantage of his work and experience in materials research to learn about the Advanced Materials Research agency wide and help market these developments to private industry. Through the various projects I have been assigned to work on in TAG, I have successfully satisfied the majority of these objectives. Work on the Problem Statement Process for TAG as well as the development of the Advanced Materials Research Brochure have provided me with the opportunity to learn about the technology transfer process from the outside looking in and the inside looking out. Because TAG covers all of the research efforts conducted at Langley, my studies with TAG were ab!e to provide me an excellent overview of Langley's contribution to the aeronautics industry.

Tcheng, Erene↗

Mixture-Tuned, Clutter Matched Filter for Remote Detection of Subpixel Spectral Signals

Mapping localized spectral features in large images demands sensitive and robust detection algorithms. Two aspects of large images that can harm matched-filter detection performance are addressed simultaneously. First, multimodal backgrounds may thwart the typical Gaussian model. Second, outlier features can trigger false detections from large projections onto the target vector. Two state-of-the-art approaches are combined that independently address outlier false positives and multimodal backgrounds. The background clustering models multimodal backgrounds, and the mixture tuned matched filter (MT-MF) addresses outliers. Combining the two methods captures significant additional performance benefits. The resulting mixture tuned clutter matched filter (MT-CMF) shows effective performance on simulated and airborne datasets. The classical MNF transform was applied, followed by k-means clustering. Then, each cluster s mean, covariance, and the corresponding eigenvalues were estimated. This yields a cluster-specific matched filter estimate as well as a cluster- specific feasibility score to flag outlier false positives. The technology described is a proof of concept that may be employed in future target detection and mapping applications for remote imaging spectrometers. It is of most direct relevance to JPL proposals for airborne and orbital hyperspectral instruments. Applications include subpixel target detection in hyperspectral scenes for military surveillance. Earth science applications include mineralogical mapping, species discrimination for ecosystem health monitoring, and land use classification.

Thompson, David R.↗

Integration of a MicroCAT Propulsion System and a PhoneSat Bus into a 1.5U CubeSat

NASA Ames Research Center and the George Washington University have developed an electric propulsion subsystem that can be integrated into the PhoneSat bus. Experimental tests have shown a reliable performance by firing three different thrusters at various frequencies in vacuum conditions. The three thrusters were controlled by a SmartPhone that was running the PhoneSat software. The subsystem is fully operational and it requires low average power to function (about 0.1 W). The interface consists of a microcontroller that sends a trigger pulses to the PPU (Plasma Processing Unit), which is responsible for the thruster operation. Frequencies ranging from 1 to 50Hz have been tested, showing a strong flexibility. A SmartPhone acts as the main user interface for the selection of commands that control the entire system. The micro cathode arc thruster MicroCAT provides a high 1(sub sp) of 3000s that allows a 4kg satellite to obtain a (delta)V of 300m/s. The system mass is only 200g with a total of volume of 200(cu cm). The propellant is based on a solid cylinder made of Titanium, which is the cathode at the same time. This simplicity in the design avoids miniaturization and manufacturing problems. The characteristics of this thruster allow an array of MicroCATs to perform attitude control and orbital correcton maneuvers that will open the door for the implementation of an extensive collection of new mission concepts and space applications for CubeSats. NASA Ames is currently working on the integration of the system to fit the thrusters and PPU inside a 1.5U CubeSat together with the PhoneSat bus into a 1.5U CubeSat. This satellite is intended to be deployed from the ISS in 2015 and test the functionality of the thrusters by spinning the satellite around its long axis and measure the rotational speed with the phone byros. This test flight will raise the TRL of the propulsion system from 5 to 7 and will be a first test for further CubeSats with propulsion systems, a key subsystem for long duration or interplanetary CubeSat missions.

PhoneSat↗

Identifying Common Use Cases across Extensible Traffic Management (xTM) for Interactions with Air Traffic Controllers

NASA’s Extensible Traffic Management (xTM) builds on the foundation and the architecture of Unmanned Aircraft Systems (UAS) Traffic Management (UTM) concept and extends it broadly to other domains, such as Advanced / Urban Air Mobility (AAM/UAM) and Upper Class E Traffic Management (ETM). These xTM concepts assume the ability to fly in airspace that is authorized to operate solely under xTM services and mostly without any air traffic control (ATC) support. However, they also assume circumstances in which the xTM vehicles would need to operate in conventional ATC-managed airspace, both during nominal and off-nominal scenarios. Due to the vast differences in the xTM vehicle performances and missions, there is a concern that ATC may have difficulty in safely managing the xTM traffic and providing appropriate services to all vehicles, unless a consistent set of roles, procedures, and data exchange requirements are defined across the diverse set of xTM vehicle operations. In this paper, we describe a set of use cases that have been identified in UTM, AAM/UAM, and ETM operations that are related to ATC interactions, and we propose to categorize these use cases across xTM domains based on common trigger events. Organizing the use cases from the perspective of ATC roles per each trigger event is expected to provide the first step in discovering common procedures and data requirements across xTM domains that could help ease the controllers’ cognitive task load and allow them to manage these interactions more safely.

Extensible Traffic Management (xTM)↗

STROBE-X: X-Ray Timing Spectroscopy on Dynamical Timescales from Microseconds to Years

We describe a probe-class mission concept that provides an unprecedented view of the X-ray sky, performing timing and 0.2-30 keV spectroscopy over timescales from microseconds to years. The Spectroscopic Time-Resolving Observatory for Broadband Energy X-rays (STROBE-X) comprises three primary instruments. The first uses an array of lightweight optics (3-m focal length) that concentrate incident photons onto solid state detectors with CCD-level (85-130 eV) energy resolution, 100 ns time resolution, and low background rates to cover the 0.2-12 keV band. This technology is scaled up from NICER, with enhanced optics to take advantage of the longer focal length of STROBE-X. The second uses large-area collimated silicon drift detectors, developed for ESA's LOFT, to cover the 2-30 keV band. These two instruments each provide an order of magnitude improvement in effective area compared with its predecessor (NICER and RXTE, respectively). Finally, a sensitive sky monitor triggers pointed observations, provides high duty cycle, high time resolution, high spectral resolution monitoring of the X-ray sky with approx. 20 times the sensitivity of the RXTE ASM, and enables multi-wavelength and multi-messenger studies on a continuous, rather than scanning basis.For the first time, the broad coverage provides simultaneous study of thermal components, non-thermal components, iron lines, and reflection features from a single platform for accreting black holes at all scales. The enormous collecting area allows detailed studies of the dense matter equation of state using both thermal emission from rotation-powered pulsars and harder emission from X-ray burst oscillations. The combination of the wide-field monitor and the sensitive pointed instruments enables observations of potential electromagnetic counterparts to LIGO and neutrino events. Additional extragalactic science, such as high quality spectroscopy of clusters of galaxies and unprecedented timing investigations of active galactic nuclei, is also obtained.

STROBE-X X-ray↗

The LOFT Mission Concept - A Status Update

The Large Observatory For x-ray Timing (LOFT) is a mission concept which was proposed to ESA as M3 and M4 candidate in the framework of the Cosmic Vision 2015-2025 program. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument and the uniquely large field of view of its wide field monitor, LOFT will be able to study the behaviour of matter in extreme conditions such as the strong gravitational field in the innermost regions close to black holes and neutron stars and the supra-nuclear densities in the interiors of neutron stars. The science payload is based on a Large Area Detector (LAD, is greater than 8m2 effective area, 2-30 keV, 240 eV spectral resolution, 1 degree collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g., GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the current technical and programmatic status of the mission.

Silicon detectors↗

STROBE-X: X-ray Timing & Spectroscopy on Dynamical Timescales from Milliseconds to Years

We describe a probe-class mission concept that provides an unprecedented view of the X-ray sky, performing timing and 0.2-30 keV spectroscopy over timescales from microseconds to years. The Spectroscopic Time-Resolving Observatory for Broadband Energy X-rays (STROBE-X) comprises three primary instruments. The first uses an array of lightweight optics (3-m focal length) that concentrate incident photons onto solid state detectors with CCD-level (85-130 eV) energy resolution, 100 ns time resolution, and low background rates to cover the 0.2-12 keV band. This technology is scaled up from NICER [1], with enhanced optics to take advantage of the longer focal length of STROBE-X. The second uses large-area collimated silicon drift detectors, developed for ESA's LOFT [2], to cover the 2-30 keV band. These two instruments each provide an order of magnitude improvement in effective area compared with its predecessor (NICER and RXTE, respectively). Finally, a sensitive sky monitor triggers pointed observations, provides high duty cycle, high time resolution, high spectral resolution monitoring of the X-ray sky with approx. 20 times the sensitivity of the RXTE ASM, and enables multi-wavelength and multi-messenger studies on a continuous, rather than scanning basis. For the first time, the broad coverage provides simultaneous study of thermal components, non-thermal components, iron lines, and reflection features from a single platform for accreting black holes at all scales. The enormous collecting area allows detailed studies of the dense matter equation of state using both thermal emission from rotation-powered pulsars and harder emission from X-ray burst oscillations. The combination of the wide-field monitor and the sensitive pointed instruments enables observations of potential electromagnetic counterparts to LIGO and neutrino events. Additional extragalactic science, such as high quality spectroscopy of clusters of galaxies and unprecedented timing investigations of active galactic nuclei, is also obtained

STROBE-↗

Systemic Risk From the Perspective of Climate, Environmental and Disaster Risk Science and Practice

Understanding and managing systemic risk is more important than ever due to our immense global connectivity (e.g., between sectors, such as food-health-water-energy, countries and continents, down to individuals). Despite the fact that the notion of systemic risk is several decades old, the term is used in diverse ways across different disciplines (e.g., financial systems, medicine, earth system sciences, disaster risk research and climate science). Triggered by the repercussions of the global financial crisis of the late 2000s, and more recently the COVID-19 pandemic, which are clear realization of systemic risk, the perception of systemic risk has often been focused on global and catastrophic or even existential risks. Systemic risk, however, can be seen as a feature of systems at all possible scales (e.g., global, national, regional, local) with system boundaries varying depending on the context. Addressing current societal challenges, such as climate change, in terms of systemic risk requires integrating different systems perspectives and fostering system thinking, while implementing key intergovernmental agendas, such as the Paris Agreement, the Sendai Framework for Disaster Risk Reduction and the Sustainable Development Goals. Based on insights gained and knowledge collected from an expert workshop, literature review and expert elicitation, we give an integrated perspective of climate, environmental and disaster risk science and practice on systemic risk as summarized in a Briefing Note to the International Science Council. We provide an overview of concepts of systemic risk that have evolved over time and identify commonalities across terminologies and perspectives associated with systemic risk used in different contexts. Key attributes of systemic risk are outlined without prescribing a single definition, and information and data requirements are discussed that are essential for a better and more actionable understanding of the systemic nature of risk. Finally, the opportunities to connect research and policy for addressing systemic risk are highlighted.

systemic risk↗

Onboard Science and Applications Algorithm for Hyperspectral Data Reduction

An onboard processing mission concept is under development for a possible Direct Broadcast capability for the HyspIRI mission, a Hyperspectral remote sensing mission under consideration for launch in the next decade. The concept would intelligently spectrally and spatially subsample the data as well as generate science products onboard to enable return of key rapid response science and applications information despite limited downlink bandwidth. This rapid data delivery concept focuses on wildfires and volcanoes as primary applications, but also has applications to vegetation, coastal flooding, dust, and snow/ice applications. Operationally, the HyspIRI team would define a set of spatial regions of interest where specific algorithms would be executed. For example, known coastal areas would have certain products or bands downlinked, ocean areas might have other bands downlinked, and during fire seasons other areas would be processed for active fire detections. Ground operations would automatically generate the mission plans specifying the highest priority tasks executable within onboard computation, setup, and data downlink constraints. The spectral bands of the TIR (thermal infrared) instrument can accurately detect the thermal signature of fires and send down alerts, as well as the thermal and VSWIR (visible to short-wave infrared) data corresponding to the active fires. Active volcanism also produces a distinctive thermal signature that can be detected onboard to enable spatial subsampling. Onboard algorithms and ground-based algorithms suitable for onboard deployment are mature. On HyspIRI, the algorithm would perform a table-driven temperature inversion from several spectral TIR bands, and then trigger downlink of the entire spectrum for each of the hot pixels identified. Ocean and coastal applications include sea surface temperature (using a small spectral subset of TIR data, but requiring considerable ancillary data), and ocean color applications to track biological activity such as harmful algal blooms. Measuring surface water extent to track flooding is another rapid response product leveraging VSWIR spectral information.

Chien, Steve A.↗

The Central Nervous Connections Involved in the Vomiting Reflex

The vomiting reflex may be elicited by a number of different types or classes of stimuli involving many varieties of receptor structures and considerable diversity in afferent pathways and central connections. Central relay or mediating structures thus may vary widely according to the type of initial emetic stimulus. The emetic circuits which have been most completely delineated to date are probably those in which the Chemoreceptor Trigger Zone (CTZ) in the Area Postrema (AP) functions as a key mediating structure. Even in this system, however, there are large gaps in our knowledge of the nerve tracts and central nervous connections involved. Knowledge of most other emetic circuits subserving the emetic reflex resulting from many diverse types of stimuli such, for example, as emotional stress (e.g. psychogenic vomiting, Wruble et al. 1982), pain (e.g. testicular trauma), and chemical or mechanical irritation of the gastrointestinal tract or urinary tract is quite incomplete at this time, thus precluding any very adequate description of their central connections at present. One physiological system, however, which has received considerable attention recently in relation to the vomiting reflex elicited by motion stimuli is the vestibular system. Due to the paucity of data on central nervous connections of several or the non-vestibular types of emetic stimuli cited above, we will devote most of our attention in this brief review to the central connections of the vestibular system which seem likely to be involved in the vomiting response to motion stimuli. However, the latter part of the review will be concerned with the concept of the reticular vomiting centre in relation to the ParviCellular Reticular Formation (PCRF), and will thus probably pertain to all of the many classes of emetic stimuli since it will address the question of the final common emetic pathway.

Brizzee, K. R.↗

Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity

Physical inactivity and unloading lead to diverse skeletal muscle alterations. Our goal was to identify the genes in skeletal muscle whose expression is most sensitive to periods of unloading/reduced physical activity and that may be involved in triggering initial responses before phenotypic changes are evident. The ability of short periods of physical activity/loading as an effective countermeasure against changes in gene expression mediated by inactivity was also tested. Affymetrix microarrays were used to compare mRNA levels in the soleus muscle under three experimental treatments (n = 20-29 rats each): 12-h hindlimb unloading (HU), 12-h HU followed by 4 h of intermittent low-intensity ambulatory and postural activity (4-h reloading), and control (with ambulatory and postural activity). Using a combination of criteria, we identified a small set of genes (approximately 1% of 8,738 genes on the array or 4% of significant expressed genes) with the most reproducible and largest responses to altered activity. Analysis revealed a coordinated regulation of transcription for a large number of key signaling proteins and transcription factors involved in protein synthesis/degradation and energy metabolism. Most (21 of 25) of the gene expression changes that were downregulated during HU returned at least to control levels during the reloading. In surprising contrast, 27 of 38 of the genes upregulated during HU remained significantly above control, but most showed trends toward reversal. This introduces a new concept that, in general, genes that are upregulated during unloading/inactivity will be more resistant to periodic reloading than those genes that are downregulated. This study reveals genes that are the most sensitive to loading/activity in rat skeletal muscle and indicates new targets that may initiate muscle alterations during inactivity.

NASA Discipline Musculoskeletal↗

A new communication protocol family for a distributed spacecraft control system

In this paper we describe the concepts behind and architecture of a communication protocol family, which was designed to fulfill the communication requirements of ESOC's new distributed spacecraft control system SCOS 2. A distributed spacecraft control system needs a data delivery subsystem to be used for telemetry (TLM) distribution, telecommand (TLC) dispatch and inter-application communication, characterized by the following properties: reliability, so that any operational workstation is guaranteed to receive the data it needs to accomplish its role; efficiency, so that the telemetry distribution, even for missions with high telemetry rates, does not cause a degradation of the overall control system performance; scalability, so that the network is not the bottleneck both in terms of bandwidth and reconfiguration; flexibility, so that it can be efficiently used in many different situations. The new protocol family which satisfies the above requirements is built on top of widely used communication protocols (UDP and TCP), provides reliable point-to-point and broadcast communication (UDP+) and is implemented in C++. Reliability is achieved using a retransmission mechanism based on a sequence numbering scheme. Such a scheme allows to have cost-effective performances compared to the traditional protocols, because retransmission is only triggered by applications which explicitly need reliability. This flexibility enables applications with different profiles to take advantage of the available protocols, so that the best rate between sped and reliability can be achieved case by case.

Baldi, Andrea↗