Respiration of the brain at raised intracranial pressure
Cerebral respiration and hypoxia at reduced blood circulation
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Cerebral respiration and hypoxia at reduced blood circulation
Mouth respiration efficiency during physical work of athletes
Prolonged bed rest effects on human respiration in physical work
Digital analysis on external respiration data for humans
Tissue respiration measurement with membrane- covered oxygen electrode, discussing effects of electrode deterioration and diffusion artifacts on accuracy
Respiration analyzing method and apparatus for determining subjects oxygen consumption in aerospace environments
Effects of positive Gy acceleration on blood oxygen saturation and pleural pressure relations in dogs breathing air and liquid fluorocarbons in whole body water immersion respirator
Studies of pressure and temperature effects on glutamic acid transport and utilization indicated that hydrostatic pressure and low temperature inhibit glutamate transport more than glutamate respiration. The effects of pressure on transport were reduced at temperatures near the optimum. Similar results were obtained for glycine, phenylalanine, and proline. Pressure effects on the transport systems of all four amino acids were reversible to some degree. Both proline and glutamic acid were able to protect their transport proteins against pressure damage. The data presented indicate that the uptake of amino acids by cells under pressure is inhibited, which is the cause of their inability to grow under pressure.
As part of the operational biomedical monitoring for Apollo manned missions, ECG and respiration rate are telemetered at selected intervals to mission control. The data were collected as part of this monitoring program. These data were evaluated for circadian and ultradian rhythmicity because of their uniqueness. The ability to detect and quantitate biorhythms in living systems during space flight is an important aspect of evaluating hypotheses concerning the underlying mechanisms of these phenomena. Circadian variation in heart rate during space flight is demonstrated here. In analyzing generated time series data it has been found that period discrimination is much better than the theoretical limit.
Changes in the physiological indices of respiration, respiratory metabolism and energy consumption in spacecrews under weightlessness conditions manifest themselves in increased metabolic rates, higher pulmonary ventilation volume, oxygen consumption and carbon dioxide elimination, energy consumption levels in proportion to reduction in neuroemotional and psychic stress, adaptation to weightlessness and work-rest cycles, and finally in a relative stabilization of metabolic processes due to hemodynamic shifts.
The feasibility of monitoring atmospheric aerosols in the respirable range from air or space platforms was studied. Secondary reflectance targets were located in the industrial area and near Galveston Bay. Multichannel remote sensor data were utilized to calculate the aerosol extinction coefficient and thus determine the aerosol size distribution. Houston Texas air sampling network high volume data were utilized to generate computer isopleth maps of suspended particulates and to establish the mass loading of the atmosphere. In addition, a five channel nephelometer and a multistage particulate air sampler were used to collect data. The extinction coefficient determined from remote sensor data proved more representative of wide areal phenomena than that calculated from on site measurements. It was also demonstrated that a significant reduction in the standard deviation of the extinction coefficient could be achieved by reducing the bandwidths used in remote sensor.
The results of an experiment which studied changes in oxygen balance under conditions of hypokinesia in rats is presented. The effect of the stress during hypokinesia is expressed most clearly in the changes of general gas exchange, and in the intensity of liver and myocardial tissue respiration.
Total plankton respiration (TPR) was measured at 17 stations within the Chesapeake Bay plume off the Virginia coast during March, June, and October 1980. Elevated rates of TPR, as well as higher concentrations of chlorophyll a and phaeopigment a, were found to be associated with the Bay plume during each survey. The TPR rates within the Bay plume were close to those found associated with the Hudson River plume for comparable times of the year. The data examined indicate that the Chesapeake Bay plume stimulates biological activity and is a source of organic loading to the contiguous shelf ecosystem.
The growth of wheat (triticum aestivum) was studied in an enclosed controlled environment for a period of 70 days. The exchange of gases (photosynthesis, respiration), water (transpiration) and the consumption of mineral elements (nitrogen, phosphorus, potassium) were continuously measured. The dynamical relations observed in the different physiological functions, under the influence of growth and in response to environment modifications are presented. The influence of carbon dioxide content during growth (normal or double percentage) was made clear.
To determine how increased atmospheric CO2 will affect the physiology of cottonwood trees, cuttings of the cloned Populus deltodies [cottonwood] were grown in open-top chambers containing ambient or elevated CO2 concentration. The control treatment was maintained at ambient Biosphere 2 atmospheric CO2 (c. 450 +/- 50 micro l/l), and elevated CO2 treatment was maintained at approximately double ambient Biosphere 2 atmospheric CO2 (c. 1000 +/- 50 micro l/l). The effects of elevated CO2 on leaf photosynthesis, and stomatal conductance were measured. The cottonwoods exposed to CO2 enrichment showed no significant indication of photosynthetic down-regulation. There was no significant difference in the maximum assimilation rate between the treatment and the control (P less than 0.24). The CO2 enriched treatment showed a decreased stomatal conductance of 15% (P less than 0.03). The elevated CO2 concentrated atmosphere had an effect on the respiration rates of the plants; the compensation point of the treatment was on average 13% higher than the control (P less than 0.01).
Sleep disruption and associated waking sleepiness and fatigue are common during space flight. A survey of 58 crew members from nine space shuttle missions revealed that most suffered from sleep disruption, and reportedly slept an average of only 6.1 hours per day of flight as compared to an average of 7.9 hours per day on the ground. Nineteen percent of crewmembers on single shift missions and 50 percent of the crewmembers in dual shift operations reported sleeping pill usage (benzodiazepines) during their missions. Benzodiazepines are effective as hypnotics, however, not without adverse side effects including carryover sedation and performance impairment, anterograde amnesia, and alterations in sleep EEG. Our preliminary ground-based data suggest that pre-sleep administration of 0.3 mg of the pineal hormone melatonin may have the acute hypnotic properties needed for treating the sleep disruption of space flight without producing the adverse side effects associated with benzodiazepines. We hypothesize that pre-sleep administration of melatonin will result in decreased sleep latency, reduced nocturnal sleep disruption, improved sleep efficiency, and enhanced next-day alertness and cognitive performance both in ground-based simulations and during the space shuttle missions. Specifically, we have carried out experiments in which: (1) ambient light intensity aboard the space shuttle is assessed during flight; (2) the impact of space flight on sleep (assessed polysomnographically and actigraphically), respiration during sleep, circadian temperature and melatonin rhythms, waking neurobehavioral alertness and performance is assessed in crew members of the Neurolab and STS-95 missions; (3) the effectiveness of melatonin as a hypnotic is assessed independently of its effects on the phase of the endogenous circadian pacemaker in ground-based studies, using a powerful experimental model of the dyssomnia of space flight; (4) the effectiveness of melatonin as a hypnotic is assessed during the STS-90 (Neurolab) and STS-95 missions in a double-blind placebo-controlled trial. In both flight-based experiments, the effects of melatonin on sleep stages and spectral composition of the EEG during sleep will be determined as well as its effects on daytime alertness and performance; (5) the impact of space flight on sleep and waking neurobehavioral alertness and performance in 30-45-year-old astronauts is compared with its impact in a 77-year-old astronaut. This case study is the first to assess the effects of space flight on an older individual. Because the investigators are still blind to the treatment in this double-blind, placebo-controlled trial, preliminary results will be presented independent of the drug condition.
Frequency-domain analyses of R-R intervals are used widely to estimate levels of autonomic neural traffic to the human heart. Because respiration modulates autonomic activity, we determined for nine healthy subjects the influence of breathing frequency and tidal volume on R-R interval power spectra (fast-Fourier transform method). We also surveyed published literature to determine current practices in this burgeoning field of scientific inquiry. Supine subjects breathed at rates of 6, 7.5, 10, 15, 17.1, 20, and 24 breaths/min and with nominal tidal volumes of 1,000 and 1,500 ml. R-R interval power at respiratory and low (0.06-0.14 Hz) frequencies declined significantly as breathing frequency increased. R-R interval power at respiratory frequencies was significantly greater at a tidal volume of 1,500 than 1,000 ml. Neither breathing frequency nor tidal volume influenced average R-R intervals significantly. Our review of studies reporting human R-R interval power spectra showed that 51% of the studies controlled respiratory rate, 11% controlled tidal volume, and 11% controlled both respiratory rate and tidal volume. The major implications of our analyses are that breathing parameters strongly influence low-frequency as well as respiratory frequency R-R interval power spectra and that this influence is largely ignored in published research.
This paper evaluates simulations of atmospheric CO2 measured in 2004 at continental surface and airborne receptors, intended to test the capability to use data with high temporal and spatial resolution for analyses of carbon sources and sinks at regional and continental scales. The simulations were performed using the Stochastic Time-Inverted Lagrangian Transport (STILT) model driven by the Weather Forecast and Research (WRF) model, and linked to surface fluxes from the satellite-driven Vegetation Photosynthesis and Respiration Model (VPRM). The simulations provide detailed representations of hourly CO2 tower data and reproduce the shapes of airborne vertical profiles with high fidelity. WRF meteorology gives superior model performance compared with standard meteorological products, and the impact of including WRF convective mass fluxes in the STILT trajectory calculations is significant in individual cases. Important biases in the simulation are associated with the nighttime CO2 build-up and subsequent morning transition to convective conditions, and with errors in the advected lateral boundary condition. Comparison of STILT simulations driven by the WRF model against those driven by the Brazilian variant of the Regional Atmospheric Modeling System (BRAMS) shows that model-to-model differences are smaller than between an individual transport model and observations, pointing to systematic errors in the simulated transport. Future developments in the WRF model s data assimilation capabilities, basic research into the fundamental aspects of trajectory calculations, and intercomparison studies involving other transport models, are possible venues for reducing these errors. Overall, the STILT/WRF/VPRM offers a powerful tool for continental and regional scale carbon flux estimates.