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At least 109 records · Page 6

PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Influenza A Virus Infection, Processed Experimental Dataset Catalog

Influenza A virus (IAV) is a high risk biological agent, classified as a Category C priority pathogen (Orthomyxoviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), and is known to cause severe respiratory disease with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus [NCBITAXON:11320] experimental infection study. Host sample types include human lung adenocarcinoma cells ["Calu-3", BTO:0002750] and whole mouse lung [BTO:0000763] tissue collections.

59 BASIC BIOLOGICAL SCIENCES↗

AAFE man-made noise experiment project. Volume 2: Project and experiment discussions

An experiment for the acquisition and processing of man-made noise interference data on earth orbital altitudes is discussed. The objectives of the project are to confirm the results of analytical studies concerning radio frequency man-made noise in space. It is stated that the measurements of the amounts and types of noise in frequency bands of interest could allow the allocation and utilization of frequencies to be optimized and would also contribute to the engineering objective of optimizing flight receiving systems. A second objective of the project was to design and fabricate a noise measuring receiver which would demonstrate the feasibility of the experiment design under the project. The procedures for acquiring and processing the electromagnetic radiation data are discussed.

Source record↗

Tracking and data systems support for the Helios project. Volume 1: Project development through end of mission, phase 2

The overall evolution of the Helios Project is summarized from its conception through to the completion of the Helios-1 mission phase 2. Beginning with the project objectives and concluding with the Helios-1 spacecraft entering its first superior conjunction (end of mission phase 2), descriptions of the project, the mission and its phases, international management and interfaces, and Deep Space Network-spacecraft engineering development in telemetry, tracking, and command systems to ensure compatibility between the U.S. Deep Space Network and the German-built spacecraft are included.

Goodwin, P. S.↗

ART/Ada design project, phase 1: Project plan

The plan and schedule for Phase 1 of the Ada based ESBT Design Research Project is described. The main platform for the project is a DEC Ada compiler on VAX mini-computers and VAXstations running the Virtual Memory System (VMS) operating system. The Ada effort and lines of code are given in tabular form. A chart is given of the entire project life cycle.

Allen, Bradley P.↗

NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 15: Technical uncertainty and project complexity as correlates of information use by US industry-affiliated aerospace engineers and scientists: Results of an exploratory investigation

An exploratory study was conducted that investigated the influence of technical uncertainty and project complexity on information use by U.S. industry-affiliated aerospace engineers and scientists. The study utilized survey research in the form of a self-administered mail questionnaire. U.S. aerospace engineers and scientists on the Society of Automotive Engineers (SAE) mailing list served as the study population. The adjusted response rate was 67 percent. The survey instrument is appendix C to this report. Statistically significant relationships were found to exist between technical uncertainty, project complexity, and information use. Statistically significant relationships were found to exist between technical uncertainty, project complexity, and the use of federally funded aerospace R&D. The results of this investigation are relevant to researchers investigating information-seeking behavior of aerospace engineers. They are also relevant to R&D managers and policy planners concerned with transferring the results of federally funded aerospace R&D to the U.S. aerospace industry.

Pinelli, Thomas E.↗

Issues in NASA Program and Project Management. Special Report: 1997 Conference. Project Management Now and in the New Millennium

Topics Considered Include: NASA's Shared Experiences Program; Core Issues for the Future of the Agency; National Space Policy Strategic Management; ISO 9000 and NASA; New Acquisition Initiatives; Full Cost Initiative; PM Career Development; PM Project Database; NASA Fast Track Studies; Fast Track Projects; Earned Value Concept; Value-Added Metrics; Saturn Corporation Lessons Learned; Project Manager Credibility.

Hoffman, Edward J.↗

Exercise Countermeasures Demonstration Project During the Lunar-Mars Life Support Test Project Phase 2A

This demonstration project assessed the crew members' compliance to a portion of the exercise countermeasures planned for use onboard the International Space Station (ISS) and the outcomes of their performing these countermeasures. Although these countermeasures have been used separately in other projects and investigations, this was the first time they'd been used together for an extended period (60 days) in an investigation of this nature. Crew members exercised every day for six days, alternating every other day between aerobic and resistive exercise, and rested on the seventh day. On the aerobic exercise days, subjects exercised on an electronically braked cycle ergometer using a protocol that has been previously shown to maintain aerobic capacity in subjects exposed to a space flight analogue. On the resistive exercise days, crew members performed five major multijoint resistive exercises in a concentric mode, targeting those muscle groups and bones we believe are most severely affected by space flight. The subjects favorably tolerated both exercise protocols, with a 98% compliance to aerobic exercise prescription and a 91% adherence to the resistive exercise protocol. After 60 days, the crew members improved their peak aerobic capacity by an average 7%, and strength gains were noted in all subjects. These results suggest that these exercise protocols can be performed during ISS, lunar, and Mars missions, although we anticipate more frequent bouts with both protocols for long-duration spaceflight. Future projects should investigate the impact of increased exercise duration and frequency on subject compliance, and the efficacy of such exercise prescriptions.

Lee, Stuart M. C.↗

Overcoming the barriers to implementation of decommissioning and environmental remediation projects, the CIDER project - 15160

Much remains to be done in terms of addressing the legacies from the early development of nuclear energy, including the dismantling of redundant research and fuel cycle facilities, research reactors, and power plants, and the remediation of sites affected by past uranium mining and processing operations. Long-term solutions still need to be found for management of the resulting waste, including development of disposal facilities that meet public acceptance and safety requirements. Some countries are moving forward with dealing with these legacies, and accordingly have built up appropriate technical resources and expertise, but many national programmes still face very significant challenges. Many are the factors that constrain progress in addressing past legacies. It is recognized the importance of early implementation of decommissioning and environmental remediation (D and ER) programmes in order to safeguard people and the environment from the undesirable effects of ionizing radiation and other hazards associated with these sites. There is also an urgent need to better understand the global status of these activities and to establish mechanisms to analyze and report the barriers impeding the implementation of D and ER programmes, with the aim of outlining actions that may improve the current situation. The IAEA has thus launched the CIDER Project (Constraints to Implementing Decommissioning and Environmental Remediation) with the broad aim of contributing to improve current levels of performance on D and ER programmes through promoting greater cooperation amongst its Member States and relevant international organizations. This paper provides early results from the first phase of the project. During this phase, a survey on the global situation of D and ER was undertaken in order to better understand why these programmes proceed faster in some countries than in others; to identify major constraining factors that affect the implementation of D and ER programmes and how these impediments might be overcome. The paper aims to address policy-level issues, regulatory aspects, technological aspects, and stakeholder involvement in the decision-making process. In the next phase of the project it is intended that specific actions and/or innovative approaches will be proposed at international, regional, or national levels with the goal of facilitating progress in programme implementation. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

The Mini-CAPTAIN liquid argon time projection chamber

This manuscript describes the commissioning of the Mini-CAPTAIN liquid argon detector in a neutron beam at the Los Alamos Neutron Science Center (LANSCE), which led to a first measurement of high-energy neutron interactions in argon. The Mini-CAPTAIN detector consists of a Time Projection Chamber (TPC) with an accompanying photomultiplier tube (PMT) array sealed inside a liquid-argon-filled cryostat. The liquid argon is constantly purified and recirculated in a closed-loop cycle during operation. The specifications and assembly of the detector subsystems and an overview of their performance in a neutron beam are reported.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Gaseous time projection chambers for rare event detection: results from the T-REX project. II. Dark matter

As part of the T-REX project, a number of R and D and prototyping activities have been carried out during the last years to explore the applicability of gaseous Time Projection Chambers (TPCs) with Micromesh Gas Structures (Micromegas) in rare event searches like double beta decay, axion research and low-mass WIMP searches. While in the companion paper we focus on double beta decay, in this paper we focus on the results regarding the search for dark matter candidates, both axions and WIMPs. Small (few cm wide) ultra-low background Micromegas detectors are used to image the axion-induced x-ray signal expected in axion helioscopes like the CERN Axion Solar Telescope (CAST) experiment. Background levels as low as 0.8 × 10{sup −6} counts keV{sup −1} cm{sup −2} s{sup −1} have already been achieved in CAST while values down to ∼10{sup −7} counts keV{sup −1} cm{sup −2} s{sup −1} have been obtained in a test bench placed underground in the Laboratorio Subterráneo de Canfranc (LSC). Prospects to consolidate and further reduce these values down to ∼10{sup −8} counts keV{sup −1} cm{sup −2} s{sup −1} will be described. Such detectors, placed at the focal point of x-ray telescopes in the future International Axion Observatory (IAXO), would allow for 10{sup 5} better signal-to-noise ratio than CAST, and search for solar axions with g{sub a}γ down to few 10{sup 12} GeV{sup −1}, well into unexplored axion parameter space. In addition, a scaled-up version of these TPCs, properly shielded and placed underground, can be competitive in the search for low-mass WIMPs. The TREX-DM prototype, with ∼ 0.300 kg of Ar at 10 bar, or alternatively ∼ 0.160 kg of Ne at 10 bar, and energy threshold well below 1 keV, has been built to test this concept. We will describe the main technical solutions developed, as well as the results from the commissioning phase on surface. The anticipated sensitivity of this technique might reach ∼10{sup −44} cm{sup 2} for low mass (<10 GeV) WIMPs, well beyond current experimental limits in this mass range.

79 ASTRONOMY AND ASTROPHYSICS↗

Project Closeout Report for the MFC Firewater Replacement Project

The Material and Fuels Complex (MFC) Firewater Replacement Project was an indirectly funded Institutional General Plant Project (IGPP) capital acquisition initiated in July 2013 and completed in June 2016. Its purpose was to improve the capacity, redundancy and reliability of the MFC fire water and potable water systems, making them compliant with DOE O 420.1C and applicable state and federal regulations.

99 GENERAL AND MISCELLANEOUS↗

Project - line interaction implementing projects in JPL's Matrix

Can programmatic and line organizations really work interdependently, to accomplish their work as a community? Does the matrix produce a culture in which individuals take personal responsibility for both immediate mission success and long-term growth? What is the secret to making a matrix enterprise actually work? This paper will consider those questions, and propose that developing an effective project-line partnership demands primary attention to personal interactions among people. Many potential problems can be addressed by careful definition of roles, responsibilities, and work processes for both parts of the matrix -- and by deliberate and clear communication between project and line organizations and individuals.

project line partnership↗

Bhutan Water Resources Project Summary - Comparing Precipitation, Temperature, and Phenology Data Trends in Bhutan to Assist the Himalayan Environmental Rhythm Observation and Evaluation System (HEROES) Project

Himalayan countries, including Bhutan, have become vulnerable to warming trends which result in increasing temperature and variable rainfall and snowfall. By combining phenological and meteorological data, Earth observation platforms and sensors were used to assess trends in precipitation, temperature, and vegetation phenology in Bhutan from 1996 through 2017. This project studied precipitation using Climate Hazards Center Infrared Precipitation with Station data, analyzed temperature using the Famine Early Warning System Network Land Data Assimilation System, incorporated elevation data from the Shuttle Radar Topography Mission, and assessed vegetation phenology using Aqua and Terra Moderate Resolution Imaging Spectroradiometer (MODIS) to evaluate climate variability and its effects on Bhutan. In situ temperature and precipitation data were also collected from the Himalayan Environmental Rhythm Observation and Evaluation System (HEROES) project and Bhutan’s National Center for Hydrology and Meterology. Modeled and in situ data showed similar trends in precipitation and temperature for the Thimpu, Chhukha, and Gasa regions. Aqua and Terra MODIS phenology data were variable from year to year. However, the data suggested a late onset of spring green up. Partners at the Bhutan Foundation and locally in Bhutan can use this information to better understand and monitor climate variability and replicate these methods for future analysis.

DEVELOP Project Summary↗

The Two-Column Aerosol Project: Phase I-Overview and impact of elevated aerosol layers on aerosol optical depth

The Two-Column Aerosol Project (TCAP), conducted from June 2012 through June 2013, was a unique study designed to provide a comprehensive data set that can be used to investigate a number of important climate science questions, including those related to aerosol mixing state and aerosol radiative forcing. The study was designed to sample the atmosphere between and within two atmospheric columns; one fixed near the coast of North America (over Cape Cod, MA) and a second moveable column over the Atlantic Ocean several hundred kilometers from the coast. The U.S. Department of Energy's (DOE) Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF) was deployed at the base of the Cape Cod column, and the ARM Aerial Facility was utilized for the summer and winter intensive observation periods. One important finding from TCAP is that four of six nearly cloud-free flight days had aerosol layers aloft in both the Cape Cod and maritime columns that were detected using the nadir pointing second-generation NASA high-spectral resolution lidar (HSRL-2). In addition, these layers contributed up to 60% of the total observed aerosol optical depth (AOD). Many of these layers were also intercepted by the aircraft configured for in situ sampling, and the aerosol in the layers was found to have increased amounts of biomass burning material and nitrate compared to aerosol found near the surface. Lastly, while there was a great deal of spatial and day-to-day variability in the aerosol chemical composition and optical properties, no systematic differences between the two columns were observed.

54 ENVIRONMENTAL SCIENCES↗

Model representations of aerosol layers transported from North America over the Atlantic Ocean during the Two-Column Aerosol Project

The ability of the Weather Research and Forecasting model with chemistry (WRF-Chem) version 3.7 and the Community Atmosphere Model version 5.3 (CAM5) in simulating profiles of aerosol properties is quantified using extensive in situ and remote sensing measurements from the Two Column Aerosol Project (TCAP) conducted during July of 2012. TCAP was supported by the U.S. Department of Energy’s Atmospheric Radiation Measurement program and was designed to obtain observations within two atmospheric columns; one fixed over Cape Cod, Massachusetts and the other several hundred kilometers over the ocean. The performance is quantified using most of the available aircraft and surface measurements during July, and two days are examined in more detail to identify the processes responsible for the observed aerosol layers. The higher resolution WRF-Chem model produced more aerosol mass in the free troposphere than the coarser resolution CAM5 model so that the fraction of aerosol optical thickness above the residual layer from WRF-Chem was more consistent with lidar measurements. We found that the free troposphere layers are likely due to mean vertical motions associated with synoptic-scale convergence that lifts aerosols from the boundary layer. The vertical displacement and the time period associated with upward transport in the troposphere depend on the strength of the synoptic system and whether relatively high boundary layer aerosol concentrations are present where convergence occurs. While a parameterization of subgrid scale convective clouds applied in WRF-Chem modulated the concentrations of aerosols aloft, it did not significantly change the overall altitude and depth of the layers.

Environmental Molecular Sciences Laboratory↗