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At least 109 records · Page 6

Flexure-Ring for Centering a Concave Lens in a Bore of a Housing for an Optical System

A flexure-ring is provided for centering a lens in a bore of a housing with 3N lens contacting stubs, where N is an integer equal to or greater than one. The stubs are formed by increasing the inside diameter of the ring made to fit tightly around a lens except at 3N locations for the aforesaid stubs, and said ring having an outside diameter made to fit tightly inside the housing bore locations. Behind each stub, a segment of the ring is removed down to a chord perpendicular to a ring diameter passing through the center of each stub. That chord is selected to have a length greater than the lens contacting surface of the stub, thereby to produce a reduced cross section of the ring on both sides of the stub to serve as flexures in relieving stresses due to different coefficients of thermal expansion of the three parts involved due to changes in temperature while in use.

Viriginia Gordon Ford↗

OGLE-2012-bLG-0950Lb: the First Planet Mass Measurement From Only Microlens Parallax and Lens Flux

We report the discovery of a microlensing planet OGLE-2012-BLG-0950Lb with a planet/host mass ratio Periapsis Approx. = 2 x10(exp. -4). A long term distortion detected in both MOA and OGLE light curve can be explained by themicrolens parallax due to the Earths orbital motion around the Sun. Although the finite source effect is not detected, we obtain the lens flux by the high resolution Keck AO observation. Combining the microlens parallax and the lens flux reveal the nature of the lens: a planet with mass of M(sub p) = 35(+17/-)M compared to Earth is orbiting around an M-dwarf with mass of M(sub host) = 0.56(+0.12/-0.16) M compared to the Sun with a planet-host projected separation of r1 = 2.7(+0.6/-0.7) au located at Luminosity Distance = 3.0(+0.8/-1.1) kpc from us. This is the first mass measurement from only microlens parallax and the lens flux without the finite source effect. In the coming space observation-era with Spitzer, K2, Euclid, and WFIRST, we expect many such events for which we will not be able to measure any finite source effect. This work demonstrates an ability of mass measurements in such events.

microlens parallax↗

A Telescope at the Solar Gravitational Lens: Problems and Solutions

By Einstein's general theory of relativity, gravity of a massive body deflects light, and thus the sun can be used as a lens. The focus of the sun's gravitational lens is about 550 AU (Astronomical Units). (The sun continues to act as a lens beyond this minimum; at longer distances, the focused light passes increasingly far from the solar limb.) A mission to the gravitational focus of the sun, beyond the edge of the solar system, but far closer than the nearest stars, could be a target for an interstellar precursor. Proposed methods of reaching the focal distance include electric propulsion or laser- or solar sails. An objective for such a mission is to use the gravitational lens to image and map an extrasolar planet.

Landis, Geoffrey A.↗

Growth and differentiation of human lens epithelial cells in vitro on matrix

PURPOSE: To characterize the growth and maturation of nonimmortalized human lens epithelial (HLE) cells grown in vitro. METHODS: HLE cells, established from 18-week prenatal lenses, were maintained on bovine corneal endothelial (BCE) extracellular matrix (ECM) in medium supplemented with basic fibroblast growth factor (FGF-2). The identity, growth, and differentiation of the cultures were characterized by karyotyping, cell morphology, and growth kinetics studies, reverse transcription-polymerase chain reaction (RT-PCR), immunofluorescence, and Western blot analysis. RESULTS: HLE cells had a male, human diploid (2N = 46) karyotype. The population-doubling time of exponentially growing cells was 24 hours. After 15 days in culture, cell morphology changed, and lentoid formation was evident. Reverse transcription-polymerase chain reaction (RT-PCR) indicated expression of alphaA- and betaB2-crystallin, fibroblast growth factor receptor 1 (FGFR1), and major intrinsic protein (MIP26) in exponential growth. Western analyses of protein extracts show positive expression of three immunologically distinct classes of crystallin proteins (alphaA-, alphaB-, and betaB2-crystallin) with time in culture. By Western blot analysis, expression of p57(KIP2), a known marker of terminally differentiated fiber cells, was detectable in exponential cultures, and levels increased after confluence. MIP26 and gamma-crystallin protein expression was detected in confluent cultures, by using immunofluorescence, but not in exponentially growing cells. CONCLUSIONS: HLE cells can be maintained for up to 4 months on ECM derived from BCE cells in medium containing FGF-2. With time in culture, the cells demonstrate morphologic characteristics of, and express protein markers for, lens fiber cell differentiation. This in vitro model will be useful for investigations of radiation-induced cataractogenesis and other studies of lens toxicity.

Non-NASA Center↗

Particle irradiation induces FGF2 expression in normal human lens cells

Particle Irradiation Induces FGF2 Expression in Normal Human Lens Cells. Particle radiations, including both proton and helium-ion beams, have been used to successfully treat choroidal melanoma, but with the complication of radiation-induced cataract. We have investigated a role for radiation-induced changes in the expression of basic fibroblast growth factor (FGF2) gene expression as part of the mechanism(s) underlying lens cell injury associated with cataract. Normal human lens epithelial (HLE) cells were cultured in vitro on extracellular matrix (ECM) originated from bovine corneal endothelial cells. This study reports evidence for rapid but transient induction of FGF2 transcripts, an increase of between 5- and 8-fold, within 0.5 h after exposure to particle radiation, followed by another wave of increased transcription at 2-3 h postirradiation. Immunofluorescence results confirm the enhanced levels of FGF2 protein rapidly after exposure to protons or helium ions, followed by another wave of increased activity unique to helium at 6 h postirradiation. This second wave of increased immunoreactivity was not observed in the proton-irradiated samples. Total FGF2 protein analysis after helium-ion exposures shows induced expression of three FGF2 isoforms, with an increase of up to 2-fold in the 18-kDa low-molecular-weight species. Studies of the effects of protons on individual FGF2 protein isoforms are in progress. Several mechanisms involving a role for FGF2 in radiation-induced cataract are discussed.

NASA Discipline Radiation Health↗

Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells

DMPK, the product of the DM locus, is a member of the same family of serine-threonine protein kinases as the Rho-associated enzymes. In DM, membrane inclusions accumulate in lens fiber cells producing cataracts. Overexpression of DMPK in cultured lens epithelial cells led to apoptotic-like blebbing of the plasma membrane and reorganization of the actin cytoskeleton. Enzymatically active DMPK was necessary for both effects; inactive mutant DMPK protein did not produce either effect. Active RhoA but not constitutive GDP-state mutant protein produced similar effects as DMPK. The similar actions of DMPK and RhoA suggest that they may function in the same regulatory network. The observed effects of DMPK may be relevant to the removal of membrane organelles during normal lens differentiation and the retention of intracellular membranes in DM lenses. Copyright 2000 Wiley-Liss, Inc.

Non-NASA Center↗

Identification of the in vivo truncation sites at the C-terminal region of alpha-A crystallin from aged bovine and human lens

Total alpha-A crystallin was purified from young versus old lens, followed by digestion with cyanogen bromide. Laser desorption mass spectrometry of the C-terminal fragment demonstrated age-dependent loss of one and five amino acids from the C-terminus of alpha-A crystallin from both bovine and human lens. These results demonstrate specific peptide bonds of alpha-A crystallin are cleaved during the aging process of the normal lens. The C-terminal region is cleaved in two places between the two hydroxyl-containing amino acids present in the sequence -P-S(T)-S-.

Non-NASA Center↗

The ability of lens alpha crystallin to protect against heat-induced aggregation is age-dependent

Alpha crystallin was prepared from newborn and aged bovine lenses. SDS-PAGE and tryptic peptide mapping demonstrated that both preparations contained only the alpha-A and alpha-B chains, with no significant contamination of other crystallins. Compared with alpha crystallin from the aged lens, alpha crystallin from the newborn lens was much more effective in the inhibition of beta L crystallin denaturation and precipitation induced in vitro by heat. Together, these results demonstrate that during the aging process, the alpha crystallins lose their ability to protect against protein denaturation, consistent with the hypothesis that the alpha crystallins play an important role in the maintenance of protein native structure in the intact lens.

NASA Discipline Cell Biology↗

A plano–convex thick-lens velocity map imaging apparatus for direct, high resolution 3D momentum measurements of photoelectrons with ion time-of-flight coincidence

Since their inception, velocity map imaging (VMI) techniques have received continued interest in their expansion from 2D to 3D momentum measurements through either reconstructive or direct methods. Recently, much work has been devoted to the latter of these by relating electron time-of-flight (TOF) to the third momentum component. The challenge is having a timing resolution sufficient to resolve the structure in the narrow (<10 ns) electron TOF spread. Here, we build upon the work in VMI lens design and 3D VMI measurement by using a plano–convex thick-lens (PCTL) VMI in conjunction with an event-driven camera (TPX3CAM) providing TOF information for high resolution 3D electron momentum measurements. We perform simulations to show that, with the addition of a mesh electrode to the thick-lens geometry, the resulting plano–convex electrostatic field extends the detectable electron cutoff energy range while retaining the high resolution. This design also extends the electron TOF range, allowing for a better momentum resolution along this axis. We experimentally demonstrate these capabilities by examining above-threshold ionization in xenon, where the apparatus is shown to collect electrons of energy up to ∼7 eV with a TOF spread of ∼30 ns, both of which are improved compared to a previous work by factors of ∼1.4 and ∼3.75, respectively. Finally, the PCTL-VMI is equipped with a coincident ion TOF spectrometer, which is shown to effectively extract unique 3D momentum distributions for different ionic species in a gas mixture. These techniques have the potential to lend themselves to more advanced measurements involving systems where the electron momentum distributions possess non-trivial symmetries.

Instruments & Instrumentation↗

On the detectability of the moving lens signal in CMB experiments

Abstract Upcoming cosmic microwave background (CMB) experiments are expected to detect new signals probing interaction of CMB photons with intervening large-scale structure. Among these the moving-lens effect, the CMB temperature anisotropy induced by cosmological structures moving transverse to our line of sight, is anticipated to be measured to high significance in the near future. In this paper, we investigate two possible strategies for the detection of this signal: pairwise transverse-velocity estimation and oriented stacking. We expand on previous studies by including in the analysis realistic simulations of competing signals and foregrounds. We confirm that the moving lens effect can be detected at ≥ 10σlevel by a combination of CMB-S4 and LSST surveys. We show that the limiting factors in the detection depend on the strategy: for the stacking analysis, correlated extragalactic foregrounds, namely the cosmic infrared background and thermal Sunyaev Zel'dovich effect, play the most important role. The addition of foregrounds make the signal-to-noise ratio be most influenced by large and nearby objects. As for the pairwise detection, halo lensing and pair number counts are the main issues. In light of our findings, we elaborate on possible strategies to improve the analysis approach for the moving lens detection with upcoming experiments. We also deliver to the community all the simulations and tools we developed for this study.

Astronomy & Astrophysics↗

McMillan electron lens in a system with space charge

Space charge (SC) forces of a circulating beam in a ring have both linear (defocusing) and nonlinear components, due to a nonuniform beam distribution. The linear component of SC forces produces a betatron tune shift, which is the largest for a zero-amplitude particle, while the nonlinear component produces an amplitude-dependent betatron tune spread. These SC effects are responsible for several undesirable phenomena in accelerators: emittance growth, particle losses, beam halo, etc. In this paper, we investigate the possibility to mitigate the distributed SC forces by a thin McMillan lens, providing an axially-symmetric kick, which is qualitatively opposite to the accumulated effect of beam's own SC. Experimentally, the proposed concept can be tested in Fermilab's IOTA ring. A thin McMillan lens can be implemented by a short (70) insertion of an electron beam with a specifically chosen density distribution in transverse directions. In this article, to test if McMillan lenses can reduce the tune spread induced by SC, we make several simulations with a 6-D particle tracking code, Synergia. We choose such beam and lattice parameters that the SC tune spread is roughly 0.5 and the emittance growth due to the half-integer resonance is clearly observed without the SC compensation. Then, we focus on reducing the emittance growth by adjusting the bare betatron tunes using the ring quadrupoles, and reducing the tune spread by the McMillan lenses. The results of reducing a large tune spread (≈ 0.5), reported here, are not perfect, but substantial. There is still room for further investigation. The simulations performed so far in this work indicate that McMillan lenses can cope with an SC tune spread of ≈ 0.1 per lens.

43 PARTICLE ACCELERATORS↗

Dark Energy Survey Year 3 results: redshift calibration of the MagLim lens sample from the combination of SOMPZ and clustering and its impact on cosmology

ABSTRACT We present an alternative calibration of the MagLim lens sample redshift distributions from the Dark Energy Survey (DES) first 3 yr of data (Y3). The new calibration is based on a combination of a self-organizing-map-based scheme and clustering redshifts to estimate redshift distributions and inherent uncertainties, which is expected to be more accurate than the original DES Y3 redshift calibration of the lens sample. We describe in detail the methodology, and validate it on simulations and discuss the main effects dominating our error budget. The new calibration is in fair agreement with the fiducial DES Y3 n(z) calibration, with only mild differences (<3σ) in the means and widths of the distributions. We study the impact of this new calibration on cosmological constraints, analysing DES Y3 galaxy clustering and galaxy–galaxy lensing measurements, assuming a Lambda cold dark matter cosmology. We obtain Ωm = 0.30 ± 0.04, σ8 = 0.81 ± 0.07, and S8 = 0.81 ± 0.04, which implies a ∼0.4σ shift in the Ω − S8 plane compared to the fiducial DES Y3 results, highlighting the importance of the redshift calibration of the lens sample in multiprobe cosmological analyses.

79 ASTRONOMY AND ASTROPHYSICS↗

Dark Energy Survey Year 6 results: Redshift calibration of the MagLim++ lens sample

In this work, we derive and calibrate the redshift distribution of the MagLim++ lens galaxy sample used in the Dark Energy Survey Year 6 (DES Y6) 3 x 2pt cosmology analysis. The 3 x 2pt analysis combines galaxy clustering from the lens galaxy sample and weak gravitational lensing. The redshift distributions are inferred using the SOMPZ method - a Self-Organizing Map framework that combines deep-field multi-band photometry, wide-field data, and a synthetic source injection ( B alrog) catalog. Key improvements over the DES Year 3 (Y3) calibration include a noise-weighted SOM metric, an expanded Balrog catalogue, and an improved scheme for propagating systematic uncertainties, which allows us to generate O(10 8 ) redshift realizations that collectively span the dominant sources of uncertainty. These realizations are then combined with independent clustering-redshift measurements via importance sampling. The resulting calibration achieves typical uncertainties on the mean redshift of 1-2%, corresponding to a 20-30% average reduction relative to DES Y3. We compress the n(z) uncertainties into a small number of orthogonal modes for use in cosmological inference. Marginalizing over these modes leads to only a minor degradation in cosmological constraints. Here, this analysis establishes the MagLim++ sample as a robust lens sample for precision cosmology with DES Y6 and provides a scalable framework for future surveys.

dark energy↗

Direct detection of dark matter substructure in strong lens images with convolutional neural networks

Strong gravitational lensing is a potential way of uncovering the nature of dark matter, by finding perturbations to images that cannot be accounted for well by modeling the lens galaxy without additional structure, be it subhalos (smaller halos within the smooth lens) or line-of-sight (LOS) halos. Here, we introduce results attempting to infer the presence of substructure from images without requiring an intermediate step in which a smooth model has to be subtracted, using a simple convolutional neural network (CNN). We find that the network is only able to infer the presence of subhalos with greater than 75% accuracy when they have masses of greater than or equal to 5 × 10 9 M ⊙ if they lie within the main lens galaxy. Since less massive foreground LOS halos can have the same effect as higher-mass subhalos, the CNN can probe lower masses in the halo mass function. The accuracy does not improve significantly if we add a population of less massive subhalos. With the expectation of experiments such as Hubble Space Telescope and Euclid yielding thousands of high-quality strong lensing images in the next years, having a way of analyzing images quickly to identify candidates that merit further analysis to determine individual subhalo properties while preventing extensive resources being used for images that would yield null detections could be very useful. By understanding the sensitivity as a function of substructure mass, nondetections could be combined with the information from images with substructure to constrain the cold dark matter scenario, in particular if the sensitivity can be pushed to lower masses.

79 ASTRONOMY AND ASTROPHYSICS↗

Concept Lens: Visual Comparison and Evaluation of Generative Model Manipulations

Generative models are becoming a transformative technology for the creation and editing of images. However, it remains challenging to harness these models for precise image manipulation. These challenges often manifest as inconsistency in the editing process, where both the type and amount of semantic change, depend on the image being manipulated. Moreover, there exist many methods for computing image manipulations, whose development is hindered by the matter of inconsistency. This paper aims to address these challenges by improving how we evaluate, compare, and explore the space of manipulations offered by a generative model. We present Concept Lens, a visual interface that is designed to aid users in understanding semantic concepts carried in image manipulations, and how these manipulations vary over generated images. Given the large space of possible images produced by a generative model, Concept Lens is designed to support the exploration of both generated images, and their manipulations, at multiple levels of detail. To this end, the layout of Concept Lens is informed by two hierarchies: a hierarchical organization of (1) original images, grouped by their similarities, and (2) image manipulations, where manipulations that induce similar changes are grouped together. This layout allows one to discover the types of images that consistently respond to a group of manipulations, and vice versa, manipulations that consistently respond to a group of codes. We show the benefits of this design across multiple use cases, specifically, studying the quality of manipulations for a single method, and offering a means of comparing different methods.

clustering↗

ML-driven Strong Lens Discoveries: Down to θ E ~ $0^{_{''}}_{^.}03$ and M halo < 10 11 M ⊙

We present results on extending the strong lens discovery space down to much smaller Einstein radii ( θ E ≲ $0^{_{''}}_{^.}03$) and much lower halo mass (M halo < 10 11 M ⊙ ) through the combination of JWST observations and machine learning (ML) techniques. First, we forecast detectable strong lenses with JWST using CosmoDC2 as the lens catalog, and a source catalog down to 29th magnitude. By further incorporating the VELA hydrodynamical simulations of high-redshift galaxies, we simulate strong lenses. We train a ResNet on these images, achieving near-100% completeness and purity for “conventional” strong lenses ( θ E ≳ $0^{_{''}}_{^.}05$), applicable to JWST, the Hubble Space Telescope (HST), the Roman Space Telescope, and Euclid VIS. For the first time, we also search for very low halo mass strong lenses (M halo < 10 11 M ⊙ ) in simulations, with θ E << $0^{_{''}}_{^.}05$, down to the best resolution ($0^{_{''}}_{^.}03$) and depth (10,000 s) limits of JWST using ResNet. A U-Net model is employed to pinpoint these small lenses in images, which are otherwise virtually impossible for human detection. Our results indicate that JWST can find ∼17/deg 2 such low-halo-mass lenses, with the locations of ∼1.1/deg 2 of these detectable by the U-Net at ∼100% precision (and ∼7.0/deg 2 at a 99.0% precision). To validate our model for finding “conventional” strong lenses, we apply it to HST images, discovering two new strong lens candidates previously missed by human classifiers in a crowdsourcing project (E. O. Garvin et al. 2022). This study demonstrates the (potentially “superhuman”) advantages of ML combined with current and future space telescopes for detecting conventional, and especially, low-halo-mass strong lenses, which are critical for testing cold dark matter models.

Silver, Ethan [Harvard University, Cambridge, MA (↗

Ion-retarding lens improves the abundance sensitivity of tandem mass spectrometers

Ion-retarding lens which increases the abundance sensitivity of tandem magnetic-analyzer mass spectrometers measures isotopes of low abundance in mass positions adjacent to isotopes of high abundance. The lens increases the abundance sensitivity for isotopes lying farther from high abundance isotopes than the energy cutoff of the lens.

Kaiser, K. A.↗

Fabry lens.

Discussion of the properties, operation, and applications of the Fabry lens. As used in stellar photometry, a Fabry lens is nothing more than a simple converging lens inserted into the optical train of a photometer to construct an image of the objective on the photomultiplier cathode. The thereby derived advantages are reviewed, and some techniques designed to maximize these advantages are outlined.

Michlovic, J.↗