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At least 109 records · Page 6

The High Luminosity LHC interaction region magnets towards series production

The High Luminosity Large Hadron Collider (HL-LHC) is the new flagship project of CERN. First endorsed in 2013 and approved in 2016, HL-LHC is an upgrade of the accelerator aiming to increase by a factor of ten the statistics of the LHC collisions at the horizon of 2035-2040. HL-LHC relies on cutting edge technologies: among them, large aperture superconducting magnets will replace the present hardware to allow a smaller beam size in two interaction points (IPs). The project involves the construction of about 150 magnets of six different types: the quadrupole triplet, two main dipoles and three orbit correctors. The triplet, manufactured at CERN and in the USA, will consist of 30 magnets based on Nb3Sn technology, with an operational peak field of 11.4 T. These will be the first quadrupole Nb3Sn magnets installed in a particle accelerator. The other five types of magnets, all relying on Nb-Ti technology, present non-trivial challenges in the design and construction; they will be manufactured as part of in-kind contribution under the responsibility of institutes in Japan, China, Spain, and Italy. The project is now in the phase of transition between qualification through short models and prototypes and the beginning of the series construction. In this paper we review the magnet requirements, the reasons for selecting the design, the technological challenges with respect to previous projects, and we summarize the steps that have been taken to validate the baseline.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Status and Challenges of the Interaction Region Magnets for HL-LHC

About one hundred magnets of six different types shall be installed in the High Luminosity LHC (HL-LHC) in the years 2026-2028 at CERN. The magnets design, construction and test are based on CERN collaborations with institutes and industrial partners in USA, Spain, Italy, Japan and China. Three types of correctors are based on Nb-Ti technology and feature conductor peak fields in the 2 to 4 T range: for all of them the prototype phase has been successfully completed. The production is well advanced for the superferric correctors, and is starting for the canted cosine theta correctors and for the nested correctors. The separation and recombination Nb-Ti dipoles D1 and D2, with a 4.5-6 T bore field range, are both in the prototype phase after the completion of the short model program. The most challenging magnet, the Nb 3 Sn quadrupole with conductor peak field above 11 T, is in the prototype phase at CERN and halfway through the production phase in the USA. In this paper we will give, for each type of magnet, an overview of the main achievements obtained so far and we will outline the technical points still needing validation from the prototype program.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Alternative solenoid compensation scheme for the FCC-ee interaction region

We present the optics design of the solenoid compensation scheme at the FCC-ee. The 2T solenoids from the experiments induce coupling on the beams, generating an increase on vertical emittance. This compensation scheme minimizes emittance growth, with a final value of approximately 5% of the nominal. A screening solenoid is placed around the Final Focus Quadrupoles to protect them from the experiment’s field. A skew quadrupole component is added to the Final Doublet, aligning the magnet axis to the rotated reference frame of the beam. Two anti-solenoids placed approximately ±20 m from the IP are used to cancel the field integral. The vertical orbit generated by the horizontal crossing angle in the detector field is compensated by vertical correctors placed right after the beam pipe separation and next to the final focus quadrupoles. We describe the IR optics in this scheme, including the detector solenoid and the magnetic elements used for compensation.

43 PARTICLE ACCELERATORS↗

gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII

The protein gC1qR/C1qBP/HABP-1 plays an essential role in mitochondrial biogenesis, but becomes localized at the cellular surface in numerous pathophysiological states. When this occurs on endothelial cells, surface-exposed gC1qR activates the classical pathway of complement. It also promotes assembly of a multi-protein complex comprised of coagulation factor XII (FXII), pre-kallikrein (PK), and high-molecular weight kininogen (HMWK) that activates the contact system and the kinin-generating system. Since surface-exposed gC1qR triggers intravascular inflammatory pathways, there is interest in identifying molecules that block gC1qR function. Here we further that objective by reporting the outcome of a structure/function investigation of gC1qR, its interactions with FXII, and the impact of a panel of monoclonal anti-gC1qR antibodies on FXII binding to gC1qR. Although deletion mutants have been used extensively to assess gC1qR function, none of these proteins have been characterized structurally. To that end, we determined a 2.2 Å resolution crystal structure of a gC1qR mutant lacking both of its acidic loops, but which retained nanomolar-affinity binding to FXII and FXIIa. This structure revealed that the trimeric gC1qR assembly was maintained despite loss of roughly thirty residues. Characterization of a novel panel of anti-gC1qR monoclonal antibodies identified several with biochemical properties distinct from previously described antibodies, as well as one which bound to the first acidic loop of gC1qR. Intriguingly, we found that each of these antibodies could partly inhibit binding of FXII and FXIIa to gC1qR. Based on these results and previously published studies, we offer new perspectives for developing gC1qR inhibitors.

60 APPLIED LIFE SCIENCES↗

Evidence for interplanetary acceleration of nucleons in corotating interaction regions

Simultaneous measurements of protons and helium in the energy range 0.5-2 MeV per nucleon on IMP-8 (at 1 AU) and Pioneer-10 and Pioneer-11 (between 1 and 8 AU) have revealed a correlation which develops beyond about 2.5 AU between the positions of double peaks in recurring proton intensity increases and the leading and trailing edges of recurring regions of fast solar wind streams and enhanced magnetic field. From these correlations and the study of energy spectra and the proton-to-helium abundance ratios, it is concluded that there is local acceleration of nucleons, probably near the boundary regions where shocks are observed, even if the nucleons are injected initially at the sun.

Barnes, C. W.↗

Free stream turbulence and density ratio effects on the interaction region of a jet in a cross flow

Jets of low temperature air are introduced into the aft sections of gas turbine combustors for the purpose of cooling the high temperature gases and quenching the combustion reactions. Research studies, motivated by this complex flow field, have been executed by introducing a heated jet into the cross stream of a wind tunnel. The investigation by Kamotani and Greber stands as a prime example of such investigations and it serves as the principal reference for the present study. The low disturbance level of the cross stream, in their study and in similar research investigations, is compatible with an interest in identifying the basic features of this flow field. The influence of the prototypes' strongly disturbed cross flow is not, however, made apparent in these prior investigations.

Wark, C. E.↗

Interplanetary Discontinuities in Corotating Streams and Their Interaction Regions

In this study, we investigate the discontinuity properties in the low altitude corotating stream regions which are encountered during Ulyssses traveling from the south to north heliographic poles in 1995. Through the occurrence rates of directional discontinuites and tangential discontinuities, we find that there are three different regions around a high speed stream.

RDs TDs coronal mass ejections↗