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In situ resource utilization (ISRU) is the practice of producing mission consumables from local lunar/planetary resources, thereby minimizing system launch mass requirements, mainly through the production of propellant fuel components and life support resources. Modeling full ISRU technology architectures significantly impacts the design and optimization of individual unit processes and facilitates their introduction into service with the Science Technology Mission Directorate (STMD) logistical planning and operation space. The Mission Analysis and Integration Tool (MAIT) is a modeling framework that connects individual ISRU subsystem models for the purposes of technology down select, scaling & optimization, and end-to-end process planning. The development project team seeks to address specific STMD capability gaps by simulating ISRU systems in MAIT. The goal is to produce system architectures for the Moon and Mars that are linked to Key Performance Parameters (KPP) and environmental requirements. To that end, the framework is adaptive, flexible, and suitable for collaboration among government, private sector, and international entities. Our approach currently provides conventional outputs, such as mass, power, and volume, to analyze whole system trade spaces. However, the framework was designed to validate current breadboard subsystems, simulate future process design capacity, and allow flexibility to any external developer-driven subsystem model that is in a state of evolution.