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DOE OSTI2021

Exploring the Interface of Skin-Layered Titanium Fibers for Electrochemical Water Splitting

Water electrolysis is the key to a decarbonized energy system, as it enables the conversion and storage of renewably generated intermittent electricity in the form of hydrogen. However, reliability challenges arising from titanium-based porous transport layers (PTLs) have hitherto restricted the deployment of next-generation water-splitting devices. Here, it is shown for the first time how PTLs can be adapted so that their interface remains well protected and resistant to corrosion across ˜4000 h under real electrolysis conditions. It is also demonstrated that the malfunctioning of unprotected PTLs is a result triggered by additional fatal degradation mechanisms over the anodic catalyst layer beyond the impacts expected from iridium oxide stability. Now, superior durability and efficiency in water electrolyzers can be achieved over extended periods of operation with less-expensive PTLs with proper protection, which can be explained by the detailed reconstruction of the interface between the different elements, materials, layers, and components presented in this work.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2021

Profiling B cell immunodominance after SARS-CoV-2infection reveals antibody evolution to non-neutralizing viral targets

Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used single-cell sequencing to profile SARS-CoV-2-reactive B cells in 38 COVID-19 patients. Using oligo-tagged antigen baits, we isolated B cells specific to the SARS-CoV-2 spike, nucleoprotein (NP), open reading frame 8 (ORF8), and endemic human coronavirus (HCoV) spike proteins. SARS-CoV-2 spike-specific cells were enriched in the memory compartment of acutely infected and convalescent patients several months post symptom onset. With severe acute infection, substantial populations of endemic HCoV-reactive antibody-secreting cells were identified and possessed highly mutated variable genes, signifying preexisting immunity. Finally, MBCs exhibited pronounced maturation to NP and ORF8 over time, especially in older patients. Monoclonal antibodies against these targets were non-neutralizing and non-protective in vivo. These findings reveal antibody adaptation to non-neutralizing intracellular antigens during infection, emphasizing the importance of vaccination for inducing neutralizing spike-specific MBCs.

antibody↗

DOE OSTI2026

A funnel approach to enable analyses of epitope-specific human CD4 T cells specific for influenza and SARS-CoV-2

Protection against pathogens relies heavily on the adaptive immune response, whose key regulators are CD4 T cells. CD4 T cells, notable for their complex repertoire and functional potential, can most easily be dissected by identifying, quantifying, characterizing, and isolating epitope-specific cells. In the study reported here, we present a systematic and unbiased strategy that has enabled the identification of highly immunogenic peptide epitopes derived from influenza virus and SARS-CoV-2, presented by human HLA-DR proteins. Coupling the use of HLA-DR transgenic mice with infection and vaccination and highly sensitive epitope-specific cytokine ELISpot assays, we have narrowed the potential epitopes from 450 to 600 peptides to 5–15 peptides for each allele by an iterative process of elimination and selection, which we have termed a funnel approach. These epitopes have been validated in HLA-DR-typed human CD4 T cells directly ex vivo and enabled the derivation and implementation of HLA-DR peptide tetramers. Tetramer staining of human PBMCs enriched for CD4 T memory populations from healthy adult subjects, highlighted this approach as a sensitive and specific method for identifying novel epitopes, and subsequent CD4 T-cell responses to human viral infections.

CD4 T cell↗

DOE OSTI2022

Harmonized Automatic Relay Mitigation of Nefarious Intentional Events (HARMONIE) - Special Protection Scheme (SPS)

The harmonized automatic relay mitigation of nefarious intentional events (HARMONIE) special protection scheme (SPS) was developed to provide adaptive, cyber-physical response to unpredictable disturbances in the electric grid. The HARMONIE-SPS methodology includes a machine learning classification framework that analyzes real time cyber-physical data and determines if the system is in normal conditions, cyber disturbance, physical disturbance, or cyber-physical disturbance. This classification then informs response, if needed and/or suitable, and included cyber-physical corrective actions. Beyond standard power system mitigations, a few novel approaches were developed that included a consensus algorithm-based relay voting scheme, an automated power system triggering condition and corrective action pairing algorithm, and a cyber traffic routing optimization algorithm. Both the classification and response techniques were tested within a newly integrated emulation environment composed of a real-time digital simulator (RTDS) and SCEPTRE™. This report details the HARMONIE-SPS methodology, highlighting both the classification and response techniques, and the subsequent testing results from the emulation environment.

24 POWER TRANSMISSION AND DISTRIBUTION↗

NASA NTRS1992

Accurate Inventories Of Irrigated Land

System for taking land-use inventories overcomes two problems in estimating extent of irrigated land: only small portion of large state surveyed in given year, and aerial photographs made on 1 day out of year do not provide adequate picture of areas growing more than one crop per year. Developed for state of California as guide to controlling, protecting, conserving, and distributing water within state. Adapted to any large area in which large amounts of irrigation water needed for agriculture. Combination of satellite images, aerial photography, and ground surveys yields data for computer analysis. Analyst also consults agricultural statistics, current farm reports, weather reports, and maps. These information sources aid in interpreting patterns, colors, textures, and shapes on Landsat-images.

Wall, S.↗

NASA NTRS2007

Noise-Canceling Helmet Audio System

A prototype helmet audio system has been developed to improve voice communication for the wearer in a noisy environment. The system was originally intended to be used in a space suit, wherein noise generated by airflow of the spacesuit life-support system can make it difficult for remote listeners to understand the astronaut s speech and can interfere with the astronaut s attempt to issue vocal commands to a voice-controlled robot. The system could be adapted to terrestrial use in helmets of protective suits that are typically worn in noisy settings: examples include biohazard, fire, rescue, and diving suits. The system (see figure) includes an array of microphones and small loudspeakers mounted at fixed positions in a helmet, amplifiers and signal-routing circuitry, and a commercial digital signal processor (DSP). Notwithstanding the fixed positions of the microphones and loudspeakers, the system can accommodate itself to any normal motion of the wearer s head within the helmet. The system operates in conjunction with a radio transceiver. An audio signal arriving via the transceiver intended to be heard by the wearer is adjusted in volume and otherwise conditioned and sent to the loudspeakers. The wearer s speech is collected by the microphones, the outputs of which are logically combined (phased) so as to form a microphone- array directional sensitivity pattern that discriminates in favor of sounds coming from vicinity of the wearer s mouth and against sounds coming from elsewhere. In the DSP, digitized samples of the microphone outputs are processed to filter out airflow noise and to eliminate feedback from the loudspeakers to the microphones. The resulting conditioned version of the wearer s speech signal is sent to the transceiver.

Seibert, Marc A.↗

NASA NTRS2014

The Ergonomics of Human Space Flight: NASA Vehicles and Spacesuits

Space...the final frontier...these are the voyages of the starship...wait, wait, wait...that's not right...let's try that again. NASA is currently focusing on developing multiple strategies to prepare humans for a future trip to Mars. This includes (1) learning and characterizing the human system while in the weightlessness of low earth orbit on the International Space Station and (2) seeding the creation of commercial inspired vehicles by providing guidance and funding to US companies. At the same time, NASA is slowly leading the efforts of reestablishing human deep space travel through the development of the Multi-Purpose Crew Vehicle (MPCV) known as Orion and the Space Launch System (SLS) with the interim aim of visiting and exploring an asteroid. Without Earth's gravity, current and future human space travel exposes humans to micro- and partial gravity conditions, which are known to force the body to adapt both physically and physiologically. Without the protection of Earth's atmosphere, space is hazardous to most living organisms. To protect themselves from these difficult conditions, Astronauts utilize pressurized spacesuits for both intravehicular travel and extravehicular activities (EVAs). Ensuring a safe living and working environment for space missions requires the creativity of scientists and engineers to assess and mitigate potential risks through engineering designs. The discipline of human factors and ergonomics at NASA is critical in making sure these designs are not just functionally designed for people to use, but are optimally designed to work within the capacities specific to the Astronaut Corps. This lecture will review both current and future NASA vehicles and spacesuits while providing an ergonomic perspective using case studies that were and are being carried out by the Anthropometry and Biomechanics Facility (ABF) at NASA's Johnson Space Center.

Reid, Christopher R.↗

NASA NTRS1998

High sustained +Gz acceleration: physiological adaptation to high-G tolerance

Since the early 1940s, a significant volume of research has been conducted in an effort to describe the impact of acute exposures to high-G acceleration on cardiovascular mechanisms responsible to maintaining cerebral perfusion and conscious in high performance aircraft pilots during aerial combat maneuvers. The value of understanding hemodynamic characteristics that underlie G-induced loss of consciousness has been instrumental in the evolution of optimal technology development (e.g., G-suits, positive pressure breathing, COMBAT EDGE, etc.) and pilot training (e.g., anti-G straining maneuvers). Although the emphasis of research has been placed on the development of protection against acute high +Gz acceleration effects, recent observations suggest that adaptation of cardiovascular mechanism associated with blood pressure regulation may contribute to a protective 'G-training' effect. Regular training at high G enhances G tolerance in humans, rats, guinea pigs, and dogs while prolonged layoff from exposure in high G profiles (G-layoff) can result in reduced G endurance. It seems probable that adaptations in physiological functions following chronically-repeated high G exposure (G training) or G-layoff could have significant impacts on performance during sustained high-G acceleration since protective technology such as G-suits and anit-G straining maneuvers are applied consistently during these periods of training. The purpose of this paper is to present a review of new data from three experiments that support the notion that repeated exposure on a regular basis to high sustained +Gz acceleration induces significant physiological adaptations which are associated with improved blood pressure regulation and subsequent protection of cerebral perfusion during orthostatic challenges.

Review, Tutorial↗

NASA NTRS2011

Pilot Study: Unique Response of Bone Tissue During an Investigation of Radio-Adaptive Effects in Mice

PURPOSE: We obtained bone tissue to evaluate the collateral effects of experiments designed to investigate molecular mechanisms of radio-adaptation in a mouse model. Radio-adaptation describes a process by which the prior exposure to low dose radiation can protect against the toxic effect of a subsequent high dose exposure. In the radio-adaptation experiments, C57Bl/6 mice were exposed to either a Sham or a priming Low Dose (5 cGy) of Cs-137 gamma rays before being exposed to either a Sham or High Dose (6 Gy) 24 hours later. ANALYSIS: Bone tissue were obtained from two experiments where mice were sacrificed at 3 days (n=3/group, 12 total) and at 14 days (n=6/group, 24 total) following high dose exposure. Tissues were analyzed to 1) evaluate a radio-adaptive response in bone tissue and 2) describe cellular and microstructural effects for two skeletal sites with different rates of bone turnover. One tibia and one lumbar vertebrae (LV2), collected at the 3-day time-point, were analyzed by bone histomorphometry and micro-CT to evaluate the cellular response and any evidence of microarchitectural impact. Likewise, tibia and LV2, collected at the 14-day time-point, were analyzed by micro-CT alone to evaluate resulting changes to bone structure and microarchitecture. The data were analyzed by 2-way ANOVA to evaluate the effects of the priming low dose radiation, of the high dose radiation, and of any interaction between the priming low and high doses of radiation. Bone histomorphometry was performed in the cancellous bone (aka trabecular bone) compartments of the proximal tibial metaphysis and of LV2. RESULTS: Cellular Response @ 3 Days The priming Low Dose radiation decreased osteoblast-covered bone perimeter in the proximal tibia and the total cell density in the bone marrow in the LV2. High Dose radiation, regardless of prior exposure to priming dose, dramatically reduced total cell density in bone marrow of both the long bone and vertebra. However, in the proximal tibia, High Dose radiation increased the osteoclast-covered bone perimeters, the density of adipocytes in bone marrow, and the area of bone marrow occupied by fat cells -- while in the LV2, adipocytes were rare and not stimulated by High Dose radiation. In an unexpected response, High Dose radiation dramatically increased (10-fold) osteoblast-covered bone perimeter in the LV2.

Sibonga, J. D.↗

DOE OSTI2026

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models

Ebola virus (EBOV) is the causative agent of Ebola disease (EBOD), a viral hemorrhagic fever with a notably high case fatality rate. Current treatments for EBOD are limited to monoclonal antibodies or two licensed viral vector vaccines, a recombinant vesicular stomatitis virus (rVSV)-vectored vaccine or an adenovirus and modified vaccinia Ankara regimen. However, comparisons of protection, efficacy, and durability with alternative nucleotide platforms remain understudied. Here, we evaluated the immunogenicity of an mRNA vaccine expressing the EBOV glycoprotein (GP) in parallel with rVSV- and DNA-based vaccine platforms. The mRNA EBOV-GP vaccine, formulated in lipid nanoparticles, elicited significantly higher levels of total IgG and neutralizing antibody titers compared to the rVSV-EBOV-GP vaccine. Linear antibody epitope analysis indicated a preference for targeting the mucin-like domain in EBOV-GP1 following rVSV-based vaccination, while the mRNA platform distinctly targeted the internal fusion loop of EBOV-GP2. After characterizing the immunogenicity of the mRNA vaccine, two models of EBOD were used to demonstrate its protective efficacy: a surrogate rVSV-based challenge model of EBOD using type-I interferon deficient C57BL/6 mice and infection of BALB/c mice with authentic mouse-adapted EBOV. In both studies, the EBOV mRNA vaccine fully protected the mouse cohorts against morbidity and mortality. Additionally, the EBOV mRNA vaccine produced greater neutralizing antibody titers compared to the DNA EBOV-GP vaccine. These results suggest that an mRNA vaccine expressing EBOV-GP can induce robust, functional humoral responses that are protective against EBOD, warranting further development as an alternative to, or as part of a vaccine strategy including, viral vectored vaccines.

DNA vaccines↗

NASA NTRS1979

Adaptation of solar sounding rocket payloads for Shuttle

The advent of the Shuttle will permit small solar sounding rocket class payloads to be used for orbital applications as a sub satellite. Solutions to such problems as thermal protection, deployment and retrieval and Shuttle bay storage will be presented. Adapting sounding rocket hardware such as solar telescopes, solar attitude control systems and data acquisition modules along with extending power and control gas requirements is discussed. This resulting hardware may be used either in a sounding rocket or Shuttle payload. This paper will combine the solar sounding rocket quick reaction, low cost techniques with the Shuttle Transportation System.

Windsor, R. M.↗

DOE OSTI2021

Reconfigurable Framework for Resilient Semantic Segmentation for Space Applications

Deep learning (DL) presents new opportunities for enabling spacecraft autonomy, onboard analysis, and intelligent applications for space missions. However, DL applications are computationally intensive and often infeasible to deploy on radiation-hardened (rad-hard) processors, which traditionally harness a fraction of the computational capability of their commercial-off-the-shelf counterparts. Commercial FPGAs and system-on-chips present numerous architectural advantages and provide the computation capabilities to enable onboard DL applications; however, these devices are highly susceptible to radiation-induced single-event effects (SEEs) that can degrade the dependability of DL applications. In this article, we propose Reconfigurable ConvNet (RECON), a reconfigurable acceleration framework for dependable, high-performance semantic segmentation for space applications. In RECON, we propose both selective and adaptive approaches to enable efficient SEE mitigation. In our selective approach, control-flow parts are selectively protected by triple-modular redundancy to minimize SEE-induced hangs, and in our adaptive approach, partial reconfiguration is used to adapt the mitigation of dataflow parts in response to a dynamic radiation environment. Combined, both approaches enable RECON to maximize system performability subject to mission availability constraints. We perform fault injection and neutron irradiation to observe the susceptibility of RECON and use dependability modeling to evaluate RECON in various orbital case studies to demonstrate a 1.5–3.0× performability improvement in both performance and energy efficiency compared to static approaches.

97 MATHEMATICS AND COMPUTING↗

NASA NTRS2022

Sea Level Rise and City-Level Climate Action

Background: Climate change is the greatest threat to global health in the 21st century. Rising sea levels are one particularly concerning manifestation of this and many of the world’s largest cities are vulnerable to sea level rise (SLR). Thus, urban climate adaptation and mitigation policies are increasingly important to protect population health. Objectives: This study aimed to determine whether being at risk of SLR was associated with city-level climate action. It also aimed to assess the wider drivers of climate action in cities, in order to guide ongoing efforts to motivate climate action, assess public health preparedness and identify research gaps. Methods: This is an ecological cross-sectional study using secondary data from CDP, the Urban Climate Change Research Network (UCCRN), World Bank, United Nations Cities and EM-DAT (Emergency Events Database). The study population consisted of 517 cities who participated in CDP’s 2019 Cities Survey. Multivariable logistic regression was utilized to assess the relationship between risk of SLR and city-level climate action, and secondly, to assess the wider determinants of city-level climate action. Results: There was evidence of crude associations between risk of SLR and three outcome variables representing city-level climate action. However, after adjusting for confounding variables, these crude associations disappeared. World region, national income status and urban population were shown to be stronger predictors of city-level climate action. Conclusion: It is concerning for population health that there is no association demonstrated between risk of SLR and climate action. This could indicate a lack of awareness of the risks posed by SLR within urban governance. To fulfil their health protection responsibilities, it is essential that public health professionals take a leading role in advocating for climate action.

sea level rise↗

NASA NTRS2024

Space Environmental Effects on Cleanroom Microbes: A Pathfinder Study

Microbes have an extraordinary ability to adapt to their environment, but little is known about the effects of space irradiation on microbial survival and adaptation. Microbial responses are relevant to both Planetary Protection (PP), where microbes could contaminate planetary bodies and inhibit scientific investigation, and in crew wellbeing where microbes may develop unknown, dangerous resistance mechanisms that impact human health. This project aimed to determine survivability of a collection of isolates collected from NASA Marshall Space Flight Center (MSFC) cleanrooms. In this study, we developed a standard process for exposing dried microbes to various levels of proton irradiation, followed by evaluation of survival. Through multiple exposures at various intensities, we were able to narrow down a shortlist of cleanroom microbes deemed of highest threat to both PP and crew health. These findings could help to more clearly and accurately define risks associated with radiation impacts on microbes.

Planetary Protection↗

NASA NTRS1987

SMI adaptive antenna arrays for weak interfering signals

The performance of adaptive antenna arrays is studied when a sample matrix inversion (SMI) algorithm is used to control array weights. It is shown that conventional SMI adaptive antennas, like other adaptive antennas, are unable to suppress weak interfering signals (below thermal noise) encountered in broadcasting satellite communication systems. To overcome this problem, the SMI algorithm is modified. In the modified algorithm, the covariance matrix is modified such that the effect of thermal noise on the weights of the adaptive array is reduced. Thus, the weights are dictated by relatively weak coherent signals. It is shown that the modified algorithm provides the desired interference protection. The use of defocused feeds as auxiliary elements of an SMI adaptive array is also discussed.

Gupta, I. J.↗

NASA NTRS2024

Cape Hatteras Ecological Conservation: Delineating Shoreline and Mapping Change Along the Cape Hatteras National Seashore for Coastline Management and Transportation Corridor Adaptation Strategies

The National Park Service at Cape Hatteras National Seashore works to protect North Carolina’s Outer Banks where frequent storms bring heavy winds and flooding, leading to overwash events on the main highway, North Carolina Highway 12. Shorelines are susceptible to erosion directly affecting transportation and housing infrastructures. Storm events can disrupt transportation on NC-12 and ferry service from Ocracoke Island to Hatteras Island, leaving inhabitants stranded on Ocracoke Island for indefinite amounts of time. The National Park Service’s current decision-making practices involve mitigating infrastructure damage by enlisting the help of North Carolina’s Department of Transportation and finding ways to relocate this infrastructure, as well as dredging and sediment placement that support beach nourishment efforts. Our NASA DEVELOP team partnered with the National Park Service to explore the use of optical data to delineate shoreline and map coastline change from 2014 to 2024. We used Earth observations collected by Landsat 8 Operational Land Imager, Landsat 9 Operational Land Imager-2, and Sentinel-2 MultiSpectral instrument to support decision-making related to prioritizing strategic planning for transportation corridor adaptations including potential relocation of infrastructure, and beach nourishment efforts. We derived coastline maps by consolidating images from each year to create composite images for winter and summer coastline seasonal oscillation patterns. The results highlight shoreline loss over the ~10-year study period, and the difference in shoreline inundation in the winter and summer seasons. These observations create a better understanding of successful mitigation efforts and allow the National Park Service to continue to focus on plans for infrastructure updates.

Ella Haugen↗

DOE OSTI2023

Designing a boron nitride polyethylene composite for shielding neutrons

Neutrons are encountered in many different fields, including condensed matter physics, space exploration, nuclear power, and healthcare. Neutrons interacting with a biological target produce secondary charged particles that are damaging to human health. The most effective way to shield neutrons is to slow them to thermal energies and then capture the thermalized neutrons. These factors lead us to consider potential materials solutions for neutron shields that maximize the protection of humans while minimizing the shield mass and adapt well to modern additive manufacturing techniques. Using hexagonal boron nitride (hBN) as a capture medium and high-density polyethylene (HDPE) as a thermalization medium, we aim to design the optimal internal structure of h 10 BN/HDPE composites by minimizing the effective dose, which is a measure of the estimated radiation damage exposure for a human. Through Monte Carlo simulations in Geant4, we find that the optimal structure reduces the effective dose up to a factor of 72 over aluminum (Al) and up to a factor of 4 over HDPE; this is a significant improvement in shielding effectiveness that could dramatically reduce the radiation exposure of occupational workers.

36 MATERIALS SCIENCE↗

DOE OSTI2025

Secure and Resilient Operations Using Open-Source Distributed Systems Platform (OpenDSP)

The goal of this project is to identify and address cybersecurity gaps by developing a multi-layer multi-channel cyber-physical defense and survival mechanism for operating distribution networks with high penetration of solar / inverter-based resource (IBR) / distributed energy resource (DER). The proposed security enhancements are built upon the distributed framework and solution architecture for both information technology (IT) and operational technology (OT) systems. The technical solutions consist of two composite functionalities and six layers: proactive defense (vulnerability assessment, communication protection, and attack detection, as layers 1-3), and adaptive self-healing (attack-resilient control, adaptive recovery, and resilient survival, as layers 4-6). These layers, built on and extended from DHS CISA Cyber Framework, establish an integrated and robust cybersecurity framework for operating large-scale distribution networks.

14 SOLAR ENERGY↗