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At least 109 records · Page 6

All sources NASA NTRS DOE OSTI

DOE OSTI2015

Sealed Crawl Spaces with Integrated Whole-House Ventilation in a Cold Climate

One method of code-compliance for crawlspaces is to seal and insulate the crawlspace, rather than venting to the outdoors. However, codes require mechanical ventilation; either via conditioned supply air from the HVAC system, or a continuous exhaust ventilation strategy. As the CARB's building partner, Ithaca Neighborhood Housing Services, intended to use the unvented crawlspace in a recent development, CARB was interested in investigating a hybrid ventilation method that includes the exhaust air from the crawlspace as a portion of an ASHRAE 62.2 compliant whole-house ventilation strategy. This hybrid ventilation method was evaluated through a series of long-term monitoring tests that observed temperature, humidity, and pressure conditions through the home and crawlspace.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2017

Evaluating the Toxicity Reduction With Computed Tomographic Ventilation Functional Avoidance Radiation Therapy

Purpose: Computed tomographic (CT) ventilation imaging is a new modality that uses 4-dimensional (4D) CT information to calculate lung ventilation. Although retrospective studies have reported on the reduction in dose to functional lung, no work to our knowledge has been published in which the dosimetric improvements have been translated to a reduction in the probability of pulmonary toxicity. Our work estimates the reduction in toxicity for CT ventilation–based functional avoidance planning. Methods and Materials: Seventy previously treated lung cancer patients who underwent 4DCT imaging were used for the study. CT ventilation maps were calculated with 4DCT deformable image registration and a density change–based algorithm. Pneumonitis was graded on the basis of imaging and clinical presentation. Maximum likelihood methods were used to generate normal tissue complication probability (NTCP) models predicting grade 2 or higher (2+) and grade 3+ pneumonitis as a function of dose (V5 Gy, V10 Gy, V20 Gy, V30 Gy, and mean dose) to functional lung. For 30 patients a functional plan was generated with the goal of reducing dose to the functional lung while meeting Radiation Therapy Oncology Group 0617 constraints. The NTCP models were applied to the functional plans and the clinically used plans to calculate toxicity reduction. Results: By the use of functional avoidance planning, absolute reductions in grade 2+ NTCP of 6.3%, 7.8%, and 4.8% were achieved based on the mean fV20 Gy, fV30 Gy, and mean dose to functional lung metrics, respectively. Absolute grade 3+ NTCP reductions of 3.6%, 4.8%, and 2.4% were achieved with fV20 Gy, fV30 Gy, and mean dose to functional lung. Maximum absolute reductions of 52.3% and 16.4% were seen for grade 2+ and grade 3+ pneumonitis for individual patients. Conclusion: Our study quantifies the possible toxicity reduction from CT ventilation–based functional avoidance planning. Reductions in grades 2+ and 3+ pneumonitis were 7.1% and 4.7% based on mean dose-function metrics, with reductions as high as 52.3% for individual patients. Our work provides seminal data for determining the potential toxicity benefit from incorporating CT ventilation into thoracic treatment planning.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2013

A multiscale MDCT image-based breathing lung model with time-varying regional ventilation

A novel algorithm is presented that links local structural variables (regional ventilation and deforming central airways) to global function (total lung volume) in the lung over three imaged lung volumes, to derive a breathing lung model for computational fluid dynamics simulation. The algorithm constitutes the core of an integrative, image-based computational framework for subject-specific simulation of the breathing lung. For the first time, the algorithm is applied to three multi-detector row computed tomography (MDCT) volumetric lung images of the same individual. A key technique in linking global and local variables over multiple images is an in-house mass-preserving image registration method. Throughout breathing cycles, cubic interpolation is employed to ensure C{sub 1} continuity in constructing time-varying regional ventilation at the whole lung level, flow rate fractions exiting the terminal airways, and airway deformation. The imaged exit airway flow rate fractions are derived from regional ventilation with the aid of a three-dimensional (3D) and one-dimensional (1D) coupled airway tree that connects the airways to the alveolar tissue. An in-house parallel large-eddy simulation (LES) technique is adopted to capture turbulent-transitional-laminar flows in both normal and deep breathing conditions. The results obtained by the proposed algorithm when using three lung volume images are compared with those using only one or two volume images. The three-volume-based lung model produces physiologically-consistent time-varying pressure and ventilation distribution. The one-volume-based lung model under-predicts pressure drop and yields un-physiological lobar ventilation. The two-volume-based model can account for airway deformation and non-uniform regional ventilation to some extent, but does not capture the non-linear features of the lung.

42 ENGINEERING↗

DOE OSTI2016

WE-AB-202-01: Evaluating the Toxicity Reduction with CT-Ventilation Functional Avoidance Radiation Therapy

Purpose: CT-ventilation is an exciting new imaging modality that uses 4DCTs to calculate lung ventilation. Studies have proposed to use 4DCT-ventilation imaging for functional avoidance radiotherapy which implies designing treatment plans to spare functional portions of the lung. Although retrospective studies have been performed to evaluate the dosimetric gains to functional lung; no work has been done to translate the dosimetric gains to an improvement in pulmonary toxicity. The purpose of our work was to evaluate the potential reduction in toxicity for 4DCT-ventilation based functional avoidance. Methods: 70 lung cancer patients with 4DCT imaging were used for the study. CT-ventilation maps were calculated using the patient’s 4DCT, deformable image registrations, and a density-change-based algorithm. Radiation pneumonitis was graded using imaging and clinical information. Log-likelihood methods were used to fit a normal-tissue-complication-probability (NTCP) model predicting grade 2+ radiation pneumonitis as a function of doses (mean and V20) to functional lung (>15% ventilation). For 20 patients a functional plan was generated that reduced dose to functional lung while meeting RTOG 0617-based constraints. The NTCP model was applied to the functional plan to determine the reduction in toxicity with functional planning Results: The mean dose to functional lung was 16.8 and 17.7 Gy with the functional and clinical plans respectively. The corresponding grade 2+ pneumonitis probability was 26.9% with the clinically-used plan and 24.6% with the functional plan (8.5% reduction). The V20-based grade 2+ pneumonitis probability was 23.7% with the clinically-used plan and reduced to 19.6% with the functional plan (20.9% reduction). Conclusion: Our results revealed a reduction of 9–20% in complication probability with functional planning. To our knowledge this is the first study to apply complication probability to convert dosimetric results to toxicity improvement. The results presented in the current work provide seminal data for prospective clinical trials in functional avoidance. YV discloses funding from State of Colorado. TY discloses National Lung Cancer Partnership; Young Investigator Research grant.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2016

WE-AB-202-04: Statistical Evaluation of Lung Function Using 4DCT Ventilation Imaging: Proton Therapy VS IMRT

Purpose: Variation in function of different lung regions has been ignored so far for conventional lung cancer treatment planning, which may lead to higher risk of radiation induced lung disease. 4DCT based lung ventilation imaging provides a novel yet convenient approach for lung functional imaging as 4DCT is taken as routine for lung cancer treatment. Our work aims to evaluate the impact of accounting for spatial heterogeneity in lung function using 4DCT based lung ventilation imaging for proton and IMRT plans. Methods: Six patients with advanced stage lung cancer of various tumor locations were retrospectively evaluated for the study. Proton and IMRT plans were designed following identical planning objective and constrains for each patient. Ventilation images were calculated from patients’ 4DCT using deformable image registration implemented by Velocity AI software based on Jacobian-metrics. Lung was delineated into two function level regions based on ventilation (low and high functional area). High functional region was defined as lung ventilation greater than 30%. Dose distribution and statistics in different lung function area was calculated for patients. Results: Variation in dosimetric statistics of different function lung region was observed between proton and IMRT plans. In all proton plans, high function lung regions receive lower maximum dose (100.2%–108.9%), compared with IMRT plans (106.4%–119.7%). Interestingly, three out of six proton plans gave higher mean dose by up to 2.2% than IMRT to high function lung region. Lower mean dose (lower by up to 14.1%) and maximum dose (lower by up to 9%) were observed in low function lung for proton plans. Conclusion: A systematic approach was developed to generate function lung ventilation imaging and use it to evaluate plans. This method hold great promise in function analysis of lung during planning. We are currently studying more subjects to evaluate this tool.

60 APPLIED LIFE SCIENCES↗

NASA NTRS1937

Tank tests of two models of flying-boat hulls to determine the effect of ventilating the step

The results of tests made in the N.A.C.A. tank on two models of flying-boat hulls to determine the effect of ventilating the step are given graphically. The step of N.A.C.A. model 11-C was ventilated in several different ways and it was found that the resistance of the normal form is not appreciably affected by artificial ventilation in any of the forms tried. Further tests made with the depth of the step of model 11-C reduced likewise show no appreciable effect on the resistance from ventilation of the step. Tests were made on a model of the hull of the Navy P3M-1 flying-boat hull both with and without ventilation of the step. It was found that the discontinuity which is obtained in the resistance curves of this model is eliminated by ventilating the step.

Dawson, John R↗

NASA NTRS2008

Regenerative Blower for EVA Suit Ventilation Fan

Portable life support systems in future space suits will include a ventilation subsystem driven by a dedicated fan. This ventilation fan must meet challenging requirements for pressure rise, flow rate, efficiency, size, safety, and reliability. This paper describes research and development that showed the feasibility of a regenerative blower that is uniquely suited to meet these requirements. We proved feasibility through component tests, blower tests, and design analysis. Based on the requirements for the Constellation Space Suit ventilation fan, we designed the critical elements of the blower. We measured the effects of key design parameters on blower performance using separate effects tests, and used the results of these tests to design a regenerative blower that will meet the ventilation fan requirements. We assembled a proof-of-concept blower and measured its performance at low pressures that simulate a PLSS environment. We obtained head/flow performance curves over a range of operating speeds, identified the maximum efficiency point for the blower, and used these results to specify the design and operating conditions for the ventilation fan. We designed a compact motor that can drive the blower under all anticipated operating requirements and operate with high efficiency during normal operation. We identified materials for the blower that will enhance safety for operation in a lunar environment. We produced a solid model that illustrates the final design. The proof-of-concept blower produced the flow rate and pressure rise needed for the CSSS ventilation subsystem while running at 5400 rpm and consuming only 9 W of electric power and using a non-optimized, commercial motor and controller and inefficient bearings. Scaling the test results to a complete design shows that a lightweight, compact, reliable, and low power blower can meet the performance requirements for future PLSSs.

Paul, Heather↗

NASA NTRS2016

Results from Carbon Dioxide Washout Testing Using a Suited Manikin Test Apparatus with a Space Suit Ventilation Test Loop

NASA is developing an advanced portable life support system (PLSS) to meet the needs of a new NASA advanced space suit. The PLSS is one of the most critical aspects of the space suit providing the necessary oxygen, ventilation, and thermal protection for an astronaut performing a spacewalk. The ventilation subsystem in the PLSS must provide sufficient carbon dioxide (CO2) removal and ensure that the CO2 is washed away from the oronasal region of the astronaut. CO2 washout is a term used to describe the mechanism by which CO2 levels are controlled within the helmet to limit the concentration of CO2 inhaled by the astronaut. Accumulation of CO2 in the helmet or throughout the ventilation loop could cause the suited astronaut to experience hypercapnia (excessive carbon dioxide in the blood). A suited manikin test apparatus (SMTA) integrated with a space suit ventilation test loop was designed, developed, and assembled at NASA in order to experimentally validate adequate CO2 removal throughout the PLSS ventilation subsystem and to quantify CO2 washout performance under various conditions. The test results from this integrated system will be used to validate analytical models and augment human testing. This paper presents the system integration of the PLSS ventilation test loop with the SMTA including the newly developed regenerative Rapid Cycle Amine component used for CO2 removal and tidal breathing capability to emulate the human. The testing and analytical results of the integrated system are presented along with future work.

Chullen, Cinda↗

NASA NTRS2016

Results from Carbon Dioxide Washout Testing Using a Suited Manikin Test Apparatus with a Space Suit Ventilation Test Loop

Chullen, Cinda↗

NASA NTRS2017

Magnetic Resonance Imaging of Ventilation and Perfusion in the Lung

Methods, devices, and systems are disclosed for implementing a fully quantitative non-injectable contrast proton MRI technique to measure spatial ventilation-perfusion (VA/Q) matching and spatial distribution of ventilation and perfusion. In one aspect, a method using MRI to characterize ventilation and perfusion in a lung includes acquiring an MR image of the lung having MR data in a voxel and obtaining a breathing frequency parameter, determining a water density value, a specific ventilation value, and a perfusion value in at least one voxel of the MR image based on the MR data and using the water density value to determine an air content value, and determining a ventilation-perfusion ratio value that is the product of the specific ventilation value, the air content value, the inverse of the perfusion value, and the breathing frequency.

Prisk, Gordon Kim↗

DOE OSTI2013

ADMINISTRATIVE AND ENGINEERING CONTROLS FOR THE OPERATION OF VENTILATION SYSTEMS FOR UNDERGROUND RADIOACTIVE WASTE STORAGE TANKS

Liquid radioactive wastes from the Savannah River Site are stored in large underground carbon steel tanks. The majority of the waste is confined in double shell tanks, which have a primary shell, where the waste is stored, and a secondary shell, which creates an annular region between the two shells, that provides secondary containment and leak detection capabilities should leakage from the primary shell occur. Each of the DST is equipped with a purge ventilation system for the interior of the primary shell and annulus ventilation system for the secondary containment. Administrative flammability controls require continuous ventilation to remove hydrogen gas and other vapors from the waste tanks while preventing the release of radionuclides to the atmosphere. Should a leak from the primary to the annulus occur, the annulus ventilation would also serve this purpose. The functionality of the annulus ventilation is necessary to preserve the structural integrity of the primary shell and the secondary. An administrative corrosion control program is in place to ensure integrity of the tank. Given the critical functions of the purge and annulus ventilation systems, engineering controls are also necessary to ensure that the systems remain robust. The system consists of components that are constructed of metal (e.g., steel, stainless steel, aluminum, copper, etc.) and/or polymeric (polypropylene, polyethylene, silicone, polyurethane, etc.) materials. The performance of these materials in anticipated service environments (e.g., normal waste storage, waste removal, etc.) was evaluated. The most aggressive vapor space environment occurs during chemical cleaning of the residual heels by utilizing oxalic acid. The presence of NO{sub x} and mercury in the vapors generated from the process could potentially accelerate the degradation of aluminum, carbon steel, and copper. Once identified, the most susceptible materials were either replaced and/or plans for discontinuing operations are executed.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

DOE OSTI2020

Dynamic metrics of natural ventilation cooling effectiveness for interactive modeling

The evaluation of natural ventilation potential for cooling indoor spaces during the early design phases is of great interest to researchers and practitioners. Among various definitions and usages for natural ventilation potential (NVP) in early design evaluation, this paper reviews and identifies the key performance indicators, and proposes two new dynamic metrics—natural ventilation cooling effectiveness (NVCE) and climate potential utilization ratio (CPUR). The metrics are dynamically responsive to various design options, in both steady and transient states, allowing consideration of thermal mass. Assisting in design development processes, the metrics quantify how well indoor spaces make use of natural ventilation’s cooling capacity. Case studies are presented to demonstrate how NVCE and CPUR enable designers to evaluate the predicted performance and how to apply the information to improve building design. Finally, the results of the design iterations showed that the relationship among various design parameters should be dynamically understood in order to evaluate the performance of natural ventilation, confirming that “the more the airflow, the greater the potential,” and “the heavier the thermal mass, the greater the energy saving” were not always true.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2023

Analysis of Frost Prevention for Heat Recovery Ventilation in an Arctic Facility

Sub-Arctic environments present a unique challenge for the continuous operation of mechanical ventilation systems in occupied buildings where cold temperatures create complications for maintaining adequate air quality, efficiency, and system operability. Heat recovery ventilation is most difficult at the coldest temperatures, when there is the greatest availability to transfer heat between airstreams, due to the potential for frost accumulation in the exhaust airstream. Frost limits heat transfer and creates the potential for subsequent blockage of airflow. A successful frost prevention strategy is necessary to ensure that recovery ventilation systems function in locations with a large amount of annual heating degree days. Commonly, this is achieved by preheating outdoor air above freezing temperatures via airflow through a glycol-water mix hydronic coil before heat exchange occurs. Preheating the outdoor air proactively inhibits frost formation but is associated with a penalty to recovery efficiency. A commercial-scale heat recovery ventilator in a facility in Fairbanks, Alaska was analyzed for sensible recovery effectiveness and exhaust temperature at different winter conditions. The system utilized the common defrost strategy of preheating the air above-freezing with a static temperature control scheme. The heat transfer efficiency of the recovery ventilator was observed to be poor at various winter conditions with elevated exhaust temperatures indicating lost heat recovery effectiveness. Using prior findings on strategies for sub-freezing temperatures along with observed field conditions it was determined that a dynamic relationship between the coil and the exterior conditions would reduce the energy required to preheat the air and allow the heat exchanger to maximize effectiveness due to temperate difference. This reduction in preheated temperature of the air is achieved by modulating the temperature of the coil to keep the discharge air stream above a certain dewpoint temperature threshold, likely leading to energy savings for other sub-Arctic facilities using this frost control strategy.

ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATION↗

DOE OSTI2023

Mechanical Ventilation and Indoor Air Quality in Recently Constructed U.S. Homes in Marine and Cold-Dry Climates Data from Building America Project

Data were collected to characterize whole-house mechanical ventilation (WHMV) and indoor air quality (IAQ) in 55 homes in the Marine climate of Oregon and Cold-Dry climate of Colorado in the U.S. Sixteen homes were monitored for two weeks, with and without WHMV operating. Ventilation airflows; airtightness; time-resolved CO2, PM2.5 and radon; and time-integrated NO2, NOX and formaldehyde were measured. Participants provided information about IAQ-impacting activities, perceptions and ventilation use. All homes had operational cooktop ventilation and bathroom exhaust. Thirty homes had equipment that could meet the ASHRAE 62.2-2010 standard with continuous or controlled runtime and 34 had some WHMV operating as found. Thirty-five of 46 participants with WHMV reported they did not know how to operate it, and only half of the systems were properly labeled. Two-week homes had lower formaldehyde, radon, CO2, and NO (NOX-NO2) when operated with WHMV; and also had faster PM2.5 decays following indoor emission events. Overall IAQ satisfaction was similar in Oregon and Colorado, but more Colorado participants (19 vs. 3%) felt their IAQ could be improved and more reported dryness as a problem (58 vs. 14%). The collected data indicate that there are benefits of operating WHMV, even when continuous use may not be needed because outdoor pollutant concentrations are low and indoor sources do not present substantial challenges.

air quality↗

DOE OSTI2014

Evaluation of Ventilation Strategies in New Construction Multifamily Buildings

In multifamily buildings, particularly in the Northeast, exhaust ventilation strategies are the norm as a means of meeting both local exhaust and whole-unit mechanical ventilation rates. The issue of where the "fresh" air is coming from is gaining significance as air-tightness standards for enclosures become more stringent. CARB researchers have found that most new high performance, multifamily housing in the Northeast use one of four strategies for ventilation: continuous exhaust only with no designated supply or make-up air source, continuous exhaust with ducted make-up air to apartments, continuous exhaust with supply through a make-up air device integral to the unit HVAC, and continuous exhaust with supply through a passive inlet device, such as a trickle vent. Insufficient information is available to designers on how these various systems are best applied. Product performance data are based on laboratory tests, but there is no guarantee that those conditions will exist consistently in the finished building. In this research project, CARB evaluated the four ventilation strategies in the field to validate system performance.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2023

Benefits assessment of cool skin and ventilated cavity skin: Saving energy and mitigating heat and grid stress

This study assessed the energy-saving and climate-adaptive potential of cool skin and ventilated cavity skin facade technologies in Seoul's high-rise apartment buildings. We created weather scenarios for historical, mid-term future, and long-term future conditions using Coordinated Regional Downscaling EXperiment (CORDEX) method. Building energy simulations were conducted on a South Korean high-rise apartment model to evaluate their performance under different weather conditions. The results indicate that cool skin and ventilated cavity skin technologies can save cooling energy during summers but lead to heating energy penalties in winters. Ventilated cavity skin outperforms cool skin, offering better cooling energy savings and reduced heating penalties. Combining both technologies yields the highest overall energy savings, with 7 %, 9 %, and 10 % cooling energy savings for cool skin, ventilated cavity skin, and the combined package, respectively. However, cool skin increases heating energy consumption by 5 %, while ventilated cavity skin has minimal impact on heating energy. These envelope technologies also reduce peak electricity demand by at least 5 %, 8 %, and 9 %, respectively. They contribute to heat stress reduction, enhance resilience, and decrease extreme heat risks for occupants during power outages by at least 18 % under various weather conditions. Considering the prevalence of aging high-rise apartments in South Korea, adopting these envelope renovation strategies can effectively reduce cooling loads, enhance thermal comfort, and boost resilience under future climates, while avoiding costly reconstruction.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2021

The novel Mechanical Ventilator Milano for the COVID-19 pandemic

This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Furthermore, following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world

60 APPLIED LIFE SCIENCES↗

DOE OSTI2013

Optimization of Ventilation Energy Demands and Indoor Air Quality in the ZEBRAlliance Homes

High-performance homes require that ventilation energy demands and indoor air quality (IAQ) be simultaneously optimized. Researchers have primarily addressed these two areas independently because of the assumption that their goals have to be mutually exclusive. This assumption is based on the fact that the typical mechanism to reduce the concentration of indoor air pollutants has been dilution through increased ventilation, which causes heating, ventilation and air conditioning (HVAC) units to consume more energy. High-performance homes aim to provide the essential energy end-uses (for example, water heating, refrigeration, space heating, and air conditioning) in an energy efficient manner. Given that IAQ is among these essential energy end-uses, we investigated means to optimize the concentration of indoor air pollutants and ventilation energy demands. To this end, we conducted tests in four houses located in Oak Ridge, TN, that were 11 to 20 months old, energy efficient (i.e., expected to consume 50% less energy than a house built per the 2006 International Residential Code), airtight (i.e., natural ventilation rate ~0.02 to 0.2 h -1 ), unoccupied, and unfurnished. Our evaluation consisted of identifying air pollutants of concern in these homes that could generally serve as indicators of IAQ, and conducting field experiments and computer simulations to determine the effectiveness and energy required by various techniques that lessened the concentration of these contaminants.

formaldehyde↗