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At least 109 records · Page 6

Hydrothermal Liquefaction and Upgrading of Municipal Wastewater Treatment Plant Sludge: A Preliminary Techno-Economic Analysis, Rev.1

A preliminary process model and techno-economic analysis (TEA) was completed for fuel produced from hydrothermal liquefaction (HTL) of sludge waste from a municipal wastewater treatment plant (WWTP) and subsequent biocrude upgrading. The model is adapted from previous work by Jones et al. (2014) for algae HTL, using experimental data generated in fiscal year 2015 (FY15) bench-scale HTL testing of sludge waste streams. Testing was performed on sludge samples received from Metro Vancouver’s Annacis Island WWTP (Vancouver, B.C.) as part of a collaborative project with the Water Environment and Reuse Foundation (WERF). The full set of sludge HTL testing data from this effort will be documented in a separate report to be issued by WERF. This analysis is based on limited testing data and therefore should be considered preliminary. In addition, the testing was conducted with the goal of successful operation, and therefore does not represent an optimized process. Future refinements are necessary to improve the robustness of the model, including a cross-check of modeled biocrude components with the experimental GCMS data and investigation of equipment costs most appropriate at the relatively small scales used here. Environmental sustainability metrics analysis is also needed to understand the broader impact of this technology pathway. The base case scenario for the analysis consists of 10 HTL plants, each processing 100 dry U.S. ton/day (92.4 ton/day on a dry, ash-free basis) of sludge waste and producing 234 barrel per stream day (BPSD) biocrude, feeding into a centralized biocrude upgrading facility that produces 2,020 barrel per standard day of final fuel. This scale was chosen based upon initial wastewater treatment plant data collected by PNNL’s resource assessment team from the EPA’s Clean Watersheds Needs Survey database (EPA 2015a) and a rough estimate of what the potential sludge availability might be within a 100-mile radius. In addition, we received valuable feedback from the wastewater treatment industry as part of the WERF collaboration that helped form the basis for the selected HTL and upgrading plant scales and feedstock credit (current cost of disposal). It is assumed that the sludge is currently disposed of at $16.20/wet ton ($46/dry ton at 35% solids; $50/ton dry, ash-free basis) and this is included as a feedstock credit in the operating costs. The base case assumptions result in a minimum biocrude selling price of $3.8/gge and a minimum final upgraded fuel selling price of $4.9/gge. Several areas of process improvement and refinements to the analysis have the potential to significantly improve economics relative to the base case: •Optimization of HTL sludge feed solids content •Optimization of HTL biocrude yield •Optimization of HTL reactor liquid hourly space velocity (LHSV) •Optimization of fuel yield from hydrotreating •Combined large and small HTL scales specific to regions (e.g., metropolitan and suburban plants) Combined improvements believed to be achievable in these areas can potentially reduce the minimum selling price of biocrude and final upgraded fuel by about 50%. Further improvements may be possible through recovery of higher value components from the HTL aqueous phase, as being investigated under separate PNNL projects. Upgrading the biocrude at an existing petroleum refinery could also reduce the MFSP, although this option requires further testing to ensure compatibility and mitigation of risks to a refinery. And finally, recycling the HTL aqueous phase product stream back to the headworks of the WWTP (with no catalytic hydrothermal gasification treatment) can significantly reduce cost. This option is uniquely appropriate for application at a water treatment facility but also requires further investigation to determine any technical and economic challenges related to the extra chemical oxygen demand (COD) associated with the recycled water.

09 BIOMASS FUELS↗

Simulation and Optimization of Volatile Fatty Acid Upgrading Strategies for Sustainable Transportation Fuel Production

Underutilized wet waste is a promising feedstock for production of carbon-neutral or carbon-negative liquid transportation fuels. Arrested methanogenesis of wet wastes by microbes, which produces mixtures of C2-C8 carboxylic acids (volatile fatty acids, VFAs), is practiced industrially at a pilot scale and the VFA products can be catalytically upgraded to molecules suitable for use as transportation fuels (alcohols and alkanes) via sequential ketonization and hydrogenation, both steps of which have been demonstrated with high (>90%) yield at the lab scale. We present in this work a simulation-based decision-making framework which evaluates upgrading strategies of VFAs to alcohol- and hydrocarbon-based neat and blended diesel, jet, and gasoline fuels. The processes utilize sequential upgrading steps (ketonization and hydrogenation) accompanied by one distillation step (either separating VFAs before ketonization or alcohols after ketone hydrogenation) to form two liquid streams: a light alcohol stream best suited as a light-duty fuel and a heavy alcohol or hydrocarbon stream best suited as a diesel or jet fuel. Suitability of the liquid products as transportation fuels and maximum blending levels with petrofuels comes from simulation of critical fuel properties (boiling point, flash point, lower heating value, viscosity, melting point, water solubility, and cetane/octane number). Catalytic upgrading steps and fuel property mixing models used by the simulation are experimentally validated. We demonstrate the flexibility of the decision-making algorithm by evaluating processing scenarios for experimentally-observed VFA profiles with varied carbon chain length distributions. Processing scenarios are optimized for either maximum total renewable carbon utilization or production of heavy-duty (jet or diesel) fuels. We evaluate the economic viability and CO2 emissions of each proposed upgrading scenario using techno-economic and life cycle analyses. The decision-making framework developed in this work can also be used to down-select promising strategies for upgrading of other bio-based feedstocks to sustainable fuels and chemicals.

aviation fuel↗

Network upgrade exploiting multi band: S- or E-band?

Nowadays, the fiber spectrum is only partially exploited, i.e., mainly in the C-band and more recently in the C + L-band, where the fiber attenuation profile experiences the minimum. Thus, fiber communications technology—amplifiers, switching, transceivers, etc.—and networking solutions are mature for those spectrum bands. However, the continuous increase in traffic means that capacity saturation of the current infrastructure is looming. Taking advantage of the unused portions of the spectrum (e.g., the S- and E-bands) may be an efficient solution to accommodate an increase in traffic without installing new fibers. Research is thus investigating multi-band transmission and networking to evaluate and enable such network upgrades. Some issues need to be solved or taken into account, from the enabling technology (e.g., amplifiers in the S- or E-band are still under development) to physical layer effects previously neglected, such as stimulated Raman scattering (SRS). SRS affects wideband transmission, potentially degrading active channels. The contribution of this paper is the investigation of network upgrades for C + L-band systems. In particular, upgrades exploiting the E- and S-bands are compared taking into account each band capacity and the effects of SRS on both new and already deployed channels (in both the C- and L-bands). A detailed analysis of the physical layer is provided also in the presence of guard bands between previously exploited bands and the bands used for upgrade. By leveraging the physical layer assessment, a networking analysis is carried out to evaluate the supported traffic increase and also the signal quality degradation due to SRS on active channels. Overall, the results suggest that upgrades to the E- and S-bands support a comparable increase in traffic. However, the exploitation of the E-band with 14 THz of guard band between the C- and E-bands may avoid detrimental effects to already active channels in the C + L-band, suggesting this upgrade strategy can be the most effective of the two.

47 OTHER INSTRUMENTATION↗

Understanding the Costs and Barriers of Residential Electrical Panel and Service Upgrades

Upgrading electrical panels and services in U.S. homes represents a significant barrier to building modernization, imposing considerable costs, delays, and procedural uncertainties on homeowners, contractors, utilities, and building departments. Although cost databases document individual infrastructure activities, they rarely capture the integrated, whole-project perspective required to understand how electrical upgrades are planned, executed, and regulated. Existing research is often geographically constrained, narrowly scoped, or derived from limited samples, leaving significant knowledge gaps unaddressed. This study examines the timelines and costs associated with residential electrical panel and service upgrades using data from a national cross- sectional survey conducted in summer 2025. The survey captured responses from 140 stakeholders across 34 states, including building industry professionals, utility staff, and building department staff. Findings indicate that project duration and cost increase substantially with building size though patterns vary by infrastructure type. Most single-family and small multifamily projects were completed within 30 days, whereas medium and large multifamily buildings show longer and less predictable timelines. Service rating increases modestly extend project duration, but building type and size were the primary determinants of delays. Cost patterns were similar: customer-side equipment and panel replacements scale predictably with building size, while utility-side costs are highly variable, often triggered by threshold-driven infrastructure upgrades such as transformer replacements. Permit fees vary considerably between jurisdictions but generally represent a minor proportion of total project costs. These findings identify electrical upgrades as a significant barrier to residential building costs and highlight the need for improved stakeholder coordination, streamlined permitting, and strategies that reduce upgrade requirements while maintaining safety and code compliance.

Casquero-Modrego, Nuria↗

Floodplain Assessment for the Proposed Outdoor Fire Range Upgrades at TA-72 in Lower Sandia Canyon, Los Alamos National Laboratory

Los Alamos National Laboratory (LANL) is preparing to implement actions in Sandia Canyon at Technical Area (TA) 72. Los Alamos National Security (LANS) biologists conducted a floodplain determination and this project is partially located within a 100-year floodplain. The proposed project is to upgrade the existing outdoor shooting range facilities at TA-72. These upgrades will result in increased safety and efficiencies in the training for Protective Force personnel. In order to remain current on training requirements, the firing ranges at TA-72 will be upgraded which will result in increased safety and efficiencies in the training for Protective Force personnel (Figure 1). These upgrades will allow for an increase in class size and more people to be qualified at the ranges. Some of these upgrades will be built within the 100-year floodplain. The upgrades include: concrete pads for turning target systems and shooting positions, new lighting to illuminate the firing range for night fire, a new speaker system for range operations, canopies at two locations, an impact berm at the far end of the 300-yard mark, and a block wall for road protection.

Basic Biological Sciences(59)↗

Canted Undulator Upgrade for GeoSoilEnviroCARS Sector 13 at the Advanced Photon Source

Support for the beamline component of the canted undulator upgrade of Sector 13 (GeoSoilEnviroCARS; managed and operated by the University of Chicago) at the Advanced Photon Source (APS; Argonne National Laboratory) was received from three agencies (equally divided): NASA-SRLIDAP (now LARS), NSF-EAR-IF (ARRA) and DOE-Single Investigator Small Group (SISGR). The associated accelerator components (undulators, canted front end) were provided by the APS using DOE-ARRA funding. The intellectual merit of the research enabled by the upgrade lies in advancing our knowledge of the composition, structure and properties of earth materials; the processes they control; and the processes that produce them. The upgrade will facilitate scientific advances in the following areas: high pressure mineral physics and chemistry, non-crystalline and nano-crystalline materials at high pressure, chemistry of hydrothermal fluids, reactions at mineral-water interfaces, biogeochemistry, oxidation states of magmas, flow dynamics of fluids and solids, and cosmochemistry. The upgrade, allowing the microprobe to operate 100% of the time and the high pressure and surface scattering and spectroscopy instruments to receive beam time increases, will facilitate much more efficient use of the substantial investment in these instruments. The broad scientific community will benefit by the increase in the number of scientists who conduct cutting-edge research at GSECARS. The user program in stations 13ID-C (interface scattering) and 13ID-D (laser heated diamond anvil cell and large volume press) recommenced in June 2012. The operation of the 13ID-E microprobe station began in the Fall 2012 cycle (Oct.-Dec 2012). The upgraded canted beamlines double the amount of undulator beam time at Sector 13 and provide new capabilities including extended operations of the X-ray microprobe down to the sulfur K edge and enhanced brightness at high energy. The availability of the upgraded beamlines will advance the research being conducted at Sector 13.

47 OTHER INSTRUMENTATION↗

Upgrading the Space Shuttle Caution and Warning System

A report describes the history and the continuing evolution of an avionic system aboard the space shuttle, denoted the caution and warning system, that generates visual and auditory displays to alert astronauts to malfunctions. The report focuses mainly on planned human-factors-oriented upgrades of an alphanumeric fault-summary display generated by the system. Such upgrades are needed because the display often becomes cluttered with extraneous messages that contribute to the difficulty of diagnosing malfunctions. In the first of two planned upgrades, the fault-summary display will be rebuilt with a more logical task-oriented graphical layout and multiple text fields for malfunction messages. In the second upgrade, information displayed will be changed, such that text fields will indicate only the sources (that is, root causes) of malfunctions; messages that are not operationally useful will no longer appear on the displays. These and other aspects of the upgrades are based on extensive collaboration among astronauts, engineers, and human-factors scientists. The report describes the human-factors principles applied in the upgrades.

McCandless, Jeffrey W.↗

Nuclear Thermal Rocket Element Environmental Simulator (NTREES) Upgrade Activities

Over the past year the Nuclear Thermal Rocket Element Environmental Simulator (NTREES) has been undergoing a significant upgrade beyond its initial configuration. The NTREES facility is designed to perform realistic non-nuclear testing of nuclear thermal rocket (NTR) fuel elements and fuel materials. Although the NTREES facility cannot mimic the neutron and gamma environment of an operating NTR, it can simulate the thermal hydraulic environment within an NTR fuel element to provide critical information on material performance and compatibility. The first phase of the upgrade activities which was completed in 2012 in part consisted of an extensive modification to the hydrogen system to permit computer controlled operations outside the building through the use of pneumatically operated variable position valves. This setup also allows the hydrogen flow rate to be increased to over 200 g/sec and reduced the operation complexity of the system. The second stage of modifications to NTREES which has just been completed expands the capabilities of the facility significantly. In particular, the previous 50 kW induction power supply has been replaced with a 1.2 MW unit which should allow more prototypical fuel element temperatures to be reached. The water cooling system was also upgraded to so as to be capable of removing 100% of the heat generated during. This new setup required that the NTREES vessel be raised onto a platform along with most of its associated gas and vent lines. In this arrangement, the induction heater and water systems are now located underneath the platform. In this new configuration, the 1.2 MW NTREES induction heater will be capable of testing fuel elements and fuel materials in flowing hydrogen at pressures up to 1000 psi at temperatures up to and beyond 3000 K and at near-prototypic reactor channel power densities. NTREES is also capable of testing potential fuel elements with a variety of propellants, including hydrogen with additives to inhibit corrosion of certain potential NTR fuel forms. Additional diagnostic upgrades included in the present NTREES set up include the addition of a gamma ray spectrometer located near the vent filter to detect uranium fuel particles exiting the fuel element in the propellant exhaust stream to provide additional information any material loss occurring during testing. Other aspects of the upgrade included reworking NTREES to reduce the operational complexity of the system despite the increased complexity of the induction heating system. To this end, many of the controls were consolidated on fewer panels. As part of this upgrade activity, the Safety Assessment (SA) and the Standard Operating Procedures (SOPs) for NTREES were extensively rewritten. The new 1.2 MW induction heater consists of three physical units consisting of a transformer, rectifier, and inverter. This multiunit arrangement facilitated increasing the flexibility of the induction heater by more easily allowing variable frequency operation. Frequency ranges between 20 and 60 kHz can be accommodated in the new induction heater allowing more representative power distributions to be generated within the test elements.

Emrich, William J., Jr.↗

Characterization of the Upgraded NASA GRC Single Stage Axial Compressor and Fan Facility

In order to meet the emissions and efficiency goals established by the aviation community, next generation aircraft engines will require low pressure ratio, distortion tolerant fans. Maturation of the necessary technologies will require facilities which are capable of accurately testing the fan performance. To achieve this, the Single Stage Axial Compressor and Fan facility at NASA Glenn Research Center was upgraded. Details of the goals and upgrades undertaken were documented in the 2022 Turbo Expo paper, “Upgrades to the Single Stage Axial Compressor and Fan Facility for Low Pressure Ratio Boundary Layer Ingesting Fan Research.” The performance of the upgraded facility will be documented in this paper. This paper will review the challenges associated with testing low pressure ratio and distortion tolerant fans and briefly review the upgrades undertaken and their goals. Then the performance of the facility upgrades and the extent to which they were able to achieve the stated goals will be discussed. This includes mass flow measurements, test section temperature, pressure, flow angle at two axial locations, and turbulence levels at the inlet and test section. The paper also documents the performance of distortion generating swirl vanes and total pressure screens to achieve desired distorted conditions at the Aerodynamic Interface Plane.

BLI↗

Characterization of the Upgraded NASA GRC Single Stage Axial Compressor and Fan Facility

In order to meet the emissions and efficiency goals established by the aviation community, next generation aircraft engines will require low pressure ratio, distortion tolerant fans. Maturation of the necessary technologies will require facilities capable of accurately testing the fan performance are needed. To achieve this, the Single Stage Axial Compressor and Fan facility at NASA Glenn Research Center was upgraded. Details of the goals and upgrades undertaken were documented in the 2022 Turbo Expo paper, “Upgrades to the Single Stage Axial Compressor and Fan Facility for Low Pressure Ratio Boundary Layer Ingesting Fan Research.” The performance of the upgraded facility will be documented in this paper. This paper will review the challenges associated with testing low pressure ratio and distortion tolerant fans and briefly review the upgrades undertaken and their goals. Then the performance of the facility upgrades and the extent to which they were able to achieve the stated goals. This includes mass flow measurements, test section temperature, pressure, flow angle at two axial locations, and turbulence levels at the inlet and test section. The paper also documents the performance of distortion generating swirl vanes and total pressure screens to achieve desired distorted conditions at the Aerodynamic Interface Plane.

BLI↗

Simulation and Optimization of Volatile Fatty Acid Upgrading Strategies for Sustainable Transportation Fuel Production

The multicomponent nature of and variability of biomass makes chemical upgrading via a single process stream to a single end use infeasible for most feedstocks. A more promising approach is to identify upgrading strategies (encompassing bioprocessing, catalysis, and separations) which valorize varied biomass fractions to distinct products to which each is best suited. A robust procedure to carry out this goal should incorporate comparison of various upgrading procedures as well as suitability of products to a slate of identified end uses. We applied this strategy to one biomass-derived feedstock, volatile fatty acids (VFAs) derived from wet waste arrested anaerobic digestion, by developing a computer program, VFA Upgrading to Liquid Transportation fUels Refinery Estimation (VULTURE) which evaluates VFA catalytic upgrading to liquid transportation fuels. VULTURE considers multiple separations, catalysis (ketonization, hydrogenation), and fuel application options, generating hundreds of candidate scenarios for a given VFA stream, then selects several promising strategies that optimize bio-content of products with properties best suited for target fuel types. We find that VFAs are upgraded most efficiently when separate light alcohol (C3-6) and heavy hydrocarbon or alcohol (C7-13) fractions are targeted to create gasoline and heavy-duty (diesel or jet) fuels or fuel blends. Surrogate property testing of VULTURE-recommended fuels reveals that most predictive models employed are robust, while rigorous process simulation shows that the simple unit operation assumptions used in VULTURE are largely accurate, especially for heavy-duty fuel synthesis. Techno-economic and life-cycle analyses show that VFA-derived fuels are profitable and have dramatically (=57%) lower carbon intensities than fossil analogs.

BIOMASS FUELS↗

Early implementation of digital upgrades on simulators - 347

An important aspect of successful Nuclear Power Plant (NPP) digital control system upgrade projects is to upgrade the Operator Training Simulator (OTS) or a related Engineering Simulator (ES), prior to installation of the Distributed Control System (DCS) on the plant allowing for early testing of the digital controls/HMI and for early training of the plant operators while maintaining OTS configuration management (i.e. OTS in sync with the plant's current design). Experience has shown that early implementation of digital upgrades on the OTS and/or an ES can reduce plant startup duration (related to digital systems commissioning) and ensure operators are proficient with the new digital systems to ensure safe and reliable plant operation. Including simulators in the design process offers many benefits including early identification of design deficiencies, testing deficiency fixes, developing and validating plant procedures and supporting human factors engineering, to name a few. Implementing digital upgrades on the OTS is also a regulatory requirement driven by the ANSI/ANS-3.5-2009 standard (Nuclear Power Plant Simulators for Use in Operator Training and Examination) if the new DCS affects actions to be taken by the plant operator in the main control room. This paper presents the benefits of implementing digital upgrades on the OTS and/or ES prior to plant implementation. The various simulator implementation strategies (stimulation, emulation, simulation or a hybrid solution) and selection factors are discussed. The paper also covers four (4) case studies demonstrating how digital upgrades can be implemented on simulators. The first case study covers the implementation of a Siemens offgas Programmable Logic Controller (PLC) system on the Enrico Fermi OTS (Michigan). The second case study covers the implementation of a GE main generator excitation system on the Cernavoda OTS (Romania). The third case study covers the implementation of a Siemens main feedwater control system on the Callaway OTS and ES (Missouri). The final case study covers the implementation of the non-safety related and safety related DCS on the Nuclear New Build (NNB) Hongyanhe Phase I dual-purpose OTS/ES (China). (authors)

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Meta-analysis of biogas upgrading to renewable natural gas through biological CO 2 conversion

Biogas upgrading through CO 2 conversion by hydrogenotrophic methanogenesis is receiving an increasing attention worldwide because of the demand for renewable natural gas. Herein, a holistic and statistical study of the operation conditions, driving forces, performances, and potential implementation of biogas upgrading via biological CO 2 conversion was conducted. Based on a systematic review and meta-analysis of 46 existing publications that were selected from 1475 papers, we have compiled a global dataset of CO 2 bioconversion biogas upgrading, encompassing 308 study cases. Subsequently, we employed a rigorous analytical framework incorporating data processing and mixed effects linear regression analysis to examine the dataset. This analysis revealed a significant positive relationship between the H 2 :CO 2 ratio and the methane percentage in the upgraded biogas when using the study as a random effect. Furthermore, we performed meta-analysis on observations taken when the ratio was close to 4:1 and found that ex situ reactors (91.93% [88.11%, 95.75%]) can perform better than in situ reactors (84.74% [80.69%, 88.80%]). No evidence of differential performance was found based on the present dataset between different temperature regimes or operation modes. Furthermore, those findings establish a database that will contribute to a deeper understanding of the biogas upgrading via biological CO 2 conversion.

Biogas upgrading↗

Upgrading of Intermediate Bio-Oil Produced by Catalytic Pyrolysis

The objectives of this project were to (1) develop a process to upgrade catalytic pyrolysis bio-oil, (2) investigate new upgrading catalysts suited for upgrading catalytic pyrolysis bio-oil, (3) demonstrate upgrading system operation for more than 1,000 hours using a single catalyst charge, and (4) produce a final upgraded product that can be blended to 30 percent by weight with petroleum fuels or that is compatible with existing petroleum refining operations. This project has, to the best of our knowledge, for the first time enabled a commercially viable bio-oil hydrotreatment process to produce renewable blend stock for transportation fuels.

09 BIOMASS FUELS↗

Upgrades to the International Space Station Urine Processor Assembly

Since November 2008, the ISS Urine Processor Assembly (UPA) has successfully generated distillate from crew urine. Several rounds of modifications and upgrades have also been implemented to improve overall system performance throughout the years. The Distillation Assembly (DA) is the latest upgraded unit available, installed in September 2020. This unit has shown immediate performance improvements and redesign success. Most significant upgrades have been a redesigned drive train to eliminate belt slips, improved sealing to reduce leak paths and improve wear, and a redesigned liquid level sensor. The Purge Pump and Separator Assembly (PPSA) technology demonstration is the next available upgraded unit and has finished ground assembly and testing and is targeted for ISS delivery within the coming year. Most recent ground studies have identified areas to focus future UPA upgrade considerations with exploration missions in mind, specifically for better fault detection and isolations approaches as well as potential hardware redesigns to facilitate successful dormancy operations.

Urine Processor Assembly↗

Upgrading Fast Pyrolysis Liquids

The liquid formed by the fast pyrolysis (FP) of biomass is commonly termed bio-oil. Biomass is converted to bio-oil through FP at 400-550°C typically at 1 atm. During FP, the biomass is held at temperature for a residence time on the order of 1-2 seconds. FP is beneficial from the standpoint that a large portion of the total mass and carbon contained in the biomass is converted and retained in the liquid bio-oil fraction. However, bio-oil is acidic, viscous, and thermally unstable. Bio-oil must be upgraded in order to be considered as a liquid transportation fuel or separated and further treated to produce value-added chemicals. Bio-oil is generally regarded as difficult to upgrade due to its thermal instability and chemical complexity which is derived in part from the incorporation of highly reactive species such as aldehydes and terminal olefins as well as the presence of sugars and anhydrosugar species which undergo secondary polymerization reactions when heated. Upgrading strategies considered in this chapter include methods to stabilize and deoxygenate bio-oil through low temperature hydroprocessing to stabilize bio-oil followed by higher temperature “deep hydrotreating” to remove the majority of oxygen present; converting bio-oil catalytically (often with zeolites such as HZSM-5) prior to condensation with catalysts inside the FP reactor or in a separate fixed or fluidized bed after the FP reactor; catalytic cracking with acid catalysts such as zeolites after condensation; or through physical or chemical separations to improve bio-oil stability, extract valuable chemicals, or produce H¬2. Bio-oil upgrading by co-processing with refinery streams such as vacuum gas oil in a fluid catalytic cracking (FCC) unit in a refinery has also been investigated. Numerous excellent reviews, perspectives and other chapters have been published in the preceding 7 years.[1-10] Reviews specific to individual sections within this chapter are at the beginning of the individual sections. This chapter is intended as an update to the original article authored by Prof. Anthony V. Bridgwater, Thermochemical Processing of Biomass: Conversion into Fuels, Chemicals and Power, First Edition, Edited by Robert C. Brown, © 2011 John Wiley & Sons, Ltd. We gratefully acknowledge the original contribution by Prof. Bridgwater and have kept much of his original discussions intact with updated references. The scope of this updated chapter includes references published since about 2010. In the interest of space many of the original references included in the original version were not included. Thus, Prof. Bridgwater’s original chapter should be viewed as a companion to this updated chapter to provide a holistic set of references to the numerous bio-oil upgrading processes discussed herein.

Albrecht, Karl O.↗

Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients

Purpose: Radiation oncologists rely on available clinical information (biopsy Gleason score and prostate-specific antigen [PSA]) to determine the optimal treatment regimen for each prostate cancer patient. Existing published nomograms correlating clinical to pathologic extent of disease were based on patients treated in the 1980s and 1990s at select academic institutions. We used the Surveillance, Epidemiology, and End Results (SEER) database to examine pathologic outcomes (Gleason score and cancer stage) in early prostate cancer patients based on biopsy Gleason score and PSA concentration. Methods and Materials: This analysis included 25,858 patients whose cancer was diagnosed between 2010 and 2011, with biopsy Gleason scores of 6 to 7 and clinical stage T1 to T2 disease, who underwent radical prostatectomy. In subgroups based on biopsy Gleason score and PSA level, we report the proportion of patients with pathologically advanced disease (positive surgical margin or pT3-T4 disease) or whose Gleason score was upgraded. Logistic regression was used to examine factors associated with pathologic outcomes. Results: For patients with biopsy Gleason score 6 cancers, 84% of those with PSA <10 ng/mL had surgical T2 disease with negative margins; this decreased to 61% in patients with PSA of 20 to 29.9 ng/mL. Gleason score upgrading was seen in 43% (PSA: <10 ng/mL) to 61% (PSA: 20-29.9 ng/mL) of biopsy Gleason 6 patients. Patients with biopsy Gleason 7 cancers had a one-third (Gleason 3 + 4; PSA: <10 ng/mL) to two-thirds (Gleason 4 + 3; PSA: 20-29.9 ng/mL) probability of having pathologically advanced disease. Gleason score upgrading was seen in 11% to 19% of patients with biopsy Gleason 4 + 3 cancers. Multivariable analysis showed that higher PSA and older age were associated with Gleason score upgrading and pathologically advanced disease. Conclusions: This is the first population-based study to examine pathologic extent of disease and pathologic Gleason score upgrading based on clinically available information in modern patients. These data inform the selection of radiation therapy strategies and an understanding of whether prostatectomy alone is likely to be curative for patients with early prostate cancers.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

The STAR BES-II and Forward Rapidity Physics and Upgrades

The second phase of the Beam Energy Scan at RHIC, BES-II, is scheduled to start in 2019 and will explore with precision measurements the high baryon density region of the QCD phase diagram. The detector upgrades will enhance some of the key measurements by extending STAR’s kinematical reach. Examples are the kurtosis of net-protons, which could pinpoint the position of a critical point. The upgrades currently under way comprise: the replacement of the inner TPC sectors, the Event Plane Detector and the end-cap TOF. Building on these upgrades STAR is planning to further enhance its detector capabilities by installing a Forward Calorimeter System integrating an electromagnetic and hadronic calorimeter and a Forward Tracking System combining 3 Silicon mini-strip disks and 4 Small-Strip Thin Gap Chamber (sTGC) wheels. The forward upgrade is motivated by studying the initial state of nucleons and nuclei and the exploration of cold QCD physics in the very high and low regions of x. This proceeding will highlight these upgrades and some of their selected physics opportunities.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗