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At least 109 records · Page 6

Development of an accelerator-based neutron source to prototype Mo-99 production, part I: A liquid LBE windowless target

In this article, Molybdenum-99 (Mo-99)’s decay product, technetium-99 (Tc-99 m), is one of the most critical isotopes for medical diagnostics. To provide U.S. domestic supply of Mo-99 without using high-enriched uranium (HEU), a subcritical uranium target assembly (UTA) is irradiated by an accelerator-based neutron source to create Mo-99 through fission. This study discusses the development of the accelerator-based neutron source. The high-energy electrons from the accelerator irradiate a liquid lead-bismuth eutectic (LBE) target to produce neutrons. Part I of this work focuses on numerical and experimental analysis towards the development of a liquid LBE windowless target. Unlike the existing windowless targets in literature, the current design creates a vertical free surface for a beam to irradiate. First, a hydrodynamic analysis of the LBE windowless target is performed. Simplified analytical calculations are assisted by 2D computational fluid dynamics (CFD) simulations to design the target, with the focus on eliminating recirculation zones and avoiding cavitation. With the optimized geometry, the experimental study is performed to investigate the flow hydrodynamics using liquid LBE. The experiments (1) compare pressure drop in the system to correlation predictions; (2) visualize the free surface liquid LBE flow from the beam view; (3) validate the LBE flow profile using temperature sensitive paint from the side view; and (4) validate the liquid LBE film thickness using gamma densitometer measurements. Second, the power handling capability of the designed windowless target is investigated. The divider plate in the current design is susceptible to overheating due to the thin LBE film in front. As LBE erosion and corrosion is likely to occur at an LBE velocity of 2.0 m/s and temperature above 500 °C, a power limit of 10 kW of beam power was established to prevent this corrosion from occurring, which is calculated by a Nusselt number correlation. The divider plate surface temperature at 10 kW agrees well with the 3D CFD simulation results. Part I demonstrates the fundamental physics in liquid LBE windowless target design and associated testing. A companion paper, Part II will demonstrate how to couple this windowless target into the Mo-99 production system, including an accelerator system operating under an ultra-high vacuum and the UTA cooled by water at room temperature.

43 PARTICLE ACCELERATORS↗

Density evolution after shock release from laser-driven polystyrene (CH) targets in inertial confinement fusion

The evolution of the plasma density in the rarefaction wave formed after a laser-driven shock is released from a CH foil was measured using optical interferometry. Here, it was found that the plasma density profile is very sensitive to the conditions at the back surface of the foil before the shock release. Dedicated experiments demonstrated that radiation preheat by coronal x-rays caused early expansion of the back surface and faster expansion of the rarefaction wave. Radiation-hydrodynamics simulations with accurate modeling of radiation preheat from the plasma corona are in good agreement with the experimental results. The early expansion of material interfaces due to coronal x-ray preheat must be evaluated in designing and interpreting laser-driven inertial confinement fusion experiments.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Superconductivity Reinforces Charge-Density-Wave Phase Coherence across Cuprates

For decades, superconductivity in high-𝑇 c cuprates has been viewed as a competitor that suppresses charge-density-wave (CDW) order by reducing its amplitude and spatial extent. Here, in this study, we show that this picture is incomplete, as superconductivity is accompanied by a systematic enhancement of CDW phase coherence across multiple cuprate families. Using resonant soft x-ray scattering combined with a coherence-sensitive momentum-profile analysis, we uncover a BCS-like growth of phase coherence below 𝑇 c , which phenomenologically manifests as the absence of CDW peak broadening and near-perfect wave-vector locking. This enhancement remains visible even in a disorder-dominated regime created by long-term crystal aging and follows a common trend when compared with published data on Bi-, Hg-, Y-, and Nd-based cuprates. These results indicate that superconductivity reshapes CDW order in two distinct ways, suppressing its amplitude while strengthening its phase coherence, and reveal an additional phase-level interplay with lattice coupling in high-𝑇 c cuprates.

Lee, H. [SLAC National Accelerator Laboratory (SLA↗

Foreground-immune CMB lensing reconstruction with polarization

Extragalactic foregrounds are known to generate significant biases in temperature based CMB lensing reconstruction. Several techniques, which include "source hardening'" and "shear-only estimators'' have been proposed to mitigate contamination and have been shown to be very effective at reducing foreground-induced biases. Here we extend both techniques to polarization, which will be an essential component of CMB lensing reconstruction for future experiments and investigate the "large lens'' limit analytically to gain insight on the origin and scaling of foreground biases, as well as the sensitivity to their profiles. Furthermore, using simulations of polarized point sources, we estimate the expected bias to both Simons Observatory and CMB-S4 like (polarization-based) lensing reconstruction, finding that biases to the former are minuscule while those to the latter are potentially non-negligible at small scales ($L$ ~ $1000-2000$). In particular, we show that for a CMB-S4 like experiment, an optimal linear combination of point-source hardened estimators can reduce the (point-source induced) bias to the CMB lensing power spectrum by up to two orders of magnitude, at a ~ 4% noise cost relative to the global minimum variance estimator.

79 ASTRONOMY AND ASTROPHYSICS↗

COVID-19 biomarkers based on respiratory microbiome content

COVID-19 patient care management would greatly benefit from new tools that enable accurate assessment of disease severity and stage, potentially enabling a personalized medicine approach. Detection of the SARS-CoV-2 virus itself, or even quantitation of viral loads, is not sufficient for accurate assessment of disease state beyond diagnosis of infection [eg, doi:10.1093/cid/ciaa344]. Levels of usual suspect protein biomarkers associated with host response to infection [eg, C-reactive protein (CRP); cytokines like IL-6, TNF-alpha, and IL-10; complement proteins like C3a and C5a], and of individual blood cell types (eg, leukocytes, lymphocytes, and subsets thereof), show limited correlation with disease severity and stage, with high patient-to-patient and study-to-study variability [eg, doi:10.1093/cid/ciaa248]. High-dimensional panels of biomarkers should have greater predictive power and resilience to unavoidable sources of variability; however, their assembly from proteins and cell types is extremely difficult, due to technical limitations in analyte measurement, especially with regard to starting material requirements and detection sensitivity. Host response profiling through Next Generation Sequencing (NGS) of gene expression patterns (ie, RNA-Seq) is a promising approach, but at the time of this project there were only two publicly available datasets of relevance [doi:10.1093/cid/ciaa203, doi:10.1080/22221751.2020.1747363], and close inspection of them revealed that each had at least one major flaw that severely undermined its value in supporting robust analysis of host response to SARS-CoV- 2 infection. However, the first of these studies [doi:10.1093/cid/ciaa203] fortuitously collected NGS data not only from host cells, but also from bacteria present in bronchoalveolar lavage fluid (BALF) recovered from COVID-19 patients; and because the respiratory microbiome (in terms of bacterial species content) is far less complex than the human transcriptome, the NGS data collected were sufficient to provide coverage depth supporting robust analysis. Surprisingly, the authors of the study did not carry out a detailed analysis of these data and their potential for revealing important new information about COVID-19. Therefore, we carried out a meta-analysis of the dataset as a first step in evaluating the potential for profiling of respiratory microbiome dynamics as a means of accurately assessing COVID-19 disease state.

59 BASIC BIOLOGICAL SCIENCES↗

A novel candidate hepatitis C virus genotype 4 subtype identified by next generation sequencing full-genome characterization in a patient from Saudi Arabia

Background and aim: Hepatitis C virus (HCV) infection is a major global public health concern, being a leading cause of chronic liver diseases such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The virus is classified into 8 genotypes and 93 subtypes, each displaying distinct geographic distributions. Genotype 4 is the most predominant in the Middle East and Eastern Mediterranean and is associated with high rates of hepatitis C infection worldwide. This study used next-generation sequencing to fully characterize the HCV genome and identify a novel subtype within genotype 4 isolated from a 64-year-old Saudi man diagnosed with hepatitis C. Methods: We analyzed the complete genome of the 141-HCV isolate using whole-genome sequencing. Results: Our phylogenetic reconstructions, based on the entire genome of HCV-4 strains, revealed that the 141-HCV isolate formed a distinct group within the genotype 4 classification, providing valuable new insights into the variability of HCV. Conclusion: This discovery of a previously unclassified HCV subtype within genotype 4 sheds light on the ongoing evolution and diversity of the virus. Such knowledge has significant implications for diagnostic and therapeutic approaches, as different subtypes may exhibit varying drug sensitivities and resistance profiles.

60 APPLIED LIFE SCIENCES↗

The upper Jovian atmosphere aerosol content determined from a satellite eclipse observation

An eclipse of Ganymede observed in 30 colors with a multichannel spectrometer and the 5-m Hale telescope is analyzed to determine the aerosol content of the upper Jovian atmosphere. Contemporary radiative-equilibrium atmospheric models are used, and less restrictive a priori assumptions about the aerosol distribution are made than in previous studies. Preliminary processing of the raw data to correct for telescope aperture change and to remove scattered light is described, eclipse light-curve theory is reviewed, and light-curve features are examined. The primary 'cloudy' atmospheric model employed is outlined along with the computational method, and results are presented on aerosol profiles, the upper limit of the aerosol region, the aerosol structure, the sensitivity of the aerosol profiles to various parameters, and the stratospheric aerosol distribution. The aerosol profiles are found to indicate a very dilute stratospheric haze overlying a tenuous tropopause cloud or cloud top.

Smith, D. W.↗

A comparison of quasar absorption line systems with absorption by the galactic halo

Milky Way halo and quasar absorption spectra contain a number of remarkable similarities which include mixed ion absorption, a general absence of excited fine structure levels with the possible exception of excited C II, similar column densities, and similar multicomponent line profiles. The extreme sensitivity of UV lines to small amounts of gas is well illustrated in a comparison of 21-cm H I emission with UV absorption toward the Large Magellanic Cloud. This sensitivity shows that galaxies are likely to appear significantly larger in UV absorption than in 21-cm emission and that the size problem for galactic halos is probably not a serious one. It is concluded that many of the absorption line systems seen in the spectra of quasars are probably produced in the gaseous halos of intervening galaxies.

Savage, B. D.↗

Martian volatiles determined using the Mars observer gamma ray spectrometer

The relative abundances of H2O and CO2 and their latitude, longitude, and depth profiles on Mars sensitively reflect, as well as help control, past and present Martian climate patterns. Seasonal variations of their distributions at high latitudes also reflect and help control global weather patterns and erosion through surface weathering. A combined analysis of gamma ray line and neutron flux maps constructed from data measured using the Mars Observer Gamma Ray Spectrometer (MOGRS) should allow a determination of seasonal changes in both the horizontal and vertical structure of CO2 ice that covers the north polar cap during winter and the south polar cap throughout the year and both the horizontal and vertical structure of residual H2O ice within the top meter of the surface that was predicted from Viking observations to exist primarily at high latitudes. Particularly important in this regard will be maps of thermal and epithermal neutron fluxes measured using the MOGRS anticoincidence shield, the intensity of the hydrogen, neutron capture gamma ray line at 2.223 MeV, the intensity of a capture gamma ray line as 1.725 MeV from iron, and the intensity of an inelastic scatter gamma ray line as 1.779 MeV from silicon.

Feldman, W. C.↗

AstroBioLab: A Mobile Biotic and Soil Analysis Laboratory

The Jet Propulsion Laboratory, Scripps Institution of Oceanography, and NASA Ames Research Center are currently developing a mobile Astrobiology Laboratory (AstroBioLab) for a series of field campaigns using the Chilean Atacama Desert as a Martian surface analog site. The Astrobiology Science and Technology for Exploring Planets (ASTEP) program funded AstroBioLab is designed around the Mars Organic Detector (MOD) instrument and the Mars Oxidant Instrument (MOI) which provide complementary data sets. Using this suite of Mars Instrument Development Program (MIDP) and Planetary Instrument Definition and Development Program (PIDDP) derived in situ instruments, which provide state-of-the-art organic compound detection (attomolar sensitivity) and depth profiling of oxidation chemistry, we measure and correlate the interplay of organic compounds, inorganic oxidants, UV irradiation and water abundance. This mobile laboratory studies the proposition that intense UV irradiation coupled with low levels of liquid water generates metastable oxidizing species that can consume moderate amounts of seeded organic compounds. Results from the initial spring 2003 field campaign will be presented.

J L Bada↗

Characterization of Downstream Ion Energy Distributions From a High Current Hollow Cathode in a Ring Cusp Discharge Chamber

The presence of energetic ions produced by a hollow cathodes operating at high emission currents (greater than 10 Angstroms) has been documented in the literature. As part of an ongoing effort to uncover the underlying physics of the formation of these ions, ion efflux from a high current hollow cathode operating in an ion thruster discharge chamber was investigated. Using a spherical sector electrostatic energy analyzer located downstream of the discharge cathode, the ion energy distribution over a 0 to 60 eV energy range was measured. The sensitivity of the ion energy distribution function to zenith angle was also assessed at 3 different positions: 0, 15, and 25 degrees. The measurements suggest that the majority of the ion current at the measuring point falls into the analyzer with an energy approximately equal to the discharge voltage. The ion distribution, however, was found to be quite broad. The high energy tail of the distribution function tended to grow with increasing discharge current. Sensitivity of the profiles to flow rate at fixed discharge current was also investigated. A simple model is presented that provides a potential mechanism for the production of ions with energies above the discharge voltage.

Foster, John E.↗

The Distribution of Methane in Titan's Stratosphere from Cassini/CIRS Observations

Cassini/CIRS spectra in the far- and mid-infrared region are used to determine the abundance of methanein Titans lower stratosphere and investigate its distribution with latitude. The CIRS spectra include emissionfrom both the CH4 v4 band at 7.7 micron and pure rotational lines longwards of 50 micron, which show differential sensitivities to thermal profile and methane mole fraction. We analyze nadir and limb data taken over the first part of the Cassini mission (August 2005 to June 2010), including a selection of 12 latitudes that provides a reasonably complete and regular sampling of both hemispheres. Unexpectedly, but in a consistent manner for limb and nadir geometries, large variations of the methane mole fraction near 15 mbar (approx. 85 km) are found, with values ranging from approx. 1.0% (at low latitudes and near +/-50-55 deg) to approx. 1.5% (at +/-30-35 deg and polar latitudes). Error bars on the retrieved methane mole fraction are 0.07-0.12% at low latitudes in the Southern hemisphere and 0.14-0.21% northward of 40 deg N. A 1.0% methanemole fraction at low latitudes permits us to reconcile the HASI-measured temperatures below 147 kmaltitude (2.7 mbar) with inferences from CIRS. The roughly hemispherically-symmetric distribution ofmethane gas is reminiscent of that observed or predicted for the tropospheric methane clouds, whichon a yearly-averaged basis, show preferential occurrences at tropical and polar latitudes. We speculatethat convective events at these latitudes result into local stratospheric methane enrichment, whichmay persist year-round due to dynamical mixing times in the lower stratosphere only moderately shorterthan a Titan year.

Methane↗

Preferential Acceleration of Heavy Ions in a Spontaneously Fragmenting Flare Current Sheet

We study the ion acceleration in a mesoscale, spontaneously fragmenting flare current sheet (SFCS) characterized by the presence of a plasmoid cascade. The main subject of our investigation is to determine whether and how plasmoid cascades at intermediate scales in a fragmented current sheet of a solar flare can impact the (preferential) acceleration of specific ions. The time evolution of the SFCS is obtained from high-resolution 2.5D MHD simulations. The ion trajectories (in the background fields resulting from the MHD model), energies, and pitch angles are calculated using a relativistic test-particle code based on the half-acceleration–rotation–half-acceleration method. For light ions, the main acceleration effects of electromagnetic fields within the SFCS are analyzed using the guiding center approximation. We identify regions with the most-efficient ion acceleration within the SFCS, the accelerator efficiency, and spectra of the accelerated ions. The influence of the charge-to-mass ratio on ion behavior is also studied and resulting ion abundances are compared with observational data. The main ion acceleration takes place in the regions with a strong polarization term, which is part of the first-order Fermi acceleration. Because the term is mass dependent, heavier ions undergo preferential acceleration. The ion energy spectra, abundance-enhancement factors, and differential fluxes, obtained from the model, exhibit power-law profiles, in agreement with observed solar energetic particle events. Nonetheless, the obtained slopes for the abundance-enhancement factor do not exactly match the observed data. The computed slopes and profiles are not sensitive to changes in the initial plasma temperature.

David Kramoliš↗

CTA and SWGO can discover Higgsino dark matter annihilation

Thermal Higgsino dark matter (DM), with a mass near 1.1 TeV, is one of the most well-motivated and untested DM candidates. Leveraging recent hydrodynamic cosmological simulations that give DM density profiles in Milky Way analog galaxies we show that the linelike gamma-ray signal predicted from Higgsino annihilation in the Galactic Center could be detected at high significance with the upcoming Cherenkov Telescope Array (CTA) and Southern Wide-field Gamma-ray Observatory (SWGO) for all but the most pessimistic DM profiles. We perform the most sensitive search to-date for the linelike signal using 15 years of data from the Fermi Large Area Telescope, coming within an order one factor of the necessary sensitivity to detect the Higgsino for some Milky Way analog DM density profiles. We show that H.E.S.S. has subleading sensitivity relative to Fermi for the Higgsino at present. In contrast, we analyze H.E.S.S. inner Galaxy data for the thermal wino model with a mass near 2.8 TeV; we find no evidence for a DM signal and exclude the wino by over a factor of two in cross section for all DM profiles considered. In the process, we identify and attempt to correct what appears to be an inconsistency in previous H.E.S.S. inner Galaxy analyses for DM annihilation related to the analysis effective area, which may weaken the DM cross-section sensitivity claimed in those works by around an order of magnitude.

79 ASTRONOMY AND ASTROPHYSICS↗

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models

Test compounds used on in vitro model systems are conventionally delivered to cell culture wells as fixed concentration bolus doses; however, this poorly replicates the pharmacokinetic (PK) concentration changes seen in vivo and reduces the predictive value of the data. Herein, proof-of-concept experiments were performed using a novel microfluidic device, the Microformulator, which allows in vivo like PK profiles to be applied to cells cultured in microtiter plates and facilitates the investigation of the impact of PK on biological responses. We demonstrate the utility of the device in its ability to reproduce in vivo PK profiles of different oncology compounds over multiweek experiments, both as monotherapy and drug combinations, comparing the effects on tumour cell efficacy in vitro with efficacy seen in in vivo xenograft models. In the first example, an ERK1/2 inhibitor was tested using fixed bolus dosing and Microformulator-replicated PK profiles, in 2 cell lines with different in vivo sensitivities. The Microformulator-replicated PK profiles were able to discriminate between cell line sensitivities, unlike the conventional fixed bolus dosing. In a second study, murine in vivo PK profiles of multiple Poly(ADP-Ribose) Polymerase 1/2 (PARP) and DNA-dependent protein kinase (DNA-PK) inhibitor combinations were replicated in a FaDu cell line resulting in a reduction in cell growth in vitro with similar rank ordering to the in vivo xenograft model. Additional PK/efficacy insight into theoretical changes to drug exposure profiles was gained by using the Microformulator to expose FaDu cells to the DNA-PK inhibitor for different target coverage levels and periods of time. We demonstrate that the Microformulator enables incorporating PK exposures into cellular assays to improve in vitro–in vivo translation understanding for early therapeutic insight.

Singh, Dharaminder (ORCID:0000000346306403)↗

On Combining Thermal-Infrared and Radio-Occultation Data of Saturn's Atmosphere

Radio-occultation and thermal-infrared measurements are complementary investigations for sounding planetary atmospheres. The vertical resolution afforded by radio occultations is typically approximately 1 km or better, whereas that from infrared sounding is often comparable to a scale height. On the other hand, an instrument like CIRS can easily generate global maps of temperature and composition, whereas occultation soundings are usually distributed more sparsely. The starting point for radio-occultation inversions is determining the residual Doppler-shifted frequency, that is the shift in frequency from what it would be in the absence of the atmosphere. Hence the positions and relative velocities of the spacecraft, target atmosphere, and DSN receiving station must be known to high accuracy. It is not surprising that the inversions can be susceptible to sources of systematic errors. Stratospheric temperature profiles on Titan retrieved from Cassini radio occultations were found to be very susceptible to errors in the reconstructed spacecraft velocities (approximately equal to 1 mm/s). Here the ability to adjust the spacecraft ephemeris so that the profiles matched those retrieved from CIRS limb sounding proved to be critical in mitigating this error. A similar procedure can be used for Saturn, although the sensitivity of its retrieved profiles to this type of error seems to be smaller. One issue that has appeared in inverting the Cassini occultations by Saturn is the uncertainty in its equatorial bulge, that is, the shape in its iso-density surfaces at low latitudes. Typically one approximates that surface as a geopotential surface by assuming a barotropic atmosphere. However, the recent controversy in the equatorial winds, i.e., whether they changed between the Voyager (1981) era and later (after 1996) epochs of Cassini and some Hubble observations, has made it difficult to know the exact shape of the surface, and it leads to uncertainties in the retrieved temperature profiles of one to a few kelvins. This propagates into errors in the retrieved helium abundance, which makes use of thermal-infrared spectra and synthetic spectra computed with retrieved radio-occultation temperature profiles. The highest abundances are retrieved with the faster Voyager-era winds, but even these abundances are somewhat smaller than those retrieved from the thermal-infrared data alone (albeit with larger formal errors). The helium abundance determination is most sensitive to temperatures in the upper troposphere. Further progress may include matching the radio-occultation profiles with those from CIRS limb sounding in the upper stratosphere.

Flasar, F. M.↗

Constraints on the Profiles of Total Water PDF in AGCMs from AIRS and a High-Resolution Model

Atmospheric general circulation model (AGCM) cloud parameterizations generally include an assumption about the subgrid-scale probability distribution function (PDF) of total water and its vertical profile. In the present study, the Atmospheric Infrared Sounder (AIRS) monthly-mean cloud amount and relative humidity fields are used to compute a proxy for the second moment of an AGCM total water PDF called the RH01 diagnostic, which is the AIRS mean relative humidity for cloud fractions of 0.1 or less. The dependence of the second moment on horizontal grid resolution is analyzed using results from a high-resolution global model simulation.The AIRS-derived RH01 diagnostic is generally larger near the surface than aloft, indicating a narrower PDF near the surface, and varies with the type of underlying surface. High-resolution model results show that the vertical structure of profiles of the AGCM PDF second moment is unchanged as the grid resolution changes from 200 to 100 to 50 km, and that the second-moment profiles shift toward higher values with decreasing grid spacing.Several Goddard Earth Observing System, version 5 (GEOS-5), AGCM simulations were performed with several choices for the profile of the PDF second moment. The resulting cloud and relative humidity fields were shown to be quite sensitive to the prescribed profile, and the use of a profile based on the AIRS-derived proxy results in improvements relative to observational estimates. The AIRS-guided total water PDF profiles, including their dependence on underlying surface type and on horizontal resolution, have been implemented in the version of the GEOS-5 AGCM used for publicly released simulations.

Molod, Andrea↗

Flow Characterization of the NASA Langley Unitary Plan WindTunnel, Test Section 2: Computational Results

Flow in the empty Unitary Planform Wind Tunnel at the NASA Langley Research Center issimulated with computational fluid dynamics methods. The objectives are to assess CFD’s truepredictive capability and to generate flow-field maps upstream of the tunnel’s test section foruse in associated vehicle tests. Multiple CFD solvers, grid adaption methods, and turbulencemodels are used by five teams doing the simulations. The simulation domain is as large aspractical: from the start of the settling chamber, just downstream of the last set of turningvanes, to well downstream of the test section. Simulations are done at three Mach numbers andseveral Reynolds numbers that cover most of the tunnel’s operating range. The sensitivity ofthe CFD solutions to simulation process details, including turbulence model, spatial resolutionand settling-chamber inflow velocity profile, is characterized. Significant sensitivities in somedetails of the predicted test section flow are described. CFD predicts that details of flow inthe settling chamber can affect the flow in the test section. Turning of the flow through thetunnel contraction and past nozzle-block hardware generates streamwise vortices, some ofwhich survive into the core of the test section, principally at low Mach number. Preliminarycomparisons to experimental measurements are given. The major flow characteristics andthe dynamical vortices predicted by CFD exist in the experiment. Several details in CFD andexperiment are observed to differ, including the effects of the vortices and features that appearto be Mach waves in the test section. Sensitivity to grid resolution and turbulence modelingis noted in the vortices; no potential cause for the differences in Mach waves has yet beenidentified in the CFD sensitivity studies.

wind tunnel↗