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In this perspective, we highlight the need to integrate data management infrastructure across scales to best take advantage of advancements in automated and autonomous experimental methods in materials science.
Explosive stellar environments such as neutron star mergers, supernovae and X-ray bursts contribute significantly to the synthesis of many chemical elements known in the universe. Understanding the underlying explosion mechanisms and stellar conditions, as well as the observed signatures of chemical elements at a variety of these sites require a considerable effort from the nuclear physics community. An overview of several explosive stellar environments have been summarized, along with brief highlights of recent experimental efforts to better constrain the nucleosynthesis from these environments using recent advances of rare isotope beam facilities and measurement techniques.
Abstract The release of GENIE v3.0.0 was a major milestone in the long history of the GENIE project, delivering several alternative comprehensive neutrino interaction models, improved charged-lepton scattering simulations, a range of beyond the Standard Model simulation capabilities, improved experimental interfaces, expanded core framework capabilities, and advanced new frameworks for the global analysis of neutrino scattering data and tuning of neutrino interaction models. Steady progress continued following the release of GENIE v3.0.0. New tools and a large number of new physics models, comprehensive model configurations, and tunes have been made publicly available and planned for release in v3.2.0. This article highlights some of the most recent technical and physics developments in the GENIE v3 series.
Abstract Convective self-aggregation refers to a phenomenon in which random convection can self-organize into large-scale clusters over an ocean surface with uniform temperature in cloud-resolving models. Previous literature studies convective aggregation primarily by analyzing vertically integrated (VI) moist static energy (MSE) variance. That is the global MSE variance, including both the local MSE variance at a given altitude and the covariance of MSE anomalies between different altitudes. Here we present a vertically resolved (VR) MSE framework that focuses on the local MSE variance to study convective self-aggregation. Using a cloud-resolving simulation, we show that the development of self-aggregation is associated with an increase of local MSE variance, and that the diabatic and adiabatic generation of the MSE variance is mainly dominated by the boundary layer (BL; the lowest 2 km). The results agree with recent numerical simulation results and the available potential energy analyses showing that the BL plays a key role in the development of self-aggregation. Additionally, we find that the lower free troposphere (2–4 km) also generates significant MSE variance in the first 15 days. We further present a detailed comparison between the global and local MSE variance frameworks in their mathematical formulation and diagnostic results, highlighting their differences.
Tropical areas with mean upward motion—and as such the zonal-mean intertropical convergence zone (ITCZ)—are projected to contract under global warming. To understand this process, a simple model based on dry static energy and moisture equations is introduced for zonally symmetric overturning driven by sea surface temperature (SST). Processes governing ascent area fraction and zonal mean precipitation are examined for insight into Atmospheric Model Intercomparison Project (AMIP) simulations. Bulk parameters governing radiative feedbacks and moist static energy transport in the simple model are estimated from the AMIP ensemble. Uniform warming in the simple model produces ascent area contraction and precipitation intensification—similar to observations and climate models. Contributing effects include stronger water vapor radiative feedbacks, weaker cloud-radiative feedbacks, stronger convection-circulation feedbacks, and greater poleward moisture export. The simple model identifies parameters consequential for the inter-AMIP-model spread; an ensemble generated by perturbing parameters governing shortwave water vapor feedbacks and gross moist stability changes under warming tracks inter-AMIP-model variations with a correlation coefficient ~0.46. Here, the simple model also predicts the multimodel mean changes in tropical ascent area and precipitation with reasonable accuracy. Furthermore, the simple model reproduces relationships among ascent area precipitation, ascent strength, and ascent area fraction observed in AMIP models. A substantial portion of the inter-AMIP-model spread is traced to the spread in how moist static energy and vertical velocity profiles change under warming, which in turn impact the gross moist stability in deep convective regions—highlighting the need for observational constraints on these quantities.
Abstract The intrinsic tenase (Xase) complex, formed by factors (f) VIIIa and fIXa, forms on activated platelet surfaces and catalyzes the activation of factor X to Xa, stimulating thrombin production in the blood coagulation cascade. The structural organization of the membrane-bound Xase complex remains largely unknown, hindering our understanding of the structural underpinnings that guide Xase complex assembly. Here, we aimed to characterize the Xase complex bound to a lipid nanodisc with biolayer interferometry (BLI), Michaelis–Menten kinetics, and small-angle X-ray scattering (SAXS). Using immobilized lipid nanodiscs, we measured binding rates and nanomolar affinities for fVIIIa, fIXa, and the Xase complex. Enzyme kinetic measurements demonstrated the assembly of an active enzyme complex in the presence of lipid nanodiscs. An ab initio molecular envelope of the nanodisc-bound Xase complex allowed us to computationally model fVIIIa and fIXa docked onto a flexible lipid membrane and identify protein–protein interactions. Our results highlight multiple points of contact between fVIIIa and fIXa, including a novel interaction with fIXa at the fVIIIa A1–A3 domain interface. Lastly, we identified hemophilia A/B-related mutations with varying severities at the fVIIIa/fIXa interface that may regulate Xase complex assembly. Together, our results support the use of SAXS as an emergent tool to investigate the membrane-bound Xase complex and illustrate how mutations at the fVIIIa/fIXa dimer interface may disrupt or stabilize the activated enzyme complex.
This publication highlights achievements in nuclear security, science, technology and engineering, mission operations, and community relations at Los Alamos National Laboratory.
This publication highlights achievements in nuclear security, science, technology and engineering, mission operations, and community relations at Los Alamos National Laboratory.
Monthly newsletter highlights for areas including Nuclear Security, Science, Technology, and Engineering, Mission Operations and Community Relations. Information for selected media coverage is also included.
Bulleted highlights including progress report for NSRC's Rocky Flats Digitization Lab, the Online Vault bulk upload, patching and system updates, and information about publishing NSRC-produced The Vault .
Brief highlights are given from the National Security Research Center (NSRC), Los Alamos National Laboratory (LANL).
Highlights are given in the following areas: Nuclear Security, Science, Technology and Engineering, Mission Operations, and, Community Relations.
This presentation highlights the activities of Los Alamos National Laboratory (LANL) in fiscal year 2021.These include the celebration of the tenth anniversary of NCERC operations, a large experiment campaign (IER 488 - MUSiC: Measurements of Uranium Subcritical and Critical), preparation for FY22 experiments, the completion of several ongoing experiments, and a control system upgrade project.
Slides for a presentation discussing the history and mission of Los Alamos National Laboratory, as well as the career highlights of some of its current employees.
October 2023 monthly newsletter provides highlights in the following areas: nuclear security; science, technology, and engineering; mission operations; and, community relations.
This report contains a summary of highlights and top achievements from Los Alamos National Laboratory from December 2023, including Nuclear Security, Science Technology & Engineering, Mission Operations, and Community Relations.
SQMS Center Progress and Highlights and response to PAC recommendations
This presentation details budget and spending details for Fiscal Year (FY) 2023 for ORNL NCSP. Highlights and accomplishments from ORNL are provided for FY2023.