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At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
NASA NTRS1987

Comparison of smooth pursuit and combined eye-head tracking in human subjects with deficient labyrinthine function

The effects of deficient labyrinthine function on smooth visual tracking with the eyes and head were investigated, using ten patients with bilateral peripheral vestibular disease and ten normal controls. Active, combined eye-head tracking (EHT) was significantly better in patients than smooth pursuit with the eyes alone, whereas normal subjects pursued equally well in both cases. Compensatory eye movements during active head rotation in darkness were always less in patients than in normal subjects. These data were used to examine current hypotheses that postulate central cancellation of the vestibulo-ocular reflex (VOR) during EHT. A model that proposes summation of an integral smooth pursuit command and VOR/compensatory eye movements is consistent with the findings. Observation of passive EHT (visual fixation of a head-fixed target during en bloc rotation) appears to indicate that in this mode parametric gain changes contribute to modulation of the VOR.

Leigh, R. J.↗
NASA NTRS1995

A Compact Fiber Optic Eye Diagnostic System

A new fiber optic probe developed for determining transport properties of sub-micron particles in fluid experiments in a microgravity environment has been applied to study different parts of an eye. The probe positioned in front of an eye, delivers a low power (approximately few microW) light from a laser diode into the eye and guides the light which is back scattered by different components (aqueous humor, lens, and vitreous humor) of the eye through a receiving optical fiber to a photo detector. The probe provides rapid determination of macromolecular diffusivities and their respective size distributions in the eye lens and the gel-like materials in the vitreous humor. In a clinical setting, the probe can be mounted on a standard slit-lamp apparatus simply using a Hruby lens holder. The capability of detecting cataracts, both nuclear and cortical, in their early stages of formation, in a non invasive and quantitative fashion, has the potential in patient monitoring and in developing and testing new drugs or diet therapies to 'dissolve' or slow down the cataract formation before the surgery becomes necessary. The ability to detect biochemical and macromolecular changes in the vitreous structure can be very useful in identifying certain diseases of the posterior chamber and their complications, e.g., posterior vitreous detachment and diabetic retinopathy.

Ansari, Rafat R.↗
NASA NTRS1995

A Compact Fiber Optic Eye Diagnostics System

A new fiber optic probe development for determining transport properties of sub-micron particles in fluids experiments in a microgravity environment has been applied to study different parts of the eye. The probe positioned in front of an eye, delivers a low power (approximately a few mu W) light from a laser diode into the eye and guides the light which is back scattered by different components (aqueous humor, lens, and vitreous humor) of the eye through a receiving optical fiber to a photo detector. The probe provides rapid determination of macromolecular diffusivities and their respective size distributions in the eye lens and the gel-like material in the vitreous humor. For a clinical use, the probe is mounted on a standard slit-lamp apparatus simply using Hruby lens holder. The capability of detecting cataracts, both nuclear and cortical, in their early stages of formation, in a non invasive and quantitative fashion, has the potential in patient monitoring and in developing and testing new drugs or diet therapies to 'dissolve' or slow down the cataract formation before the surgery becomes necessary. The ability to detect biochemical and macromolecular changes in the vitreous structure can be very useful in identifying certain diseases of the posterior chamber and their complications, e.g., posterior vitreous detachment and diabetic retinopathy.

Ansari, Rafat R.↗
NASA NTRS1996

Eye Movements Reveal Hierarchical Motion Processing

Purpose: In the analysis of visual motion, local features such as orientation are analyzed early in the cortical processing stream (V1), while integration across orientation and space is thought to occur in higher cortical areas such as MT, MST, etc. If all areas provide inputs to eye movement control centers, we would expect that local properties would drive eye movements with relatively short latencies, while global properties would require longer latencies. When such latencies are observed, they can provide information about when (and where?) various stimulus properties are analyzed. Methods: The stimulus employed was an elliptical Gabor patch with a drifting carrier, in which the orientations of the carrier grating and the contrast window were varied independently. We have previously demonstrated that the directional percepts evoked by this stimulus vary between the "grating direction" (the normal to the grating's orientation) and the "window direction", and that similar effects can be observed in reflexive eye movements. Subjects viewed such a stimulus while attempting to maintain steady fixation on the center of the pattern, and the small reflexive eye movements ("stare OKN") were recorded. In the middle of the trial, the orientation of either the grating or the window was rotated smoothly by 30 degrees. Results: Responses to the shift of both grating orientation and window orientation are seen in the average OKN slow phase velocity. Grating rotations produce a rapid OKN rotation to the grating direction (100 ms latency, 300 ms time constant), followed by a slower rebound to the steady state perceived direction midway between the grating and window directions. Window rotations, on the other hand, evoke a slower response (200 ms latency, 500 ms time constant). Conclusions: The results demonstrate multiple cortical inputs to eye movement control: a fast, early input driven by orientation, and a slower input from higher areas sensitive to global stimulus properties.

Mulligan, Jeffrey B.↗
NASA NTRS1997

Eye Movement Latencies to Direction Change for Different Classes of Motion

In the analysis of visual motion, local features such as orientation are analyzed early in the cortical processing stream (V1), while integration across orientation and space is thought to occur in higher cortical areas such as MT, MST, etc. If all areas provide inputs to eye movement control centers, we would expect that local properties would drive eye movements with relatively short latencies, while global properties would require longer latencies. When such latencies are observed, they can provide information about when (and where?) various stimulus properties are analyzed. To this end, a stimulus was employed in which local and global properties determining perceived direction-of-motion could be manipulated independently: an elliptical Gabor patch with a drifting carrier, with variable orientation of the carrier grating and the contrast window. We have previously demonstrated that the directional percepts evoked by this stimulus vary between the "grating direction" (the normal to the grating's orientation) and the "window direction" (ARVO 91, 94), and that similar effects can be observed in reflexive eye movements (ARVO 95). Subjects viewed such a stimulus while attempting to maintain steady fixation on the center of the pattern, and the small reflexive eye movements ("stare OKN") were recorded. In the middle of the trial, the orientation of either the grating or the window was rotated smoothly by 30 degrees. Responses to the shift of both grating orientation and window orientation are seen in the average OKN slow phase velocity. Grating rotations produce a rapid OKN rotation to the grating direction (100 ms latency, 300 ms time constant), followed by a slower rebound to the steady state perceived direction midway between the grating and window directions. Window rotations, on the other hand, evoke a slower response (200 ms latency, 500 ms time constant). The results demonstrate multiple cortical inputs to eye movement control: a taste early input driven by orientation, and a slower input from higher areas sensitive to global stimulus properties.

Mulligan, Jeffrey B.↗
NASA NTRS2001

Stimulus-response incompatibility activates cortex proximate to three eye fields

We used functional magnetic resonance imaging (fMRI) to investigate cortical activation during the performance of three oculomotor tasks that impose increasing levels of cognitive demand. (1) In a visually guided saccade (VGS) task, subjects made saccades to flashed targets. (2) In a compatible task, subjects made leftward and rightward saccades in response to foveal presentation of the uppercase words "LEFT" or "RIGHT." (3) In a mixed task, subjects made rightward saccades in response to the lowercase word "left" and leftward saccades in response to the lowercase word "right" on incompatible trials (60%). The remaining 40% of trials required compatible responses to uppercase words. The VGS and compatible tasks, when compared to fixation, activated the three cortical eye fields: the supplementary eye field (SEF), the frontal eye field (FEF), and the parietal eye field (PEF). The mixed task, when compared to the compatible task, activated three additional cortical regions proximate to the three eye fields: (1) rostral to the SEF in medial frontal cortex; (2) rostral to the FEF in dorsolateral prefrontal cortex (DLPFC); (3) rostral and lateral to the PEF in posterior parietal cortex. These areas may contribute to the suppression of prepotent responses and in holding novel visuomotor associations in working memory. Copyright 2001 Academic Press.

NASA Discipline Neuroscience↗
DOE OSTI2016

Poster - 08: Preliminary Investigation into Collapsed-Cone based Dose Calculations for COMS Eye Plaques

Purpose: To investigate the accuracy of model-based dose calculations using a collapsed-cone algorithm for COMS eye plaques loaded with I-125 seeds. Methods: The Nucletron SelectSeed 130.002 I-125 seed and the 12 mm COMS eye plaque were incorporated into a research version of the Oncentra® Brachy v4.5 treatment planning system which uses the Advanced Collapsed-cone Engine (ACE) algorithm. Comparisons of TG-43 and high-accuracy ACE doses were performed for a single seed in a 30×30×30 cm{sup 3} water box, as well as with one seed in the central slot of the 12 mm COMS eye plaque. The doses along the plaque central axis (CAX) were used to calculate the carrier correction factor, T(r), and were compared to tabulated and MCNP6 simulated doses for both the SelectSeed and IsoAid IAI-125A seeds. Results: The ACE calculated dose for the single seed in water was on average within 0.62 ± 2.2% of the TG-43 dose, with the largest differences occurring near the end-welds. The ratio of ACE to TG-43 calculated doses along the CAX (T(r)) of the 12 mm COMS plaque for the SelectSeed was on average within 3.0% of previously tabulated data, and within 2.9% of the MCNP6 simulated values. The IsoAid and SelectSeed T(r) values agreed within 0.3%. Conclusions: Initial comparisons show good agreement between ACE and MC doses for a single seed in a 12 mm COMS eye plaque; more complicated scenarios are being investigated to determine the accuracy of this calculation method.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1996

Spatial orientation perception and reflexive eye movements--a perspective, an overview, and some clinical implications

When head motion includes a linear velocity component, eye velocity required to track an earth-fixed target depends upon: a) angular and linear head velocity, b) target distance, and c) direction of gaze relative to the motion trajectory. Recent research indicates that eye movements (LVOR), presumably otolith-mediated, partially compensate for linear velocity in small head excursions on small devices. Canal-mediated eye velocity (AVOR), otolith-mediated eye velocity (LVOR), and Ocular Torsion (OT) can be measured, one by one, on small devices. However, response dynamics that depend upon the ratio of linear to angular velocity in the motion trajectory and on subject orientation relative to the trajectory are present in a centrifuge paradigm. With this paradigm, two 3-min runs yields measures of: LVOR differentially modulated by different subject orientations in the two runs; OT dynamics in four conditions; two directions of "steady-state" OT, and two directions of AVOR. Efficient assessment of the dynamics (and of the underlying central integrative processes) may require a centrifuge radius of 1.0 meters or more. Clinical assessment of the spatial orientation system should include evaluation of central integrative processes that determine the dynamics of these responses.

Review, Tutorial↗
NASA NTRS2019

Measuring Pilot Eye Fixations: What Have We Learned About Monitoring?

There is a substantial literature on eye-tracking measurement for pilots. These measures offer one method for studying pilot visual attention. This presentation reviews this literature to identify the range of eye-tracking measures used; the primary findings from eye tracking as it relates to commercial transport pilots; and whether we can learn anything from these studies about pilot monitoring. We identify gaps between the process of pilot monitoring and what we can know from studying eye tracking. This is a brief presentation.

Commercial Aviation↗
NASA NTRSDate not supplied

Limitations on the Use of Eye-Tracking Data to Understand Operator Awareness

Safety events in commercial aviation have implicated failures of attention and awareness, and the need for improved attention and awareness has pushed trainers toward eye-tracking systems as a primary tool for evaluating monitoring performance. Further, in the last 15 years, eye-tracking technology has become easier to acquire and use in operationally realistic settings. Although we believe that eye-tracking can be a useful evaluation tool, this paper describes basic limitations on relying on eye-tracking as the sole means for evaluating attention and awareness. A set of other measures are offered that can better identify where performance breakdowns occur.

aviation↗
NASA NTRSDate not supplied

Limitations on the Use of Eye-Tracking Data to Understand Operator Awareness

In the last 20 years, a number of accidents and incidents in commercial aviation have pointed to poor flight crew awareness of basic flight path parameters (e.g., airspeed, bank, pitch). As a result, there is a desire to improve pilot situation awareness and how attention is allocated. Eye-tracking has been a commonly used measure of awareness; it can aid in understanding whether specific indications were fixated, and perhaps how a pilot gathered information (that is, which indications in which sequence). In this paper, we discuss limitations on what eye-tracking data can reveal about pilot awareness and understanding. First, previous studies (e.g., Sarter et al., 2007) have shown that fixation on an indication may not ensure awareness or understanding. Further, an operator may have awareness of information not fixated. Additional measures—such as self-report or control inputs—can help to better establish the extent of pilot awareness and understanding. Second, sequences of fixations (scan patterns) have also become a performance measure. While a small number of recognized scan patterns have been validated for a small set of parameters on the Primary Flight Display (PFD), scan patterns have not been identified to support the broader context of flight path management or flight operations. More important is to understand the full set of drivers underlying the larger pattern of eye fixations; this approach moves away from the idea of well-established scan patterns as a marker of skilled performance and gives a larger role to pilot cognition. Pilots have various reasons to direct attention to specific elements on the interface, such as: - feedback tied to control inputs - a check on compliance with flight path targets - a reaction to an alert or a call out - attempt to understand an unexpected indication - assess progress toward a flight path target The importance of cognition is further implicated in the finding that pilot interviews show that fixating typically is accompanied by expectation; generally, pilots have a strong expectation of what value or indication they will see, which allows more efficient integration of information and an ability to identify indications that suggest an alternative account of the current system state. We will describe a range of eye-tracking measures and how they should and should not be used.

aviation↗
DOE OSTI2019

Determining Beta Radiation Protection Factors for Eye Shields

The purpose of this experiment was to determine the efficacy of INL eye shields in attenuating beta radiation and was performed in response to changes in international and national standards and guidelines. Two methods were used to determine the protection factor for each eye shield: A Fixed Evaluation and a Dosimetry Evaluation. Both evaluations showed the PAPR hood as the least protective eye shield and the respirator face mask as having the highest protection factor. Seven of the eye shields challenge the INL protection factor criteria of 3 and will require further testing. Though the two methods varied widely, the results were consistent.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2017

Geometry and Gesture-Based Features from Saccadic Eye-Movement as a Biometric in Radiology

In this study, we present a novel application of sketch gesture recognition on eye-movement for biometric identification and estimating task expertise.The study was performed for the task of mammographic screening with simultaneous viewing of four coordinated breast views as typically done in clinical practice. Eye-tracking data and diagnostic decisions collected for 100 mammographic cases (25 normal, 25 benign, 50 malignant) and 10 readers (three board certified radiologists and seven radiology residents), formed the corpus for this study.Sketch gesture recognition techniques were employed to extract geometric and gesture-based features from saccadic eye-movements.Our results show that saccadic eye-movement, characterized using sketch-based features, result in more accurate models for predicting individual identity and level of expertise than more traditional eye-tracking features.

Alamudun, Folami↗
DOE OSTI2018

Numerical Simulation of Slag Eye Formation and Slag Entrapment in a Bottom-Blown Argon-Stirred Ladle

A transient mathematical model is developed for simulating the bubble-steel-slag-top gas four-phase flow in a bottom-blown argon-stirred ladle with a 70-ton capacity. The Lagrangian discrete phase model (DPM) is used for describing the moving behavior of bubbles in the steel and slag. To observe the formation process of slag eye, the volume of fluid (VOF) model is used to track the interfaces between three incompressible phases: metal/slag, metal/gas, and slag/gas. The complex multiphase turbulent flow induced by bubble-liquid interactions is solved by a large eddy simulation (LES) model. Slag eye area and slag droplet dispersion are investigated under different gas flow rates. The results show that the movement of bubbles, formation and collapse of slag eye, volatility of steel/slag interface and behavior of slag entrapment can be properly predicted in the current model. When the gas flow rate is 300 L/min, the circulation driven by the bubble plume will stir the entire ladle adequately and form a slag eye of the right size. At the same time, it will not cause strong erosion to the ladle wall, and the fluctuation of the interface is of adequate intensity, which will be helpful for improving the desulfurization efficiency; the slag entrapment behavior can also be decreased. Interestingly, with the motion of liquid steel circulation, the collision and coalescence of dispersed slag droplets occur during the floating process in the vicinity of the wall.

36 MATERIALS SCIENCE↗
DOE OSTI2017

Human tear-production rate from closed-eye Schirmer-strip capillary dynamics

A Schirmer tear test (STT) is commonly used to gauge human tear production, especially when dry-eye symptoms present. In an STT, the rounded tip of a standardized paper strip is inserted into the lower fornix of the eye, and the wetted length extending out from the lower lid is recorded after 5 min of eye closure. Longer wetted lengths suggest higher tear production rates. To date, however, there is no methodology to transform STT transient wetting lengths into basal tear- production rates. We develop a physical model to elucidate wetting kinetics in a Schirmer strip. Tear evaporation from the exposed portion of the strip and gravity are accounted for. Careful consideration of the initial depletion of tear in the closed-eye tear prism reveals an initial fast increase in wetted length followed by slower growth. Excellent agreement of the proposed model is achieved with experimental observation. When evaporation is negligible, the slow-growth regime exhibits a linear increase of wetted length in time. The linear-length-growth time regime permits simple calculation of quantitative tear-production rates. In this paper, we suggest measuring several dynamic wetting lengths along a sheathed Schirmer strip and near the 5-min insertion duration followed by fitting to a straight line. The slope of the length-versus-time data gives the basal lacrimal-supply rate.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Control of laser-beam spatial distribution for correcting the shape and refraction of eye cornea

The results of calculation and development of a device aimed at forming a laser beam with an annular intensity distribution and spatial mode homogenisation, as well as approbation of this device for biological phantoms and eyes in ex vivo experiments with laser non-ablative correction of the cornea profile, are presented. The radiation intensities and thermal field distributions on the surfaces of a phantom and isolated rabbit’s eye are investigated. The absence of significant heating in the central region of eye is confirmed. It is shown that this device can be used for laser impact in order to change symmetrically eye’s refraction. (paper)

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2019

X-ray study of the double source plane gravitational lens system Eye of Horus observed with XMM–Newton

ABSTRACT A double source plane (DSP) system is a precious probe for the density profile of distant galaxies and cosmological parameters. However, these measurements could be affected by the surrounding environment of the lens galaxy. Thus, it is important to evaluate the cluster-scale mass for detailed mass modelling. We observed the Eye of Horus, a DSP system discovered by the Hyper Suprime-Cam Subaru Strategic Survey (HSC–SSP), with XMM–Newton. We detected two X-ray extended emissions, originating from two clusters, one centred at the Eye of Horus, and the other located ∼100 arcsec north-east to the Eye of Horus. We determined the dynamical mass assuming hydrostatic equilibrium, and evaluated their contributions to the lens mass interior of the Einstein radius. The contribution of the former cluster is $1.1^{+1.2}_{-0.5}\times 10^{12}\, \mathrm{M}_{\odot }$, which is $21\!-\!76{{\ \rm per\ cent}}$ of the total mass within the Einstein radius. The discrepancy is likely due to the complex gravitational structure along the line of sight. On the other hand, the contribution of the latter cluster is only $\sim 2{{\ \rm per\ cent}}$ on the Eye of Horus. Therefore, the influence associated with this cluster can be ignored.

Tanaka, Keigo↗
DOE OSTI2012

BEDVH--A method for evaluating biologically effective dose volume histograms: Application to eye plaque brachytherapy implants

Purpose: A method is introduced to examine the influence of implant duration T, radionuclide, and radiobiological parameters on the biologically effective dose (BED) throughout the entire volume of regions of interest for episcleral brachytherapy using available radionuclides. This method is employed to evaluate a particular eye plaque brachytherapy implant in a radiobiological context. Methods: A reference eye geometry and 16 mm COMS eye plaque loaded with {sup 103}Pd, {sup 125}I, or {sup 131}Cs sources were examined with dose distributions accounting for plaque heterogeneities. For a standardized 7 day implant, doses to 90% of the tumor volume ( {sub TUMOR}D{sub 90}) and 10% of the organ at risk volumes ( {sub OAR}D{sub 10}) were calculated. The BED equation from Dale and Jones and published {alpha}/{beta} and {mu} parameters were incorporated with dose volume histograms (DVHs) for various T values such as T = 7 days (i.e., {sub TUMOR} {sup 7}BED{sub 10} and {sub OAR} {sup 7}BED{sub 10}). By calculating BED throughout the volumes, biologically effective dose volume histograms (BEDVHs) were developed for tumor and OARs. Influence of T, radionuclide choice, and radiobiological parameters on {sub TUMOR}BEDVH and {sub OAR}BEDVH were examined. The nominal dose was scaled for shorter implants to achieve biological equivalence. Results: {sub TUMOR}D{sub 90} values were 102, 112, and 110 Gy for {sup 103}Pd, {sup 125}I, and {sup 131}Cs, respectively. Corresponding {sub TUMOR} {sup 7}BED{sub 10} values were 124, 140, and 138 Gy, respectively. As T decreased from 7 to 0.01 days, the isobiologically effective prescription dose decreased by a factor of three. As expected, {sub TUMOR} {sup 7}BEDVH did not significantly change as a function of radionuclide half-life but varied by 10% due to radionuclide dose distribution. Variations in reported radiobiological parameters caused {sub TUMOR} {sup 7}BED{sub 10} to deviate by up to 46%. Over the range of {sub OAR}{alpha}/{beta} values, {sub OAR} {sup 7}BED{sub 10} varied by up to 41%, 3.1%, and 1.4% for the lens, optic nerve, and lacrimal gland, respectively. Conclusions: BEDVH permits evaluation of the relative biological effectiveness for brachytherapy implants. For eye plaques, {sub TUMOR}BEDVH and {sub OAR}BEDVH were sensitive to implant duration, which may be manipulated to affect outcomes.

61 RADIATION PROTECTION AND DOSIMETRY↗