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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
NASA NTRS1994

Fluence-based relative biological effectiveness for charged particle carcinogenesis in mouse Harderian gland

Neoplasia in the rodent Harderian gland has been used to determine the carcinogenic potential of irradiation by HZE particles. Ions from protons to lanthanum at energies up to 670 MeV/a have been used to irradiate mice, and prevalence of Harderian gland tumors has been measured 16 months after irradiation. The Relative Biological Effectiveness (RBE) for tumor induction has been expressed as the RBE(sub max), which is the ratio of the initial slopes of the dose vs prevalence curve. The RBE(sub max) has been found to be approximately 30 for ions with Linear Energy Transfer (LET) values in excess of 100 keV/micrometer. Analysis on the basis of fluence as a substitute for dose has shown that on a per particle basis all of the ions with LET values in excess of 100 keV/micrometer have equal effectiveness. An analysis of the probabilities of ion traversals of the nucleus has shown that for these high stopping powers that a single hit is effective in producing neoplastic transformation.

Alpen, E. L.↗
DOE OSTI2024

Development of The DOME Shield Model For The NRIC Virtual Test Bed

As several advanced reactor concepts are maturing, test beds are needed to accelerate the demonstration and deployment of these advanced nuclear technologies. The National Reactor Innovation Center (NRIC) is building new or enhancing existing US Department of Energy infrastructure to support testing of components and systems. Demonstration of Microreactor Experiments (DOME) will utilize the Experimental Breeder Reactor-II (EBR-II) dome containment structure to host reactor demonstrations. A reactor supplemental shielding is needed so that DOME dose requirements are met. To accelerate the confirmatory analysis required for the reactor demonstration, the NRIC Virtual Test Bed (VTB) is developing a virtual model of the DOME shield that will be made available on the VTB public repository. This will allow developers to leverage advanced modeling and simulation tools to ensure their reactor demonstration concept will meet dose requirement and the limit concrete temperature in the shield during steady state and transient operation conditions. This paper presents the model developed for the DOME shield using open-source tools: MOOSE heat transfer module, Monte Carlo code OpenMC, and Cardinal to calculate the DOME shield temperature distribution during steady state

22 - GENERAL STUDIES OF NUCLEAR REACTORS↗
NASA NTRS1995

A study of the radiation environment on board the space shuttle flight STS-57

A joint NASA-Russian study of the radiation environment inside a SPACEHAB 2 locker on space shuttle flight STS-57 was conducted. The shuttle flew in a nearly circular orbit of 28.5 deg inclination and 462 km altitude. The locker carried a charged particle spectrometer, a tissue equivalent proportional counter (TEPC), and two area passive detectors consisting of combined NASA plastic nuclear track detectors (PNTD's) and thermoluminescent detectors (TLD's), and Russian nuclear emulsions, PNTD's, and TLD's. All the detector systems were shielded by the same shuttle mass distribution. This makes possible a direct comparison of the various dose measurement techniques. In addition, measurements of the neutron energy spectrum were made using the proton recoil technique. The results show good agreement between the integral LET spectrum of the combined galactic and trapped particles using the tissue equivalent proportional counter and track detectors between about 15 keV/micron and 200 keV/micron. The LET spectrum determined from nuclear emulsions was systematically lower by about 50%, possibly due to emulsion fading. The results show that the TEPC measured an absorbed dose 20% higher than TLD's, due primarily to an increased TEPC response to neutrons and a low sensitivity of TLD's to high LET particles under normal processing techniques. There is a significant flux of high energy neutrons that is currently not taken into consideration in dose equivalent calculations. The results of the analysis of the spectrometer data will be reported separately.

Badhwar, G. D.↗
NASA NTRS2002

Micro-Raman Analysis of Irradiated Diamond Films

Owing to its unique and robust physical properties, diamond is a much sought after material for use in advanced technologies such as Microelectromechanical Systems (MEMS). The volume and weight savings promised by MEMS-based devices are of particular interest to spaceflight applications. However, much basic materials science research remains to be completed in this field. Results of micro-Raman analysis of proton (1015 - 1017 H+/cm2 doses) irradiated chemical vapor deposited (CVD) diamond reveals that the microstructure is retained even after high radiation exposure.

Newton, R. L.↗
DOE OSTI2025

Insulation Activation and Contamination in Low-Power Experiments

Among the diverse advanced nuclear reactor concepts being developed are designs that expect to operate at much higher temperatures than conventional light-water reactors, and therefore require alternative materials for components capable of withstanding these extreme temperatures. Insulation is one such component where alternative high-temperature industrial composites are being considered. Low-power experiments can provide an opportunity for advancing our understanding of material behavior under irradiation; however, these experiments are not without occupational hazards. The focus of this paper is the potential for activation of insulating composites when exposed to neutron fluence during reactor experiments, and to discuss the subsequent contamination of the testing area. This paper will also discuss practical measures for preventing the creation and inhalation of activated particulate matter (i.e., dust), such as engineering and administrative controls and personal protective equipment. This paper evaluates the suitability of several insulation materials for use in reactor experiments based on their activation from neutron irradiation. The materials considered are Pyrogel XTE by Aspen Aerogel, Cerablanket and Kaowool by Morgan Advanced Materials, Thermo-12 Gold by Johns Manville, and Maxsil CF6-2000 by McAllister Mills. Although these materials are not yet widely used in the nuclear industry, they are common in other industries due to their thermal insulating properties. These materials produce dust while handling that can pose health and safety hazards, which could be further exacerbated by activation. The analysis presented in this paper utilizes a deterministic method developed to predict the activation source term of the provided insulation materials. The method calculates the atomic density of each element within the composites and simulates their exposure to a specified neutron flux density representative of low power experimental conditions. During the irradiation phase and throughout the extensive cooling period, neutron absorptions and nuclear decays are tracked for relevant isotopes. The residual activity within each composite is then assessed to identify the material with the lowest potential radiological hazard to workers. Dust will be created during installation and removal of insulating materials and may also be generated during the experiment. Contamination of surrounding surfaces due to dispersion is highly likely unless preventative measures are taken. The results of this analysis are used to estimate an internal dose from inhalation of activated dust, which is significantly lower than the allowable whole-body dose. However, the risk of internal exposure may increase if the dust becomes a transport vector for nuclear material. The goals of this paper are to enhance the understanding of the potential activation and contamination hazards from the use of these insulating materials in low-power nuclear experiments and to foster safer work environments through informed decision-making and strategic planning. This work ultimately contributes to a broader understanding of how new non-nuclear materials for advanced reactors impact the radiological safety of co-located workers, helping to ensure the responsible management of radioactive materials during installation and decommissioning activities.

12 - MGMT OF RADIOACTIVE AND NON-RADIOACTIVE WASTE↗
NASA NTRS2010

Radioadaptive Cytoprotective Pathways in the Mouse Retina

Exposure to cosmic radiation implies a risk of tissue degeneration. Radiation retinopathy is a complication of radiotherapy and exhibits common features with other retinopathies and neuropathies. Exposure to a low radiation dose elicits protective cellular events (radioadaptive response), reducing the stress of a subsequent higher dose. To assess the risk of radiation-induced retinal changes and the extent to which a small priming dose reduces this risk, we used a mouse model exposed to a source of Cs-137-gamma radiation. Gene expression profiling of retinas from non-irradiated control C57BL/6J mice (C) were compared to retinas from mice treated with a low 50 mGy dose (LD), a high 6 Gy dose (HD), and a combined treatment of 50 mGy (priming) and 6 Gy (challenge) doses (LHD). Whole retina RNA was isolated and expression analysis for selected genes performed by RTqPCR. Relevant target genes associated with cell death/survival, oxidative stress, cellular stress response and inflammation pathways, were analyzed. Cellular stress response genes were upregulated at 4 hr after the challenge dose in LHD retinas (Sirt1: 1.5 fold, Hsf1: 1.7 fold, Hspa1a: 2.5 fold; Hif1a: 1.8 fold, Bag1: 1.7). A similar trend was observed in LD animals. Most antioxidant enzymes (Hmox1, Sod2, Prdx1, Cygb, Cat1) and inflammatory mediators (NF B, Ptgs2 and Tgfb1) were upregulated in LHD and LD retinas. Expression of the pro-survival gene Bcl2 was upregulated in LD (6-fold) and LHD (4-fold) retinas. In conclusion, cytoprotective gene networks activation in the retina suggests a radioadaptive response to a priming irradiation dose, with mitigation of the deleterious effects of a subsequent high dose exposure. The enhancement of these cytoprotective mechanisms has potential value as a countermeasure to ocular alterations caused by radiation alone or in combination with other factors in spaceflight environments.

Zanello, Susana B.↗
NASA NTRS2018

Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion

The loss of bone mass and alteration in bone physiology during space flight are one of the major health risks for astronauts. Although the lack of weight bearing in microgravity is considered a risk factor for bone loss and possible osteoporosis, organisms living in space are also exposed to cosmic radiation and other environmental stress factors. As such, it is still unclear as to whether and by how much radiation exposure contributes to bone loss during space travel, and whether the effects of microgravity and radiation exposure are additive or synergistic. Bone is continuously renewed through the resorption of old bone by osteoclast cells and the formation of new bone by osteoblast cells. In this study, we investigated the combined effects of microgravity and radiation by evaluating the maturation of a hematopoietic cell line to mature osteoclasts. RAW 264.7 monocyte/macrophage cells were cultured in rotating wall vessels that simulate microgravity on the ground. Cells under static 1g or simulated microgravity were exposed to γ rays of varying doses, and then cultured in receptor activator of nuclear factor-κB ligand (RANKL) for the formation of osteoclast giant multinucleated cells (GMCs) and for gene expression analysis. Results of the study showed that radiation alone at doses as low as 0.1 Gy may stimulate osteoclast cell fusion as assessed by GMCs and the expression of signature genes such as tartrate resistant acid phosphatase (Trap) and dendritic cell-specific transmembrane protein (Dcstamp). However, osteoclast cell fusion decreased for doses greater than 0.5 Gy. In comparison to radiation exposure, simulated microgravity induced higher levels of cell fusion, and the effects of these two environmental factors appeared additive. Interestingly, the microgravity effect on osteoclast stimulatory transmembrane protein (Ocstamp) and Dcstamp expressions was significantly higher than the radiation effect, suggesting that radiation may not increase the synthesis of adhesion molecules as much as microgravity.

Zhang, Ye↗
NASA NTRS2017

Space Weathering Experiments on Spacecraft Materials

A project to investigate space environment effects on specific materials with interest to remote sensing was initiated in 2016. The goal of the project is to better characterize changes in the optical properties of polymers found in multi-layered spacecraft insulation (MLI) induced by electron bombardment. Previous analysis shows that chemical bonds break and potentially reform when exposed to high energy electrons like those seen in orbit. These chemical changes have been shown to alter a material's optical reflectance, among other material properties. This paper presents the initial experimental results of MLI materials exposed to various fluences of high energy electrons, designed to simulate a portion of the geosynchronous Earth orbit (GEO) space environment. It is shown that the spectral reflectance of some of the tested materials changes as a function of electron dose. These results provide an experimental benchmark for analysis of aging effects on satellite systems which can be used to improve remote sensing and space situational awareness. They also provide preliminary analysis on those materials that are most likely to comprise the high area-to-mass ratio (HAMR) population of space debris in the geosynchronous orbit environment. Finally, the results presented in this paper serve as a proof of concept for simulated environmental aging of spacecraft polymers that should lead to more experiments using a larger subset of spacecraft materials.

Engelhart, D. P.↗
NASA NTRS2003

Radiation-Related Risk Analysis for Atmospheric Flight Civil Aviation Flight Personnel

Human data on low dose rate radiation exposure and consequent effects are not readily available, and this fact generates groundtruth concerns for all risk assessment techniques for possible health effects induced by the space radiation environment, especially for long term missions like those foreseen now and in the near future. A large amount of such data may be obtained through civil aviation flight personnel cohorts, in the form of epidemiological studies on delayed health effects induced by the cosmic-ray generated atmospheric radiation environment, a high- LET low dose and low dose rate ionizing radiation with its typical neutron component, to which flight personnel are exposed all throughout their work activity. In the perspective of worldwide studies on radiation exposure of the civil aviation flight personnel, all the available results from previous studies on flight personnel radiation exposure have been examined in various ways (i.e. literature review, meta-analysis) to evaluate possible significant associations between atmospheric ionizing radiation environment and health risks, and to assess directions for future investigations. The physical characteristics of the atmospheric ionizing radiation environment make the results obtained for atmospheric flight personnel relevant for space exploration.

DeAngelis, G.↗
NASA NTRS2014

Compendium of Single Event Effects, Total Ionizing Dose, and Displacement Damage for Candidate Spacecraft Electronics for NASA

We present results and analysis investigating the effects of radiation on a variety of candidate spacecraft electronics to proton and heavy ion induced single event effects (SEE), proton-induced displacement damage (DD), and total ionizing dose (TID). Introduction: This paper is a summary of test results.NASA spacecraft are subjected to a harsh space environment that includes exposure to various types of ionizing radiation. The performance of electronic devices in a space radiation environment is often limited by its susceptibility to single event effects (SEE), total ionizing dose (TID), and displacement damage (DD). Ground-based testing is used to evaluate candidate spacecraft electronics to determine risk to spaceflight applications. Interpreting the results of radiation testing of complex devices is quite difficult. Given the rapidly changing nature of technology, radiation test data are most often application-specific and adequate understanding of the test conditions is critical. Studies discussed herein were undertaken to establish the application-specific sensitivities of candidate spacecraft and emerging electronic devices to single-event upset (SEU), single-event latchup (SEL), single-event gate rupture (SEGR), single-event burnout (SEB), single-event transient (SET), TID, enhanced low dose rate sensitivity (ELDRS), and DD effects.

Single Event Effects↗
NASA NTRS2002

Karyotypes of Human Lymphocytes Exposed to High-Energy Iron Ions

Chromosomal aberrations were analyzed using multicolor fluorescence in situ hybridization (mFISH) in human peripheral blood lymphocytes after in vitro exposure to gamma rays or accelerated (56)Fe ions (1 GeV/nucleon, 145 keV/microm) at Brookhaven National Laboratory (Upton, NY). Doses of 0.3 and 3 Gy were used for both radiation types. Chromosomes were prematurely condensed by a phosphatase inhibitor (calyculin A) to avoid the population selection bias observed at metaphase as a result of the severe cell cycle delays induced by heavy ions. A total of 1053 karyotypes (G(2) and M phases) were analyzed in irradiated lymphocytes. Results revealed different distribution patterns for chromosomal aberrations after low- and high-LET radiation exposures: Heavy ions induced a much higher fraction of cells with multiple aberrations, while the majority of the aberrant cells induced by low doses of gamma rays contained a single aberration. The high fraction of complex-type exchanges after heavy ions leads to an overestimation of simple-type asymmetrical interchanges (dicentrics) from analysis of Giemsa-stained samples. However, even after a dose of 3 Gy iron ions, about 30% of the cells presented no complex-type exchanges. The involvement of individual chromosomes in exchanges was similar for densely and sparsely ionizing radiation, and no statistically significant evidence of a nonrandom involvement of specific chromosomes was detected.

NASA Center JSC↗
NASA NTRS1992

LDEF radiation measurements: preliminary results

The Long Duration Exposure Facility (LDEF), retrieved by the Space Shuttle mission STS-32 after nearly 6 yr in orbit, is the focus of a broad-based study of the radiation environment in low Earth orbit (LEO) and its effects on materials. A combination of passive techniques has been used to study this environment via detectors which were contained in experiments aboard the LDEF spacecraft and through analysis of induced radioactivities. Preliminary results for absorbed dose measurements and for induced activities in various materials are presented. A number of effects have been observed which reflect the anisotropy of the charged particle flux in low Earth orbit. Quantitative results from these measurements should provide an accurate means of confirming environmental flux models and techniques for predicting radiation encountered in future LEO missions, particularly those of extended duration.

NASA Discipline Number 00-00↗
NASA NTRS2007

Break Point Distribution on Chromosome 3 of Human Epithelial Cells exposed to Gamma Rays, Neutrons and Fe Ions

Most of the reported studies of break point distribution on the damaged chromosomes from radiation exposure were carried out with the G-banding technique or determined based on the relative length of the broken chromosomal fragments. However, these techniques lack the accuracy in comparison with the later developed multicolor banding in situ hybridization (mBAND) technique that is generally used for analysis of intrachromosomal aberrations such as inversions. Using mBAND, we studied chromosome aberrations in human epithelial cells exposed in vitro to both low or high dose rate gamma rays in Houston, low dose rate secondary neutrons at Los Alamos National Laboratory and high dose rate 600 MeV/u Fe ions at NASA Space Radiation Laboratory. Detailed analysis of the inversion type revealed that all of the three radiation types induced a low incidence of simple inversions. Half of the inversions observed after neutron or Fe ion exposure, and the majority of inversions in gamma-irradiated samples were accompanied by other types of intrachromosomal aberrations. In addition, neutrons and Fe ions induced a significant fraction of inversions that involved complex rearrangements of both inter- and intrachromosome exchanges. We further compared the distribution of break point on chromosome 3 for the three radiation types. The break points were found to be randomly distributed on chromosome 3 after neutrons or Fe ions exposure, whereas non-random distribution with clustering break points was observed for gamma-rays. The break point distribution may serve as a potential fingerprint of high-LET radiation exposure.

Hada, M.↗
DOE OSTI2026

Statistical Uncertainty of Inhalation Dose Coefficients in Consequence Management: Propagated Dose Uncertainty in ICRP 66 Human Respiratory Tract Model

Reference inhalation dose models rely on deterministic biokinetics and reference computational phantoms, limiting their applicability to the variability present in population-specific exposures encountered in emergency response scenarios. Here, this study introduces REDCAL, a Python-based computational framework developed to propagate uncertainty in inhalation dose coefficients using the International Commission on Radiological Protection (ICRP) Publication 66 Human Respiratory Tract Model. REDCAL integrates ICRP deposition and clearance models, systemic biokinetics, and governing physics principles, and leverages Sandia National Laboratories’ Dakota toolkit for uncertainty quantification via Latin Hypercube Sampling. REDCAL was validated against DCAL, with biokinetic retention results differing by less than 1% and effective dose coefficients by less than 2% across all tested radionuclides. Stochastic sampling introduced variability in dose coefficients, with geometric standard deviations (GSD) in committed effective dose coefficients (CEDC) ranging from 1.0 to 1.5, based on lognormal distribution fits. Analysis demonstrated that variations in the activity median aerodynamic diameter (AMAD) notably influenced the computed CEDC values. Smaller particles (<1 µm) increased doses by 20–30% due to deeper lung deposition and prolonged retention for alpha emitting radionuclides, such as 241 Am and 239 Pu. Radionuclides with fast clearance, such as 133 I, demonstrated a dose reduction exceeding 50%, as AMAD increased beyond 5 µm due to upper airway deposition and rapid mucociliary clearance. The greatest GSD among the radionuclides reported in this study was for 241 Am. In most cases, the largest GSDs in the CEDC were associated with larger particle sizes, an expected outcome, as ICRP Publication 66 defines GSD in particle size as a function of AMAD, resulting in an extended tail of the lognormal distribution. The findings support improved inhalation dose assessments and enhance consequence management strategies for the U.S. Federal Radiological Monitoring and Assessment Center by quantifying uncertainty in dose coefficients and strengthening decision-making for emergency response scenarios.

Biokinetic Modeling↗
NASA NTRS1996

Stability of the translocation frequency following whole-body irradiation measured in rhesus monkeys

Chromosome translocations are persistent indicators of prior exposure to ionizing radiation and the development of 'chromosome painting' to efficiently detect translocations has resulted in a powerful biological dosimetry tool for radiation dose reconstruction. However, the actual stability of the translocation frequency with time after exposure must be measured before it can be used reliably to obtain doses for individuals exposed years or decades previously. Human chromosome painting probes were used here to measure reciprocal translocation frequencies in cells from two tissues of 8 rhesus monkeys (Macaca mulatta) irradiated almost three decades previously. Six of the monkeys were exposed in 1965 to whole-body (fully penetrating) radiation and two were unexposed controls. The primates were irradiated as juveniles to single doses of 0.56, 1.13, 2.00, or 2.25 Gy. Blood lymphocytes (and skin fibroblasts from one individual) were obtained for cytogenetic analysis in 1993, near the end of the animals' lifespans. Results show identical dose-response relationships 28 y after exposure in vivo and immediately after exposure in vitro. Because chromosome aberrations are induced with identical frequencies in vivo and in vitro, these results demonstrate that the translocation frequencies induced in 1965 have not changed significantly during the almost three decades since exposure. Finally, our emerging biodosimetry data for individual radiation workers are now confirming the utility of reciprocal translocations measured by FISH in radiation dose reconstruction.

Non-NASA Center↗
NASA NTRS1972

Application of transport techniques to the analysis of NERVA shadow shields

A radiation shield internal to the NERVA nuclear rocket reactor required to limit the neutron and photon radiation levels at critical components located external to the reactor was evaluated. Two significantly different shield mockups were analyzed: BATH, a composite mixture of boron carbide, aluminum and titanium hydride, and a borated steel-liquid hydrogen system. Based on the comparisons between experimental and calculated neutron and photon radiation levels, the following conclusions were noted: (1) The ability of two-dimensional discrete ordinates code to predict the radiation levels internal to and at the surface of the shield mockups was clearly demonstrated. (2) Internal to the BATH shield mockups, the one-dimensional technique predicted the axial variation of neutron fluxes and photon dose rates; however, the magnitude of the neutron fluxes was about a factor of 1.8 lower than the two-dimensional analysis and the photon dose rate was a factor of 1.3 lower.

Capo, M. A.↗
NASA NTRSDate not supplied

Nuclear Thermal Propulsion (NTP) Fission Product and Source Term Analysis

Nuclear thermal propulsion (NTP) is an in-space propulsion technology that uses a nuclear reactor to directly heat a propellant to provide high thrust, at higher efficiencies than achievable with conventional chemical propulsion systems. Due to the ability of NTP rockets to efficiently provide high thrust, this technology has been proposed for long duration space missions such as crewed missions to Mars and beyond. A primary hurdle for NTP technology development is the demonstration of an integrated reactor engine system to verify its functionality and performance. This primarily requires the manufacture and testing of candidate reactor and engine technologies to demonstrate the proposed design enables desired performance and exhibits acceptable response under all known operation modes. A major component in this testing is fission product accumulation, since after operation radioactive isotopes can be produced and pose radiological dose concerns. This paper explains the background behind fission product analysis and the methodology used to evaluate current reactor designs and identify the amount of fission products present and their radiological impact. Results of multiple thrust level engines at different time periods are discussed and highlight the need for additional experimental testing to confirm fractional release levels of fission products out of the system. Benchmarking of models and future paths of analysis are also discussed.

Fission↗