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At least 109 records · Page 6

Increased secretion of insulin and proliferation of islet {beta}-cells in rats with mesenteric lymph duct ligation

Highlights: Black-Right-Pointing-Pointer Insulin secretion was increased during the OGTT or IVGTT in mesenteric lymph duct-ligated rats. Black-Right-Pointing-Pointer Proliferation of islet {beta}-cells was upregulated in lymph duct-ligated rats. Black-Right-Pointing-Pointer Mesenteric lymph duct flow has a role in glucose metabolism. -- Abstract: Background and aims: It has been suggested that intestinal lymph flow plays an important role in insulin secretion and glucose metabolism after meals. In this study, we investigated the influence of ligation of the mesenteric lymph duct on glucose metabolism and islet {beta}-cells in rats. Methods: Male Sprague-Dawley rats (10 weeks old) were divided into two groups: one underwent ligation of the mesenteric lymph duct above the cistern (ligation group), and the other underwent a sham operation (sham group). After 1 and 2 weeks, fasting plasma concentrations of glucose, insulin, triglyceride, glucose-dependent insulinotropic polypeptide (GIP), and the active form of glucagon-like peptide-1 (GLP-1) were measured. At 2 weeks after the operation, the oral glucose tolerance test (OGTT) and intravenous glucose tolerance test (IVGTT) were performed. After the rats had been sacrificed, the insulin content of the pancreas was measured and the proliferation of {beta}-cells was assessed immunohistochemically using antibodies against insulin and Ki-67. Results: During the OGTT, the ligation group showed a significant decrease in the plasma glucose concentration at 120 min (p < 0.05) and a significant increase in the plasma insulin concentration by more than 2-fold at 15 min (p < 0.01). On the other hand, the plasma GIP concentration was significantly decreased at 60 min (p < 0.01) in the ligated group, while the active form of GLP-1 showed a significantly higher level at 90 min (1.7-fold; p < 0.05) and 120 min (2.5-fold; p < 0.01). During the IVGTT, the plasma insulin concentration in the ligation group was significantly higher at 2 min (more than 1.4-fold; p < 0.05). Immunohistochemistry showed that the ratios of {beta}-cell area/acinar cell area and {beta}-cell area/islet area, and also {beta}-cell proliferation, were significantly higher in the ligation group than in the sham group (p < 0.05, p < 0.01 and p < 0.01, respectively). The insulin content per unit wet weight of pancreas was also significantly increased in the ligation group (p < 0.05). Conclusions: In rats with ligation of the mesenteric lymph duct, insulin secretion during the OGTT or IVGTT was higher, and the insulin content and {beta}-cell proliferation in the pancreas were also increased. Our data show that mesenteric lymph duct flow has a role in glucose metabolism.

60 APPLIED LIFE SCIENCES↗

Robotic Left Hepatectomy and Roux-en-Y Hepaticojejunostomy After Bile Duct Injury

Background: Bile duct injuries after cholecystectomy remain a major concern because their incidence has not changed through the years despite technical advances. This video presents a robotic left hepatectomy and Roux-en-Y hepaticojejunostomy as a treatment for a complex bile duct injury after laparoscopic cholecystectomy. Methods: A 52-year-old man underwent laparoscopic cholecystectomy at another institution 8 years previously, which resulted in a bile duct injury. His postoperative period was complicated by jaundice and cholangitis. He was treated with endoscopic retrograde cholangiopancreatography and multiple endoprostheses for 3 years, after which the endoprostheses were removed, and he was sent to the authors’ institution. Computed tomography showed that the left liver had signs of disturbed perfusion and dilation of the left intrahepatic bile duct. The patient was asymptomatic and refused any further attempt at surgical correction of the lesion. He was accompanied for 5 years. Magnetic resonance imaging showed progressive atrophy of the left liver. Finally, 3 months before this writing, he presented with intermittent episodes of cholangitis. A multidisciplinary team decided to perform left hepatectomy with Roux-en-Y hepatojejunostomy via a robotic approach. The left liver was atrophied, and left hepatectomy was performed. Fluorescence imaging was used to identify the right bile duct. At opening of the right bile duct, small stones were found and removed. Antecolic Roux-en-Y hepaticojejunostomy then was performed. Results: The operative time was 335 min. Recovery was uneventful, and the patient was discharged on postoperative day 4. Conclusions: Robotic repair of bile duct injuries is feasible and safe, even when liver resection is necessary. This video may help oncologic surgeons to perform this complex procedure.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Drive turbine systems for 20-inch turbofan simulators. 1: Duct turbine design

A study was made to evolve the turbine drive systems for 20-inch turbofan engine simulators. The fan designs used in the simulators included single-stage and two-stage configurations that covered a wide range of rotative speed and power requirement. The objective assumed for the study was to evolve one core turbine design that could drive all of the single-stage fans and, when operated in combination with one duct turbine design, drive all of the two-stage fans. The duct turbine power output is then needed to determine the make-up power required of the core turbine over the range of two-stage fan operating conditions. The duct turbine design analysis is reported and includes the selection of the duct turbine velocity diagram, a description of the blade design, and a determination of its off-design performance. Adjustable stators were found to be quite advantageous to the duct turbine off-design operation. The use of adjustable stators enabled the duct turbine to accommodate fan mass flow at all operating points and caused the duct turbine power output to increase as the total power requirement increased. This in turn resulted in a core turbine make-up power requirement that was not significantly greater than that required for driving the single-stage fans.

Whitney, W. J.↗

Design integration and noise studies for jet STOL aircraft. Task 7C: Augmentor wing cruise blowing valveless system. Volume 2: Small-scale development testing of augmentor wing critical ducting components

Augmentor wing ducting system studies conducted on a valveless system configuration that provides cruise thrust from the augmentor nozzles have shown that most of the duct system pressure loss would occur in the strut-wing duct y-junction and the wing duct-augmentor lobe nozzles. These components were selected for development testing over a range of duct Mach numbers and pressure ratios to provide a technical basis for predicting installed wing thrust loading and for evaluating design wing loading of a particular wing aspect ratios. The flow characteristics of ducting components with relatively high pressure loss coefficients were investigated. The turbulent pressure fluctuations associated with flows at high Mach numbers were analyzed to evaluate potential duct fatigue problems.

Runnels, J. N.↗

Analysis of sound propagation in ducts using the wave envelope concept

A finite difference formulation is presented for sound propagation in a rectangular two-dimensional duct without steady flow for plane wave input. Before the difference equations are formulated, the governing Helmholtz equation is first transformed to a form whose solution does not oscillate along the length of the duct. This transformation reduces the required number of grid points by an order of magnitude, and the number of grid points becomes independent of the sound frequency. Physically, the transformed pressure represents the amplitude of the conventional sound wave. Example solutions are presented for sound propagation in a one-dimensional straight hard-wall duct and in a two-dimensional straight soft-wall duct without steady flow. The numerical solutions show evidence of the existence along the duct wall of a developing acoustic pressure diffusion boundary layer which is similar in nature to the conventional viscous flow boundary layer. In order to better illustrate this concept, the wave equation and boundary conditions are written such that the frequency no longer appears explicitly in them. The frequency effects in duct propagation can be visualized solely as an expansion and stretching of the suppressor duct.

Baumeister, K. J.↗

Propagation of plane waves in a variable area duct carrying a compressible subsonic flow

A complete numerical solution is obtained for plane wave propagation in a variable-area duct which carries a mean compressible flow. The equation solved is a matrix formulation of the equations first derived by Tsien in 1952. Sample calculations are presented for four particular flow configurations: (1) a duct-nozzle-duct combination with the acoustic wave traveling with the flow, (2) a duct-nozzle-duct combination with the acoustic wave traveling against the flow, (3) an inlet-nozzle-duct configuration with the acoustic wave traveling against the flow, and (4) a duct-nozzle-exit configuration with the acoustic wave traveling with the flow. For each of these cases, the variation of energy flux with frequency is shown for particular geometry and flow condition.

Davis, S. S.↗

Sound propagation in curved ducts

An analysis of the sound field in a circularly curved duct of rectangular cross-section is carried out for both rigid and locally-reacting absorbing walls. The field is excited by a piston source at one end of the duct section, and comparisons of the acoustic field and the net power flow along the duct axis are made with corresponding results for a straight duct section for various frequencies. It is found that in general the curved duct yields a significant increase in sound attenuation along the duct axis as compared to the straight duct.

Myers, M. K.↗

Aeroacoustics: Fan noise and control; Duct acoustics; Rotor noise

The recent progress in duct acoustic research is reflected by fourteen papers which cover essentially the areas of linear duct acoustics, the characteristics of absorbent materials, and nonlinear duct acoustics. With respect to propagation in ducts, emphasis is placed on computational methods aimed at attaining effective economical modeling of propagation in variable-geometry and in hard-wall or soft-wall ducts. Computational methods developed to reduce computer processing and storage requirements are outlined, along with a wave envelope technique for reducing processing and storage needs. The latter technique is applied to the optimum segmented acoustic duct linear design. A finite difference technique is used in combination with conformal mapping to compute the optimum multisection duct linear design.

Schwartz, I. R.↗

An estimate of the noise shielding on the fuselage resulting from installing a short duct around an advanced propeller

A simple barrier shielding model was used to estimate the amount of noise shielding on the fuselage that could result from installing a short duct around a wing-mounted advanced propeller. With the propeller located one-third of the duct length from the inlet, estimates for the maximum blade passing tone attenuation varied from 7 dB for a duct 0.25 propeller diameter long to 16.75 dB for a duct 1 diameter long. Attenuations for the higher harmonics would be even larger because of their shorter wavelengths relative to the duct length. These estimates show that the fuselage noise reduction potential of a ducted compared with an unducted propeller is significant. Even more reduction might occur if acoustic attenuation material were installed in the duct.

Dittmar, James H.↗

Investigation in the 7-by-10 Foot Wind Tunnel of Ducts for Cooling Radiators within an Airplane Wing

Report presents the results of an investigation made in the NACA 7 by 10-foot wind tunnel of a large-chord wing model with a duct to house a simulated radiator suitable for a liquid-cooled engine. The duct was expanded to reduce the radiator losses, and the installation of the duct and radiator was made entirely within the wing to reduce form and interference drag. The tests were made using a two-dimensional-flow setup with a full-span duct and radiator. Section aerodynamic characteristics of the basic airfoil are given and also curves showing the characteristics of the various duct-radiator combinations. An expression for efficiency, the primary criterion of merit of any duct, and the effect of the several design parameters of the duct-radiator arrangement are discussed. The problem of throttling is considered and a discussion of the power required for cooling is included.

Harris, Thomas A↗

Active Control of Fan Noise: Feasibility Study: Numerical Computation of Acoustic Mode Reflection Coefficients for an Unflanged Cylindrical Duct - Volume 5

A computational method to predict modal reflection coefficients in cylindrical ducts has been developed based on the work of Homicz, Lordi, and Rehm, which uses the Wiener-Hopf method to account for the boundary conditions at the termination of a thin cylindrical pipe. The purpose of this study is to develop a computational routine to predict the reflection coefficients of higher order acoustic modes impinging on the unflanged termination of a cylindrical duct. This effort was conducted wider Task Order 5 of the NASA Lewis LET Program, Active Noise Control of aircraft Engines: Feasibility Study, and will be used as part of the development of an integrated source noise, acoustic propagation, ANC actuator coupling, and control system algorithm simulation. The reflection coefficient prediction will be incorporated into an existing cylindrical duct modal analysis to account for the reflection of modes from the duct termination. This will provide a more accurate, rapid computation design tool for evaluating the effect of reflected waves on active noise control systems mounted in the duct, as well as providing a tool for the design of acoustic treatment in inlet ducts. As an active noise control system design tool, the method can be used preliminary to more accurate but more numerically intensive acoustic propagation models such as finite element methods. The resulting computer program has been shown to give reasonable results, some examples of which are presented. Reliable data to use for comparison is scarce, so complete checkout is difficult, and further checkout is needed over a wider range of system parameters. In future efforts the method will be adapted as a subroutine to the GEAE segmented cylindrical duct modal analysis program.

Kraft, R. E.↗

Coupling of Low Speed Fan Stator Vane Unsteady Pressures to Duct Modes: Measured versus Predicted

Uniform-flow annular-duct Green's functions are the essential elements of the classical acoustic analogy approach to the problem of computing the noise generated by rotor-stator interaction inside the fan duct. This paper investigates the accuracy of this class of Green's functions for predicting the duct noise levels when measured stator vane unsteady surface pressures are used as input to the theoretical formulation. The accuracy of the method is evaluated by comparing the predicted and measured acoustic power levels for the NASA 48 inch low speed Active Noise Control Fan. The unsteady surface pressures are measured,by an array of microphones imbedded in the suction and pressure sides of a single vane, while the duct mode levels are measured using a rotating rake system installed in the inlet and exhaust sections of the fan duct. The predicted levels are computed using properly weighted integrals of measured surface pressure distribution. The data-theory comparisons are generally quite good particularly when the mode cut-off criterion is carefully interpreted. This suggests that, at least for low speed fans, the uniform-flow annular-duct Green's function theory can be reliably used for prediction of duct mode levels if the cascade surface pressure distribution is accurately known.

Sutliff, Daniel L.↗

Flow Duct Data for Validation of Acoustic Liner Codes for Impedance Eduction

The objective of the study reported here was to acquire acoustic and flow data with hard and lined duct wall duct sections for validation of a liner prediction code being developed at NASA LaRC. Both the mean flowfield and acoustic flowfields were determined in a cross-plane of the rectangular duct. A flow duct facility with acoustic drivers connected to a rectangular (4.7 x 2.0 inch) source section and a linear acoustic liner mounted downstream of the source section was used in this study. The liner section was designed to allow liner materials to be placed on all 4 walls of the duct. The test liner was of the locally-reacting type and was made from a ceramic material. The material, consisting of a tubular structure, was provided by NASA LaRC. The liner was approximately 8.89 cm (3.5 inches) thick. For the current study, only the two "short" sides of the duct were lined with liner material. The other two sides were hard walls. Two especially built instrumentation sections were attached on either sides of the liner section to allow acoustic and flow measurements to be made upstream and downstream of the liner. The two instrumentation duct sections were built to allow measurement of acoustic and flow properties at planes perpendicular to flow upstream and downstream of the liner section. The instrumentation section was also designed to provide a streamwise gradient in acoustic (complex) pressure from which the acoustic particle velocity, needed for the model validation, can be computed. Flow measurements included pressure, temperature, and velocity profiles upstream of the liner section. The in-flow sound pressure levels and phases were obtained with a microphone probe equipped with a nose cone in two cross planes upstream of the liner and two cross plane downstream of the liner. In addition to the acoustic measurements at the cross planes. axial centerline acoustic data was acquired using an axially traversing microphone probe which was traversed from a location upstream of the liner to some distance downstream of the liner. All probes used here had to be calibrated with respect to a standard microphone equipped with a nose cone to allow for the effects of flow.

Ahuja, K. K.↗

Investigation of Pneumatic Inlet and Diffuser Blowing on a Ducted Fan Propulsor in Static Thrust Operation

Tilting ducted fans present a solution for the lifting and forward flight propulsion requirements of VTOL aircraft. However, the geometry of the duct enshrouding the propeller has great a effect on the efficiency of the fan in various flight modes. Shroud geometry controls the velocity and pressure at the face of the fan, while maintaining a finite loading out at the tips of the fan blades. A duct tailored for most efficient generation of static lifting thrust will generally suffer from performance deficiencies in forward flight. The converse is true as well, leaving the designer with a difficult trade affecting the overall performance and sizing of the aircraft. Ideally, the shroud of a vertical lifting fan features a generous bell mouth inlet promoting acceleration of flow into the face of the fan, and terminating in a converging nozzle at the exit. Flow entering the inlet is accelerated into the fan by the circulation about the shroud, resulting in an overall increase in thrust compared to an open propeller operating under the same conditions . The accelerating shroud design is often employed in lifting ducted fans to benefit from the thrust augmentation; however, such shroud designs produce significant drag penalties in axial flight, thus are unsuitable for efficient forward flight applications. Decelerating, or diffusing, duct designs are employed for higher speed forward flight configurations. The lower circulation on the shroud tends to decelerate the flow into the face of the fan, which is detrimental to static thrust development; however, net thrust is developed on the shroud while the benefits of finite blade loading are retained. With judicious shroud design for intended flight speeds, a net increase in efficiency can be obtained over an open propeller. In this experiment, conducted under contract to NASA LaRC (contract NAG-1-02093) circulation control is being applied to a mildly diffusing shroud design, intended for improved forward flight performance, to generate circulation in the sense of an accelerating duct design. The intent is to improve static thrust performance of a ducted fan tailored for high speed axial flight, while at the same time significantly reduce the pressure signature on the ground plane. Circulation control on the fan shroud is achieved by the Coanda effect.

Kondor, Shayne↗

Generation of Higher Order Modes in a Rectangular Duct

Advanced noise control methodologies to reduce sound emission from aircraft engines take advantage of the modal structure of the noise in the duct. This noise is caused by the interaction of rotor wakes with downstream obstructions such as exit guide vanes. Mode synthesis has been accomplished in circular ducts and current active noise control work has made use of this capability to cancel fan noise. The goal of the current effort is to examine the fundamental process of higher order mode propagation through an acoustically treated, curved duct. The duct cross-section is rectangular to permit greater flexibility in representation of a range of duct curvatures. The work presented is the development of a feedforward control system to generate a user-specified modal pattern in the duct. The multiple-error, filtered-x LMS algorithm is used to determine the magnitude and phase of signal input to the loudspeakers to produce a desired modal pattern at a set of error microphones. Implementation issues, including loudspeaker placement and error microphone placement, are discussed. Preliminary results from a 9-3/8 inch by 21 inch duct, using 12 loudspeakers and 24 microphones, are presented. These results demonstrate the ability of the control system to generate a user-specified mode while suppressing undesired modes.

Gerhold, Carl H.↗

Curved Duct Noise Prediction Using the Fast Scattering Code

Results of a study to validate the Fast Scattering Code (FSC) as a duct noise predictor, including the effects of curvature, finite impedance on the walls, and uniform background flow, are presented in this paper. Infinite duct theory was used to generate the modal content of the sound propagating within the duct. Liner effects were incorporated via a sound absorbing boundary condition on the scattering surfaces. Simulations for a rectangular duct of constant cross-sectional area have been compared to analytical solutions and experimental data. Comparisons with analytical results indicate that the code can properly calculate a given dominant mode for hardwall surfaces. Simulated acoustic behavior in the presence of lined walls (using hardwall duct modes as incident sound) is consistent with expected trends. Duct curvature was found to enhance weaker modes and reduce pressure amplitude. Agreement between simulated and experimental results for a straight duct with hard walls (no flow) was excellent.

Dunn, M. H.↗

Coupled parametric design of flow control and duct shape

A method for designing gas turbine engine components using a coupled parametric analysis of part geometry and flow control is disclosed. Included are the steps of parametrically defining the geometry of the duct wall shape, parametrically defining one or more flow control actuators in the duct wall, measuring a plurality of performance parameters or metrics (e.g., flow characteristics) of the duct and comparing the results of the measurement with desired or target parameters, and selecting the optimal duct geometry and flow control for at least a portion of the duct, the selection process including evaluating the plurality of performance metrics in a pareto analysis. The use of this method in the design of inter-turbine transition ducts, serpentine ducts, inlets, diffusers, and similar components provides a design which reduces pressure losses and flow profile distortions.

Florea, Razvan↗

Differentiation of pancreatic head ductal adenocarcinoma from inflammatory pancreatic pseudomass by MR cholangio-pancreatography: utility of the duct-interrupted, corona, and attraction signs

Purpose: To determine sensitivity and specificity of the “duct-interrupted,” “corona,” and “attraction” signs on MR cholangio-pancreatography (MRCP) in distinguishing pancreatic head ductal adenocarcinoma (PDAC) from inflammatory pancreatic pseudomass (IPP). Materials and methods: This study included 53 adults (33 men and 20 women, mean age, 55 years; range, 17–87 years) with a pancreatic head mass who underwent MRCP. Three blinded radiologists independently reviewed each MRCP exam and three signs were assessed: (1) the “duct-interrupted” sign, deemed positive for PDAC if the duct within the mass demonstrated complete interruption with upstream dilation; (2) the “corona” sign, considered positive for PDAC if dilated side-branches were located exclusively outside the mass; and (3) the “attraction” sign, deemed positive for IPP if the dilated common bile duct showed attraction and angulation towards the mass. Sensitivity, specificity, and positive and negative predictive values of the signs were calculated, as well as interobserver agreement. Results: Out of 53 masses, 17 (32%) were PDAC and 36 (68%) were IPP. Sensitivity, specificity, and positive and negative predictive values of the “duct-interrupted” sign to differentiate between PDAC from IPP for the three readers were 29–53%, 89–95%, 56–82% and 73–81%, respectively (κ = 0.41); for the “corona” sign, they were 29–53%, 81–100%, 56–100%, and 75–78%, respectively (κ = 0.4), and for the “attraction” sign, they were 20–25%, 71–82%, 64–75%, and 31–34%, respectively (κ = 0.54). Conclusion: The “duct-interrupted” and “corona” MRCP signs have high specificity for diagnosing PDAC, while the “attraction” sign has good specificity for identifying IPP.

62 RADIOLOGY AND NUCLEAR MEDICINE↗