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Prenatal exposure to environmental contaminants and body composition at age 7–9 years

The study aim was to investigate the association between prenatal exposure to endocrine disrupting chemicals (EDCs) and the body composition of 7 to 9 year old Flemish children. The subjects were 114 Flemish children (50% boys) that took part in the first Flemish Environment and Health Study (2002–2006). Cadmium, PCBs, dioxins, p,p′-DDE and HCB were analysed in cord blood/plasma. When the child reached 7–9 years, height, weight, waist circumference and skinfolds were measured. Significant associations between prenatal exposure to EDCs and indicators of body composition were only found in girls. After adjustment for confounders and covariates, a significant negative association was found in girls between prenatal cadmium exposure and weight, BMI and waist circumference (indicator of abdominal fat) and the sum of four skinfolds (indicator of subcutaneous fat). In contrast, a significant positive association (after adjustment for confounders/covariates) was found between prenatal p,p′-DDE exposure and waist circumference as well as waist/height ratio in girls (indicators of abdominal fat). No significant associations were found for prenatal PCBs, dioxins and HCB exposure after adjustment for confounders/covariates. This study suggests a positive association between prenatal p,p′-DDE exposure and indicators of abdominal fat and a negative association between prenatal cadmium exposure and indicators of both abdominal as well as subcutaneous fat in girls between 7 and 9 years old. - Highlights: • Associations between prenatal contaminant exposure and anthropometrics in children. • Significant association only found in girls. • No significant associations found for prenatal PCBs, dioxins and HCB exposure. • Girls: negative association between cadmium and abdominal and subcutaneous fat. • Girls: positive association between p,p′-DDE and indicators of abdominal fat.

54 ENVIRONMENTAL SCIENCES↗

SU-E-T-117: Dose to Organs Outside of CT Scan Range- Monte Carlo and Hybrid Phantom Approach

Purpose: Epidemiological study of second cancer risk for cancer survivors often requires the dose to normal tissues located outside the anatomy covered by radiological imaging, which is usually limited to tumor and organs at risk. We have investigated the feasibility of using whole body computational human phantoms for estimating out-of-field organ doses for patients treated by Intensity Modulated Radiation Therapy (IMRT). Methods: Identical 7-field IMRT prostate plans were performed using X-ray Voxel Monte Carlo (XVMC), a radiotherapy-specific Monte Carlo transport code, on the computed tomography (CT) images of the torso of an adult male patient (175 cm height, 66 kg weight) and an adult male hybrid computational phantom with the equivalent body size. Dose to the liver, right lung, and left lung were calculated and compared. Results: Considerable differences are seen between the doses calculated by XVMC for the patient CT and the hybrid phantom. One major contributing factor is the treatment method, deep inspiration breath hold (DIBH), used for this patient. This leads to significant differences in the organ position relative to the treatment isocenter. The transverse distances from the treatment isocenter to the inferior border of the liver, left lung, and right lung are 19.5cm, 29.5cm, and 30.0cm, respectively for the patient CT, compared with 24.3cm, 36.6cm, and 39.1cm, respectively, for the hybrid phantom. When corrected for the distance, the mean doses calculated using the hybrid phantom are within 28% of those calculated using the patient CT. Conclusion: This study showed that mean dose to the organs located in the missing CT coverage can be reconstructed by using whole body computational human phantoms within reasonable dosimetric uncertainty, however appropriate corrections may be necessary if the patient is treated with a technique that will significantly deform the size or location of the organs relative to the hybrid phantom.

60 APPLIED LIFE SCIENCES↗

Upper Surface Nacelle Influence on SCAR Aerodynamic Characteristics at Transonic Speeds

The arrow-wing transport configuration with detached engines located over the wing to produce upper surface exhaust flow effects was tested at angles of attack from -4 deg to 8 deg and jet total-pressure ratios from 1 (Jet off) to approximately 10. Wing tip leading edge flap deflections of -10 deg to 10 deg were tested with the wing-body configuration only (no nacelles). Tests were made with various nacelle chordwise, spanwise, and vertical height locations over the Mach number, angle of attack, and jet total-pressure ratio ranges. Deflecting the wing tip leading edge flap from 0 deg to -10 deg increased maximum lift to drag ratio by 1.0 at subsonic speeds. Installation of upper surface nacelles (no wing/nacelle pylons) increased the wing-body pitching moment at all Mach numbers and decreased the drag of the wing-body configuration at subsonic Mach numbers. Jet exhaust interference effects were negligible.

Mercer, C. E.↗

Pool Fire Analysis Methodology for Assessing Damage to Waste Containers

This document provides guidelines, whereby the physical parameters associated with postulated flammable/combustible liquid pool fires are determined (thermal analysis) in order to estimate the number of waste containers impacted. Pool fire damage to waste containers may occur due to a container being fully engulfed (within the periphery of the pool), partially engulfed, or within the critical heat flux distance. The methodology described here for estimating the size of the pool fire is developed using spill characteristics outlined in Chapter 65 of the SFPE Handbook (Ref. 7) and testing done by Hansen (Ref. 25). For exposures, the critical flux height is determined using the detailed method of Shokri and Beyler (Ref. 8) from the flame height, calculated as described by Heskestad (Ref. 7) and the average black body emissive power, determined using the method of Shokri and Beyler (Ref. 8). Three types of liquid pool fires should be considered; unconfined crash/instantaneous spill fires, unconfined continuously flowing (also called metered leak) spill fires, and confined spill fires. All fuel sources should be considered consistent with the facility Fire Hazard Analysis (FHA). However, the most likely liquid fuel sources present in TRU waste facilities are those present on TRU waste handling vehicles (forklifts, pallet movers, transport trucks, etc.). This method can also be used for assessing damage to items other than waste containers or other methods of analysis may be used with appropriate justification.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Dynamical response of the dayside ionosphere of Venus to the solar wind

Dayside ion composition measurements made by the orbiter ion mass spectrometer and the orbiter electron temperature probe on the Pioneer Venus orbiter are used to infer the dominant processes involved in the dynamic response of the Venus ionosphere to the solar wind. The analysis is confined to the topside ionosphere in the vicinity of the subsolar point, where the ionosphere-solar wind interaction is expected to be maximized. Height profiles of the ion composition and plasma temperatures in the main body of the topside ionosphere, lying between the ionopause and chemical equilibrium regions, reveal that the ionosphere is in a compressed state. This region of the ionosphere is interpreted in terms of a stationary equilibrium where the compression is derived from the ponderomotive force j x B. The estimated magnitude of this force is confirmed by the magnetic field measurements made by the orbiter magnetometer.

Hartle, R. E.↗

A fundamental approach to the sticking of insect residues to aircraft wings

The sticking of insect residues to aircraft wings is investigated. The major topics of this review are: Experimentally tested methods, testing techniques, the effect of surface roughness height on aerodynamic drag, materials tested and, the adhesive properties of insect body fluids are reviewed.

Eiss, N. S., Jr.↗

A Combined Length-of-Day Series Spanning 1832-1997

The Earth's rotation is not constant but exhibits minute changes on all observable time scales ranging from subdaily to secular. This rich spectrum of observed Earth rotation changes reflects the rich variety of astronomical and geophysical phenomena that are causing the Earth's rotation to change, including, but not limited to, ocean and solid body tides, atmospheric wind and pressure changes, oceanic current and sea level height changes, post-glacial rebound, and torques acting at the core-mantle boundary. In particular, the decadal-scale variations of the Earth's rotation are thought to be largely caused by interactions between the Earth's outer core and mantle. Comparing the inferred Earth rotation variations caused by the various core-mantle interactions to observed variations requires Earth rotation observations spanning decades, if not centuries. During the past century many different techniques have been used to observe the Earth's rotation. By combining the individual Earth rotation series determined by each of these techniques, a series of the Earth's rotation can be obtained that is based upon independent measurements spanning the greatest possible time interval. In this study, independent observations of the Earth's rotation are combined to generate a length-of-day series spanning 1832-1997. The observations combined include lunar occultation measurements spanning 1832-1955, optical astrometric measurements spanning 1956-1982, lunar laser ranging measurements spanning 1970-1997, and very long baseline interferometric measurements spanning 1978-1998. These series are combined using a Kalman filter developed at JPL for just this purpose. The resulting combined length-of-day series will be presented and compared with other available length-of-day series of similar duration.

Gross, Richard S.↗

Waves in Radial Gravity Using Magnetic Fluid

Terrestrial laboratory experiments studying various fluid dynamical processes are constrained, by being in an Earth laboratory, to have a gravitational body force which is uniform and unidirectional. Therefore fluid free-surfaces are horizontal and flat. Such free surfaces must have a vertical solid boundary to keep the fluid from spreading horizontally along a gravitational potential surface. In atmospheric, oceanic, or stellar fluid flows that have a horizontal scale of about one-tenth the body radius or larger, sphericity is important in the dynamics. Further, fluids in spherical geometry can cover an entire domain without any sidewall effects, i.e. have truly periodic boundary conditions. We describe spherical body-force laboratory experiments using ferrofluid. Ferrofluids are dilute suspensions of magnetic dipoles, for example magnetite particles of order 10 nm diameter, suspended in a carrier fluid. Ferrofluids are subject to an additional body force in the presence of an applied magnetic field gradient. We use this body force to conduct laboratory experiments in spherical geometry. The present study is a laboratory technique improvement. The apparatus is cylindrically axisymmetric. A cylindrical ceramic magnet is embedded in a smooth, solid, spherical PVC ball. The geopotential field and its gradient, the body force, were made nearly spherical by careful choice of magnet height-to-diameter ratio and magnet size relative to the PVC ball size. Terrestrial gravity is eliminated from the dynamics by immersing the "planet" and its ferrofluid "ocean" in an immiscible silicone oil/freon mixture of the same density. Thus the earth gravity is removed from the dynamics of the ferrofluid/oil interface and the only dynamically active force there is the radial magnetic gravity. The entire apparatus can rotate, and waves are forced on the ferrofluid surface by exterior magnets. The biggest improvement in technique is in the wave visualization. Fluorescing dye is added to the oil/freon mixture and an argon ion laser generates a horizontal light that can be scanned vertically. Viewed from above, the experiment is a black circle with wave deformations surrounded by a light background. A contour of the image intensity at any light sheet position gives the surface of the ferrofluid "ocean" at that "latitude". Radial displacements of the waves as a function of longitude are obtained by subtracting the contour line positions from a no-motion contour at that laser sheet latitude. The experiments are run by traversing the forcing magnet with the laser sheet height fixed and images are frame grabbed to obtain a time-series at one latitude. The experiment is then re-run with another laser-sheet height to generate a full picture of the three-dimensional wave structure in the upper hemisphere of the ball as a function of time. We concentrate here on results of laboratory studies of waves that are important in Earth's atmosphere and especially the ocean. To get oceanic scaling in the laboratory, the experiment must rotate rapidly (4-second rotation period) so that the wave speed is slow compared to the planetary rotation speed as in the ocean. In the Pacific Ocean, eastward propagating Kelvin waves eventually run into the South American coast. Theory predicts that some of the wave energy should scatter into coastal-trapped Kelvin waves that propagate north and south along the coast. Some of this coastal wave energy might then scatter into mid-latitude Rossby waves that propagate back westward. Satellite observations of the Pacific Ocean sea-surface temperature and height seem to show signatures of westward propagating mid-latitude Rossby waves, 5 to 10 years after the 1982-83 El Nino. The observational data is difficult to interpret unambiguously owing to the large range of motions that fill the ocean at shorter timescales. This series of reflections giving eastward, north- ward, and then westward traveling waves is observed cleanly in the laboratory experiments, confirming the theoretical expectations.

Ohlsen, D. R.↗

X-59 Sonic Boom Test Results from the NASA Glenn 8- by 6-Foot Supersonic Wind Tunnel

A wind tunnel test was conducted to investigate near-field sonic boom pressure signatures of the X-59 Low-Boom Flight Demonstrator aircraft. A 1.62%-scale model of the aircraft was fabricated for the wind tunnel test, which took place in the NASA Glenn 8- by 6-Foot Supersonic Wind Tunnel in September and October 2021. The model had provisions for being mounted by a swept blade strut that attached at top of model ahead of the inlet, or by a rear-entry sting that held the model at the location of the nacelle. The model had alternate parts for ±0.5° deflections of the flaps, ailerons, and stabilator, and ±1° deflections of the T-tail. Off-body static pressure measurements of the flow field below the model were made on a pressure rail which had 420 orifices along its tip. The model was positioned at various heights from the rail by vertical movement of the tunnel strut, and at various longitudinal stations relative to the rail by means of a linear actuator mounted between the wind tunnel strut and the balance. Spatial averaging of model pressure signatures acquired over a range of longitudinal positions reduced the effects of tunnel flow distortions and the interference of the rail flow field and shocks on the model pressure signatures. The test was run at approximate Mach numbers of 1.36, 1.4, and 1.47, and the model was set at various angles of attack and roll relative to the rail. Plots of the model signatures for representative variations of Mach number, model angles, control deflections, and height relative to the rail are provided throughout the report. Repeatability was generally very good and gave confidence in the quality of the measurements. The signatures measured at various heights from the rail provided insight into the aging of the model shocks as they propagated from 1.2 to 3 body lengths from the model. Off-track signatures up to 45° from centerline obtained by rolling the model gave indications of the shock flow fields across the width of the sonic boom carpet. The deflections of the various control surfaces allowed assessment of the boom sensitivity to the control surface movements.

Sonic boom↗

X-59 Sonic Boom Test Results from the NASA Glenn 8- by 6-Foot Supersonic Wind Tunnel

A wind tunnel test was conducted to investigate near-field sonic boom pressure signatures of the X-59 Low-Boom Flight Demonstrator aircraft. A 1.62%-scale model of the aircraft was fabricated for the wind tunnel test, which took place in the NASA Glenn 8- by 6-Foot Supersonic Wind Tunnel in September and October 2021. The model had provisions for being mounted by a swept blade strut that attached at top of model ahead of the inlet, or by a rear-entry sting that held the model at the location of the nacelle. The model had alternate parts for ±0.5° deflections of the flaps, ailerons, and stabilator, and ±1° deflections of the T-tail. Off-body static pressure measurements of the flow field below the model were made on a pressure rail which had 420 orifices along its tip. The model was positioned at various heights from the rail by vertical movement of the tunnel strut, and at various longitudinal stations relative to the rail by means of a linear actuator mounted between the wind tunnel strut and the balance. Spatial averaging of model pressure signatures acquired over a range of longitudinal positions reduced the effects of tunnel flow distortions and the interference of the rail flow field and shocks on the model pressure signatures. The test was run at approximate Mach numbers of 1.36, 1.4, and 1.47, and the model was set at various angles of attack and roll relative to the rail. Plots of the model signatures for representative variations of Mach number, model angles, control deflections, and height relative to the rail are provided throughout the report. Repeatability was generally very good and gave confidence in the quality of the measurements. The signatures measured at various heights from the rail provided insight into the aging of the model shocks as they propagated from 1.2 to 3 body lengths from the model. Off-track signatures up to 45° from centerline obtained by rolling the model gave indications of the shock flow fields across the width of the sonic boom carpet. The deflections of the various control surfaces allowed assessment of the boom sensitivity to the control surface movements.

Sonic boom↗

X-59 Sonic Boom Test Results from the NASA Glenn 8- by 6-Foot Supersonic Wind Tunnel

A wind tunnel test was conducted to investigate near-field sonic boom pressure signatures from a model of the X-59 Low-Boom Flight Demonstrator aircraft. A 1.62%-scale model of the aircraft in the C612A configuration was fabricated for the wind tunnel test, which took place in the NASA Glenn 8- by 6-Foot Supersonic Wind Tunnel in September and October 2021. The model had provisions for two different mounting options: a swept blade strut that attached at the top of model ahead of the inlet, and rear-entry sting that was made as one piece with a dummy nacelle, and which had a 2”-long cylindrical segment aft of the nozzle exit before tapering up in size. The blade strut allowed for a clean aft end of the model for evaluation of the shocks from that region, while the sting avoided the significant distortions of the flow and shocks from the blade strut along the top of the model. Both the sting and the strut had adapters that attached to a force balance. The model had alternate parts for ±0.5° deflections of the flaps, ailerons, and stabilator, and ±1° deflections of the T-tail horizontal surface. Off-body static pressure measurements of the flow field below the model were made by use of a pressure rail which had 420 orifices along its tip. The model was positioned at various heights from the rail by vertical movement of the wind tunnel strut, and at various longitudinal stations relative to the rail by means of a linear actuator mounted between the tunnel strut and the balance. The longitudinal positioning allowed multiple pressure signatures to be obtained along different portions of the rail. These signatures were aligned by accounting for the model longitudinal movement and then averaged to take out the effects of tunnel flow distortions and the interference of the rail flow field and shocks on the model pressure signatures. The test was run at approximate Mach numbers of 1.36, 1.4, and 1.47, and the model was set at various angles of attack and roll relative to the rail. Plots of the model signatures for all the variations of Mach number, model angles, control deflections, and height relative to the rail are provided throughout the report. Repeatability was generally very good and gave confidence in the quality of the measurements. The signatures measured at various heights from the rail provided insight into the aging of the model shocks as they propagated from 1.2 to 3 body lengths from the model. Off-track signatures up to 45° from centerline obtained by rolling the model gave indications of the shock flow fields across the width of the sonic boom carpet. The deflections of the various control surfaces allowed assessment of the boom sensitivity to the control surface movements.

Sonic boom↗

Heat transfer to a thin liquid film with a free surface

The numerically computed flow field and heat transfer coefficient are presented for the free surface flow of a thin liquid film in the presence or absence of a gravitational body force. The results of an approximate analysis using the Pohlhausen integral method is also discussed. The flow systems studied here include both plane and radial film flows in the presence or absence of a gravitational body force. The heating conditions include isothermal and uniformly heated surfaces. The transport conditions considered at the free surface are an adiabatic condition and an evaporative free surface maintained at its saturation temperature. The height of the free surface, flow field and heat transfer coefficient, were found to be strongly affected by the gravitational body force. They were also found to depend on the Reynolds number and Froude number of the incoming fluid. In the presence of gravity, a hydraulic jump was found to occur under some flow conditions.

Rahman, M. M.↗

Effect of meteoroid rotation on atmospheric entry heating and meteor beginning height

The beginning height of a meteor varies by approximately 10 km depending on the rotation state of a spherical meteoroid as long as the body sustains a temperature gradient. Such gradients build up in friable stony meteoroids larger than approximately 0.1 cm and in iron meteoroids that are approximately 1 cm or larger. The height where 100 microns or smaller zodiacal dust particles ablate is nearly independent of rotation. Stony particles in the 100 microns size range ablate near 120 km while both larger and smaller meteoroids penetrate deeper. All calculations were made with a nominal speed of 30 km/s and a zenithal distance equal to z(sub r) = 0 deg. Larger meteoroids cool their surface by conduction to the interior while smaller meteoroids decelerate significantly due to their large surface area to mass ratio so that the surface receives a lower energy flux. Some micro-meteoroids smaller than approximately 10 microns may escape abalation altogether at the nominal velocity. The effect of rotation on particle temperature during atmospheric flight is significant on meteoroids larger than 0.1 cm but may be negligible on micro-meteorites that are typically 10-50 microns in diameter.

Adolfsson, L. G.↗

Conservative GRMHD simulations of moderately thin, tilted accretion disks

This paper presents our latest numerical simulations of accretion disks that are misaligned with respect to the rotation axis of a Kerr black hole. In this work, we use a new, fully conservative version of the Cosmos++ general relativistic magnetohydrodynamics (GRMHD) code, coupled with an ad hoc cooling function designed to control the thickness of the disk. Together these allow us to simulate the thinnest tilted accretion disks ever using a GRMHD code. In this way, we are able to probe the regime where the dimensionless stress and scale height of the disk become comparable. We present results for both prograde and retrograde cases. The simulated prograde tilted disk shows no sign of Bardeen-Petterson alignment even in the innermost parts of the disk. The simulated retrograde tilted disk, however, does show modest alignment. The implication of these results is that the parameter space associated with Bardeen-Petterson alignment for prograde disks may be rather small, only including very thin disks. Unlike our previous work, we find no evidence for standing shocks in our simulated tilted disks. We ascribe this to the black hole spin, tilt angle, and disk scale height all being small in these simulations. We also add to the growing body of literature pointing out that the turbulence driven by the magnetorotational instability in global simulations of accretion disks is not isotropic. Finally, we provide a comparison between our moderately thin, untilted reference simulation and other numerical simulations of thin disks in the literature.

79 ASTRONOMY AND ASTROPHYSICS↗

Why the SL9 Plumes Were All About the Same Height

Several of the SL9 ejecta plumes were observed by the HST to reach approximately the same height, about 3000 km above the jovian cloud tops. The duration of the infrared events, which were produced by the plume falling back on the atmosphere, measures time aloft and hence provides a second, more sensitive measure of plume height; the light curves indicate that the largest impacts produced modestly higher plumes. Evidently these plumes were launched with about the same vertical velocity, roughly 10-13 kilometers per second. As the impactors themselves were not all the same, nor the impacts equally luminous, nor the plumes equally opaque, the similar plume heights has been seen as a puzzle needing explanation. A second, closely related matter that needs to addressed quantitatively is the popular contention that a big plume requires a big impact. This view is misleading at best, yet plume heights can be used to constrain impact parameters. Dimensional analysis indicates that plume height goes as z alpha v (sup 2) (sub ej) alpha E/pH (sup 2), where v (sub ej) is the ejection velocity, E the explosion energy, and p and H the ambient pressure and scale height at termination. Using a semi-analytic model for the deceleration, disintegration, and destruction of intruding bodies by an ever-vigilant atmosphere, we find that the ratio E/pH(sup 2) is roughly constant for fragments with diameters of order 100 m to 1000 m. Constancy of v(sub ej) is in part due to the greater role of radiative ablation on the flight of smaller objects. We conclude that similar plume heights is a direct consequence of smaller impactors exploding at higher altitudes, in such a way that the different explosions were geometrically similar.

Zahnle, K.↗

Arterial Pressure Gradients during Upright Posture and 30 deg Head Down Tilt

Gravity alters local blood pressure within the body so that arterial pressures in the head and foot are lower and higher, respectively, than that at heart level. Furthermore, vascular responses to local alterations of arterial pressure are probably important to maintain orthostatic tolerance upon return to the Earth after space flight. However, it has been difficult to evaluate the body's arterial pressure gradient due to the lack of noninvasive technology. This study was therefore designed to investigate whether finger arterial pressure (FAP), measured noninvasively, follows a normal hydrostatic pressure gradient above and below heart level during upright posture and 30 deg head down tilt (HDT). Seven healthy subjects gave informed consent and were 19 to 52 years old with a height range of 158 to 181 cm. A Finapres device measured arterial pressure at different levels of the body by moving the hand from 36 cm below heart level (BH) to 72 cm above heart level (AH) in upright posture and from 36 cm BH to 48 cm AH during HDT in increments of 12 cm. Mean FAP creased by 85 mmHg transitioning from BH to AH in upright posture, and the pressure gradient calculated from hydrostatic pressure difference (rho(gh)) was 84 mmHg. In HDT, mean FAP decreased by 65 mmHg from BH to AH, and the calculated pressure gradient was also 65 mmHg. There was no significant difference between the measured FAP gradient and the calculated pressure gradient, although a significant (p = 0.023) offset was seen for absolute arterial pressure in upright posture. These results indicate that arterial pressure at various levels can be obtained from the blood pressure at heart level by calculating rho(gh) + an offset. The offset equals the difference between heart level and the site of measurement. In summary, we conclude that local blood pressure gradients can be measured by noninvasive studies of FAP.

Sanchez, E. R↗

A new model for estimating total body water from bioelectrical resistance

Estimation of total body water (T) from bioelectrical resistance (R) is commonly done by stepwise regression models with height squared over R, H(exp 2)/R, age, sex, and weight (W). Polynomials of H(exp 2)/R have not been included in these models. We examined the validity of a model with third order polynomials and W. Methods: T was measured with oxygen-18 labled water in 27 subjects. R at 50 kHz was obtained from electrodes placed on the hand and foot while subjects were in the supine position. A stepwise regression equation was developed with 13 subjects (age 31.5 plus or minus 6.2 years, T 38.2 plus or minus 6.6 L, W 65.2 plus or minus 12.0 kg). Correlations, standard error of estimates and mean differences were computed between T and estimated T's from the new (N) model and other models. Evaluations were completed with the remaining 14 subjects (age 32.4 plus or minus 6.3 years, T 40.3 plus or minus 8 L, W 70.2 plus or minus 12.3 kg) and two of its subgroups (high and low) Results: A regression equation was developed from the model. The only significant mean difference was between T and one of the earlier models. Conclusion: Third order polynomials in regression models may increase the accuracy of estimating total body water. Evaluating the model with a larger population is needed.

Siconolfi, S. F.↗

SU-D-16A-01: A Novel Method to Estimate Normal Tissue Dose for Radiotherapy Patients to Support Epidemiologic Studies of Second Cancer Risk

Purpose: Patient cohort of second cancer study often involves radiotherapy patients with no radiological images available: We developed methods to construct a realistic surrogate anatomy by using computational human phantoms. We tested this phantom images both in a commercial treatment planning system (Eclipse) and a custom Monte Carlo (MC) transport code. Methods: We used a reference adult male phantom defined by International Commission on Radiological Protection (ICRP). The hybrid phantom which was originally developed in Non-Uniform Rational B-Spline (NURBS) and polygon mesh format was converted into more common medical imaging format. Electron density was calculated from the material composition of the organs and tissues and then converted into DICOM format. The DICOM images were imported into the Eclipse system for treatment planning, and then the resulting DICOM-RT files were imported into the MC code for MC-based dose calculation. Normal tissue doses were calculation in Eclipse and MC code for an illustrative prostate treatment case and compared to each other. Results: DICOM images were generated from the adult male reference phantom. Densities and volumes of selected organs between the original phantom and ones represented within Eclipse showed good agreements, less than 0.6%. Mean dose from Eclipse and MC code match less than 7%, whereas maximum and minimum doses were different up to 45%. Conclusion: The methods established in this study will be useful for the reconstruction of organ dose to support epidemiological studies of second cancer in cancer survivors treated by radiotherapy. We also work on implementing body size-dependent computational phantoms to better represent patient's anatomy when the height and weight of patients are available.

60 APPLIED LIFE SCIENCES↗