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At least 1,063 records · Page 59

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NASA NTRS1976

Conceptual design of a biological specimen holding facility

An all-important first step in the development of the Spacelab Life Science Laboratory is the design of the Biological Specimen Holding Facility (BSHF) which will provide accommodation for living specimens for life science research in orbit. As a useful tool in the understanding of physiological and biomedical changes produced in the weightless environment, the BSHF will enable biomedical researchers to conduct in-orbit investigations utilizing techniques that may be impossible to perform on human subjects. The results of a comprehensive study for defining the BSHF, description of its experiment support capabilities, and the planning required for its development are presented. Conceptual designs of the facility, its subsystems and interfaces with the Orbiter and Spacelab are included. Environmental control, life support and data management systems are provided. Interface and support equipment required for specimen transfer, surgical research, and food, water and waste storage is defined. New and optimized concepts are presented for waste collection, feces and urine separation and sampling, environmental control, feeding and watering, lighting, data management and other support subsystems.

Jackson, J. K.↗

NASA NTRS1977

The capuchin monkey as a flight candidate

The highly evolved nervous system and associated complex behavioral capabilities of the nonhuman primates make them good candidates for certain studies in the space environment since deleterious changes in these more complex aspects of a biological status can only be demonstrated by species which share such highly evolved features with man. Important assets which urge the selection of the capuchin monkey for space experiments include his small size, high intelligence, relative disease resistance, nutritional requirements, and lower volume life support systems. The species is particularly suited for experiments on the nervous system or on process under neural control because of the similarity of capuchin and human blood chemistry profiles and endocrine systems involved in the maintenance of homeostasis and vasomotor tone.

Winget, C. M.↗

NASA NTRS2001

Escalating trends in the urban metabolism of Hong Kong: 1971-1997

Urban metabolism measures quantitatively a city's load on the natural environment. We update the Newcombe et al. (3) pioneering study of Hong Kong's urban metabolism in 1971, highlighting trends in resource consumption and waste generation. Per capita food, water and materials consumption have surged since the early 1970s by 20%, 40%, and 149%, respectively. Tremendous pollution has accompanied this growing affluence and materialism, and total air emissions, CO2 outputs, municipal solid wastes, and sewage discharges have risen by 30%, 250%, 245%, and 153%. As a result, systemic overload of land, atmospheric and water systems has occurred. While some strategies to tackle deteriorating environmental quality have succeeded, greater and more far-reaching changes in consumer behavior and government policy are needed if Hong Kong is to achieve its stated goal of becoming "a truly sustainable city" in the 21st century.

Environmental Pollution↗

NASA NTRS2008

Evolution of the Earth Observing System (EOS) Data and Information System (EOSDIS)

One of the strategic goals of the U.S. National Aeronautics and Space Administration (NASA) is to "Develop a balanced overall program of science, exploration, and aeronautics consistent with the redirection of the human spaceflight program to focus on exploration". An important sub-goal of this goal is to "Study Earth from space to advance scientific understanding and meet societal needs." NASA meets this subgoal in partnership with other U.S. agencies and international organizations through its Earth science program. A major component of NASA s Earth science program is the Earth Observing System (EOS). The EOS program was started in 1990 with the primary purpose of modeling global climate change. This program consists of a set of space-borne instruments, science teams, and a data system. The instruments are designed to obtain highly accurate, frequent and global measurements of geophysical properties of land, oceans and atmosphere. The science teams are responsible for designing the instruments as well as scientific algorithms to derive information from the instrument measurements. The data system, called the EOS Data and Information System (EOSDIS), produces data products using those algorithms as well as archives and distributes such products. The first of the EOS instruments were launched in November 1997 on the Japanese satellite called the Tropical Rainfall Measuring Mission (TRMM) and the last, on the U.S. satellite Aura, were launched in July 2004. The instrument science teams have been active since the inception of the program in 1990 and have participation from Brazil, Canada, France, Japan, Netherlands, United Kingdom and U.S. The development of EOSDIS was initiated in 1990, and this data system has been serving the user community since 1994. The purpose of this chapter is to discuss the history and evolution of EOSDIS since its beginnings to the present and indicate how it continues to evolve into the future. this chapter is organized as follows. Sect. 7.2 provides a discussion of EOSDIS, its elements and their functions. Sect. 7.3 provides details regarding the move towards more distributed systems for supporting both the core and community needs to be served by NASA Earth science data systems. Sect. 7.4 discusses the use of standards and interfaces and their importance in EOSDIS. Sect. 7.5 provides details about the EOSDIS Evolution Study. Sect. 7.6 presents the implementation of the EOSDIS Evolution plan. Sect. 7.7 briefly outlines the progress that the implementation has made towards the 2015 Vision, followed by a summary in Sect. 7.8.

Ramapriyan, Hampapuram K.↗

NASA NTRS2015

Prospective Observational Study of Ocular Health in ISS Crews - The Ocular Health Study

The Visual Impairment Intracranial Pressure (VIIP) syndrome is currently NASA's number one human space flight risk. The syndrome, which is related to microgravity exposure, manifests with changes in visual acuity (hyperopic shifts, scotomas), changes in eye structure (optic disc edema, choroidal folds, cotton wool spots, globe flattening, and dilated optic nerve sheaths), and in some cases with documented increased intracranial pressure (ICP) postflight. While the eye appears to be the main affected end organ of this syndrome, the ocular effects are thought to be related to underlying changes in the vascular system and the central nervous system. The leading hypotheses for the development of VIIP involve microgravity-induced head-ward fluid shifts along with a loss of gravity-assisted drainage of venous blood from the brain, leading to cephalic congestion, decreased CSF resorption and increased ICP. Since 70% of ISS crewmembers have manifested clinical signs or symptoms of the VIIP syndrome, it is assumed that the majority have some degree of ICP elevation in-flight compared to the ground. Prolonged elevations of ICP can cause long-term reduced visual acuity and loss of peripheral visual fields, and have been reported to cause mild cognitive impairment in the analog terrestrial population of Idiopathic Intracranial Hypertension (IIH). These potentially irreversible health consequences underscore the importance of identifying the factors that lead to this syndrome and mitigating them.

Otto, C.↗

NASA NTRS2019

Test Bed for Human Performance in Mockup Suit

Crewmembers' ability to adjust to changes in gravity and sensorimotor function is essential for successful suited mobility in lunar and planetary missions. Setups for current pressurized spacesuit testing require suit technicians, specialized medical clearances, and test support personnel along with increased risk to the subject. Furthermore, suited setups constrain the types of additional hardware that can be used. A test bed was developed with the goal to evaluate human suited performance using an unpressurized Mark III mockup suit and virtual reality (VR) system. The mockup suit provides a means of performing proof-of-concept tasks for suited performance with lower time and cost demands. Additionally, VR goggles provide a means for projecting an immersive planetary environment and applying perturbations to the visuo-vestibular system with minimal equipment. Furthermore, the test bed will be developed to allow room for improvement in fidelity for future suited applications.

Beltran, Eduerdo J.↗

NASA NTRS2019

Test Bed for Human Performance in Mockup Suit

Beltran, Eduardo↗

NASA NTRS2024

GCAS Visualization Codebase Augmentation Migration to Modern Standards and Feature Enhancements

The Glenn Research Center Communication Analysis Suite (GCAS) includes many analysis tools that can be used to support a wide range of scenarios. It includes a visualization tool that implements the three.js graphics library to display a three-dimensional (3D) representation of its results. This software will enable researchers, engineers, and mission planners to interact intuitively with and understand the results of their analyses, which might not be apparent from raw data. With NASA’s efforts to return humans to the Moon as a part of the Artemis missions, the GCAS has been used extensively for lunar terrain and landing system development analysis, which is vital to ensuring mission achievability and safety. This has created the need to add several significant features to the visualization tool, such as the ability to display the terrain of the lunar surface accurately and to provide information demonstrating how a given region might impact mission objectives. Many of the changes made to the visualization tool can be separated into one of three general advancements: code restructuring to adhere to modern coding standards and practices, new user camera controls for first-person and third-person perspective views, and a terrain generation feature to enable rendering highly accurate terrains based on any celestial body’s digital elevation model (DEM) in GeoTIFF format. These improvements notably elevate the visualization tool's functionality, accuracy, and user interaction while providing a robust foundation for future development.

Visualization↗

NASA NTRS2004

Multimodality instrument for tissue characterization

A system with multimodality instrument for tissue identification includes a computer-controlled motor driven heuristic probe with a multisensory tip. For neurosurgical applications, the instrument is mounted on a stereotactic frame for the probe to penetrate the brain in a precisely controlled fashion. The resistance of the brain tissue being penetrated is continually monitored by a miniaturized strain gauge attached to the probe tip. Other modality sensors may be mounted near the probe tip to provide real-time tissue characterizations and the ability to detect the proximity of blood vessels, thus eliminating errors normally associated with registration of pre-operative scans, tissue swelling, elastic tissue deformation, human judgement, etc., and rendering surgical procedures safer, more accurate, and efficient. A neural network program adaptively learns the information on resistance and other characteristic features of normal brain tissue during the surgery and provides near real-time modeling. A fuzzy logic interface to the neural network program incorporates expert medical knowledge in the learning process. Identification of abnormal brain tissue is determined by the detection of change and comparison with previously learned models of abnormal brain tissues. The operation of the instrument is controlled through a user friendly graphical interface. Patient data is presented in a 3D stereographics display. Acoustic feedback of selected information may optionally be provided. Upon detection of the close proximity to blood vessels or abnormal brain tissue, the computer-controlled motor immediately stops probe penetration. The use of this system will make surgical procedures safer, more accurate, and more efficient. Other applications of this system include the detection, prognosis and treatment of breast cancer, prostate cancer, spinal diseases, and use in general exploratory surgery.

Mah, Robert W.↗

NASA NTRS1988

Integration of task level planning and diagnosis for an intelligent robot

The use of robots in the future must go beyond present applications and will depend on the ability of a robot to adapt to a changing environment and to deal with unexpected scenarios (i.e., picking up parts that are not exactly where they were expected to be). The objective of this research is to demonstrate the feasibility of incorporating high level planning into a robot enabling it to deal with anomalous situations in order to minimize the need for constant human instruction. The heuristics can be used by a robot to apply information about previous actions towards accomplishing future objectives more efficiently. The system uses a decision network that represents the plan for accomplishing a task. This enables the robot to modify its plan based on results of previous actions. The system serves as a method for minimizing the need for constant human instruction in telerobotics. This paper describes the integration of expert systems and simulation as a valuable tool that goes far beyond this project. Simulation can be expected to be used increasingly as both hardware and software improve. Similarly, the ability to merge an expert system with simulation means that we can add intelligence to the system. A malfunctioning space satellite is described. The expert system uses a series of heuristics in order to guide the robot to the proper location. This is part of task level planning. The final part of the paper suggests directions for future research. Having shown the feasibility of an expert system embedded in a simulation, the paper then discusses how the system can be integrated with the MSFC graphics system.

Gerstenfeld, Arthur↗

NASA NTRS2004

Evidence of Urban Precipitation Anomalies from Satellite and Ground-Based Measurements

Urbanization is one of the extreme cases of land use change. Most of world s population has moved to urban areas. Although currently only 1.2% of the land is considered urban, the spatial coverage and density of cities are expected to rapidly increase in the near future. It is estimated that by the year 2025,60% of the world s population will live in cities. Human activity in urban environments also alters weather and climate processes. However, our understanding of urbanization on the total Earth-weather-climate system is incomplete. Recent literature continues to provide evidence that anomalies in precipitation exist over and downwind of major cities. Current and future research efforts are actively seeking to verify these literature findings and understand potential cause- effect relationships. The novelty of this study is that it utilizes rainfall data from multiple satellite data sources (e.g. TRMM precipitation radar, TRMM-geosynchronous-rain gauge merged product, and SSM/I) and ground-based measurements to identify spatial anomalies and temporal trends in precipitation for cities around the world. Early results will be presented and placed within the context of weather prediction, climate assessment, and societal applications.

Shepherd, J. M.↗

NASA NTRS2004

Evidence of Urban Precipitation Anomalies from Satellite and Ground-Based Measurements

Urbanization is one of the extreme cases of land use change. Most of world's population has moved to urban areas. Although currently only 1.2% of the land is considered urban, the spatial coverage and density of cities are expected to rapidly increase in the near future. It is estimated that by the year 2025, 60% of the world's population will live in cities. Human activity in urban environments also alters weather and climate processes. However, our understanding of urbanization on the total Earth-weather-climate system is incomplete. Recent literature continues to provide evidence that anomalies in precipitation exist over and downwind of major cities. Current and future research efforts are actively seeking to verify these literature findings and understand potential cause-effect relationships. The novelty of this study is that it utilizes rainfall data from multiple satellite data sources (e.g. TRMM precipitation radar, TRMM-geosynchronous-rain gauge merged product, and SSM/I) and ground-based measurements to identify spatial anomalies and temporal trends in precipitation for cities around the world. Early results will be presented and placed within the context of weather prediction, climate assessment, and societal applications.

Shepherd, J. Marshall↗

NASA NTRS1998

Uncoupling of the baroreflex by N(N)-cholinergic blockade in dissecting the components of cardiovascular regulation

Systemic administration of adrenergic agonists and nitric oxide donors is used extensively to determine cardiovascular receptor sensitivity. Conclusions regarding receptor sensitivity in the presence of the baroreflex may be misleading. In 8 normal volunteers, we determined the heart rate and blood pressure changes after incremental bolus doses of isoproterenol, phenylephrine, and sodium nitroprusside before and during neuronal nicotinic cholinergic (N(N)-cholinergic) blockade with trimethaphan. Results are given as median (25th/75th percentile). With trimethaphan, the baroreflex slope (as determined by bolus doses of nitroprusside and phenylephrine) decreased from 24 (22/26) to 0.00 (0.00/0.09) ms/mm Hg (P<0.01). The dose of isoproterenol that decreased systolic blood pressure (SBP) 12.5 mm Hg changed from 0.61 (0.51/5.3) to 0.17 (0.12/0.21) microg (P<0.01); the dose required to increase heart rate 12.5 bpm changed from 0.22 (0.17/0.41) to 0.74 (0.33/2.3) microg (P<0.01). The dose of nitroprusside required to decrease SBP 12.5 mm Hg changed from 2.3 (1.3/3.4) to 0.18 (0.14/0.24) microg/kg (P<0.01). The dose of phenylephrine required to increase SBP 12.5 mm Hg changed from 135 (110/200) to 16 (10/30) microg (P<0.01). We conclude that the efferent arc of the baroreflex can be completely interrupted with N(N)-cholinergic blockade. Estimation of adrenoreceptor sensitivity and sensitivity to nitric oxide donors by systemic administration of agonists is severely confounded by baroreflexes. Uncoupling of the baroreflex by N(N)-cholinergic blockade may be a useful method to obtain an integrated measure of adrenergic receptor sensitivity and sensitivity to nitric oxide donors in humans. This approach would permit the comparison of normal and abnormal physiological states without the "noise" of baroreflex buffering.

NASA Discipline Regulatory Physiology↗

NASA NTRS2018

In Flight miRNA Isolation and Recovery on the ISS

Due to advancements in RNA research, mi (micro) RNAs and other small nucleotide RNAs have become a major research field in biology including spaceflight research. The regulation of RNA transcription and processing by miRNAs makes miRNAs an appealing topic for genetics and molecular research. It has been estimated that over 60% of human gene transcripts are targets of miRNA regulation. In fact, this is true for all organisms, including plants and insects. Small nucleotide RNAs can also play a role in regulating gene expression, meaning that gene expression alone is not a complete picture of the potential genetic changes that occur in an organism during spaceflight. The goal of the WetLab-2 project is to isolate and recover miRNAs from various tissue sources on the International Space Station (ISS). No system currently exists that can isolate and recover small nucleotide RNA in space. However, the WetLab-2 system that was validated on the ISS in 2016 can be adapted to fit this purpose. We are currently testing the new modified protocols by running plant and mouse blood experiments in parallel, allowing us to demonstrate the effectiveness of the procedure on different sample types. We expect to be able to optimize and implement the modified miRNA protocols for use on future ISS flights.

miRNA↗

NASA NTRS2024

iGCE and MitoFlyght Spaceflight Missions: Unraveling Oxidative Stress Responses in Space

Thriving In DEep Space (TIDES) initiative aims to comprehensively understand how hostile environments such as the Moon and Mars affect human physiology. Here we present two NASA-selected spaceflight experiments under the TIDES portfolio, iGCE (Integrated Gravity Continuum Experiment) and MitoFlyght (Mitochondrial Investigation of Oxidative Stress in Flies). We hypothesize that exposure to spaceflight conditions induces oxidative stress responses that negatively impact physiology. The iGCE mission employs two well-established spaceflight models, Drosophila melanogaster and C.elegans, using Redwire’s Multi-use Variable-g Platform (MVP) hardware to assess changes in cardiac, muscle, and nervous systems across five different gravities: Hypergravity (2g), Earth (1g), Mars (0.37g), Moon (0.16g), and microgravity (ug). This mission focuses on uncovering alterations in protein homeostasis, autophagy, and mitochondrial function conserved across species. In the MitoFlyght mission to the ISS, Drosophila will be housed in the Vented Fly Box (VFB). This mission evaluates the oxidative stress response and autophagic pathway in muscle, heart, and nervous system. Additionally, we will (a) use the genetic mutant, Tor7/P to test whether increased autophagy is beneficial or a maladaptive response to the spaceflight stressors, and (b) utilize fly lines with tissue-specific expression (neuronal, muscle, and cardiac) of an antioxidant gene, SOD2 (superoxide dismutase) as a potential countermeasure. Data from these missions will be compared with previous LEO-based datasets to identify shared signatures. Furthermore, cross-species analysis of the transcriptomic data from other invertebrate and vertebrate spaceflight studies will help determine evolutionarily conserved pathways perturbed by space stressors. Overall, both these missions aim to provide crucial insights into the mechanisms underlying oxidative stress responses, synaptic changes, and heart and muscle deficits, facilitating the identification of diagnostic and therapeutic targets to mitigate the adverse health effects of long-duration space habitation. Ultimately, this research will enhance our ability to thrive in deep space and inform future missions.

Janani Iyer↗

NASA NTRSDate not supplied

Integrated Trajectory, Habitat, and Logistics Analysis and Trade Study for Human Mars Missions

Environmental Control and Life Support System (ECLSS) architecture selection has profound implications for mission cost and mass extending far beyond the ECLSS itself. Similarly, other mission architecture decisions – particularly involving transportation systems – can influence optimal ECLSS architectures. Loop closure influences requirements for water, oxygen, and other consumables. System maintainability and reliability influences spares mass and risk. System, consumables, and spares mass interact with transportation system architectures, including propellant demands and propulsion element sizing. All these interactions with other systems must be considered when evaluating ECLSS options. Analyses that focus only on maximizing ECLSS loop closure – or minimizing ECLSS mass, or minimizing ECLSS life cycle cost – may lead to sub-optimal or even counterproductive system architecture and investment decisions at the mission level. For example, an ECLSS architecture that minimizes ECLSS life cycle cost but results in excessively high logistics mass could lead to significantly increased transportation system costs or make interplanetary transportation infeasible. Increased loop closure could result in higher development costs and higher mass if system/spares mass increases outweigh consumables reduction. In addition, systems mass and consumables mass are not directly comparable and have different impacts on propellant requirements, as consumables mass changes over the course of the mission. This paper presents an integrated analysis examining the overall impact of different ECLSS and transportation architectures on Earth departure mass for a crewed Mars mission, including the habitat and transportation systems as well as consumables, spares, and propellant. Key observations are discussed, along with opportunities for further sensitivity analysis and model development. Overall, ECLSS development activities must consider their impacts at the mission level, as part of an integrated system, rather than in isolation.

Mars↗

NASA NTRS2001

Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight

BACKGROUND: The extent to which sleep loss may predispose astronauts to a state of altered immunity during extended space travel prompts evaluation with ground-based models. OBJECTIVE: We sought to measure plasma levels of selected cytokines and their receptors, including the putative sleep-regulation proteins soluble TNF-alpha receptor (sTNF-alpha R) I and IL-6, in human subjects undergoing 2 types of sleep deprivation during environmental confinement with performance demands. METHODS: Healthy adult men (n = 42) were randomized to schedules that varied in severity of sleep loss: 4 days (88 hours) of partial sleep deprivation (PSD) involving two 2-hour naps per day or 4 days of total sleep deprivation (TSD). Plasma samples were obtained every 6 hours across 5 days and analyzed by using enzyme-linked immunoassays for sTNF-alpha RI, sTNF-alpha RII, IL-6, soluble IL-2 receptor, IL-10, and TNF-alpha. RESULTS: Interactions between the effects of time and sleep deprivation level were detected for sTNF-alpha RI and IL-6 but not for sTNF-alpha RII, soluble IL-2 receptor, IL-10, and TNF-alpha. Relative to the PSD condition, subjects in the TSD condition had elevated plasma levels of sTNF-alpha RI on day 2 (P =.04), day 3 (P =.01), and across days 2 to 4 of sleep loss (P =.01) and elevated levels of IL-6 on day 4 (P =.04). CONCLUSIONS: Total sleep loss produced significant increases in plasma levels of sTNF-alpha RI and IL-6, messengers that connect the nervous, endocrine, and immune systems. These changes appeared to reflect elevations of the homeostatic drive for sleep because they occurred in TSD but not PSD, suggesting that naps may serve as the basis for a countermeasures approach to prolonged spaceflight.

Non-NASA Center↗

NASA NTRS1986

Modified Petri net model sensitivity to workload manipulations

Modified Petri Nets (MPNs) are investigated as a workload modeling tool. The results of an exploratory study of the sensitivity of MPNs to work load manipulations in a dual task are described. Petri nets have been used to represent systems with asynchronous, concurrent and parallel activities (Peterson, 1981). These characteristics led some researchers to suggest the use of Petri nets in workload modeling where concurrent and parallel activities are common. Petri nets are represented by places and transitions. In the workload application, places represent operator activities and transitions represent events. MPNs have been used to formally represent task events and activities of a human operator in a man-machine system. Some descriptive applications demonstrate the usefulness of MPNs in the formal representation of systems. It is the general hypothesis herein that in addition to descriptive applications, MPNs may be useful for workload estimation and prediction. The results are reported of the first of a series of experiments designed to develop and test a MPN system of workload estimation and prediction. This first experiment is a screening test of MPN model general sensitivity to changes in workload. Positive results from this experiment will justify the more complicated analyses and techniques necessary for developing a workload prediction system.

White, S. A.↗