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At least 1,045 records · Page 58

Hemodynamic and hormonal responses to lower body negative pressure in men with varying profiles of strength and aerobic power

Hemodynamic, cardiac, and hormonal responses to lower-body negative pressure (LBNP) were examined in 24 healthy men to test the hypothesis that responsiveness of reflex control of blood pressure during orthostatic challenge is associated with interactions between strength and aerobic power. Subjects underwent treadmill tests to determine peak oxygen uptake (VO2max) and isokinetic dynamometer tests to determine knee extensor strength. Based on predetermined criteria, subjects were classified into one of four fitness profiles of six subjects each, matched for age, height, and body mass: (a) low strength/average aerobic fitness, (b) low strength/high aerobic fitness, (c) high strength/average aerobic fitness, and (d) high strength/high aerobic fitness. Following 90 min of 0.11 rad (6 degrees) head-down tilt (HDT), each subject underwent graded LBNP to -6.7 kPa or presyncope, with maximal duration 15 min, while hemodynamic, cardiac, and hormonal responses were measured. All groups exhibited typical hemodynamic, hormonal, and fluid shift responses during LBNP, with no intergroup differences between high and low strength characteristics. Subjects with high aerobic power exhibited greater (P < 0.05) stroke volume and lower (P < 0.05) heart rate, vascular peripheral resistance, and mean arterial pressure during rest, HDT, and LBNP. Seven subjects, distributed among the four fitness profiles, became presyncopal. These subjects showed greatest reduction in mean arterial pressure during LBNP, had greater elevations in vasopressin, and lesser increases in heart rate and peripheral resistance. Neither VO2max nor leg strength were associated with fall in arterial pressure or with syncopal episodes. We conclude that interactions between aerobic and strength fitness characteristics do not influence responses to LBNP challenge.

Norepinephrine/blood↗

Ozone Profiles and Tropospheric Ozone from Global Ozone Monitoring Experiment

Ozone profiles are derived from backscattered radiances in the ultraviolet spectra (290-340 nm) measured by the nadir-viewing Global Ozone Monitoring Experiment using optimal estimation. Tropospheric O3 is directly retrieved with the tropopause as one of the retrieval levels. To optimize the retrieval and improve the fitting precision needed for tropospheric O3, we perform extensive wavelength and radiometric calibrations and improve forward model inputs. Retrieved O3 profiles and tropospheric O3 agree well with coincident ozonesonde measurements, and the integrated total O3 agrees very well with Earth Probe TOMS and Dobson/Brewer total O3. The global distribution of tropospheric O3 clearly shows the influences of biomass burning, convection, and air pollution, and is generally consistent with our current understanding.

Liu, X.↗

Subsonic Gas Flow Past A Wing Profile

The use of the linearized equations of Chaplygin to calculate the subsonic flow of a gas permits solving the problem of the flow about a wing profile for absence and presence of circulation. The solution is obtained in a practical convenient form that permits finding all the required magnitudes for the gas flow (lift, lift moment velocity distribution over the profile, and critical Mach number). This solution is not expressed in simple closed form; for a certain simplifying assumption, however, the equations of Chaplygin can be reduced to equations with constant coefficients, and solutions are obtained by using only the mathematical apparatus of the theory of functions of a complex variable. The method for simplifying the equations was pointed out by Chaplygin himself. These applied similar equations to the solution of the flow problem and obtained a solution for the case of the absence of circulation.

Christianovich, S. A.↗

Investigation of a Related Series of Turbine-Blade Profiles in Cascade

An application of airfoil design methods was used to design series of related turbine-blade profiles to satisfy the conditions of inlet flow angle and turning angle encountered in the usual range of turbine operation. A series of blade profiles applicable to most turbine blading requirements and a secondary series with particular reference to impulse conditions were designed. Five blade sections from these series ranging in mean-line turning angles from 63 deg. to 120 deg. were tested in low-speed cascade tunnels. From low-speed test results optimum blade angles of attack were selected at each test condition. The induced angle and the deviation angle of the flow were determined from the low-speed data. If these angles are known for the solidity and inlet angle of an application, the necessary camber is specified. A method of predicting high-speed pressure distributions from low-speed cascade test results is presented to extend the usefulness of the low-speed data. Sample high-speed tests of two of the five blade sections were made at Mach numbers up to the critical value. The results indicated satisfactory flow conditions in all of the blade passages tested.

Dunavant, James C.↗

Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles

Genome-wide expression profiles contain global patterns that evade visual detection in current gene clustering analysis. Here, a Gene Expression Dynamics Inspector (GEDI) is described that uses self-organizing maps to translate high-dimensional expression profiles of time courses or sample classes into animated, coherent and robust mosaics images. GEDI facilitates identification of interesting patterns of molecular activity simultaneously across gene, time and sample space without prior assumption of any structure in the data, and then permits the user to retrieve genes of interest. Important changes in genome-wide activities may be quickly identified based on 'Gestalt' recognition and hence, GEDI may be especially useful for non-specialist end users, such as physicians. AVAILABILITY: GEDI v1.0 is written in Matlab, and binary Matlab.dll files which require Matlab to run can be downloaded for free by academic institutions at http://www.chip.org/~ge/gedihome.html Supplementary information: http://www.chip.org/~ge/gedihome.html.

Database Management Systems↗

Vertical Profiles of Light Scattering, Light Absorption, and Single Scattering Albedo during the Dry, Biomass Burning Season in Southern Africa and Comparisons of In Situ and Remote Sensing Measurements of Aerosol Optical Depths

Airborne in situ measurements of vertical profiles of aerosol light scattering, light absorption, and single scattering albedo (omega (sub 0)) are presented for a number of locations in southern Africa during the dry, biomass burning season. Features of the profiles include haze layers, clean air slots, and marked decreases in light scattering in passing from the boundary layer into the free troposphere. Frequency distributions of omega (sub 0) reflect the strong influence of smoke from biomass burning. For example, during a period when heavy smoke was advected into the region from the north, the mean value of omega (sub 0) in the boundary layer was 0.81 +/- 0.02 compared to 0.89 +/- 0.03 prior to this intrusion. Comparisons of layer aerosol optical depths derived from the in situ measurements with those measured by a Sun photometer aboard the aircraft show excellent agreement.

Magi, Brian I.↗

Siderophile Element Profile Measurements in Iron Meteorites Using Laser Ablation ICP-MS

Understanding the behaviour of siderophile elements during cooling of iron meteorites can lead to insight into the general thermal histories of the meteorites as well as their respective parent bodies. Traditionally trace element analyses in meteorites have been done using techniques that only measure the average concentration in each phase. With these methods, all of the spatial information with respect to the distribution of an element within one phase is lost. Measuring concentration profiles of trace elements in meteorites is now possible, with the advent of high-resolution analytical techniques such as laser ablation, inductively coupled plasma mass spectrometry (LA-ICP-MS) with spatial resolution <20 microns. [e.g. 1,2] and secondary ion mass spectrometry [3]. These profiles can give more insight into both the partitioning and diffusive behavior of siderophile elements in metal systems relevant to iron meteorites, as well as parent body cooling rates.

Watson, H. C.↗

New Technology-Large-Area Three- Dimensional Surface Profiling Using Only Focused Air-Coupled Ultrasound-Given 1999 R&D 100 Award

Surface topography, which significantly affects the performance of many industrial components, is normally measured with diamond-tip profilometry over small areas or with optical scattering methods over larger areas. To develop air-coupled surface profilometry, the NASA Glenn Research Center at Lewis Field initiated a Space Act Agreement with Sonix, Inc., through two Glenn programs, the Advanced High Temperature Engine Materials Program (HITEMP) and COMMTECH. The work resulted in quantitative surface topography profiles obtained using only high-frequency, focused ultrasonic pulses in air. The method is nondestructive, noninvasive, and noncontact, and it does not require light-reflective surfaces. Air surface profiling may be desirable when diamond-tip or laserbased methods are impractical, such as over large areas, when a significant depth range is required, or for curved surfaces. When the configuration is optimized, the method is reasonably rapid and all the quantitative analysis facilities are online, including two- and three-dimensional visualization, extreme value filtering (for faulty data), and leveling.

Roth, Don J.↗

Simultaneous measurement of multiple radiation-induced protein expression profiles using the Luminex(TM) system

Space flight results in the exposure of astronauts to a mixed field of radiation composed of energetic particles of varying energies, and biological indicators of space radiation exposure provides a better understanding of the associated long-term health risks. Current methods of biodosimetry have employed the use of cytogenetic analysis for biodosimetry, and more recently the advent of technological progression has led to advanced research in the use of genomic and proteomic expression profiling to simultaneously assess biomarkers of radiation exposure. We describe here the technical advantages of the Luminex(TM) 100 system relative to traditional methods and its potential as a tool to simultaneously profile multiple proteins induced by ionizing radiation. The development of such a bioassay would provide more relevant post-translational dynamics of stress response and will impart important implications in the advancement of space and other radiation contact monitoring. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

NASA Center JSC↗

Transcriptional profile of a myotube starvation model of atrophy

Skeletal muscle wasting is a pervasive phenomenon that can result from a wide range of pathological conditions as well as from habitual muscular inactivity. The present work describes a cell-culture condition that induces significant atrophy in skeletal muscle C2C12 myotubes. The failure to replenish differentiation media in mature myotubes leads to rapid atrophy (53% in diameter), which is referred to here as starvation. Affymetrix microarrays were used to develop a transcriptional profile of control (fed) vs. atrophied (nonfed) myotubes. Myotube starvation was characterized by an upregulation of genes involved in translational inhibition, amino acid biosynthesis and transport, and cell cycle arrest/apoptosis, among others. Downregulated genes included several structural and regulatory elements of the extracellular matrix as well as several elements of Wnt/frizzled and TGF-beta signaling pathways. Interestingly, the characteristic transcriptional upregulation of the ubiquitin-proteasome system, calpains, and cathepsins known to occur in multiple in vivo models of atrophy were not seen during myotube starvation. With the exception of the downregulation of extracellular matrix genes, serine protease inhibitor genes, and the upregulation of the translation initiation factor PHAS-I, this model of atrophy in cell culture has a transcriptional profile quite distinct from any study published to date with atrophy in whole muscle. These data show that, although the gross morphology of atrophied muscle fibers may be similar in whole muscle vs. myotube culture, the processes by which this phenotype is achieved differ markedly.

NASA Discipline Musculoskeletal↗

STS-114: Multi-Cut Profiles and Mission Overviews

Profiles of the seven crewmembers of the STS-114 Discovery are shown. Eileen Collins, Commander, talks about her fascination with flying as a young child and her eagerness to have someone teach her to fly at age 19. Her eagerness and hard work earned her a master's in operations research from Stanford University in 1986 and a master's in space systems management from Webster University in 1989. Jim Kelly, Pilot, talks about his desire to become an astronaut at a very young age. Charles Camarda, Mission Specialist, always wanted to become an astronaut and earned a Bachelor's degree in aerospace engineering from Polytechnic Institute of Brooklyn in 1974, a Master's in engineering Science from George Washington University in 1980 and a doctorate in aerospace engineering from Virginia Polytechnic Institute and State University in 1990. Wendy Lawrence, Mission Specialist decided that she wanted to become an astronaut when she saw the first man to walk on the moon. Soichi Noguchi, Mission Specialist from JAXA expresses that people like scientists, doctors and engineers could fly and he also wanted to venture into spaceflight. Steve Robinson, Mission Specialist says that he was fascinated with things that flew as a child and wanted to make things fly. Australian born Andrew Thomas, Mission Specialist wanted to become an astronaut as a young boy but never realized that he would fulfill his dream. The crewmember profiles end with an overview of the STS-114 Discovery mission. Paul Hill, Lead Flight Director talks about the main goal of the STS-114 mission which is to demonstrate that changes to the Orbiter and flight procedures are good and the second goal is to finish construction of the International Space Station. Sergei Krikalev, Commander talks about increasing the capability of the International Space Station, Jim Kelly discusses the work that is being performed in the external tank, Andy Thomas talks about procedures done to stop foam release and Soichi Noguchi discusses his duty to film the external tank after separation.

Source record↗

Optimal Estimation of Rain Rate Profiles from Single-Frequency Radar Echoes

It is well-documented (Hitschfeld and Bordan 1954, Meneghini 1978, Haddad et al 1993) that there are significant ambiguites inherent in the determination of a particular vertical rain intensity profile from a given time profile of radar echo powers measured by a downward-looking (spaceborne or airborne) radar at a single attenuating frequency.

stochastic constraints Ku-band Precipitation Radar↗

The Dryline on 22 May 2002 during IHOP_2002: Convective-Scale Measurements at the Profiling Site

A detailed analysis of the structure of a double dryline observed over the Oklahoma panhandle during the first International H2O Project (IHOP_2002) convective initiation (CI) mission on 22 May 2002 is presented. A unique and unprecedented set of high temporal and spatial resolution measurements of water vapor mixing ratio, wind, and boundary layer structure parameters were acquired using the National Aeronautics and Space Administration (NASA) scanning Raman lidar (SRL), the Goddard Lidar Observatory for Winds (GLOW), and the Holographic Airborne Rotating Lidar Instrument Experiment (HARLIE), respectively. These measurements are combined with the vertical velocity measurements derived from the National Center for Atmospheric Research (NCAR) Multiple Antenna Profiler Radar (MAPR) and radar structure function from the high-resolution University of Massachusetts frequency-modulated continuous-wave (FMCW) radar to reveal the evolution and structure of the late afternoon double-dryline boundary layer. The eastern dryline advanced and then retreated over the Homestead profiling site in the Oklahoma panhandle, providing conditions ripe for a detailed observation of the small-scale variability within the boundary layer and the dryline. In situ aircraft data, dropsonde and radiosonde data, along with NCAR S-band dual-polarization Doppler radar (S-Pol) measurements, are also used to provide the larger-scale picture of the double-dryline environment. Moisture and temperature jumps of about 3 g kg(sup -1) and 1 -2 K, respectively, were observed across the eastern radar fine line (dryline), more than the moisture jumps (1-2 g kg(sup -1)) observed across the western radar fine line (secondary dryline). Most updraft plumes observed were located on the moist side of the eastern dryline with vertical velocities exceeding 3 m s(sup -1) and variable horizontal widths of 2-5 km, although some were as wide as 7-8 km. These updrafts were up to 1.5 g kg(sup -1) moister than the surrounding environment. Although models suggested deep convection over the Oklahoma panhandle and several cloud lines were observed near the dryline, the dryline itself did not initiate any storms over the intensive observation region (IOR). Possible reasons for this lack of convection are discussed. Strong capping inversion and moisture detrainment between the lifting condensation level and the level of free convection related to an overriding drier air, together with the relatively small near-surface moisture values (less than 10 g kg(sup -1)), were detrimental to CI in this case.

Demoz, Belay↗

DIAL Measurements of Free-Tropospheric Ozone Profiles in Huntsville, AL

A tropospheric ozone Differential Absorption Lidar (DIAL) system, developed jointly by NASA and the University of Alabama at Huntsville (UAH), measures free-tropospheric ozone profiles between 4-10 km. Located at 192 meters altitude in the Regional Atmospheric Profiling Laboratory for Discovery (RAPCD) on the UAH campus in Huntsville, AL, USA, this tropospheric ozone lidar operates under both daytime and nighttime conditions. Frequent coincident ozonesonde flights and theoretical calculations provide evidence to indicate the retrieval accuracy ranges from better than 8% at 4km to 40%-60% at 10 kin with 750-m vertical resolution and 30-minute integration. With anticipated improvements to allow retrievals at both higher and lower altitudes, this ozone lidar, along with co-located aerosol and Doppler Wind Lidars, will provide a unique 18 dataset for investigations of PBL and free-tropospheric chemical and dynamic processes.

Kuang, Shi↗

Optical profile determining apparatus and associated methods including the use of a plurality of wavelengths in the reference beam and a plurality of wavelengths in a reflective transit beam

An optical profile determining apparatus includes an optical detector and an optical source. The optical source generates a transmit beam including a plurality of wavelengths, and generates a reference beam including the plurality of wavelengths. Optical elements direct the transmit beam to a target, direct a resulting reflected transmit beam back from the target to the optical detector, and combine the reference beam with the reflected transmit beam so that a profile of the target is based upon fringe contrast produced by the plurality of wavelengths in the reference beam and the plurality of wavelengths in the reflected transmit beam.

Montgomery, Robert M.↗

Mars Sample Return: The Value of Depth Profiles

Sample return from Mars offers the promise of data from Martian materials that have previously only been available from meteorites. Return of carefully selected samples may yield more information about the history of water and possible habitability through Martian history. Here we propose that samples collected from Mars should include depth profiles of material across the interface between weathered material on the surface of Mars into unweathered parent rock material. Such profiles have the potential to yield chemical kinetic data that can be used to estimate the duration of water and information about potential habitats on Mars.

Hausrath, E. M.↗

Use of In Situ Cloud Condensation Nuclei, Extinction, and Aerosol Size Distribution Measurements to Test a Method for Retrieving Cloud Condensation Nuclei Profiles From Surface Measurements

If the aerosol composition and size distribution below cloud are uniform, the vertical profile of cloud condensation nuclei (CCN) concentration can be retrieved entirely from surface measurements of CCN concentration and particle humidification function and surface-based retrievals of relative humidity and aerosol extinction or backscatter. This provides the potential for long-term measurements of CCN concentrations near cloud base. We have used a combination of aircraft, surface in situ, and surface remote sensing measurements to test various aspects of the retrieval scheme. Our analysis leads us to the following conclusions. The retrieval works better for supersaturations of 0.1% than for 1% because CCN concentrations at 0.1% are controlled by the same particles that control extinction and backscatter. If in situ measurements of extinction are used, the retrieval explains a majority of the CCN variance at high supersaturation for at least two and perhaps five of the eight flights examined. The retrieval of the vertical profile of the humidification factor is not the major limitation of the CCN retrieval scheme. Vertical structure in the aerosol size distribution and composition is the dominant source of error in the CCN retrieval, but this vertical structure is difficult to measure from remote sensing at visible wavelengths.

Ghan, Stephen J.↗

Dial Measurements of Free-Tropospheric Ozone Profiles in Huntsville, AL

A tropospheric ozone DIfferential Absorption Lidar (DIAL) system has been developed jointly by NASA and the University of Alabama at Huntsville (UAH). Two separated Nd:YAG pumped dye laser systems produce the laser pulses with wavelengths of 285 and 291 nm at 20 Hz frequency. The receiver is a Newtonian telescope with a 40 cm primary and a two-channel aft optics unit. The detection system currently uses photon counting to facilitate operations at the maximum achievable altitude. This lidar measures free-tropospheric ozone profiles between 4-10 km at Regional Atmospheric Profiling Laboratory for Discovery (RAPCD) in UAH campus (ASL 206 m) under both daytime and nighttime conditions. Frequent coincident ozonesonde flights and theoretical calculations provide evidence to indicate the retrieval accuracy ranges from approx.5% at 4 km to approx.60% at 10 km with 750-m vertical resolution and 30-minute integration. Three Hamamatsu 7400 PMTs and analog detection technique will be added on the current system to extend the measurement to approx.100 m above ground to monitor the PBL and lower tropospheric ozone variations.

Newchurch, Mike↗