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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,045 records · Page 58
All sourcesNASA NTRSDOE OSTI
NASA NTRS1994

OH/IR stars near the Galactic Center: Pulsation periods, luminosities, and polarimetry

17 stars in the direction of the Galactic Center, 15 of which are OH/IR stars, have been monitored at infrared wavelengths over a period of nearly eight years. Pulsation periods, bolometric luminosities, and light curves for 14 OH/IR stars are presented. The Galactic Center OH/IR stars range in luminosity between M(sub Bol) = -4.5 to M(sub Bol) = -6, implying main sequence progenitors with masses less than 3 solar mass. When compared to optically visible long period variables in the Large Magellanic Cloud (LMC) with similar bolometric luminosities, the Galactic Center OH/IR stars have pulsation periods on average 30% longer. This shift to longer periods is consistent with the current picture of late asymptotic giant branch evolution, placing the OH/IR stars in a phase immediately following the optically visible Mira variable phase during which the star dramatically increases its mass loss rate, becoming invisible at optical wavelength. Infrared polarimetry of 11 of the stars is also presented. The polarization for all of the stars is consistent with purely interstellar polarization, with little evidence for a significant intrinsic component. When compared to OH/IR stars in the galactic plane, the Galactic Center OH/IR stars appear similar in photometric characteristics, except none of the Galactic Center OH/IR stars shows the extremely thick dust shells or very high intrinsic polarization found in the more extreme galactic plane OH/IR stars.

Jones, Terry Jay↗
NASA NTRS1996

DKRZ workload analysis

The UniTree product as it is released emits a rather large amount of logging information into various log files, but this data typically is meant for operator information in difficult operational situations or directly for debugging purposes. It is strongly advised that the existing logging functionality in the standard release is advanced by adding messages with relevant parameters for every major event in the course of executing file or device oriented requests as described. This upgrade would be relatively easy in terms of implementation effort. The benefit is a complete sequence of transaction descriptions generated by external user requests or by internal administration commands. This collection of transaction records can be used for intensive statistics and performance evaluations. It is furthermore a perfect source to drive realistic system simulations to study the effects of possible hardware or software changes.

Fichter, Hartmut↗
NASA NTRSDate not supplied

GL4U: GeneLab for Colleges and Universities

GeneLab for Colleges and Universities (GL4U) will provide space biology-relevant training in bioinformatics to the next generation of scientists through direct and indirect approaches. The GeneLab (GL) team will host two annual data processing bootcamps, one for college-level students (direct) and one for college educators (indirect – Training of Trainers), in which participants learn to analyze space-relevant omics data hosted on GL. The first bootcamp took place in early June 2021 with about 30 SJSU undergraduate students and covered space biology-specific lectures and hands-on instruction using Jupyter Notebooks (JNs) for RNA sequence (RNAseq) data analysis. All training materials including the enclosed files listed below will be made publicly available on GitHub. RNAseq Bootcamp Lectures (attached in combined file): Introduction to NASA, Space Biology, GeneLab, and the Command Line: NASA_GL_CL_Intro_FINAL.pdf - DRAFT from initial submission NASA_SB_GL_CL_Intro_FULL.pdf - FINAL version presented during the bootcamp - only minor edits from the draft version RNAseq and Data Processing Overview: RNAseq_Overview_FINAL.pdf - DRAFT from initial submission RNAseq_Overview_FULL.pdf - FINAL version presented during the bootcamp - only minor edits from the draft version Overview of the Statistics Used for RNAseq Data Analysis: SJSU_Statistics_Intro_Lecture_FINAL.pdf - DRAFT from initial submission Statistics_Overview_FULL.pdf - FINAL version presented during the bootcamp - only minor edits from the draft version Completed JNs in HTML format (attached in combined file): Unix_Intro_JN_06-2021_completed.html R_Intro_JN_06-2021_completed.html RNAseq_fastq_to_counts_JN_06-2021_completed.html RNAseq_DGE_JN_06-2021_completed.html RNAseq Bootcamp Recordings (attached): GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day1_Part_1_of_5.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day1_Part_2_of_5.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day1_Part_3_of_5.mp4 *There were issues with the part 4 recording so that is not available GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day1_Part_5_of_5.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day2_Part_1_of_3.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day2_Part_2_of_3.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day2_Part_3_of_3.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day3_Part_1_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day3_Part_2_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day3_Part_3_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day3_Part_4_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day4_Part_1_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day4_Part_2_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day4_Part_3_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day4_Part_4_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day5_Part_1_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day5_Part_2_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day5_Part_3_of_4.mp4 GL4U_RNAseq_Bootcamp_June_2021_Pilot_Day5_Part_4_of_4.mp4

GeneLab↗
DOE OSTI2025

Dynamics of implosion, bounce, and re-implosion of a shell directly driven by a time-shaped laser pulse

Gas-filled plastic spherical shells have been imploded using the 60-beam OMEGA laser. The same laser pulse was used as in a previous experiment, which demonstrated the dynamic formation of a shell by irradiating a homogeneous plastic foam sphere. In the present experiment, the shell initially implodes, bounces, and expands; a new shell then forms and undergoes a second implosion. Analysis of x-ray self-emission-streaked images and sequences of 2D x-ray self-emission framing camera images show shell evolution that is in reasonable agreement with 1D simulations. Shell integrity and symmetry are well maintained until the formation of the new shell. The final implosion, instead, is affected by substantial asymmetries.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2024

Bench-Scale Development of a Novel Direct Air Capture Technology Using High-Capacity Structured Sorbents

The work performed under this project has resulted into development of a DAC technology utilizing a structured sorbent to capture CO 2 from ambient air with a key innovation of direct Joule heating of the sorbent for CO 2 desorption. A working SMA, fully integrated with an electrically resistive heating layer, high surface area support, and high CO 2 capacity sorbent coated onto a commercial ceramic monolithic substrate, was successfully developed and demonstrated over >200 adsorption-desorption cycles in a high-fidelity bench test unit directly using ambient air. A cordierite-based monolith was selected as a substrate owing to its high surface area, low bulk density, low heat capacity, and commercial availability. Reaction kinetics study conducted during this project led to development of a promoter for the base Na 2 CO 3 sorbent that could be incorporated into the sorbent to enhance to achieve higher CO 2 adsorption/desorption rates, greater working capacity, and reduced regeneration temperature. An accelerated aging study was conducted in a TGA to determine sorbent stability and no degradation in the sorbent performance was observed even after 250 adsorption-desorption cycles. An electrically resistive heating layer was developed with tunable electrical properties. The heating layer was coated onto the selected cordierite substrate. Aging studies performed showed the electrical properties and heating performance was stable after 500 heating and cooling cycles. The collective findings on the selected cordierite substrate, robust heating layer, promoter and sorbent selection were used to synthesize a full, 6”x6” SMA for bench-scale testing. The bench-scale DAC system was constructed to test full size SMAs using real ambient air for adsorption and joule heating for regeneration. After completing shakedown and commissioning of the 1 kg/day of CO 2 capacity DAC bench unit, an extended operation was performed to complete over 230 cycles with the full size SMA. This testing showed no observable degradation in sorbent performance. A detailed process model, TEA and LCA were developed for a conceptual 100,000 TPY CO 2 removal DAC facility. The LCA results show the net CO 2 e emissions from the DAC system are highly dependent on the electricity source. All other factors, including SMA manufacturing, materials for facility enclosure, etc., are minor cost contributors compared to the energy consumption required for CO 2 removal. With the successful development and validation of the SMA for the sustained performance for CO 2 removal from ambient air with joule heated regeneration in this project, a fully integrated 1 TPY bench-scale DAC system is currently in development with the support of DOE/FECM (DE-FE0032243). The project objective is to demonstrate the engineering design of the DAC system to produce a continuous, high purity CO 2 stream from ambient air. This project will address and validate key engineering features of the DAC system including the gas sealing mechanism and panels, enclosure and air contactor design, and automation sequence to achieve continuous CO 2 production.

42 ENGINEERING↗
DOE OSTI2024

In-situ HRTEM observations of intermediate phase transformation in lattice reorientation in HCP rhenium

In-situ high-resolution transmission electron microscopy (HRTEM) is performed to investigate the deformation behavior of hexagonal close-packed rhenium (Re) which is compressed along the $\langle1\overline{1}00\rangle$ direction. Atomistic simulations are also conducted to better understand the deformation mechanisms. Two types of lattice reorientation are observed during compression. The first type involves the reorientation of one lattice by ~90° around $\langle1\overline{1}00\rangle$, which is accomplished by the formation of an intermediate face-center-cubic (FCC) phase at the interface. This transformation sequence can be described as {$1\overline{1}00$} matrix → {$111$} FCC → ($0001$) twin . In the second type, a new grain is formed but does not satisfy any known twin relationship with the matrix, and an intermediate FCC phase is also formed. The transformation sequence can be described as {$1\overline{1}00$} matrix → {$111$} FCC → ($0001$) grain . Mechanisms responsible for the observed lattice reorientation and sequential phase transitions are analyzed by conducting lattice correspondence analyses on the simulation results. Strain accommodation is also analyzed to explain the mechanisms for lattice reorientation and the intermediate phase transformations. In conclusion, the results provide new insight into the deformation behavior of HCP metals

36 MATERIALS SCIENCE↗
DOE OSTI2022

Genetic mapping and prediction of flowering time and plant height in a maize Stiff Stalk MAGIC population

Abstract The Stiff Stalk heterotic pool is a foundation of US maize seed parent germplasm and has been heavily utilized by both public and private maize breeders since its inception in the 1930s. Flowering time and plant height are critical characteristics for both inbred parents and their test crossed hybrid progeny. To study these traits, a 6-parent multiparent advanced generation intercross population was developed including maize inbred lines B73, B84, PHB47 (B37 type), LH145 (B14 type), PHJ40 (novel early Stiff Stalk), and NKH8431 (B73/B14 type). A set of 779 doubled haploid lines were evaluated for flowering time and plant height in 2 field replicates in 2016 and 2017, and a subset of 689 and 561 doubled haploid lines were crossed to 2 testers, respectively, and evaluated as hybrids in 2 locations in 2018 and 2019 using an incomplete block design. Markers were derived from a practical haplotype graph built from the founder whole genome assemblies and genotype-by-sequencing and exome capture-based sequencing of the population. Genetic mapping utilizing an update to R/qtl2 revealed differing profiles of significant loci for both traits between 635 of the DH lines and 2 sets of 570 and 471 derived hybrids. Genomic prediction was used to test the feasibility of predicting hybrid phenotypes based on the per se data. Predictive abilities were highest on direct models trained using the data they would predict (0.55–0.63), and indirect models trained using per se data to predict hybrid traits had slightly lower predictive abilities (0.49–0.55). Overall, this finding is consistent with the overlapping and nonoverlapping significant quantitative trait loci found within the per se and hybrid populations and suggests that selections for phenology traits can be made effectively on doubled haploid lines before hybrid data is available.

Genetics & Heredity↗
DOE OSTI2026

LibraryX: A Framework for Cross-Library-Call Optimization

Scientific applications utilize performance libraries as a software engineering concept: these libraries encapsulate important and well-understood (mathematical) operations, allow for reuse, and are implemented and tuned by experts. Domain scientists then implement complex algorithms based on these domainspecific libraries. While individual library calls are optimized, larger performance gains across sequences of calls—sometimes spanning multiple libraries—are often unrealized, forcing a trade-off between performance and implementation complexity.To overcome this issue, we propose LibraryX, an approach and a system that allows for cross-library-call optimization even when library calls stem from multiple performance libraries. LibraryX annotates library calls with semantic information and optimizes entire directed acyclic graphs (DAGs) of calls dynamically using the SPIRAL code generation system. We demonstrate its effectiveness across a range of memory bound workloads, achieving significant speedups on Nvidia, AMD, and Intel accelerators compared to code using native libraries without cross-call optimization.

Rao, Sanil [Carnegie Mellon University,Department ↗
DOE OSTI2023

Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates

Small CD4-mimetic compound (CD4mc), which inhibits the interaction between gp120 with CD4, acts as an entry inhibitor and induces structural changes in the HIV-1 envelope glycoprotein trimer (Env) through its insertion within the Phe43 cavity of gp120. Here, we recently developed YIR-821, a novel CD4mc, that has potent antiviral activity and lower toxicity than the prototype NBD-556. To assess the possibility of clinical application of YIR-821, we tested its antiviral activity using a panel of HIV-1 pseudoviruses from different subtypes. YIR-821 displayed entry inhibitor activity against 53.5% (21/40) of the pseudoviruses tested and enhanced neutralization mediated by coreceptor binding site (CoRBS) antibodies in 50% (16/32) of these. Furthermore, when we assessed the antiviral effects using a panel of pseudoviruses and autologous plasma IgG, enhancement of antibody-mediated neutralization activity was observed for 48% (15/31) of subtype B strains and 51% (28/55) of non-B strains. The direct antiviral activity of YIR-821 as an entry inhibitor was observed in 53% of both subtype B (27/51) and non-B subtype (40/75) pseudoviruses. Enhancement of antibody-dependent cellular cytotoxicity was also observed with YIR-821 for all six selected clinical isolates, as well as for the transmitted/founder (T/F) CH58 virus-infected cells. The sequence diversity in the CD4 binding site as well as other regions, such as the gp120 inner domain layers or gp41, may be involved in the multiple mechanisms related to the sensitive/resistant phenotype of the virus to YIR-821. Our findings may facilitate the clinical application of YIR-821.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Sensitivity Calculations for Systems with Polyethylene Reflector Materials Using CLUTCH

The SCALE 6.2.4 code package contains four sequences for calculating $k_{eff}$ sensitivity coefficients. Two of these sequences use deterministic transport solvers: a one-dimensional (1D) capability based on XSDRN, and a two-dimensional (2D) capability based on NEWT. These sequences are restricted to the multigroup (MG) treatment of neutron energy. The three-dimensional (3D) sequences use the KENO V.a or KENO-VI Monte Carlo transport codes and can be used to calculate sensitivity coefficients with either MG or continuous-energy (CE) transport. The 3D sensitivities are ultimately reported in an MG structure, regardless of the method used in the transport calculations. If desired, the sensitivity coefficients can be reported with very fine energy resolution from a CE calculation, but they are calculated only in the MG library structure in the MG mode. CE TSUNAMI methods are available in SCALE starting in SCALE version 6.2. Sensitivity coefficients were generated using the 3D sequences as part of the generation of the SCALE 6.2.2 Validation Report; difficulties encountered when using the CLUTCH method for thick, fissionable-material reflectors were discussed and investigated as documented in a previous paper. This paper discusses the difficulties encountered in generating accurate sensitivity coefficients using the CLUTCH technique for polyethylene reflectors for two fast spectrum benchmarks. Direct perturbation (DP) calculations were performed to confirm the accuracy of the total sensitivity coefficient for important isotopes with large sensitivities in the system. Discrepancies were detected for CLUTCH-calculated sensitivity coefficients in the reflector of a critical experiment with a radial polyethylene reflector. A simple polyethylene-reflected plutonium sphere was then used to further investigate the discrepancy. Calculations performed using the iterated fission probability (IFP) method generated accurate sensitivity coefficients in both cases. The results of this study emphasize the need to confirm CLUTCH sensitivity results with DP calculations. IFP calculations are generally less efficient but more reliable than CLUTCH calculations. Improvements to the CLUTCH methodology that retain the greater efficiency but address identified difficulties are therefore potentially useful to analysts.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
NASA NTRS1975

The peculiar object HD 44179 /'The red rectangle'/

A strong infrared source detected in the AFCRL sky survey is confirmed, and is identified with the binary star HD 44179, embedded in a peculiar nebula. UBVRI and broad-band photometry between 2.2 and 27 microns are combined with blue, red, and near-infrared spectra, polarimetry and spectrophotometry of the star, and a range of direct and image-tube photographs of the nebula, to suggest a composite model of the system. In this model, the infrared radiation derives from thermal emission by dust grains contained in a disklike geometry about the central object, which appears to be of spectral type B9-A0 III and which may be in pre-main-sequence evolution. Two infrared emission features are found, peaking at 8.7 and 11.3 microns, the latter corresponding to the feature seen in the spectrum of the planetary nebula NGC 7027. The complex nebular structure is discussed on the basis of photographs through narrow-band continuum and emission-line filters. The polarization data support the suggestion of a disk containing some large particles. No radio continuum emission is detected.

Cohen, M.↗
NASA NTRS1998

Software Development Technologies for Reactive, Real-Time, and Hybrid Systems: Summary of Research

This research is directed towards the implementation of a comprehensive deductive-algorithmic environment (toolkit) for the development and verification of high assurance reactive systems, especially concurrent, real-time, and hybrid systems. For this, we have designed and implemented the STCP (Stanford Temporal Prover) verification system. Reactive systems have an ongoing interaction with their environment, and their computations are infinite sequences of states. A large number of systems can be seen as reactive systems, including hardware, concurrent programs, network protocols, and embedded systems. Temporal logic provides a convenient language for expressing properties of reactive systems. A temporal verification methodology provides procedures for proving that a given system satisfies a given temporal property. The research covered necessary theoretical foundations as well as implementation and application issues.

Manna, Zohar↗
NASA NTRS2016

Analysis of Adult Female Mouse (Mus musculus) Group Behavior on the International Space Station (ISS)

As interest in long duration effects of space habitation increases, understanding the behavior of model organisms living within the habitats engineered to fly them is vital for designing, validating, and interpreting future spaceflight studies. A handful of papers have previously reported behavior of mice and rats in the weightless environment of space. The Rodent Research Hardware and Operations Validation (Rodent Research-1; RR1) utilized the Rodent Habitat (RH) developed at NASA Ames Research Center to fly mice on the ISS (International Space Station). Ten adult (16-week-old) female C57BL/6 mice were launched on September 21st, 2014 in an unmanned Dragon Capsule, and spent 37 days in microgravity. Here we report group behavioral phenotypes of the RR1 Flight (FLT) and environment-matched Ground Control (GC) mice in the Rodent Habitat (RH) during this long-duration flight. Video was recorded for 33 days on the ISS, permitting daily assessments of overall health and well-being of the mice, and providing a valuable repository for detailed behavioral analysis. We previously reported that, as compared to GC mice, RR1 FLT mice exhibited the same range of behaviors, including eating, drinking, exploration, self- and allo-grooming, and social interactions at similar or greater levels of occurrence. Overall activity was greater in FLT as compared to GC mice, with spontaneous ambulatory behavior, including organized 'circling' or 'race-tracking' behavior that emerged within the first few days of flight following a common developmental sequence, and comprised the primary dark cycle activity persisting throughout the remainder of the experiment. Participation by individual mice increased dramatically over the course of the flight. Here we present a detailed analysis of 'race-tracking' behavior in which we quantified: (1) Complete lap rotations by individual mice; (2) Numbers of collisions between circling mice; (3) Lap directionality; and (4) Recruitment of mice into a group phenotype. This analysis contributes to the first NASA long-duration study of rodent behavior, providing evidence for the emergence of a distinctive, organized group behavior unique to the weightless space environment.

Behavior in Space↗
DOE OSTI2021

Interfacial characteristics of P91 steel - Inconel 740H bimetallic structure fabricated using wire-arc additive manufacturing

Although bimetallic structures can offer unique solutions to engineering problems with varying functionality, joining two dissimilar alloys using additive manufacturing involves challenges such as cracking and segregation. In this work, bimetallic structures of Inconel 740H superalloy and P91 steel are processed using wire-arc additive manufacturing (WAAM) for the first time. P91 steel is directly deposited over 740H with a cooling time of 20 minutes in between the two depositions. During microstructure characterization, a large gradient zone with coarse grains spanning for ~2200 μm is observed. Moreover, the microhardness of the gradient zone is the least in comparison with the P91 and 740H deposits. No deleterious phase formation is found; however, intergranular cracks are observed along the gradient zone. In order to deduce the reason for cracking, non-equilibrium solidification simulations are performed for the mixed compositions of P91 and 740H in the gradient zone. Here, the reasons for crack formation in the gradient zone are the sudden change in the volumetric coefficient of thermal expansion due to the formation of MC carbides as well as the development of local strains from the thermal residual stresses. Therefore, altering the deposition sequence and introducing gradient layers with mixed composition between the P91 and 740H deposits will be beneficial in achieving defect-free builds. Through the integration of experiments and simulation, this work gains valuable insights into the processability of dissimilar alloy manufacturing using the WAAM technique.

20 FOSSIL-FUELED POWER PLANTS↗
DOE OSTI2022

Power Decoupling Method for Voltage Source Inverters Using Grid Voltage Modulated Direct Power Control in Unbalanced System

The grid voltage modulated direct power control (GVM-DPC) is a novel power regulation method for grid-connected voltage source inverters (VSI). However, interactions between real and reactive powers still exist in GVM-DPC under unbalanced grid voltage condition, which may deteriorate its transient performance. Here, this article proposes a power decoupling method for GVM-DPC-based VSI in unbalanced systems based on the dynamic feedforward power compensation strategy, which can reduce the coupling magnitudes of real and reactive powers in the transient stages. First, the power coupling mechanism of positive and negative sequence real and reactive powers of VSI under the unbalanced voltage condition is analyzed. Then, the power coupling magnitudes (PCM) are derived according to relationships among the positive sequence components of real power, reactive power and point of common coupling (PCC) voltages. Next, the PCM are compensated into the GVM-DPC for the better decoupling performance. Furthermore, a stability analysis of the proposed control system is studied based on the impedance model, and a comparison with the traditional power decoupling method based on virtual impedance is conducted to show the superiority of the proposed method. Finally, simulations, hardware-in-loop test and experiment are conducted to validate the effectiveness of the proposed method.

42 ENGINEERING↗
DOE OSTI2024

The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations

Abstract Repair of double-stranded breaks generated by CRISPR/Cas9 is highly dependent on the flanking DNA sequence. To learn about interactions between DNA repair and target sequence, we measure frequencies of over 236,000 distinct Cas9-generated mutational outcomes at over 2800 synthetic target sequences in 18 DNA repair deficient mouse embryonic stem cells lines. We classify the outcomes in an unbiased way, finding a specialised role forPrkdc(DNA-PKcs protein) andPolmin creating 1 bp insertions matching the nucleotide on the protospacer-adjacent motif side of the break, a variable involvement ofNbnandPolqin the creation of different deletion outcomes, and uni-directional deletions dependent on both end-protection and end-resection. Using our dataset, we build predictive models of the mutagenic outcomes of Cas9 scission that outperform the current standards. This work improves our understanding of DNA repair gene function, and provides avenues for more precise modulation of Cas9-generated mutations.

Science & Technology - Other Topics↗
DOE OSTI2022

CAPG: comprehensive allopolyploid genotyper

Genotyping by sequencing is a powerful tool for investigating genetic variation in plants, but many economically important plants are allopolyploids, where homoeologous similarity obscures the subgenomic origin of reads and confounds allelic and homoeologous SNPs. Recent polyploid genotyping methods use allelic frequencies, rate of heterozygosity, parental cross or other information to resolve read assignment, but good subgenomic references offer the most direct information. The typical strategy aligns reads to the joint reference, performs diploid genotyping within each subgenome, and filters the results, but persistent read misassignment results in an excess of false heterozygous calls. We introduce the Comprehensive Allopolyploid Genotyper (CAPG), which formulates an explicit likelihood to weight read alignments against both subgenomic references and genotype individual allopolyploids from whole-genome resequencing data. We demonstrate CAPG in allotetraploids, where it performs better than Genome Analysis Toolkit’s HaplotypeCaller applied to reads aligned to the combined subgenomic references.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Traffic Prediction for Merging Coordination Control in Mixed Traffic Scenarios

Connected and autonomous vehicles (CAVs) have the potential to bring in safety, mobility, and energy benefits to transportation. The control decisions of CAVs are usually determined for a look-ahead horizon based on previewed traffic information. This requires an effective prediction of future traffic conditions and its integration with the CAV control framework. However, the short-term traffic prediction using information from connectivity is a challenging research topic, especially for mixed traffic scenarios. This work focuses on the development of a traffic prediction framework for a merging coordination controller. The previously developed merging controller coordinates the merging sequence and travel speed of CAVs to maximize the energy efficiency and overall mobility. In mixed traffic scenarios, the controller receives information regarding the position of all the vehicles traveling inside a control zone and controls the desired speed of all CAVs. The controller has no control on the human-driven vehicles. The merging controller does not have direct information or an explicit prediction on the behaviors of human-driven vehicles. Aiming to improve the performance of the merging controller in various mixed traffic conditions, a traffic prediction algorithm is developed and evaluated in this work. The performance of this traffic prediction algorithm is investigated for various penetration rates of connectivity for a single-lane secondary road merging to a single-lane primary road. The results show that compared to a constant speed assumption of human-driven vehicles, the proposed traffic prediction algorithm is able to reduce the prediction error of the arrival time of human-driven vehicles at the merging zone by more than 50%.

Shao, Yunli↗