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At least 1,027 records · Page 57

Atg12 Maintains Skeletal Integrity by Modulating Pro-Osteoclastogenic Signals and Chondrocyte Differentiation

Weightlessness and radiation, two unique elements of space, profoundly decreases bone mass. We aimed to elucidate the role of autophagy in maintaining structural integrity of the skeleton. We hypothesize that loss of autophagy in bone leads to an imbalance in pro-osteoclastogenic and pro-osteogenic signals, resulting in net bone loss. To test our hypothesis, we performed global postnatal deletion of Atg12 using tamoxifen-inducible Cre. Compared to Vehicle (Control) groups, Tamoxifen (Atg12 iKO) groups showed decreased LC3B-I to II conversion and increased p62 protein levels, consistent with loss of autophagy. qPCR revealed increased expression of pro-osteoclastogenic cytokines in bone and marrow respectively in male iKOs compared to controls. Microcomputed tomography revealed decreased cortical bone volume, cortical thickness and periosteal perimeter consistent with bone loss; and a longer primary spongiosa in male Atg12 iKOs display compared to male controls. Histology showed that compared to male controls, male iKOs had a profound increase in chondrocyte column length of the growth plate with hyper-expansion of both proliferating and hypertrophic zones. Taken together, these findings indicate that autophagy plays an important role in the maintenance of bone structural integrity by mediating the production of pro-osteoclastogenic signals and regulating chondrocyte proliferation and differentiation.

Atg12↗

A Nuclear Security Enterprise Study of High-Reliability Systems, Collaboration, and Data

It may seem simple and trivial, but defining the difference between data and information is contested and has implications that may affect the security of United States interests and even cost lives. For security, data are raw facts or figures without context, while information is the compilation or articulation of data that forms context. Security depends on clarity in the differences between data and information and controlling them. Control is necessary to ensure that data and information are not inadvertently released to foreign governments, the public, or those without Need-to-Know. A primary concern in the practice of security is the control of data to avoid the inadvertent conversion to sensitive information. The complexity of this concern is further augmented when institutions are part of tightly coupled networks that informally share data and information. Additionally, those that share data as a function of legislative action—and/or formally integrate data and information system infrastructures—may be a higher security risk. This paper will present a case study that utilizes elements of literature from Knowledge Management and networks to tell a story of an issue in security—specifically, controlling the conversion of data to information.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗

High-Reliability Systems and the Control of National Security Data and Information

High-reliability systems are characterized by catastrophic implications in the event of failure. These implications can include substantive damage to the environment, social order, and loss of life. Examples of high-reliability systems include nuclear submarines, nuclear reactors, the electric grid, and nuclear weapons. Due to the catastrophic implications of failure, there are heightened awareness and control mechanisms surrounding related data and information. However, defining the difference between data and information is often ambiguous across scholarly disciplines and in United States policy and legislation. For high-reliability systems, the implications of ambiguity between data and information may affect the security of United States interests and even cost lives. For security, data are raw facts or figures without context, while information is the compilation or articulation of data that forms context. Security depends on clarity in the differences between data and information and how to control them. Control is necessary to ensure that data and information are not unintentionally released to foreign governments, the public, or those without need-to-know. A primary concern in the practice of security is the control of data to avoid the unintended conversion to information. Intra-institutionally, this control is highly complex given the amalgam of legacy data systems and the numerous and constantly evolving nature of modern data systems that were not necessarily designed to be integrated. The complexity of this concern is augmented when institutions are part of interinstitutional collaborations or networks of public-private partnerships that share data and information. Additionally, institutions that share data as a function of policy and legislative action— particularly formally integrated data and information system infrastructures—may be at higher security risk. This paper will present an intra-institutional paradigm that utilizes and integrates concepts from numerous disciplines to frame a critical and underspecified practical issue in security—controlling for the unintended conversion of data to information.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗

High-Reliability Systems and the Control of National Security Data and Information

High-reliability systems are characterized by catastrophic implications in the event of failure. These implications can include substantive damage to the environment, social order, and loss of life. Examples of high-reliability systems include nuclear submarines, nuclear reactors, the electric grid, and nuclear weapons. Due to the catastrophic implications of failure, there are heightened awareness and control mechanisms surrounding related data and information. However, defining the difference between data and information is often ambiguous across scholarly disciplines and in United States policy and legislation. For high-reliability systems, the implications of ambiguity between data and information may affect the security of United States interests and even cost lives. For security, data are raw facts or figures without context, while information is the compilation or articulation of data that forms context. Security depends on clarity in the differences between data and information and how to control them. Control is necessary to ensure that data and information are not unintentionally released to foreign governments, the public, or those without need-to-know. A primary concern in the practice of security is the control of data to avoid the unintended conversion to information. Intra-institutionally, this control is highly complex given the amalgam of legacy data systems and the numerous and constantly evolving nature of modern data systems that were not necessarily designed to be integrated. The complexity of this concern is augmented when institutions are part of inter-institutional collaborations or networks of public-private partnerships that share data and information. Additionally, institutions that share data as a function of policy and legislative action—particularly formally integrated data and information system infrastructures—may be at higher security risk. This paper will present an intra-institutional paradigm that utilizes and integrates concepts from numerous disciplines to frame a critical and underspecified practical issue in security—controlling for the unintended conversion of data to information.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗

A Review of Distributed Secondary Control Architectures in Islanded-Inverter-Based Microgrids

The increasing energy demand, the shortage of energy resources, and the environmental challenges faced by conventional power-generation systems are some of the ongoing challenges faced by modern power systems. Therefore, many efforts have been made by the scientific community to develop comprehensive solutions to overcome these issues. For instance, current technological advances have allowed the integration of distributed generators into the power systems, promoting the use of microgrids to overcome these issues. However, the use of renewable distributed generators have introduced new challenges to the traditional control system schemes. To overcome these challenges, a hierarchical control approach has been proposed for distributed renewable sources. In other words, the control scheme have been divided into three hierarchical levels, primary, secondary, and tertiary, to overcome the new challenges present in modern power systems. Due to extensiveness of this topic, this overview is focused on secondary control systems, mainly for AC isolated microgrids. To improve the power quality of modern systems, several secondary control schemes have been proposed to overcome the well-known problem of frequency and voltage deviation. Some of these schemes have also introduced adequate active/reactive power sharing techniques to optimize the utilization of resources. Additionally, other secondary control schemes have also focused on reducing the communication load, to lower the network cost and adding robustness against communication problems. This article presents an insight of the different control techniques used to overcome power quality and communication problems. A comprehensive overview of distributed secondary control techniques for islanded microgrids is presented. In addition, the implementation of these techniques is explained in an orderly and sequential manner.

14 SOLAR ENERGY↗

Advanced extravehicular protective systems for shuttle, space station, lunar base and Mars missions.

Advances in extravehicular life support system technology will directly influence future space mission reliability and maintainability considerations. To identify required new technology areas, an appraisal of advanced portable life support system and subsystem concepts was conducted. Emphasis was placed on thermal control and combined CO2 control/O2 supply subsystems for both primary and emergency systems. A description of study methodology, concept evaluation techniques, specification requirements, and selected subsystems and systems are presented. New technology recommendations encompassing thermal control, CO2 control and O2 supply subsystems are also contained herein.

Heimlich, P. F.↗

Operational Processing of Ground Validation Data for the Tropical Rainfall Measuring Mission

The Tropical Rainfall Measuring Mission (TRMM) satellite was successfully launched in November 1997. A primary goal of TRMM is to sample tropical rainfall using the first active spaceborne precipitation radar. To validate TRMM satellite observations, a comprehensive Ground Validation (GV) Program has been implemented for this mission. A key component of GV is the analysis and quality control of meteorological ground-based radar data from four primary sites: Melbourne, FL; Houston, TX; Darwin, Australia; and Kwajalein Atoll, RMI. As part of the TRMM GV effort, the Joint Center for Earth Systems Technology (JCET) at the University of Maryland, Baltimore County, has been tasked with developing and implementing an operational system to quality control (QC), archive, and provide data for subsequent rainfall product generation from the four primary GV sites. This paper provides an overview of the JCET operational environment. A description of the QC algorithm and performance, in addition to the data flow procedure between JCET and the TRNM science and Data Information System (TSDIS), are presented. The impact of quality-controlled data on higher level rainfall and reflectivity products will also be addressed, Finally, a brief description of JCET's expanded role into producing reference rainfall products will be discussed.

Kulie, Mark S.↗

Tuning working potential of silicon-phosphorus anode via microstructure control for high-energy lithium-ion batteries

The primary research on anode materials of lithium-ion batteries have been focused on increasing the specific capacity, while the working potential that is also closely related to the practical energy density of batteries has been paid much less attention. In this paper, starting from micrometer-sized silicon and black phosphorus, we have reported a high-energy silicon-phosphorus/carbon anode (denoted as mSPC) via a high-energy ball milling process, which demonstrates an average discharge working potential of 0.3 volts versus lithium, together with a high reversible capacity of > 2000 mAh/g, high initial coulombic efficiency of 84%, excellent cycle stability, and superior rate capability up to 15 A/g. Furthermore, in situ focused-ion-beam scanning electron microscopy reveals that the volume change of the mSPC anode during repeated (de) lithiation is effectively alleviated. In contrast, starting from nanometer-sized silicon, the resulted anode (denoted as nSPC) not only presents a lower reversible capacity (~1200 mAh/g), but also exhibits a higher charge/discharge working potential, leading to reduced energy density. Our results indicate the importance of composition/structure control in tailoring the working potential and specific capacity of alloying-type anodes towards high-energy lithium-ion batteries.

25 ENERGY STORAGE↗

Design and pilot evaluation of the RAH-66 Comanche selectable control modes

The RAH-66 Comanche helicopter has been designed to possess superior handling qualities over a wide range of flight conditions. The control laws have been tailored to satisfy the requirements of ADS-33C and the Weapon System Specification (WSS). This paper addresses the design of the Comanche Selectable Mode control laws (Velocity Stabilization/Hover Hold and Altitude Hold), which provide the additional stabilization and control augmentation needed when flying in a Degraded Visual Environment (DVE). An overview of the RAH-66 control laws is presented, including a detailed description of the Selectable Modes design. The primary focus of this paper is the results of piloted evaluation of these control laws in the Boeing motionbase simulator. These tests substantiate the detailed design of the Comanche Selectable Mode control laws. All tested DVE tasks (ADS-33C, sections 4.4 and 4.5) were rated Level 1. Other evaluation tasks confirmed the mission suitability of the control system. These control laws are ready for formal ADS-33C compliance testing in the Sikorsky Full Mission Simulator (FMS).

Phillip J Gold↗

Low Impact Docking System (LIDS)

Since 1996, NASA has been developing a docking system that will simplify operations and reduce risks associated with mating spacecraft. This effort has focused on developing and testing an original, reconfigurable, active, closed-loop, force-feedback controlled docking system using modern technologies. The primary objective of this effort has been to design a docking interface that is tunable to the unique performance requirements for all types of mating operations (i.e. docking and berthing, autonomous and piloted rendezvous, and in-space assembly of vehicles, modules and structures). The docking system must also support the transfer of crew, cargo, power, fluid, and data. As a result of the past 10 years of docking system advancement, the Low Impact Docking System or LIDS was developed. The current LIDS design incorporates the lessons learned and development experiences from both previous and existing docking systems. LIDS feasibility was established through multiple iterations of prototype hardware development and testing. Benefits of LIDS include safe, low impact mating operations, more effective and flexible mission implementation with an anytime/anywhere mating capability, system level redundancy, and a more affordable and sustainable mission architecture with reduced mission and life cycle costs. In 1996 the LIDS project, then known as the Advanced Docking Berthing System (ADBS) project, launched a four year developmental period. At the end of the four years, the team had built a prototype of the soft-capture hardware and verified the control system that will be used to control the soft-capture system. In 2001, the LIDS team was tasked to work with the X- 38 Crew Return Vehicle (CRV) project and build its first Engineering Development Unit (EDU).

LaBauve, Tobie E.↗

Stability and Control Analysis of the F-15B Quiet SpikeTM Aircraft

The primary purpose of the Quiet Spike(TradeMark) flight research program was to analyze the aerodynamic, structural, and mechanical proof-of-concept of a large multi-stage telescoping nose spike installed on the National Aeronautics and Space Administration Dryden Flight Research Center (Edwards, California) F-15B airplane. This report describes the preflight stability and control analysis performed to assess the effect of the spike on the stability, controllability, and handling qualities of the airplane; and to develop an envelope expansion approach to maintain safety of flight. The overall flight test objective was to collect flight data to validate the spike structural dynamics and loads model up to Mach 1.8. Other objectives included validating the mechanical feasibility of a morphing fuselage at operational conditions and determining the near-field shock wave characterization. The two main issues relevant to the stability and control objectives were the effects of the spike-influenced aerodynamics on the F-15B airplane flight dynamics, and the air data and angle-of-attack sensors. The analysis covered the sensitivity of the stability margins, and the handling qualities due to aerodynamic variation and the maneuvering limitations of the F-15B Quiet Spike configuration. The results of the analysis and the implications for the flight test program are also presented.

McWherter, Shaun C.↗

Simultaneous thermal vacuum testing of GPS drives for NavStar

The solar array drive assemblies for the global positioning satellite (GPS) were built and the need to perform thermal vacuum acceptance testing on at least two complete units simultaneously is emphasized. The safety of the flight hardware is of primary importance. It is found that simultaneous space simulation testing of two complete drive packages requires only minor modification to the high vacuum pump stack. Attention is given to upgrading system safeties for high vacuum operation. Major modifications are designed and implemented for the thermal control system and supporting subsystems. The automated thermal control system and test bed hardware are of primary interest.

Brown, T. G.↗

The Space Telescope Observatory

The Space Telescope is an international astronomical observatory which will be placed into a low earth orbit in December 1983. The observatory will provide astronomers the opportunity to use five different instruments (wide field/planetary camera, faint object camera, high-resolution spectrograph, faint-object spectrograph, and high speed photometer), and to do astrometry with the use of the fine guidance sensors used primarily for pointing control. These instruments, the spectral range available above the earth's atmosphere, and the spatial resolution available from the combination of a near-diffraction limited 94-in. primary mirror and the stability provided by the Pointing Control System provide a tremendous potential to the astronomical community.

Bahcall, J. N.↗

A comparison of position and rate control for telemanipulations with consideration of manipulator system dynamics

Position and rate control are the two common manual control modes in teleoperations. Human operator performance using the two modes is evaluated and compared. Simulated three-axis pick-and-place operations are used as the primary task for evaluation. First, ideal position and rate control are compared by considering several factors, such as joystick gain, joystick type, display mode, task, and manipulator work space size. Then the effects of the manipulator system dynamics are investigated by varying the natural frequency and speed limit. Experimental results show that ideal position control is superior to ideal rate control, regardless of joystick type or display mode, when the manipulation work space is small or comparable to the human operator's control space. Results also show that when the manipulator system is slow, the superiority of position control disappears. Position control is recommended for small-work-space telemanipulation tasks, while rate control is recommended for slow wide-work-space telemanipulation tasks.

Kim, Won S.↗

Precision Linear Actuators for the Spherical Primary Optical Telescope Demonstration Mirror

The Spherical Primary Optical Telescope (SPOT) is an ongoing research effort at Goddard Space Flight Center developing wavefront sensing and control architectures for future space telescopes. The 03.5 m SPOT telescope primary mirror is comprised20f 6, 0.86 m hexagonal mirror segments arranged in a single ring, with the central segment missing . The mirror segments are designed for laboratory use and are not light-weighted to reduce cost. Each primary mirror segment is actuated and has tip, tilt, and piston rigid body motions. Additionally, the radius of curvature of each mirror segment may be varied mechanically3. To provide these degrees of freedom, the SPOT mirror segment assembly requires linear actuators capable of 10 nm resolution over a total stroke of 5 mm. These actuators must withstand high static loads as they must support the mirror segment, which has a mass of approx.100 kg. A stepper motor driving a differential satellite roller screw was designed to meet these demanding requirements. Initial testing showed that the actuator is capable of sub-micron repeatability over the entire 6mm range, and was limited by 100-200 nm measurement noise levels present in the facility. Further testing must be accomplished in an isolated facility with a measurement noise floor of < 5 nm. Such a facility should be ready for use at GSFC in the early summer of 2006, and will be used to better characterize this actuator.

Budinoff, Jason↗

Precision Linear Actuators for the Spherical Primary Optical Telescope Demonstration Mirror

The Spherical Primary Optical Telescope (SPOT) is an ongoing research effort at Goddard Space Flight Center developing wavefront sensing and control architectures for future space telescopes. The 03.5-m SPOT telescope primary mirror is comprise9 of six 0.86-m hexagonal mirror segments arranged in a single ring, with the central segment missing. The mirror segments are designed for laboratory use and are not lightweighted to reduce cost. Each primary mirror segment is actuated and has tip, tilt, and piston rigid-body motions. Additionally, the radius of curvature of each mirror segment may be varied mechanically. To provide these degrees of freedom, the SPOT mirror segment assembly requires linear actuators capable of <lO-nm resolution over a total stroke of 5 mm. These actuators must withstand high static loads as they must support the mirror segment, which has a mass of -100 kg. A stepper motor driving a differential satellite roller screw was designed to meet these demanding requirements. Initial testing showed that the actuator is capable of sub-micron repeatability over the entire 6-mm range, and was limited by 100-200 nm measurement noise levels present in the facility. Further testing must be accomplished in an isolated facility with a measurement noise floor of <5 nm. Such a facility should be ready for use at GSFC in the early summer of 2006, and will be used to better characterize this actuator.

Budinoff, Jason↗

Countermeasures for Mitigation of Sensorimotor Decrements Following Head-Down Bed Rest

BACKGROUND Decrements in functional performance of tasks requiring postural and locomotor control remain common among crewmembers returning to Earth after6months on the International Space Station (ISS). These impairments will presumably be exacerbated after longer exploration-class missions with fewer exercise hardware options. Our recent studies suggest that an in-flight proprioceptive countermeasure may keep the proprioceptive system tuned to respond to upright balance challenges in a gravitational environment. Before testing a proprioceptive countermeasure in-flight, we must conduct an initial proof-of-concept study to determine its potential efficacy in a controlled unloading analog setting. OBJECTIVES We will determine if proprioceptive training during 60 days of 6° head down bed rest (HDBR) mitigates declines in functional task performance. We consider it critical to characterize the interaction between proprioceptive training and exercise. Thus, we will compare 3groupsof subjects(N=12 each): a proprioceptive training group, an exercise plus proprioceptive training group, and a control group(i.e. no training or exercise).The primary outcome measure will be the well-established and operationally relevant seat egress and walk test (also referred to as the functional mobility test)performed before and after HDBR. Other functional tests will also represent high priority exploration mission tasks that require high demand for dynamic control of postural stability. Additional measures will be used to identify the key physiological factors contributing to countermeasure benefits. COUNTERMEASURE METHODS We will use a ground version of our countermeasure to test the efficacy of proprioceptive training while maintaining HDBR constraints. Subjects will remain in the horizontal supine position on a sled that moves freely on air-bearings, similar to a puck on an air hockey table. Subjects will be loaded axially up to one full body weight via lateral cable pulleys towards their feet on an instrumented tilt board using a harness and weights system. Visual feedback of board tilt will be used to guide subjects while they make active tilts. Exercise and proprioceptive training prescriptions will represent those expected to be implemented during exploration spaceflight missions(e.g.20-minute proprioceptive training sessions3 times per week). RELEVANCE The deliverable from this project will be a proof-of-concept countermeasure design that has been fully assessed for efficacy in a spaceflight analog. The findings and lessons learned from this study will be translated for validation of this countermeasure on the ISS. An effective countermeasure will be added to the suite of operationally implemented in-flight sensorimotor countermeasures.

T R Macaulay↗