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NASA NTRSDate not supplied

Evaluating the Efficacy of Conditional Variational Autoencoders in Generating Synthetic Single Nuclei RNA-Seq Data for Space Biology Research

Astronauts are subject to unique stressors during spaceflight, leading to changes in their cellular function. However, neither astronauts nor model organisms respond the same to spaceflight, and research implicates a contribution of omics components in differential responses. Understanding how gene expression affects astronaut health is critical for the success of long-term space missions, prompting interest in developing personalized predictive models leveraging artificial intelligence (AI) and machine learning (ML) techniques. Developing such models requires extensive data, which is challenging to obtain and share. This study explores the use of conditional variational autoencoders (CVAEs) to synthetically generate single-nuclei RNA-seq (snRNA-seq) data. CVAEs build on standard variational autoencoders (VAEs) by conditioning data generation on covariates like sample identity and mission parameters, enhancing the relevance of generated data for specific contexts. For our work, we built two CVAEs with varying degrees of sparsity to optimize both interpretability and generative power. We train and validate models on existing snRNA-seq data collected from the brain tissue of mice subjected to spaceflight conditions and their ground control counterparts. We evaluate model performance using statistical tests and visualizations to compare synthetic data to real data. We aim to demonstrate that these prototype CVAE architectures could be used in future space biology work and that this is a method worth further exploring.

Sarah Golts↗

NASA NTRS1993

DMS augmented monitoring and diganosis application (DMS AMDA) prototype

The Data Management System Augmented Monitoring and Diagnosis Application (DMS AMDA) is currently under development at NASA Ames Research Center (ARC). It will provide automated monitoring and diagnosis capabilities for the Space Station Freedom (SSF) Data Management System (DMS) in the Control Center Complex (CCC) at NASA Johnson Space Center. Several advanced automation applications are under development for use in the CCC for other SSF subsystems. The DMS AMDA, however, is the first application to utilize digraph failure analysis techniques and the Extended Realtime FEAT (ERF) application as the core of its diagnostic system design, since the other projects were begun before the digraph tools were available. Model-based diagnosis and expert systems techniques will provide additional capabilities and augment ERF where appropriate. Utilization of system knowledge captured in the design phase of a system in digraphs should result in both a cost savings and a technical advantage during implementation of the diagnostic software. This paper addresses both the programmatic and technical considerations of this approach, and describes the software design and initial prototyping effort.

Patterson-Hine, F. A.↗

NASA NTRS2012

Z-1 Prototype Space Suit Testing Summary

The Advanced Space Suit team of the NASA-Johnson Space Center performed a series of test with the Z-1 prototype space suit in 2012. This paper discusses, at a summary level, the tests performed and results from those tests. The purpose of the tests were two -fold: 1) characterize the suit performance so that the data could be used in the downselection of components for the Z -2 Space Suit and 2) develop interfaces with the suitport and exploration vehicles through pressurized suit evaluations. Tests performed included isolated and functional range of motion data capture, Z-1 waist and hip testing, joint torque testing, CO2 washout testing, fit checks and subject familiarizations, an exploration vehicle aft deck and suitport controls interface evaluation, delta pressure suitport tests including pressurized suit don and doff, and gross mobility and suitport ingress and egress demonstrations in reduced gravity. Lessons learned specific to the Z -1 prototype and to suit testing techniques will be presented.

Ross, Amy J.↗

NASA NTRS2013

Z-1 Prototype Space Suit Testing Summary

The Advanced Space Suit team of the NASA-Johnson Space Center performed a series of test with the Z-1 prototype space suit in 2012. This paper discusses, at a summary level, the tests performed and results from those tests. The purpose of the tests were two-fold: 1) characterize the suit performance so that the data could be used in the downselection of components for the Z-2 Space Suit and 2) develop interfaces with the suitport and exploration vehicles through pressurized suit evaluations. Tests performed included isolated and functional range of motion data capture, Z-1 waist and hip testing, joint torque testing, CO2 washout testing, fit checks and subject familiarizations, an exploration vehicle aft deck and suitport controls interface evaluation, delta pressure suitport tests including pressurized suit don and doff, and gross mobility and suitport ingress and egress demonstrations in reduced gravity. Lessons learned specific to the Z-1 prototype and to suit testing techniques will be presented.

Ross, Amy↗

NASA NTRS2015

2nd Generation QUATARA Flight Computer Project

Single core flight computer boards have been designed, developed, and tested (DD&T) to be flown in small satellites for the last few years. In this project, a prototype flight computer will be designed as a distributed multi-core system containing four microprocessors running code in parallel. This flight computer will be capable of performing multiple computationally intensive tasks such as processing digital and/or analog data, controlling actuator systems, managing cameras, operating robotic manipulators and transmitting/receiving from/to a ground station. In addition, this flight computer will be designed to be fault tolerant by creating both a robust physical hardware connection and by using a software voting scheme to determine the processor's performance. This voting scheme will leverage on the work done for the Space Launch System (SLS) flight software. The prototype flight computer will be constructed with Commercial Off-The-Shelf (COTS) components which are estimated to survive for two years in a low-Earth orbit.

Falker, Jay↗

NASA NTRS2014

An Overview of Current Capabilities and Research Activities in the Airspace Operations Laboratory at NASA Ames Research Center

The Airspace Operations Laboratory at NASA Ames conducts research to provide a better understanding of roles, responsibilities, and requirements for human operators and automation in future air traffic management (ATM) systems. The research encompasses developing, evaluating, and integrating operational concepts and technologies for near-, mid-, and far-term air traffic operations. Current research threads include efficient arrival operations, function allocation in separation assurance and efficient airspace and trajectory management. The AOL has developed powerful air traffic simulation capabilities, most notably the Multi Aircraft Control System (MACS) that is used for many air traffic control simulations at NASA and its partners in government, academia and industry. Several additional NASA technologies have been integrated with the AOL's primary simulation capabilities where appropriate. Using this environment, large and small-scale system-level evaluations can be conducted to help make near-term improvements and transition NASA technologies to the FAA, such as the technologies developed under NASA's Air Traffic Management Demonstration-1 (ATD-1). The AOL's rapid prototyping and flexible simulation capabilities have proven a highly effective environment to progress the initiation of trajectory-based operations and support the mid-term implementation of NextGen. Fundamental questions about accuracy requirements have been investigated as well as realworld problems on how to improve operations in some of the most complex airspaces in the US. This includes using advanced trajectory-based operations and prototype tools for coordinating arrivals to converging runways at Newark airport and coordinating departures and arrivals in the San Francisco and the New York metro areas. Looking beyond NextGen, the AOL has started exploring hybrid human/automation control strategies as well as highly autonomous operations in the air traffic control domain. Initial results indicate improved capacity, low operator workload, good situation awareness and acceptability for controllers teaming with autonomous air traffic systems. While much research and development needs to be conducted to make such concepts a reality, these approaches have the potential to truly transform the airspace system towards increased mobility, safe and efficient growth in global operations and enabling many of the new vehicles and operations that are expected over the next decades. This paper describes how the AOL currently contributes to the ongoing air transportation transformation.

simulation↗

NASA NTRS2017

A Sweeping Jet Application on a High Reynolds Number Semispan Supercritical Wing Configuration

The FAST-MAC circulation control model was modified to test an array of unsteady sweeping-jet actuators at realistic flight Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center. Two types of sweeping jet actuators were fabricated using rapid prototype techniques, and directed over a 15% chord simple-hinged flap. The model was configured for low-speed high-lift testing with flap deflections of 30 deg and 60 deg, and a transonic cruise configuration having a 0 deg flap deflection. For the 30 deg flap high-lift configuration, the sweeping jets achieved comparable lift performance in the separation control regime, while reducing the mass flow by 54% as compared to steady blowing. The sweeping jets however were not effective for the 60 deg flap. For the transonic cruise configuration, the sweeping jets reduced the drag by 3.3% at an off-design condition. The drag reduction for the design lift coefficient for the sweeping jets offer is only half the drag reduction shown for the steady blowing case (6.5%), but accomplished this with a 74% reduction in mass flow.

Jones, Gregory S.↗

NASA NTRS1981

Fabrication and testing of a prototype longwall face alignment system

Fabrication and testing of a laser system for instantaneous location of a longwall shearer are summarized. Calculations and measurements for the design of a laser based system for monitoring and controlling the trajectory of the shearing machine as it progresses along the longwall face are reported. An early version was fabricated by employing simple mechanical contrivances and a standard miners lamp. It is concluded that the advantages of the early version is the ability to test the longwall face without approval from the Mine Safety and Health Administration.

Source record↗

NASA NTRS2014

Adaptive Augmenting Control Flight Characterization Experiment on an F/A-18

The NASA Marshall Space Flight Center (MSFC) Flight Mechanics and Analysis Division developed an Adaptive Augmenting Control (AAC) algorithm for launch vehicles that improves robustness and performance by adapting an otherwise welltuned classical control algorithm to unexpected environments or variations in vehicle dynamics. This AAC algorithm is currently part of the baseline design for the SLS Flight Control System (FCS), but prior to this series of research flights it was the only component of the autopilot design that had not been flight tested. The Space Launch System (SLS) flight software prototype, including the adaptive component, was recently tested on a piloted aircraft at Dryden Flight Research Center (DFRC) which has the capability to achieve a high level of dynamic similarity to a launch vehicle. Scenarios for the flight test campaign were designed specifically to evaluate the AAC algorithm to ensure that it is able to achieve the expected performance improvements with no adverse impacts in nominal or nearnominal scenarios. Having completed the recent series of flight characterization experiments on DFRC's F/A-18, the AAC algorithm's capability, robustness, and reproducibility, have been successfully demonstrated. Thus, the entire SLS control architecture has been successfully flight tested in a relevant environment. This has increased NASA's confidence that the autopilot design is ready to fly on the SLS Block I vehicle and will exceed the performance of previous architectures.

VanZwieten, Tannen S.↗

NASA NTRS2015

Integrated Ultra-Wideband Tracking and Carbon Dioxide Sensing System Design for International Space Station Applications

A three-dimensional (3D) Ultra-Wideband (UWB) Time-of-Arrival (TOA) tracking system has been studied at NASA Johnson Space Center (JSC) to provide the tracking capability inside the International Space Station (ISS) modules for various applications. One of applications is to locate and report the location where crew experienced possible high level of carbon-dioxide (CO2) and felt upset. Recent findings indicate that frequent, short-term crew exposure to elevated CO2 levels combined with other physiological impacts of microgravity may lead to a number of detrimental effects, including loss of vision. To evaluate the risks associated with transient elevated CO2 levels and design effective countermeasures, doctors must have access to frequent CO2 measurements in the immediate vicinity of individual crew members along with simultaneous measurements of their location in the space environment. To achieve this goal, a small, low-power, wearable system that integrates an accurate CO2 sensor with an ultra-wideband (UWB) radio capable of real-time location estimation and data communication is proposed. This system would be worn by crew members or mounted on a free-flyer and would automatically gather and transmit sampled sensor data tagged with real-time, high-resolution location information. Under the current proposed effort, a breadboard prototype of such a system has been developed. Although the initial effort is targeted to CO2 monitoring, the concept is applicable to other types of sensors. For the initial effort, a micro-controller is leveraged to integrate a low-power CO2 sensor with a commercially available UWB radio system with ranging capability. In order to accurately locate those places in a multipath intensive environment like ISS modules, it requires a robust real-time location system (RTLS) which can provide the required accuracy and update rate. A 3D UWB TOA tracking system with two-way ranging has been proposed and studied. The designed system will be tested in the Wireless Habitat Testbed which simulates the ISS module environment. This report describes the research and development effort for this prototype integrated UWB tracking and CO2 sensing system. The remainder of the report is organized as follows. In Section II, the TOA tracking methodology is introduced and the 3D tracking algorithm is derived. The simulation results are discussed in Section III. In Section VI, prototype system design and field tests are discussed. Some concluding remarks and future works are presented in Section V.

Ni, Jianjun (David)↗

NASA NTRS1998

Data Link Performance Analysis for LVLASO Experiments

Low-visibility Landing and Surface Operations System (LVLASO) is currently being prototyped and tested at NASA Langley Research Center. Since the main objective of the system is to maintain the aircraft landings and take-offs even during low-visibility conditions, timely exchange of positional and other information between the aircraft and the ground control is critical. For safety and reliability reasons, there are several redundant sources on the ground (e.g., ASDE, AMASS) that collect and disseminate information about the environment to the aircrafts. The data link subsystem of LVLASO is responsible for supporting the timely transfer of information between the aircrafts and the ground controllers. In fact, if not properly designed, the data link subsystem could become a bottleneck in the proper functioning of LVLASO. Currently, the other components of the system are being designed assuming that the data link has adequate capacity and is capable of delivering the information in a timely manner. During August 1-28, 1997, several flight experiments were conducted to test the prototypes of subsystems developed under LVLASO project, The back-round and details of the tests are described in the next section. The test results have been collected in two CDs by FAA and Rockwell-Collins. Under the current grant, we have analyzed the data and evaluated the performance of the Mode S datalink. In this report, we summarize the results of our analysis. Much of the results are shown in terms of graphs or histograms. The test date (or experiment number) was often taken as the X-axis and the Y-axis denotes whatever metric of focus in that chart. In interpreting these charts, one need to take into account the vehicular traffic during a particular experiment. In general, the performance of the data link was found to be quite satisfactory in terms of delivering long and short Mode S squitters from the vehicles to the ground receiver, Similarly, its performance in delivering control messages from the ground control to the vehicles (aircrafts) was also satisfactory. The report is organized as follows. In Section 2, we describe the background information for the LVLASO and the system flight experiments. Section 3 contains formats of the performance data that was analyzed during our research. Section 4 describes different experiments flight experiments and their setup. Section 5 analyzes each of the graphs produced in this report. Finally, Section 6 has a summary of observations that we make based on our research.

Mukkamala, Ravi↗

NASA NTRS1989

Flight software development for the isothermal dendritic growth experiment

The Isothermal Dendritic Growth Experiment (IDGE) is a microgravity materials science experiment scheduled to fly in the cargo bay of the shuttle on the United States Microgravity Payload (USMP) carrier. The experiment will be operated by real-time control software which will not only monitor and control onboard experiment hardware, but will also communicate, via downlink data and uplink commands, with the Payload Operations Control Center (POCC) at NASA George C. Marshall Space Flight Center (MSFC). The software development approach being used to implement this system began with software functional requirements specification. This was accomplished using the Yourdon/DeMarco methodology as supplemented by the Ward/Mellor real-time extensions. The requirements specification in combination with software prototyping was then used to generate a detailed design consisting of structure charts, module prologues, and Program Design Language (PDL) specifications. This detailed design will next be used to code the software, followed finally by testing against the functional requirements. The result will be a modular real-time control software system with traceability through every phase of the development process.

Levinson, Laurie H.↗

NASA NTRS1990

Flight software development for the isothermal dendritic growth experiment

The Isothermal Dendritic Growth Experiment (IDGE) is a microgravity materials science experiment scheduled to fly in the cargo bay of the shuttle on the United States Microgravity Payload (USMP) carrier. The experiment will be operated by real-time control software which will not only monitor and control onboard experiment hardware, but will also communicate, via downlink data and unlink commands, with the Payload Operations Control Center (POCC) at NASA George C. Marshall Space Flight Center (MSFC). The software development approach being used to implement this system began with software functional requirements specification. This was accomplished using the Yourdon/DeMarco methodology as supplemented by the Ward/Mellor real-time extensions. The requirements specification in combination with software prototyping was then used to generate a detailed design consisting of structure charts, module prologues, and Program Design Language (PDL) specifications. This detailed design will next be used to code the software, followed finally by testing against the functional requirements. The result will be a modular real-time control software system with traceability through every phase of the development process.

Levinson, Laurie H.↗

NASA NTRS1974

Computer automation of ultrasonic testing

Report describes a prototype computer-automated ultrasonic system developed for the inspection of weldments. This system can be operated in three modes: manual, automatic, and computer-controlled. In the computer-controlled mode, the system will automatically acquire, process, analyze, store, and display ultrasonic inspection data in real-time. Flaw size (in cross-section), location (depth), and type (porosity-like or crack-like) can be automatically discerned and displayed. The results and pertinent parameters are recorded.

Yee, B. G. W.↗

NASA NTRS1974

Development of a six-man, self-contained carbon dioxide collection subsystem for spacecraft application

Life Systems, working with NASA, has developed an electrochemical, six-man, self-contained carbon dioxide concentrator subsystem (CX-6) designed to normally remove 13.2 lb/day of CO2 while maintaining the CO2 partial pressure (pCO2) of the cabin atmosphere at 3 mm Hg or less. The CX-6 was subjected to extensive parametric and endurance testing. The effects of operating conditions on CO2 removal and electrical efficiencies were determined, including effects of hydrogen (H2) flow rate, process airflow rate, pCO2, operating temperature and current density. A total of 209 days of operation was accumulated. The subsystem was designed with self-contained electronic control and monitoring instrumentation. The CX-6 was redesigned and repackaged into the CO2 collection subsystem for the air revitalization group of the space station prototype.

Schubert, F. H.↗

NASA NTRS1975

Fluid infusion system

Development of a fluid infusion system was undertaken in response to a need for an intravenous infusion device operable under conditions of zero-g. The initial design approach, pursued in the construction of the first breadboard instrument, was to regulate the pressure of the motive gas to produce a similar regulated pressure in the infusion liquid. This scheme was not workable because of the varying bag contact area, and a major design iteration was made. A floating sensor plate in the center of the bag pressure plate was made to operate a pressure regulator built into the bellows assembly, effectively making liquid pressure the directly controlled variable. Other design changes were made as experience was gained with the breadboard. Extensive performance tests were conducted on both the breadboard and the prototype device; accurately regulated flows from 6 m1/min to 100 m1/min were achieved. All system functions were shown to operate satisfactorily.

Hammond, J. C.↗

NASA NTRS1976

Magnetic bearing reaction wheel

The results of a program for the development, fabrication and functional test of an engineering model magnetically suspended reaction wheel are described. The reaction wheel develops an angular momentum of + or - 0.5 foot-pound-second and is intended for eventual application in the attitude control of long-life interplanetary and orbiting spacecraft. A description of the wheel design and its major performance characteristics is presented. Recommendations for flight prototype development are made.

Sabnis, A.↗

NASA NTRS1976

Hand-held spectral radiometer to estimate gramineous biomass

A simple hand-held instrument has been designed and constructed to nondestructively estimate above-ground gramineous biomass using radiometric measurements. The prototype unit consists of a modified two-channel digital radiometer interfaced to a pocket calculator. A digital interface was constructed to join electronically and control the radiometer and calculator to enable the radiometer-calculator system to solve a linear conversion solution from radiometric units to estimated biomass. This instrument has been used to estimate radiometrically gramineous biomass in a more efficient fashion with a high degree of accuracy.

Pearson, R. L.↗