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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

SU-E-J-232: Feasibility of MRI-Based Preplan On Low Dose Rate Prostate Brachytherapy

Purpose: To investigate the feasibility of using MRI-based preplan for low dose rate prostate brachytherapy. Methods: 12 patients who received transrectal ultrasound (TRUS) guided prostate brachytherapy with Pd-103 were retrospectively studied. Our care-standard of the TRUS-based preplan served as the control. One or more prostate T2-weighted wide and/or narrow-field of view MRIs obtained within the 3 months prior to the implant were imported into the MIM Symphony software v6.3 (MIM Software Inc., Cleveland, OH) for each patient. In total, 37 MRI preplans (10 different image sequences with average thickness of 4.8mm) were generated. The contoured prostate volume and the seed counts required to achieve adequate dosimetric coverage from TRUS and MRI preplans were compared for each patient. The effects of different MRI sequences and image thicknesses were also investigated statistically using Student’s t-test. Lastly, the nomogram from the MRI preplan and TRUS preplan from our historical treatment data were compared. Results: The average prostate volume contoured on the TRUS and MRI were 26.6cc (range: 12.6∼41.3cc), and 27.4 cc (range: 14.3∼50.0cc), respectively. Axial MRI thicknesses (range: 3.5∼8.1mm) did not significantly affect the contoured volume or the number of seeds required on the preplan (R2 = 0.0002 and 0.0012, respectively). Four of the MRI sequences (AX-T2, AX-T2-Whole-Pelvis, AX-T2-FSE, and AXIALT2- Hi-Res) showed statistically significant better prostate volume agreement with TRUS than the other seven sequences (P <0.01). Nomogram overlay between the MRI and TRUS preplans showed good agreement; indicating volumes contoured on MRI preplan scan reliably predict how many seeds are needed for implant. Conclusion: Although MRI does not allow for determination of the actual implant geometry, it can give reliable volumes for seed ordering purposes. Our future work will investigate if MRI is sufficient to reliably replace TRUS preplanning in patients where preplan TRUS may be technically challenging.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2013

Multitasking mesoporous nanomaterials for biorefinery applications

Mesoporous silica nanoparticles (MSNs) have attracted great interest for last two decades due to their unique and advantageous structural properties, such as high surface area, pore volume, stable mesostructure, tunable pore size and controllable particle morphology. The robust silica framework provides sites for organic modifications, making MSNs ideal platforms for adsorbents and supported organocatalysts. In addition, the pores of MSNs provide cavities/ channels for incorporation of metal and metal oxide nanoparticle catalysts. These supported metal nanoparticle catalysts benefit from confined local environments to enhance their activity and selectivity for various reactions. Biomass is considered as a sustainable feedstock with potential to replace diminishing fossil fuels for the production of biofuels. Among several strategies, one of the promising methods of biofuel production from biomass is to reduce the oxygen content of the feedstock in order to improve the energy density. This can be achieved by creating C-C bonds between biomass derived intermediates to increase the molecular weight of the final hydrocarbon molecules. In this context, pore size and organic functionality of MSNs are varied to obtain the ideal catalyst for a C-C bond forming reaction: the aldol condensation. The mechanistic aspects of this reaction in supported heterogeneous catalysts are explored. The modification of supported organocatalyst and the effect of solvent on the reaction are rationalized. The significance of two functional surfaces of MSNs is exploited by enzyme immobilization on the external surface and organo catalyst functionalization on the internal surface. Using this bifunctional catalyst, the tandem conversion of small chain alcohols into longer chain hydrocarbon molecules is demonstrated. The ability to incorporate metal and metal oxide nanoparticles in the pores and subsequent functionalization led to develop organic modified magnetic MSNs (OM-MSNs) for applications in microalgae biorefinery. Two different integrated biorefinery systems are highlighted. (i) OM-MSNs are used to harvest microalgae and selectively sequester free fatty acids (FFAs). (ii) OM-MSNs are shown to selectively sequester FFAs and convert them into diesel-range liquid hydrocarbon fuels. A similar MSN supported metal nanoparticle catalyst is demonstrated to transform FFAs into green diesel with even greater activity and selectivity. The incorporation of a different organic functional group into MSN provides a selective adsorbent for separation and purification of α-tocopherol from microalgae oil. The functional group with electron deficient aromatic rings demonstrated high sequestration capacity and selectivity of {alpha}-tocopherol.

09 BIOMASS FUELS↗
DOE OSTI2019

Instrumentation Plan for the OSU High Temperature Test Facility, Revision 4

This instrumentation plan describes the instrumentation requirements and design for the Oregon State University (OSU) High Temperature Test Facility (HTTF). This report outlines HTTF instrumentation design specifications, data acquisition and control system (DACS) design specifications as well as a brief description of the instrumentation to be used in the HTTF. The HTTF is an integral test facility, which has been designed to model the behavior of interest for a Very High Temperature Gas Reactor (VHTR) during the Depressurized Conduction Cooldown (DCC) event. It also has the potential to conduct limited explorations into the progression of the Pressurized Conduction Cooldown (PCC) event and phenomena during normal operations. The facility is scaled 1:4 by height and 1:64 by volume. The maximum core power for the facility is approximately 2.2MW. The core region is of a modular design to allow for both the prismatic block core and the pebble bed core designs to be tested. However, only the prismatic block design is discussed in this report. A correctly scaled integral facility modeling the VHTR that can be used to examine the thermal hydraulic system behavior of the design basis and beyond design basis transients is of significant value. The experimental results obtained in such a program could be used to validate analytical tools and methods being proposed for use with the VHTR. Therefore, it is of importance that the HTTF be instrumented in such a way that the required data is collected to meet its overall goals of phenomena examination and code validation. In addition to the instrumentation used to collect data to achieve the overall goals of the HTTF test program, there is instrumentation in the HTTF, which is primarily used to ensure the safe operation of the test facility. This type of instrumentation shall be termed “Control Instrumentation” and is discussed in this report. This report discusses the DACS, which is a personal computer controlled system that is used to control both the collection and storage of the test matrix and control system data as well as electrical and mechanical operation of the test facility.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
DOE OSTI2015

Anaerobic sequencing batch reactor in pilot scale for treatment of tofu industry wastewater

The small industry of tofu production process releases the waste water without being processed first, and the wastewater is directly discharged into water. In this study, Anaerobic Sequencing Batch Reactor in Pilot Scale for Treatment of Tofu Industry was developed through an anaerobic process to produce biogas as one kind of environmentally friendly renewable energy which can be developed into the countryside. The purpose of this study was to examine the fundamental characteristics of organic matter elimination of industrial wastewater with small tofu effective method and utilize anaerobic active sludge with Anaerobic Sequencing Bath Reactor (ASBR) to get rural biogas as an energy source. The first factor is the amount of the active sludge concentration which functions as the decomposers of organic matter and controlling selectivity allowance to degrade organic matter. The second factor is that HRT is the average period required substrate to react with the bacteria in the Anaerobic Sequencing Bath Reactor (ASBR).The results of processing the waste of tofu production industry using ASBR reactor with active sludge additions as starter generates cumulative volume of 5814.4 mL at HRT 5 days so that in this study it is obtained the conversion 0.16 L of CH{sub 4}/g COD and produce biogas containing of CH{sub 4}: 81.23% and CO{sub 2}: 16.12%. The wastewater treatment of tofu production using ASBR reactor is able to produce renewable energy that has economic value as well as environmentally friendly by nature.

09 BIOMASS FUELS↗
DOE OSTI2016

Efficient and selective degradation of polyethylenes into liquid fuels and waxes under mild conditions

Polyethylene (PE) is the largest-volume synthetic polymer, and its chemical inertness makes its degradation by low-energy processes a challenging problem. We report a tandem catalytic cross alkane metathesis method for highly efficient degradation of polyethylenes under mild conditions. With the use of widely available, low-value, short alkanes (for example, petroleum ethers) as cross metathesis partners, different types of polyethylenes with various molecular weights undergo complete conversion into useful liquid fuels and waxes. Furthermore, this method shows excellent selectivity for linear alkane formation, and the degradation product distribution (liquid fuels versus waxes) can be controlled by the catalyst structure and reaction time. In addition, the catalysts are compatible with various polyolefin additives; therefore, common plastic wastes, such as post consumer polyethylene bottles, bags, and films could be converted into valuable chemical feedstocks without any pretreatment.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2024

Development of Structure–Property Relationships for Ammonium Transport through Charged Organogels

Ammonia is a promising carbon-free fuel, but current methods to produce ammonia are energy intensive. New methods are thereby needed, with one promising method being electrochemical nitrogen reduction cells. Efficient cell operation requires robust catalysts but also efficient membrane separators that permit the selective transport of ions while minimizing the transport of the products across the cell. Commercial membranes have an unknown morphology which makes designing improved cells challenging. To address this problem, we synthesized a series of membranes with controlled crosslinking density and chemical composition to understand their impact on ammonium transport. Higher crosslinking density led to lower ammonium permeability. At the highest crosslinking density, similar ammonium permeability was observed independent of the water volume fraction and hydrophobicity of the monomers. These results suggest new directions to develop membranes with reduced ammonium crossover to improve the efficiency of these electrochemical cells.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1994

Micromechanics Analysis Code (MAC) User Guide: Version 1.0

The ability to accurately predict the thermomechanical deformation response of advanced composite materials continues to play an important role in the development of these strategic materials. Analytical models that predict the effective behavior of composites are used not only by engineers performing structural analysis of large-scale composite components but also by material scientists in developing new material systems. For an analytical model to fulfill these two distinct functions it must be based on a micromechanics approach which utilizes physically based deformation and life constitutive models and allows one to generate the average (macro) response of a composite material given the properties of the individual constituents and their geometric arrangement. Here the user guide for the recently developed, computationally efficient and comprehensive micromechanics analysis code, MAC, who's predictive capability rests entirely upon the fully analytical generalized method of cells, GMC, micromechanics model is described. MAC is a versatile form of research software that 'drives' the double or triple ply periodic micromechanics constitutive models based upon GMC. MAC enhances the basic capabilities of GMC by providing a modular framework wherein (1) various thermal, mechanical (stress or strain control), and thermomechanical load histories can be imposed; (2) different integration algorithms may be selected; (3) a variety of constituent constitutive models may be utilized and/or implemented; and (4) a variety of fiber architectures may be easily accessed through their corresponding representative volume elements.

Wilt, T. E.↗
DOE OSTI2022

Network-Level Traffic Signal Cooperation: A Higher-Order Conflict Graph Approach

Traffic signal control and cooperation are extremely important to alleviate traffic congestion in a large traffic network. This study develops a higher-order conflict graph approach for network-wide traffic signal control and cooperation. A conflict graph is applied to model the traffic signal configurations, which identifies the conflict and unconflicted movements for each intersection. In conflict graph, the node represents each movement. The weight of each node can be defined as traffic volume, queue length, fuel consumption, or any weighted combinations of these measurements. The calculation of the optimal green light duration and green light sequence (for different movements) is equivalent to sequentially finding the maximum weight independent set (MWIS) in the conflict graph. The conflict graph also provides a uniform and efficient way to connect traffic signal operations among nearby intersections spatially. Then, we introduced the concept of the k -th order neighborhood to model the degree of connectivity between each movement to the movements at upstream or downstream intersections. The weight of each node in the higher-order conflict graph not only represents its own congestion level, but also relates to the traffic conditions of nearby intersections. Through this approach, the cooperation of multiple intersections can be realized by incorporating their spatial connectivity into conflict graph and solving the MWIS problem. A simulation network is built in SUMO to test the effectiveness of the proposed method. Results suggested that the proposed model outperformed other state-of-the-art signal control methods. Also, the scheme maintains good performance under varying traffic demands.

42 ENGINEERING↗
DOE OSTI2025

Localized material compression to correct distortion in wire arc additive manufacturing

Wire Arc Additive Manufacturing (WAAM) is an advanced manufacturing technology which utilizes welding systems to generate three dimensional geometries in a layer-by-layer fashion. Distortion or warping of a print substrate and WAAM components due to thermally induced residual stresses is an ongoing challenge limiting the widespread adoption of WAAM technologies for producing components. In this manuscript, a novel approach is described to address thermal distortion in deposited components by applying lateral compressions along the length of the deposited material. To demonstrate this method, a series of single-track walls were printed and compressed at evenly spaced intervals using a modified hydraulic cutter tool. The jaws of the tool were modified to compress material rather than to shear it. A mathematical model was developed to relate the curvature of the deposited material to the volume of compression required to eliminate this distortion. Validation of this model was performed using 3D scan data to compare the change in wall curvature induced by compression to the volume of the applied compressions. Substrate deflection was also compared against a control wall, and implementation of wall compression reduced maximum deflections by 93% across a series of four depositions and subsequent compressions. Wall cross sections were also analyzed to determine the impact of compression on material hardness and grain structure. The results demonstrate that successively placed lateral compressions can effectively control and potentially eliminate bending distortion in printed parts. This methodology can be further developed to form a robust model for correction of thermally-induced distortion in WAAM components.

Additive manufacturing↗
DOE OSTI2012

Differences in Radiation Dosimetry and Anorectal Function Testing Imply That Anorectal Symptoms May Arise From Different Anatomic Substrates

Purpose: To explore the influence of functional changes and dosimetric parameters on specific incontinence-related anorectal complaints after prostate external beam radiotherapy and to estimate dose-effect relations for the anal wall and rectal wall. Methods and Materials: Sixty patients, irradiated for localized prostate cancer, underwent anorectal manometry and barostat measurements to evaluate anal pressures, rectal capacity, and rectal sensory functions. In addition, 30 untreated men were analyzed as a control group. In 36 irradiated patients, the anal wall and rectal wall were retrospectively delineated on planning computed tomography scans, and dosimetric parameters were retrieved from the treatment plans. Functional and dosimetric parameters were compared between patients with and without complaints, focusing on urgency, incontinence, and frequency. Results: After external beam radiotherapy, reduced anal pressures and tolerated rectal volumes were observed, irrespective of complaints. Patients with urgency and/or incontinence showed significantly lower anal resting pressures (mean 38 and 39 vs. 49 and 50 mm Hg) and lower tolerated rectal pressures (mean 28 and 28 vs. 33 and 34 mm Hg), compared to patients without these complaints. In patients with frequency, almost all rectal parameters were reduced. Several dosimetric parameters to the anal wall and rectal wall were predictive for urgency (e.g., anal D{sub mean}>38Gy), whereas some anal wall parameters correlated to incontinence and no dose-effect relation for frequency was found. Conclusions: Anorectal function deteriorates after external beam radiotherapy. Different incontinence-related complaints show specific anorectal dysfunctions, suggesting different anatomic and pathophysiologic substrates: urgency and incontinence seem to originate from both anal wall and rectal wall, whereas frequency seems associated with rectal wall dysfunction. Also, dose-effect relations differed between these complaints. This implies that anal wall and rectal wall should be considered separate organs in radiotherapy planning.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2011

Choreographing Couch and Collimator in Volumetric Modulated Arc Therapy

Purpose: To design and optimize trajectory-based, noncoplanar subarcs for volumetric modulated arc therapy (VMAT) deliverable on both Varian TrueBEAM system and traditional accelerators; and to investigate their potential advantages for treating central nervous system (CNS) tumors. Methods and Materials: To guide the computerized selection of beam trajectories consisting of simultaneous couch, gantry, and collimator motion, a score function was implemented to estimate the geometric overlap between targets and organs at risk for each couch/gantry angle combination. An initial set of beam orientations is obtained as a function of couch and gantry angle, according to a minimum search of the score function excluding zones of collision. This set is grouped into multiple continuous and extended subarcs subject to mechanical limitations using a hierarchical clustering algorithm. After determination of couch/gantry trajectories, a principal component analysis finds the collimator angle at each beam orientation that minimizes residual target-organ at risk overlaps. An in-house VMAT optimization algorithm determines the optimal multileaf collimator position and monitor units for control points within each subarc. A retrospective study of 10 CNS patients compares the proposed method of VMAT trajectory with dynamic gantry, leaves, couch, and collimator motion (Tra-VMAT); a standard noncoplanar VMAT with no couch/collimator motion within subarcs (Std-VMAT); and noncoplanar intensity-modulated radiotherapy (IMRT) plans that were clinically used. Results: Tra-VMAT provided improved target dose conformality and lowered maximum dose to brainstem, optic nerves, and chiasm by 7.7%, 1.1%, 2.3%, and 1.7%, respectively, compared with Std-VMAT. Tra-VMAT provided higher planning target volume minimum dose and reduced maximum dose to chiasm, optic nerves, and cochlea by 6.2%, 1.3%, 6.3%, and 8.4%, respectively, and reduced cochlea mean dose by 8.7%, compared with IMRT. Tra-VMAT averaged beam-on time was comparable to Std-VMAT but significantly (45%) less than IMRT. Conclusion: Optimized couch, gantry, and collimator trajectories may be integrated into VMAT with improved mechanical flexibility and may provide better dosimetric properties and improved efficiency in the treatment of CNS tumors.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2016

Intensity Modulated Radiation Therapy for Early-Stage Primary Gastric Diffuse Large B-Cell Lymphoma: Dosimetric Analysis, Clinical Outcome, and Quality of Life

Purpose: To evaluate the dosimetric superiority, efficacy, toxicity, and quality of life (QOL) data of intensity modulated radiation therapy (IMRT) in patients with primary gastric diffuse large B-cell lymphoma (PG-DLBCL). Methods and Materials: Forty-six consecutive patients with early-stage PG-DLBCL underwent IMRT after chemotherapy. The majority of patients (61.5%) were subclassified as the non-germinal center B cell–like subtype. Dosimetric parameters of the planning target volume (PTV) and organs at risk were assessed. Survival rates were depicted with the Kaplan-Meier method and compared with the log-rank test. Quality of life was evaluated using the QLQ-C30-STO22 questionnaires at the last follow-up contact. Results: The median PTV mean dose was 41.6 Gy. Only 0.73% of the PTV received <95% of the prescribed dose, indicating excellent target coverage. The median kidney V20 and liver V30 were 14.1% and 16.1%, respectively. The 5-year overall survival (OS), progression-free survival, and locoregional control rates for all patients were 80.4%, 75.0%, and 93.2%, respectively. Stage, lactate dehydrogenase level, and immunophenotype were significant prognostic factors for OS, and only stage was a significant factor for locoregional control. Consolidation IMRT in patients with complete response after chemotherapy resulted in significantly better OS and progression-free survival than salvage IMRT in patients with non-complete response. Two of 8 patients who had chronic liver disease experienced grade 4 or grade 5 acute hepatic failure after 4 to 5 cycles of rituximab-based chemotherapy and IMRT (40 Gy). No other serious acute or late toxicity was observed. The long-term global and functional QOL scales were excellent, with negligible symptom scales. Conclusions: Intensity modulated radiation therapy yielded excellent target coverage and critical tissue sparing and achieved favorable outcomes with acceptable toxicity and good long-term QOL in early-stage PG-DLBCL.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2011

FY2011 Oak Ridge National Laboratory Annual Progress Report for the Power Electronics and Electric Machinery Program

The U.S. Department of Energy (DOE) announced in May 2011 a new cooperative research effort comprising DOE, the U.S. Council for Automotive Research (composed of automakers Ford Motor Company, General Motors Company, and Chrysler Group), Tesla Motors, and representatives of the electric utility and petroleum industries. Known as U.S. DRIVE (Driving Research and Innovation for Vehicle efficiency and Energy sustainability), it represents DOE's commitment to developing public-private partnerships to fund high risk-high reward research into advanced automotive technologies. The new partnership replaces and builds upon the partnership known as FreedomCAR (derived from 'Freedom' and 'Cooperative Automotive Research') that ran from 2002 through 2010 and the Partnership for a New Generation of Vehicles initiative that ran from 1993 through 2001. The Oak Ridge National Laboratory's (ORNL's) Power Electronics and Electric Machines (PEEM) subprogram within the DOE Vehicle Technologies Program (VTP) provides support and guidance for many cutting-edge automotive technologies now under development. Research is focused on developing revolutionary new power electronics (PE), electric motor (EM), and traction drive system technologies that will leapfrog current on-the-road technologies. The research and development (R&D) is also aimed at achieving a greater understanding of and improvements in the way the various new components of tomorrow's automobiles will function as a unified system to improve fuel efficiency. In supporting the development of advanced vehicle propulsion systems, the PEEM subprogram has enabled the development of technologies that will significantly improve efficiency, costs, and fuel economy. The PEEM subprogram supports the efforts of the U.S. DRIVE partnership through a three phase approach intended to: (1) identify overall propulsion and vehicle related needs by analyzing programmatic goals and reviewing industry's recommendations and requirements and then develop the appropriate technical targets for systems, subsystems, and component R&D activities; (2) develop and validate individual subsystems and components, including EMs and PE; and (3) determine how well the components and subsystems work together in a vehicle environment or as a complete propulsion system and whether the efficiency and performance targets at the vehicle level have been achieved. The research performed under this subprogram will help remove technical and cost barriers to enable the development of technology for use in such advanced vehicles as hybrid electric vehicles (HEVs), plug-in HEVs (PHEVs), battery electric vehicles, and fuel-cell-powered automobiles that meet the goals of the VTP. A key element in making these advanced vehicles practical is providing an affordable electric traction drive system. This will require attaining weight, volume, efficiency, and cost targets for the PE and EM subsystems of the traction drive system. Areas of development include: (1) novel traction motor designs that result in increased power density and lower cost; (2) inverter technologies involving new topologies to achieve higher efficiency with the ability to accommodate higher temperature environments while achieving high reliability; (3) converter concepts that use methods of reducing the component count and integrating functionality to decrease size, weight, and cost; (4) new onboard battery charging concepts that result in decreased cost and size; (5) more effective thermal control through innovative packaging technologies; and (6) integrated motor-inverter traction drive system concepts. ORNL's PEEM research program conducts fundamental research, evaluates hardware, and assists in the technical direction of the VTP Advanced Power Electronics and Electric Motors (APEEM) program. In this role, ORNL serves on the U.S. DRIVE Electrical and Electronics Technical Team, evaluates proposals for DOE, and lends its technological expertise to the direction of projects and evaluation of developing technologies. ORNL also executes specific projects for DOE. DOE's continuing R&D into advanced vehicle technologies for transportation offers the possibility of reducing the nation's dependence on foreign oil and the negative economic impacts of crude oil price fluctuations. It also supports the Administration's goal of deploying 1 million PHEVs by 2015.

02 PETROLEUM↗
NASA NTRS1976

Diffusion analysis for two-phase metal-matrix composite

Diffusion controlled filament matrix interaction in a metal matrix composite, where the filaments and matrix comprise a two phase binary alloy system, was mathematically modeled. The problem of a diffusion controlled, two phase moving interface by means of a one dimensional, variable grid, finite difference technique was analyzed. Concentration dependent diffusion coefficients and equilibrium solubility limits were used, and the change in filament diameter and compositional changes in the matrix were calculated as a function of exposure time at elevated temperatures. With the tungsten nickel (W-Ni) system as a model composite system, unidirectional composites containing from 0.06 to 0.44 initial filament volume fraction were modeled. Compositional changes in the matrix were calculated by superposition of the contributions from neighboring filaments. Alternate methods for determining compositional changes between first and second nearest neighbor filaments were also considered. The results show the relative importance of filament volume fraction, filament diameter, exposure temperature, and exposure time as they affect the rate and extent of filament matrix interaction.

Tenney, D. R.↗
NASA NTRS1996

Micromechanics Analysis Code (MAC). User Guide: Version 2.0

The ability to accurately predict the thermomechanical deformation response of advanced composite materials continues to play an important role in the development of these strategic materials. Analytical models that predict the effective behavior of composites are used not only by engineers performing structural analysis of large-scale composite components but also by material scientists in developing new material systems. For an analytical model to fulfill these two distinct functions it must be based on a micromechanics approach which utilizes physically based deformation and life constitutive models and allows one to generate the average (macro) response of a composite material given the properties of the individual constituents and their geometric arrangement. Here the user guide for the recently developed, computationally efficient and comprehensive micromechanics analysis code's (MAC) who's predictive capability rests entirely upon the fully analytical generalized method of cells (GMC), micromechanics model is described. MAC is a versatile form of research software that 'drives' the double or triply periodic micromechanics constitutive models based upon GMC. MAC enhances the basic capabilities of GMC by providing a modular framework wherein (1) various thermal, mechanical (stress or strain control) and thermomechanical load histories can be imposed, (2) different integration algorithms may be selected, (3) a variety of constituent constitutive models may be utilized and/or implemented, and (4) a variety of fiber and laminate architectures may be easily accessed through their corresponding representative volume elements.

Wilt, T. E.↗
DOE OSTI2012

Phase I Trial of Pelvic Nodal Dose Escalation With Hypofractionated IMRT for High-Risk Prostate Cancer

Purpose: Toxicity concerns have limited pelvic nodal prescriptions to doses that may be suboptimal for controlling microscopic disease. In a prospective trial, we tested whether image-guided intensity-modulated radiation therapy (IMRT) can safely deliver escalated nodal doses while treating the prostate with hypofractionated radiotherapy in 5 Vulgar-Fraction-One-Half weeks. Methods and Materials: Pelvic nodal and prostatic image-guided IMRT was delivered to 53 National Comprehensive Cancer Network (NCCN) high-risk patients to a nodal dose of 56 Gy in 2-Gy fractions with concomitant treatment of the prostate to 70 Gy in 28 fractions of 2.5 Gy, and 50 of 53 patients received androgen deprivation for a median duration of 12 months. Results: The median follow-up time was 25.4 months (range, 4.2-57.2). No early Grade 3 Radiation Therapy Oncology Group or Common Terminology Criteria for Adverse Events v.3.0 genitourinary (GU) or gastrointestinal (GI) toxicities were seen. The cumulative actuarial incidence of Grade 2 early GU toxicity (primarily alpha blocker initiation) was 38%. The rate was 32% for Grade 2 early GI toxicity. None of the dose-volume descriptors correlated with GU toxicity, and only the volume of bowel receiving {>=}30 Gy correlated with early GI toxicity (p = 0.029). Maximum late Grades 1, 2, and 3 GU toxicities were seen in 30%, 25%, and 2% of patients, respectively. Maximum late Grades 1 and 2 GI toxicities were seen in 30% and 8% (rectal bleeding requiring cautery) of patients, respectively. The estimated 3-year biochemical control (nadir + 2) was 81.2 {+-} 6.6%. No patient manifested pelvic nodal failure, whereas 2 experienced paraaortic nodal failure outside the field. The six other clinical failures were distant only. Conclusions: Pelvic IMRT nodal dose escalation to 56 Gy was delivered concurrently with 70 Gy of hypofractionated prostate radiotherapy in a convenient, resource-efficient, and well-tolerated 28-fraction schedule. Pelvic nodal dose escalation may be an option in any future exploration of potential benefits of pelvic radiation therapy in high-risk prostate cancer patients.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
NASA NTRSDate not supplied

NextSTEP Appendix A Modular ECLSS Effort Lessons Learned

NASA’s Artemis program provides the first steps for earth-independent exploration starting with crewed habitats in cislunar space and progressing toward crewed landings on the lunar surface that will prepare systems and crews for the exploration of Mars. The Next Space Technology for Exploration Partnerships (NextSTEP) is a public-private partnership model that facilitates commercial development of deep space exploration capabilities in support of more extensive human spaceflight missions in and beyond cislunar space. NASA issued the original NextSTEP Broad Agency Announcement (BAA) to U.S. industry in late 2014 and issued the second BAA (NextSTEP-2) in April 2016. The first appendix under NextSTEP-2, Appendix A, focused on developing deep space habitation concepts, engineering design and development, and risk reduction efforts leading to a habitation capability in cislunar space. NASA solicited concepts to develop and refine the evolvable, modular architecture, functional allocation options, standards, and common interfaces required to enable interoperability of the aggregate system to provide long duration deep space transit habitation, specifically enhancements and testing of deep space Environmental Control and Life Support Systems (ECLSS). Collins Aerospace, formerly UTC Aerospace Systems (UTAS), was awarded a Phase 1 and subsequent Phase 2 contract to “develop concepts that group ECLS systems into logical modules maximizing the use of common components and the development of unique methods and design concepts that support in-flight maintenance and repair for future exploration systems.” This paper summarizes the work accomplished under this effort, the lessons that can be applied to development of forthcoming habitation elements, and the gaps remaining to achieve a more resilient, maintainable, repairable and adaptable system capable of installation on a wide variety of habitat platforms. A primary accomplishment of this effort is the development and maturation of a modular palletization concept to enable standard rack interfaces, post-launch outfitting, and decoupling of structural supports that withstand launch environments from those needed for lower on-orbit loads in order to reduce installed mass and repurposing of panels within the habitat. In the course of the effort, Collins assessed numerous architecture trades, including the use of condensing and noncondensing heat exchangers, the ability of modular units to accommodate various habitat volumes and thermal loading, and the most appropriate order of and timing of delivery of regenerative ECLSS hardware to orbital habitats. In addition to the modularity of hardware elements, Collins developed software approaches for distributed/modular command, control, and communication systems and innovative Bayesian fault detection and isolation techniques. Finally, the effort explored advanced maintainability and supportability concepts including the definition of maintenance units (MUs) in place of the traditional Orbital Replacement Units (ORUs), increasing parts commonality to reduce the number and type of spare parts, the use of augmented reality to guide crews during maintenance and repair procedures, and how crews would prepare for and recover from long durations of habitat dormancy. Now that the NextSTEP Modular ECLSS effort has come to a close, it’s important to identify the lessons learned and where they can be leveraged to improve NASA’s broader program of ECLSS technology development and demonstration and ultimately how they can increase the performance of future surface and orbital habitats.

NextSTEP↗