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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,027 records · Page 57
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

The PRad windowless gas flow target

In this work, we report on a windowless, high-density, gas flow target at Jefferson Lab that was used to measure $r_p$, the root-mean-square charge radius of the proton. To our knowledge, this is the first such system used in a fixed-target experiment at a (non-storage ring) electron accelerator. The target achieved its design goal of an areal density of 2$\times$10$^{18}$ atoms/cm$^2$, with the gas uniformly distributed over the 4 cm length of the cell and less than 1% residual gas outside the cell. This design eliminated scattering from the end caps of the target cell, a problem endemic to previous measurements of the proton charge radius in electron scattering experiments, and permitted a precise, model-independent extraction of $r_p$ by reaching unprecedentedly low values of $Q^2$, the square of the electron's transfer of four-momentum to the proton.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2021

Design and structural assessment of the Spallation Neutron Source 2.0 MW target

The Proton Power Upgrade (PPU) project is underway at the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory. The project will double the proton accelerator power from 1.4 MW to 2.8 MW, increase power to the First Target Station (FTS), and enable a future Second Target Station (STS). The power increase partly comes from raising proton energy from 1.0 GeV to 1.3 GeV. The STS will operate at 0.7 MW at 15 Hz when completed. Until then, PPU will provide the capability to operate the FTS at 2.0 MW at 60 Hz. Maximum power at the FTS to date has been 1.4 MW at 60 Hz with 1.0 GeV protons. A new mercury target module design to operate reliably under PPU conditions has been completed after a multi-year effort. The design philosophy and assessment of the structural analysis are described here. This target underwent an unprecedented design and analysis process for SNS using the latest engineering techniques and incorporating years of operating lessons and outcomes from R&D to meet structural design criteria. Finally, it also incorporates high-flow gas injection to further mitigate pulse fatigue stresses as well as cavitation damage to the mercury vessel.

47 OTHER INSTRUMENTATION↗
DOE OSTI2012

Polarisation observables for strangeness photoproduction on a frozen spin target with CLAS at Jefferson Lab

The FROST experiment at Jefferson Lab used the CLAS detector in Hall B with the intention of performing a complete measurement of polarization observables associated with strangeness photoproduction, in combination with data from previous JLab experiments. This was achieved by utilizing the FROST polarized target in conjunction with polarized photon beams, allowing direct measurement of beam-target double polarization observables. By studying strangeness reactions, such as {gamma}p {yields} K{sup +}{Lambda}{sup 0}, it may be possible to find 'missing' baryon resonances, predicted by symmetric quark models but not observed in previous experiments, whose results are consistent with the di-quark model. It is thought these 'missing' resonances remain undiscovered because they have different coupling strengths for different reaction channels, such as the strangeness reactions, whereas the current data is dominated by studies of pN reactions. Observing these resonances therefore has important implications for our knowledge of the excited states of nucleons, and the models predicting the quark interactions within them. The G polarization observable is one of the beam-target double polarization observables, associated with a longitudinally polarized target and a linearly polarized photon beam, and its measurement for the strangeness reaction {gamma}p {yields} K{sup +}{Lambda}{sup 0} is the focus of the work presented.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2023

Stacked target irradiations and radiochemical separations for simultaneous production of short-lived Ni and Ir isotopes

A method was developed for simultaneous production of neutron-deficient Ni and Ir isotopes by irradiation of stacked targets with a 50.5 MeV proton beam, followed by radiochemical separations to remove excess target material. The target, irradiation configuration, and post-irradiation radiochemical separations were developed and tested in a proof-of-principle irradiation. Radiochemical yields and purity of the products are discussed. Finally, the stacked target method, developed herein, can be used to produce other isotope pairs with appropriate beam tailoring.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
DOE OSTI2019

Production of 230 Pa by proton irradiation of 232 Th at the LANL isotope production facility: Precursor of 230 U for targeted alpha therapy

Uranium-230 ( t 1/2 = 20.8 d) is an alpha-emitting radionuclide that has potential application in targeted alpha therapy (TAT) of cancer. Its parent isotope 230 Pa ( t 1/2 = 17.4 d), can be produced by proton irradiation of thorium metal targets. Preliminary 230 Pa production runs were performed at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF) using thin thorium metal targets and a proton beam energy of 15–30 MeV, followed by radiochemical separation of 230 Pa from the irradiated target matrix. The measured 230 Pa production yields were found to exceed the predicted values in most of the experiments that were performed. Furthermore, this data will inform further production efforts for providing 230 Pa/ 230 U for clinical trials.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2025

Benchmarking Monte Carlo codes for the modelling of low-energy neutron production target reactions

The increasing adoption of accelerator-based neutron sources (ABNS) for applications including neutron capture therapy (NCT) research has highlighted the need for accurate simulation tools. Precise modelling of the neutron production target is crucial to ensure that simulated predictions of neutron beam characteristics used for subsequent beam shaping assembly design are reliable. This work presents a comprehensive benchmarking of four widely-used Monte Carlo codes - Geant4, PHITS, FLUKA (CERN), and MCNP - for modelling low-energy neutron production target reactions. Using their recommended physics models and cross-section libraries, we evaluate each code’s performance in simulating four beam-target reactions: 7 Li(p,n) 7 Be, 9 Be(p,n) 9 B, 9 Be(d,n) 10 B, and C(d,n)N. Predictions of neutron yield, angular distributions, and energy spectra are compared against available thick target experimental data. Results show varying levels of agreement between the codes depending on the reaction type, energy range, and beam characteristics. Geant4, MCNP and PHITS are the overall best performing codes for the simulation of total neutron yield and yield in the forward direction across most reactions. Across energies where experimental benchmarks exist, inter-code discrepancies in total and forward-directed yield are typically 10 to 30%, with larger deviations at near-threshold incident ion energies. PHITS provides the best overall reproduction of experimental spectra, particularly for the 9 Be(p,n) 9 B reaction. Additionally, PHITS demonstrates superior computational performance for most reactions. These findings provide valuable guidance for ABNS design, highlighting the strengths and limitations of each code for the simulation of low-energy neutron production reactions.

43 PARTICLE ACCELERATORS↗
DOE OSTI2016

A cryogenic target for Compton scattering experiments at HIγS

We have developed a cryogenic target for use at the High Intensity γ-ray Source (HIγS). The target system is able to liquefy 4He at 4 K, hydrogen at 20 K, and deuterium at 23 K to fill a 0.3 L Kapton cell. Liquid temperatures and condenser pressures are recorded throughout each run in order to ensure that the target's areal density is known to ~1%. The target is being utilized in a series of experiments which probe the electromagnetic polarizabilities of the nucleon.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2018

Status of the JENSA gas-jet target for experiments with rare isotope beams

The JENSA gas-jet target was designed for experiments with radioactive beams provided by the rare isotope re-accelerator ReA3 at the National Superconducting Cyclotron Laboratory. The gas jet will be the main target for the Separator for Capture Reactions SECAR at the Facility for Rare Isotope Beams on the campus of Michigan State University, USA. We describe the advantages of a gas-jet target, detail the current recirculating gas system, and report recent measurements of helium jet thicknesses of up to about 10 19 atoms/cm 2 . A comparison with other supersonic gas-jet targets is presented.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2020

A liquid hydrogen target for the MUSE experiment at PSI

A 280 ml liquid hydrogen target has been constructed and tested here for the MUSE experiment at PSI to investigate the proton charge radius via simultaneous measurement of elastic muon–proton and elastic electron–proton scattering. To control systematic uncertainties at a sub-percent level, strong constraints were put on the amount of material surrounding the target and on its temperature stability. The target system was successfully operated during a commissioning run at PSI at the end of 2018. The target temperature was stable at the 0.01 K level. This indicates a density stability at the 0.02% level, which is about a factor of ten better than required.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2021

A concept for polarized 3 He targets for high luminosity scattering experiments in high magnetic field environments

In this work, we present the conceptual design of a polarized 3 He target to be used for high luminosity scattering experiments within high magnetic field environments. This two-cell target will take advantage of advancements in optical pumping techniques at high magnetic field to create 60% longitudinally polarized 3 He gas in a pumping cell within a uniform magnetic field above 1 T. By transferring the polarized gas to a cryogenic target cell, the gas density is increased to create a target thickness suitable for high luminosity applications. We discuss the general design of this scheme, and plans for its application in Jefferson Lab’s CLAS12 detector.

3He polarization↗
DOE OSTI2017

Permeation fill-tube design for inertial confinement fusion target capsules

A unique approach for permeation filling of nonpermeable inertial confinement fusion target capsules with deuterium–tritium (DT) is presented. This process uses a permeable capsule coupled into the final target capsule with a 0.03-mm-diameter fill tube. Leak free permeation filling of glow-discharge polymerization (GDP) targets using this method have been successfully demonstrated, as well as ice layering of the target, yielding an inner ice surface roughness of 1- $\unicode[STIX]{x03BC}$ m rms (root mean square). Finally, the measured DT ice-thickness profile for this experiment was used to validate a thermal model’s prediction of the same thickness profile.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2024

Target Configuration Effect on Microstructures and Properties of Vertically Aligned Nanocomposites

Vertically aligned nanocomposites (VANs) are unique thin films with vertical nanostructures embedded in a matrix material, allowing for the integration of two distinct materials. These nanocomposites offer novel combined physical properties, such as nanocomposite-based multiferroics and strongly coupled physical properties, such as magneto-optic coupling. Much work has been conducted in exploring different two-phase combinations and various processing conditions to achieve novel tunable properties that cannot be obtained by any single-phase material alone. Here, in this work, the target configuration effects are explored for the growth of LaFeO 3 –CoNi 2 O 4 VANs. Both mixed and pie-shaped targets are utilized to compare the target configuration effects on the phase separation, morphology tuning, and their resulting physical properties, including optical and magnetic properties. This work suggests that the target configuration is another important parameter for achieving the desired VAN morphology and can be used to design different two-phase VANs with tailorable properties.

36 MATERIALS SCIENCE↗
DOE OSTI2016

Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells

Many nanocarrier cancer therapeutics currently under development, as well as those used in the clinical setting, rely upon the enhanced permeability and retention (EPR) effect to passively accumulate in the tumor microenvironment and kill cancer cells. In leukemia, where leukemogenic stem cells and their progeny circulate within the peripheral blood or bone marrow, the EPR effect may not be operative. Thus, for leukemia therapeutics, it is essential to target and bind individual circulating cells. Here in this research, we investigate mesoporous silica nanoparticle (MSN)-supported lipid bilayers (protocells), an emerging class of nanocarriers, and establish the synthesis conditions and lipid bilayer composition needed to achieve highly monodisperse protocells that remain stable in complex media as assessed in vitro by dynamic light scattering and cryo-electron microscopy and ex ovo by direct imaging within a chick chorioallantoic membrane (CAM) model. We show that for vesicle fusion conditions where the lipid surface area exceeds the external surface area of the MSN and the ionic strength exceeds 20 mM, we form monosized protocells (polydispersity index <0.1) on MSN cores with varying size, shape, and pore size, whose conformal zwitterionic supported lipid bilayer confers excellent stability as judged by circulation in the CAM and minimal opsonization in vivo in a mouse model. Having established protocell formulations that are stable colloids, we further modified them with anti-EGFR antibodies as targeting agents and reverified their monodispersity and stability. Then, using intravital imaging in the CAM, we directly observed in real time the progression of selective targeting of individual leukemia cells (using the established REH leukemia cell line transduced with EGFR) and delivery of a model cargo. In conclusion, overall we have established the effectiveness of the protocell platform for individual cell targeting and delivery needed for leukemia and other disseminated disease.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2022

High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds

Abstract Morphological profiling is an omics-based approach for predicting intracellular targets of chemical compounds in which the dose-dependent morphological changes induced by the compound are systematically compared to the morphological changes in gene-deleted cells. In this study, we developed a reliable high-throughput (HT) platform for yeast morphological profiling using drug-hypersensitive strains to minimize compound use, HT microscopy to speed up data generation and analysis, and a generalized linear model to predict targets with high reliability. We first conducted a proof-of-concept study using six compounds with known targets: bortezomib, hydroxyurea, methyl methanesulfonate, benomyl, tunicamycin, and echinocandin B. Then we applied our platform to predict the mechanism of action of a novel diferulate-derived compound, poacidiene. Morphological profiling of poacidiene implied that it affects the DNA damage response, which genetic analysis confirmed. Furthermore, we found that poacidiene inhibits the growth of phytopathogenic fungi, implying applications as an effective antifungal agent. Thus, our platform is a new whole-cell target prediction tool for drug discovery.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2011

Opacity and temperature profiles through thick iron targets irradiated by short bursts of intense x-rays

We model x-ray free-electron laser (XFEL) interactions of pulses of 100 fs duration or less with thick (many attenuation lengths) solid iron targets assuming the instantaneous target opacity is determined solely by the energy absorbed for a given photon energy. Examples of the bound-free opacity dependence on energy absorbed for iron targets at photon energies of 750-2000 eV are presented. This is utilized to model XFEL pulse propagation through solid iron and to predict the resulting iron plasma opacity as the pulse progresses. Assuming the establishment of local thermodynamic equilibrium and electron-ion thermalization after a sufficiently long time interval, we calculate the temperature profiles to be expected in solid iron targets.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2011

Energy enhancement of quasi-monoenergetic proton bunches using a slice-cone target

A slice-cone target is proposed for the generation of quasi-monoenergetic proton bunches. In this new target structure, two symmetrical solid slices are adjoined obliquely to the tip of a hollow cone. Two-dimensional particle-in-cell simulations show that a large number of hot electrons are pulled out from the solid slices and accelerated forward by direct laser acceleration. Compared with the hollow cone target, a stronger electrostatic field at the rear surface of the slice-cone tip is set up by the hot electrons from the cone and the slices. As a result, the energy of the quasi-monoenergetic proton bunch produced through the target-normal sheath acceleration mechanism can be improved by 75%. It shows that the proton energy scales proportional to the square root of the laser intensity. For the incident laser with the focused intensity about 5 x 10{sup 20 }W/cm{sup 2}, one can obtain proton bunches with central energy 165 MeV and energy spread 13%.

43 PARTICLE ACCELERATORS↗
DOE OSTI2012

Efficient proton beam generation from a foam-carbon foil target using an intense circularly polarized laser

Energetic proton acceleration from interaction of intense circularly polarized laser pulse with a foam-carbon foil target is investigated using two-dimensional particle-in-cell simulation. It is found that protons from this target are accelerated to much higher energy in comparison with double-layer targets and simple flat targets. This result can be attributed to an enhancement of energy conversion efficiency from laser to electrons inside foam region. When a large number of energetic electrons are generated from the nearcritical plasma, they transport through the foil and form a strong backside sheath field which accelerates protons more efficiently.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2013

Efficient proton acceleration and focusing by an ultraintense laser interacting with a parabolic double concave target with an extended rear

A new scheme for acceleration and focusing of protons via an improved parabolic double concave target irradiated by an ultraintense laser pulse is proposed. When an intense laser pulse illuminates a concave target, the hot electrons are concentrated on the focal region of the rear cavity and they form a strong space-charge-separation field, which accelerates the protons. For a simple concave target, the proton energy spectrum becomes very broad outside the rear cavity because of transverse divergence of the electromagnetic fields. However, particle-in-cell simulations show that, when the concave target has an extended rear, the hot electrons along the wall surface induce a transverse focusing sheath field, resulting in a clear enhancement of proton focusing, which makes the lower proton energy spread, while, leads to a little reduction of the proton bunch peak energy.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗