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At least 1,027 records · Page 57

Advanced Research Projects Agency-Energy Annual Report for FY2013

This report presents a summary of the activities of the Advanced Research Projects Agency-Energy (ARPA-E) during Fiscal Year 2013 (FY2013). In FY2013, ARPA-E issued funding solicitations and selected projects for three new programs covering a broad array of energy technologies, including: $36 million to develop transformational energy storage technologies for electric vehicles; $32 million to develop cost-effective, energy-efficient manufacturing techniques for processing and recycling lightweight metals; and $34 million to develop transformational biological technologies to convert natural gas to liquids for transportation fuels. ARPA-E announced two additional funding opportunities in FY2013 with project selections that were ultimately announced in FY2014. These programs include $27 million to develop next-generation power switching devices that improve energy efficiency in a wide range of applications – including new lighting technologies, computer power supplies, industrial motor drives, and automobiles – and $30 million to advance solar energy beyond current photovoltaic (PV) and concentrated solar power (CSP) technologies. Altogether, technologies funded through these five programs have the potential to transform the way we generate, use, and store energy. In September 2013, ARPA-E also began utilizing Innovative Development in Energy-Related Applied Science (OPEN IDEAS), a rolling open solicitation that will allow ARPA-E to quickly support innovative applied energy research that has the potential to lead to new focused programs. In addition to these new programs, ARPA-E hosted the fourth annual Energy Innovation Summit from February 25-27, 2013. The Summit brought together leaders from academia, government, and business to discuss the foremost energy issues, showcase the latest technology innovations, and cultivate relationships to help advance cutting-edge technologies to market. The event drew over 2,200 attendees from 49 states and 26 countries and featured over 150 speakers and keynote addresses. At the Summit, ARPA-E recognized several preliminary indicators of likely project success, including that 17 projects had attracted over $450 million in private sector follow-on funding after ARPA-E's initial investment of approximately $70 million. Finally, ARPA-E continued to focus on providing awardees with practical training and critical business information as part of the Agency's Technology-to-Market program. This support equips projects with a clear understanding of market needs to guide technical development and help projects succeed.

Martin, C.↗

Feedstock Carbon Intensity Calculator (FD-CIC): Users’ Manual and Technical Documentation

The carbon intensities (CIs) of biofuels are determined with the life cycle analysis (LCA) technique, which accounts for the energy/material uses and emissions during the complete supply chain of biofuel including feedstock production and fuel conversion stages. Regulatory agencies such as California Air Resources Board (CARB) adopts LCA to calculate biofuel CIs. The Low Carbon Fuel Standard (LCFS) program developed by CARB allows individual biofuel conversion facilities to submit their own biofuel CIs with their facility input data and incentivizes the reduction in the CI specific to that particular facility compared to a reference fuel’s CI (Liu et al 2020). Such an incentive program has driven innovations in biorefineries to reduce their greenhouse gas (GHG) emissions by linking their revenue directly to its CI score through LCFS credit trading. Besides the biofuel conversion stage, different farming practices for feedstock growth can result in significant CI variations for feedstocks, thus for biofuels. To provide evidence-based research findings, the U.S. Department of Energy’s Advanced Research Projects Agency–Energy (ARPA-E) has supported the Systems Assessment Center of the Energy Systems and Infrastructure Analysis Division at Argonne National Laboratory to examine CI variations of different farming practices to grow agricultural crops for biofuel production. Meanwhile, the ARPA-E has launched the Systems for Monitoring and Analytics for Renewable Transportation Fuels from Agricultural Resources and Management (SMARTFARM) program to develop technologies and data platforms that enable an accurate measurement of key farming parameters that can help robust accounting of the GHG benefits of sustainable, low-carbon agronomic practices at farm level.

54 ENVIRONMENTAL SCIENCES↗

MO-E-9A-01: Risk Based Quality Management: TG100 In Action

One of the goals of quality management in radiation therapy is to gain high confidence that patients will receive the prescribed treatment correctly. To accomplish these goals professional societies such as the American Association of Physicists in Medicine (AAPM) has published many quality assurance (QA), quality control (QC), and quality management (QM) guidance documents. In general, the recommendations provided in these documents have emphasized on performing device-specific QA at the expense of process flow and protection of the patient against catastrophic errors. Analyses of radiation therapy incidents find that they are most often caused by flaws in the overall therapy process, from initial consult through final treatment, than by isolated hardware or computer failures detectable by traditional physics QA. This challenge is shared by many intrinsically hazardous industries. Risk assessment tools and analysis techniques have been developed to define, identify, and eliminate known and/or potential failures, problems, or errors, from a system, process and/or service before they reach the customer. These include, but are not limited to, process mapping, failure modes and effects analysis (FMEA), fault tree analysis (FTA), and establishment of a quality management program that best avoids the faults and risks that have been identified in the overall process. These tools can be easily adapted to radiation therapy practices because of their simplicity and effectiveness to provide efficient ways to enhance the safety and quality of treatment processes. Task group 100 (TG100) of AAPM has developed a risk-based quality management program that uses these tools. This session will be devoted to a discussion of these tools and how these tools can be used in a given radiotherapy clinic to develop a risk based QM program. Learning Objectives: Learn how to design a process map for a radiotherapy process. Learn how to perform a FMEA analysis for a given process. Learn what Fault tree analysis is all about. Learn how to design a quality management program based upon the information obtained from process mapping, FMEA and FTA.

60 APPLIED LIFE SCIENCES↗

Advanced Research Projects Agency - Energy Annual Report for FY 2014

This report presents a summary of the activities of the Advanced Research Projects Agency-Energy (ARPA-E) during Fiscal Year 2014 (FY2014). In FY2014, ARPA-E issued funding solicitations and selected projects for three new programs covering a broad array of energy technologies, including: 27 million dollars to develop next-generation power switching devices that improve energy efficiency in a wide range of applications; 30 million dollars for hybrid solar energy beyond current photovoltaic (PV) and concentrated solar power (CSP) technologies; and 33 million dollars for electrochemical technologies to enable low-cost distributed power generation. ARPA-E released three additional funding opportunities in FY2014 with project selections that were ultimately announced in FY2015. These programs include: 30 million dollars for localized heating and cooling devices to expand temperature ranges within buildings reducing energy consumption; 30 million dollars for low-cost, high-sensitivity systems to detect and measure methane emissions; and 30 million dollars for low-cost tools to aid in the future development of fusion power. ARPA-E also continued the use of a rolling open solicitation to quickly support innovative applied energy research that has the potential to lead to new focused programs. In addition to these new programs, ARPA-E hosted the fifth annual Energy Innovation Summit from February 24-26, 2014. The Summit brought together leaders from academia, government, and business to discuss the foremost energy issues, showcase the latest technology innovations, and cultivate relationships to help advance cutting-edge technologies to market. The event drew over 2,100 attendees and featured over 120 speakers and keynote addresses. At the Summit, ARPA-E announced at least 24 ARPA-E project teams that have formed new companies and more than 16 ARPA-E projects, which have partnered with other government agencies for further development. Additionally, 22 ARPA-E projects have attracted more than 625 million dollars in private-sector follow-on funding after ARPA-E’s investment of approximately 95 million dollars. Lastly, ARPA-E continued to focus on providing awardees with practical training and critical business information as part of the Agency’s Technology-to-Market program. This support equips projects with a clear understanding of market needs to guide technical development and help projects succeed the marketplace.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Propel: Tools and Methods for Practical Source Code Model Checking

The work reported here is an overview and snapshot of a project to develop practical model checking tools for in-the-loop verification of NASA s mission-critical, multithreaded programs in Java and C++. Our strategy is to develop and evaluate both a design concept that enables the application of model checking technology to C++ and Java, and a model checking toolset for C++ and Java. The design concept and the associated model checking toolset is called Propel. It builds upon the Java PathFinder (JPF) tool, an explicit state model checker for Java applications developed by the Automated Software Engineering group at NASA Ames Research Center. The design concept that we are developing is Design for Verification (D4V). This is an adaption of existing best design practices that has the desired side-effect of enhancing verifiability by improving modularity and decreasing accidental complexity. D4V, we believe, enhances the applicability of a variety of V&V approaches; we are developing the concept in the context of model checking. The model checking toolset, Propel, is based on extending JPF to handle C++. Our principal tasks in developing the toolset are to build a translator from C++ to Java, productize JPF, and evaluate the toolset in the context of D4V. Through all these tasks we are testing Propel capabilities on customer applications.

Mansouri-Samani, Massoud↗

Methods of Securing Chemical and Pharmaceutical Knowledge and Recommendations for International Institutions to Enhance Research Integrity

Here, this paper examines strategies for securing chemical and pharmaceutical expertise in a globalized research environment, focusing on safeguarding intellectual property and preventing the misuse of sensitive and potentially dual-use information. The product of collective efforts between Pacific Northwest National Laboratory, Carol Davila University of Medicine and Pharmacy, and New Bulgarian University, highlights the challenges and opportunities posed by cross-border research collaborations, particularly in the context of differing regulatory frameworks and research cultures. It explores current mechanisms to prevent data loss and unauthorized access to sensitive information while assessing the effectiveness of existing security measures, frameworks, and international export control regimes. The approach examines the differing methodologies for promoting transparency, trust-building, and mutual accountability in joint research projects to cultivate secure data-sharing practices and intellectual property. It provides recommendations for international institutions to implement security guidelines in framing research priorities, encourages continual training and education programs, and the integration of processes for monitoring research compliance. This partnership aims to advance scientific innovation while maintaining global stability, ensuring compliance with international norms, and safeguarding valuable intellectual property as measures in chemical and pharmaceutical research security practices continue to expand due to international collaboration and knowledge exchange.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Reliability and Integrity Management Scoping Study

The U.S. Nuclear Regulatory Commission (NRC) is developing the regulatory framework and technical expertise to support regulatory review of advanced non-light water reactor (ANLWR) designs. The NRC staff expects most of these designs to use the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (BPVC) Section XI, Division 2 “Requirements for Reliability and Integrity Management (RIM) Programs for Nuclear Power Plants” for developing and implementing pre-service inspection (PSI) and in-service inspection (ISI) programs. The NRC recently endorsed ASME BPVC Section XI, Division 2 (BPV XI-2) in Regulatory Guide (RG) 1.246. This new ASME code is yet to be used in any applications submitted for NRC review. This report provides an overview of the current state of knowledge and practices within the industry for the use of BPV XI-2 for the development and implementation of a PSI and ISI program for non-light water reactors.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Optimizing adiabatic quantum program compilation using a graph-theoretic framework

Adiabatic quantum computing has evolved in recent years from a theoretical field into an immensely practical area, a change partially sparked by D-Wave System’s quantum annealing hardware. These multimillion-dollar quantum annealers offer the potential to solve optimization problems millions of times faster than classical heuristics, prompting researchers at Google, NASA and Lockheed Martin to study how these computers can be applied to complex real-world problems such as NASA rover missions. Unfortunately, compiling (embedding) an optimization problem into the annealing hardware is itself a difficult optimization problem and a major bottleneck currently preventing widespread adoption. Additionally, while finding a single embedding is difficult, no generalized method is known for tuning embeddings to use minimal hardware resources. To address these barriers, we introduce a graph-theoretic framework for developing structured embedding algorithms. Using this framework, we introduce a biclique virtual hardware layer to provide a simplified interface to the physical hardware. Additionally, we exploit bipartite structure in quantum programs using odd cycle transversal (OCT) decompositions. By coupling an OCT-based embedding algorithm with new, generalized reduction methods, we develop a new baseline for embedding a wide range of optimization problems into fault-free D-Wave annealing hardware. Furthermore, to encourage the reuse and extension of these techniques, we provide an implementation of the framework and embedding algorithms.

97 MATHEMATICS AND COMPUTING↗

Integrating Mindfulness with Human Performance in High Complexity Environments - 19498

This paper includes a survey of both scientific and technical literature studies of mindfulness interventions in a variety of industries and populations and proposes potential applications in complex nuclear waste operations. Mindfulness training techniques have been utilized in various forms for decades in high consequence work in both public and private enterprise. The traditional safety nomenclature has simply used different words to describe many of the same concepts that mindfulness practice addresses. Historically, human performance improvement (HPI) has focused on task, mission and error-likely conditions. These safety programs recognize that human behavior is the source of most errors and focus on identification of specific error precursors (mind not on task, incorrect mental picture, etc.). Workers in nuclear and related industries have been trained to recognize these error precursors but have received little training on what to do about them. The techniques of mindfulness align well with HPI programs currently utilized in commercial and government nuclear operations. Indeed, Chapter 5 of the Department of Energy Human Performance Improvement Handbook (DOE-HDBK-1028-2009) includes a discussion of mindfulness with respect to human performance. Mindfulness training supplements current performance improvement efforts by giving workers the tools to not just recognize error-likely conditions within themselves, but also gives them methods to mitigate them. The mindfulness practices presented here focus on self-awareness rather than task-awareness. Workers can apply these techniques in all aspects of their lives which in turn addresses many of the distractions previously identified as error precursors (stress at home or at work, physical discomforts, mind not on task, etc.). The application of mindfulness techniques through integration with established Integrated Safety Management Systems (ISMS) has the potential to improve the safe performance of nuclear waste operations and increase the breadth of organizational safety culture. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Project Planet Earth: A Joint Project Between the NASA/Goddard Space Flight Center and the Girl Scouts of Central Maryland

Scientists of the NASA/GSFC and the staff of the Girl Scouts of Central Maryland (GSCM) have teamed up to introduce more girls and young women to earth system science. The girls now have the opportunity to earn the specially designed Planet Earth Council Patch. The Patch program includes a set of requirements tailored to the specific age level of the girl and the resource material to help the girl complete the requirements. At completion of the requirements the girl is awarded a patch to sew onto the back of her sash or vest. Girls do hands-on physical experiments, practice taking data, visit science centers and perform skits in order to complete the requirements. In addition to the Patch program, Project Planet Earth continues to encourage strong collaboration between the Girl Scouts of Maryland and NASA/GSFC. Girls volunteer at the GSFC visitor center during community events and in turn scientists are called on as keynote speakers and consultants for the Council. A special science interest group is forming for the teenage Girl Scouts of the Council that will network with scientists and help these young women pursue their interests, find internships and make career decisions.

Mattoo, Shana↗

Developing Open-Source Training Materials for AI/ML and Space Biological Sciences Using NASA Cloud-Based Data

Artificial Intelligence (AI) and Machine Learning (ML) has gained significant traction in the biological and biomedical research fields in the last two decades, in part thanks to an increasing culture of open data sharing and reuse. Due to its capability for identifying complex relationships and patterns, AI/ML methodology is particularly well suited to recognize and predict biological patterns from high-dimensional next-generation sequencing data (e.g. whole genome sequencing, transcriptomic sequencing), as well as from biological or medical imaging data (e.g. microscopy, computed tomography, ultrasound, magnetic resonance imaging, radiography). These methodologies hold particular promise for space biosciences research and automated space health monitoring systems. However, there are many key considerations for properly training, validating, and testing a machine learning model in biological research or clinical application. Even with the positive culture of Open Science and data sharing, inexperienced researchers working quickly without proper checks can produce models that perform poorly outside of the immediate training dataset. Lessons learned from biological AI/ML research indicate that Open Science principles such as data sharing and open-source code must go hand-in-hand with publicly available, high-quality training curricula in best practices, with modules centered on real-life scientific use cases and data so future AI/ML practitioners gain experience on real problems. Here we present the development of open-source training materials for AI/ML and space biosciences, as part of the NASA Transform to Open Science Training (TOPST) initiative. We develop 4 independent training programs, focused on the following topics: 1) Fundamentals of Machine Learning and Space Biosciences Domain, 2) Open Science, Artificial Intelligence, and Ethical Best Practices for Data Sharing and Analysis, 3) Using AI/ML Classification to Identify Gene Networks Affected By Space Exposure in Mouse Liver, and 4) Using Neural Networks to Find DNA Damage Patterns in Immune Cells after Radiation. All programs leverage cloud-based NASA biological datasets. The curriculum we present will enable worldwide access to training in AI/ML and scientific analysis.

James Andrew Casaletto↗

Developing Open-Source Training Materials for AI/ML and Space Biological Sciences Using NASA Cloud-Based Data

Artificial Intelligence (AI) and Machine Learning (ML) has gained significant traction in the biological and biomedical research fields, in part due to a culture of open data sharing and reuse. AI/ML methodology is well-suited to recognize and predict biological patterns from high-dimensional next-generation sequencing data (e.g. whole genome sequencing, transcriptomic sequencing), as well as from biological or medical imaging data (e.g. microscopy, computed tomography, ultrasound, magnetic resonance imaging, radiography). These methodologies hold particular promise for space biosciences research and automated space health monitoring systems. However, there are key considerations for properly training, validating, and testing a machine learning model in biological research or clinical application. Inexperienced researchers can produce models that perform poorly outside of the training dataset. Open Science principles such as data sharing and open-source code must go hand-in-hand with publicly available, high-quality training curricula in best practices, with modules centered on real-life scientific use cases and data so future AI/ML practitioners gain experience on real problems. Here we present the development of open-source training materials for AI/ML and space biosciences, as part of the NASA Transform to Open Science Training (TOPST) initiative. We develop 4 independent training programs, focused on the following topics: 1) Fundamentals of Machine Learning and Space Biosciences Domain, 2) Open Science, Artificial Intelligence, and Ethical Best Practices for Data Sharing and Analysis, 3) Using AI/ML Classification to Identify Gene Networks Affected By Space Exposure in Mouse Liver, and 4) Using Neural Networks to Find DNA Damage Patterns in Immune Cells after Radiation. All programs leverage cloud-based NASA biological datasets. The curriculum we present will enable worldwide access to training in AI/ML and scientific analysis.

James Casaletto↗

High Energy Physics Network Requirements Review: Final Report, July 2024–December 2024

The world-class research infrastructure at the US Department of Energy (DOE) Office of Science (SC) provides the research community with premier observational, experimental, computational, and network capabilities. Each user facility is designed to provide unique capabilities to advance the core DOE mission in science and technology for its SC program to stimulate rich scientific discoveries and enhance its innovation ecosystem. Research communities gather and flourish around each user facility, bringing together new and enhanced perspectives. The continual reinvention of the practice of science — as users and staff forge novel approaches expressed in research workflows — unlocks new discoveries and propels scientific progress. Within this research ecosystem, the high-performance computing (HPC) and networking user facilities stewarded by the SC’s Advanced Scientific Computing Research (ASCR) program play a dynamic cross-cutting role, enabling complex workflows demanding high-performance data, networking, and computing solutions. The ASCR facilities enterprise seeks to understand and meet the needs and requirements across SC and DOE domain science programs and priority efforts, highlighted by the formal requirements review methodology. Between July and December 2024, the Energy Sciences Network (ESnet) and the Office of High Energy Physics (HEP) of the DOE-SC organized an ESnet requirements review of HEP-supported program activities. Preparation for these events included identification of key stakeholders: program and facility management, research groups, and technology providers. Each stakeholder group was asked to prepare formal case study documents about its relationship to the HEP program to build a complete understanding of the current, near-term, and long-term status, expectations, and processes that will support the science going forward.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

SU-F-T-226: QA Management for a Large Institution with Multiple Campuses for FMEA

Purpose: To redesign our radiation therapy QA program with the goal to improve quality, efficiency, and consistency among a growing number of campuses at a large institution. Methods: A QA committee was established with at least one physicist representing each of our six campuses (22 linacs). Weekly meetings were scheduled to advise on and update current procedures, to review end-to-end and other test results, and to prepare composite reports for internal and external audits. QA procedures for treatment and imaging equipment were derived from TG Reports 142 and 66, practice guidelines, and feedback from ACR evaluations. The committee focused on reaching a consensus on a single QA program among all campuses using the same type of equipment and reference data. Since the recommendations for tolerances referenced to baseline data were subject to interpretation in some instances, the committee reviewed the characteristics of all machines and quantified any variations before choosing between treatment planning system (i.e. treatment planning system commissioning data that is representative for all machines) or machine-specific values (i.e. commissioning data of the individual machines) as baseline data. Results: The configured QA program will be followed strictly by all campuses. Inventory of available equipment has been compiled, and additional equipment acquisitions for the QA program are made as needed. Dosimetric characteristics are evaluated for all machines using the same methods to ensure consistency of beam data where possible. In most cases, baseline data refer to treatment planning system commissioning data but machine-specific values are used as reference where it is deemed appropriate. Conclusion: With a uniform QA scheme, variations in QA procedures are kept to a minimum. With a centralized database, data collection and analysis are simplified. This program will facilitate uniformity in patient treatments and analysis of large amounts of QA data campus-wide, which will ultimately facilitate FMEA.

43 PARTICLE ACCELERATORS↗

Commercial Building Partnerships Replication and Diffusion

This study presents findings from survey and interview data investigating replication efforts of Commercial Building Partnership (CBP) partners that worked directly with the Pacific Northwest National Laboratory (PNNL). PNNL partnered directly with 12 organizations on new and retrofit construction projects, which represented approximately 28 percent of the entire U.S. Department of Energy (DOE) CBP program. Through a feedback survey mechanism, along with personal interviews, PNNL gathered quantitative and qualitative data relating to replication efforts by each organization. These data were analyzed to provide insight into two primary research areas: 1) CBP partners’ replication efforts of technologies and approaches used in the CBP project to the rest of the organization’s building portfolio (including replication verification), and, 2) the market potential for technology diffusion into the total U.S. commercial building stock, as a direct result of the CBP program. The first area of this research focused specifically on replication efforts underway or planned by each CBP program participant. Factors that impact replication include motivation, organizational structure and objectives firms have for implementation of energy efficient technologies. Comparing these factors between different CBP partners revealed patterns in motivation for constructing energy efficient buildings, along with better insight into market trends for green building practices. The second area of this research develops a diffusion of innovations model to analyze potential broad market impacts of the CBP program on the commercial building industry in the United States.

Commercial Building Partnerships↗

Carving out OPE space and precise O(2) model critical exponents

We develop new tools for isolating CFTs using the numerical bootstrap. A “cutting surface” algorithm for scanning OPE coefficients makes it possible to find islands in high-dimensional spaces. Together with recent progress in large-scale semidefinite programming, this enables bootstrap studies of much larger systems of correlation functions than was previously practical. We apply these methods to correlation functions of charge-0, 1, and 2 scalars in the 3d O(2) model, computing new precise values for scaling dimensions and OPE coefficients in this theory. Our new determinations of scaling dimensions are consistent with and improve upon existing Monte Carlo simulations, sharpening the existing decades-old 8σ discrepancy between theory and experiment.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Analysis of US Industrial Assessment Centers (IACs) implementation

Industrial energy assessments are a fundamental action toward developing a decarbonization strategy at any level. They provide an understanding of where energy efficiency opportunities exist and help to make informed business decisions about the costs and benefits of implementing sustainable policies and practices. This paper examines the effectiveness of the Department of Energy's Industrial Assessment Centers Program at providing useful energy-efficiency audits as well as the barriers faced by the program and plans for future growth and improvement. This paper presents an analysis of the program between 1981 and 2022, covering 20,290 industrial assessments and 151,198 recommendations, with $2.6 billion of recommended savings. The analysis includes a breakdown of the IAC recommendations and implemented projects based on both the industrial subsectors according to the Standard Industrial Classification code, energy type, and systems evaluated. The results include a 47 % implementation rate, a gap analysis to understand the missed opportunities, and a discussion about reasons for recommendation rejection. A comparison of the IAC Program with other country-level energy auditing or assessment programs was conducted, and suggestions for improving implementation rates were mentioned.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗