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NASA NTRSDate not supplied

Harnessing Artificial Intelligence for Medical Diagnosis and Treatment During Space Exploration Missions

From May 8th to June 9th, 2023, I had the opportunity to participate in an experiential learning experience at Johnson Space Center in Houston, TX with Exploration Medical Capability (ExMC), an element of the NASA Human Research Program. During this research experience, I was not only able to work on the above titled research project, but also gain an immense exposure to the field of aerospace medicine, make numerous connections within the field, tour NASA facilities, as well as travel to the Aerospace Medical Association Annual Conference (AsMA) in New Orleans. To briefly introduce my project, it is well understood that the medical capabilities available to crew medical officers (CMOs) on the International Space Station will be different than the capabilities available and needed during deep space exploration missions to the Moon, Mars, and beyond. Ground support is particularly limited due to distance, communication delays (or lack of communication), and lack of resupply. Therefore, to support medical care by CMOs on these missions, robust clinical decision support systems (CDSSs) must be designed. The recent publication and public launch of generative artificial intelligence (AI) tools based upon large language models (LLM) such as ChatGPT provides the opportunity to create a smart assistant for onboard triage, diagnosis, and treatment of medical conditions. Ultimately, the overall purpose of the project was to research what AI tools currently exist or are in development, and to see how they might be implemented onboard during exploration class spaceflights of the future. The ExMC element is actively developing several tools to be used in preparation for and during deep space exploration missions. One of those tools, known as IMPACT, is a probabilistic risk assessment model which can be used to propose a desired medical system (based on mass and volume) and suggest the clinical outcomes likely to occur for a design reference mission (DRM). The group recently presented the IMPACT model and a DRM of interest titled “Modified Long Duration Lunar Orbital and Lunar Surface” (mLDLOLS) at the recent AsMA conference. The mLDLOLS mock mission is a 9 month and 6-day deep space exploration mission consisting of time in Moon’s orbit (3 months on the Gateway space station), on the lunar surface (3 months within habitat), and another 3 months on Gateway before return to Earth. For this DRM, IMPACT ultimately outlined a preferred medical system that was then associated with medical conditions considered to be most likely based on frequency, most likely to cause astronaut task time loss (TTL), most likely to cause return to definitive care (RTDC), and most likely cause loss of crew life (LOCL). IMPACT also highlighted the medical capabilities/skills that would be required to care for those medical conditions, such as performing a history of present illness or musculoskeletal exam with ultrasound. The primary objective of the project was to perform a survey of the AI tools and systems applicable to the conditions outlined for the proposed mLDLOLS mission. Using PubMed (including most relevant MeSH terms) and Google Scholar, we then created a robust annotated bibliography organized by condition. The 56-page and over 500 reference annotated bibliography was subsequently used to create a review outline that would become the basis for drafting of a future publication. For the review outline, we took those medical conditions researched within the annotated bibliography (condition-based approach) and deployed a systems-based approach, combining those medical conditions and related tools into ten categories. These categories included general/all-purpose CDSSs, tools to diagnose or manage respiratory, dermatologic, neurologic, auditory and vestibular, ophthalmic, musculoskeletal, infection-associated, and gynecologic conditions, as well as tools that could be deployed in the setting of trauma/emergency. With the completion of the 30-page outline, we then began drafting the review paper. To conclude the research experience, I presented the findings from our survey to the ExMC Clinical and Science team. With these objectives, I ultimately learned about the number of AI tools that exist today to assist medical professionals with the triage, diagnosis, and management of several medical conditions. These tools can span from chatbot assistants to help triage knee pain to vision transformer models that can identify ophthalmic conditions based on ocular surface images captured with a cell phone. We also highlighted the current gaps that exist in the literature alongside the advancements that are needed to make the desired CDSS for deep space exploration missions. With this experience, I certainly confirmed an existing career goal and identified several additional skills needed to become an aerospace medical doctor including knowledge of critical care in an extreme medicine setting, aerospace engineering and human integration systems, artificial intelligence, machine learning, and risk models. I also identified numerous transferable skills for this career goal including the basic knowledge of medicine (MD), deployment of the scientific method for critical thought about new scientific questions (PhD), review of published literature, including creating an annotated bibliography (PhD), as well as detailed scientific writing (PhD). The results of my research will likely guide the design of an all-encompassing onboard medical assistant for use during deep space exploration missions of the future. I plan on sharing the outcomes from this experience with my peers at a student seminar in the Fall semester on August 30th. During the seminar, I will detail the project, my experience at NASA and AsMA, as well as offer best practice guidelines for students entertaining similar experiences or careers. In conclusion, I would like to thank the WVU School of Medicine, Research and Graduate Education office, as well as NASA ExMC for the unwavering support of this life-changing experience.

Ryan A. Lacinski↗
NASA NTRSDate not supplied

Joint AFOSR/ONR/NASA HTP Boundary Layer Transition Workshop Summary for RAeS

A workshop hosted by three US government entities (the Air Force Office of Scientific Research, the Office of Naval Research, and the National Aeronautics and Space Administration Hypersonic Technology Project) was held in June 2023. This workshop focused on high supersonic and hypersonic boundary layer transition. The purpose of the workshop was to gather subject matter experts in the nation to determine the current state of the art in the field, any gaps or areas that require more studies, and the future of the field. Participants of the workshop were drawn from industry, academia, and government agencies. Prior to the workshop they were provided a questionnaire to spark discussion during the workshop. Roadmaps for six different areas were created as one of the final end products of the workshop.

boundary layer transition↗
NASA NTRSDate not supplied

End-user Assessment of the NASA SPoRT GLM Stoplight Product

National Weather Service (NWS) offices monitor and forecast the threat for lightning within their County Warning Areas for various impact-based decision support services (IDSS). These forecasts are provided routinely for aviation operations, but irregularly for large-scale, outdoor events, which typically have varying safety requirements with regards to lightning. Lightning monitoring and forecasting can require synthesizing a plethora of data, so products that make this process more efficient and effective are sought by the operational community. The NASA Short-term Prediction Research and Transition (SPoRT) Center has begun to develop several products to address these operational challenges during the lifecycle of lightning activity, and conduct evaluations in concentrated (Research-to-Operations/Operations-to-Research) efforts. The product evaluated for this study is the Geostationary Lightning Mapper (GLM) Stoplight product, which addresses lightning safety specifically with regards to lightning recency and cessation. The GLM Stoplight product displays the spatial extent of lightning and uses color-coded pixels to show the recency of lightning in 10-minute increments. This presentation highlights results from an assessment of the GLM Stoplight product by select NWS offices, as well as emergency managers, that took place over a 5-week period from May 1st to June 2nd. Feedback was collected on the GLM Stoplight product and on a new and interactive lightning viewer, which allowed participants to tailor visualization of the product based on their location and desired application. Results will help NASA SPoRT gain a better understanding of how forecasters and emergency managers use lightning data for safety applications. In addition, the assessment will inform research on any necessary modifications to this and future lightning products to assist end users.

Kelley Murphy↗
NASA NTRSDate not supplied

NASA’s Human Landing System: A Sustaining Presence on the Moon

For more than a decade, efforts have been ongoing at NASA’s Marshall Space Flight Center (MSFC) in Huntsville, Alabama, to land humans and cargo on planetary bodies like the Moon and Mars and today this work continues under the Center’s Lander Programs (LP) office. In August of 2019, NASA stood up the Human Landing System (HLS) program to be responsible for spacecrafts that will land astronauts on the Moon under Artemis. Work is well underway with the historic Artemis III mission to land the first Americans on the lunar surface in more than 50 years through the Appendix H Option A [1] contract with SpaceX. In November, NASA awarded SpaceX an Option B modification to its existing HLS Appendix H contract, which will further develop its Starship HLS to meet NASA’s sustaining lander requirements for lunar missions beyond Artemis III. In September of 2022, NASA issued an HLS Sustaining Lunar Development solicitation under the NextSTEP-2 Appendix P Broad Agency Announcement [2] asking a second provider, in addition to SpaceX, to develop and demonstrate a lander that meets the program’s extended set of requirements for missions beyond Artemis III. Under the umbrella of Sustaining Lunar Development [3], these requirements will meet NASA’s needs for recurring, long-term access to the lunar surface. Proposals were received from industry late last year and NASA is planning to award an Appendix P contract in the summer of 2023. This paper will provide an update of the Lander Program office’s progress and will discuss how the program is bridging from the initial demonstration phase of development for the Human Landing System program to the Sustaining Lunar Development phase. The paper will include publicly available information on SpaceX’s Starship HLS design as well as near-term and future milestones for HLS and the Artemis program.

Lisa Watson-Morgan↗
NASA NTRSDate not supplied

Ensuring Safety of Government Personnel During Suborbital Spaceflight

The NASA Suborbital Crew (SubC) office is focused on enabling flights by NASA civil servants, such as scientists and engineers conducting research, on suborbital vehicles. A broader goal is ensuring that commercial human spaceflight is both viable and safe. Within the Commercial Crew Program (CCP), the SubC office is exploring game-changing methods to perform safety assessments to enable NASA personnel to fly on suborbital missions. Commercial suborbital space flight capabilities are anticipated to be more accessible, affordable, and available than missions to the International Space Station and could provide additional opportunities for testing and qualification of space flight hardware, human-tended microgravity research, and further cutting-edge research enabled by the space environment. Although NASA currently supports human tended suborbital payloads for non-civil servants under auspices of NASA’s Flight Opportunities Program, the SubC effort will enable civil servant scientists, researchers, and engineers to accompany their experiments and tests into the space microgravity environment.

Risk Management↗
NASA NTRS2023

Double Asteroid Redirection Test (DART) Mission

NASA’s Double Asteroid Redirection Test (DART) mission was humanity’s first attempt to move a celestial body, demonstrating the capability to perform a kinetic impact on a planetary defense–relevant sized asteroid. DART was part of the international collaboration known as the Asteroid Impact & Deflection Assessment (AIDA), involving NASA, the European Space Agency (ESA), the Agenzia Spaziale Italiana (ASI), and scientists around the world. DART was a key step to demonstrating preparedness to respond to planetary defense scenarios, and it provides a crucial data point for likely outcomes. Near-Earth objects (NEOs) greater than 140 m in size are of particular interest to planetary defense because they have the potential to cause significant damage if they were to impact Earth, and also because they are difficult to detect, with less than 50% of the predicted population discovered as of 2022 (National Academies Press, 2022). With an appropriately sized spacecraft and enough warning (typically many years to decades), a kinetic impact can slightly alter the orbit of an asteroid in a way that, over time, prevents the asteroid from colliding with Earth in the future. DART’s target was Dimorphos, the smaller (~150-m-diameter) member of the binary asteroid system (65803) Didymos, which is a near-Earth, potentially hazardous, and well-characterized asteroid system. By simply observing changes to the system after impact and comparing them with a pre-impact reference, it was possible to use ground-based telescopes to observe the deflection in the orbit of Dimorphos after impact. Developed and operated by the Johns Hopkins University Applied Physics Laboratory (APL), the mission entered formulation in 2015 after multiple years of concept development. The project was administered according to NPR 7120.5, with technical oversight and funding through the Planetary Missions Program Office (PMPO) at Marshall Space Flight Center (MSFC) and overall support as a directed mission from NASA’s Planetary Defense Coordination Office (PDCO). The DART spacecraft hosted a singular payload, the Didymos Reconnaissance and Asteroid Camera for Optical navigation (DRACO), and a deployable CubeSat contributed by ASI named the Light Italian CubeSat for Imaging of Asteroids (LICIACube). On 11 September 2022, DART deployed LICIACube, which subsequently followed the DART spacecraft at a safe distance and observed the immediate aftermath of the DART impact. DART was designed to autonomously detect, navigate to, and impact Dimorphos. This autonomous design was chosen to maximize the probability of impact, since commanding from the ground could result in course corrections arriving too late. On the day of impact, 26 September 2022, the spacecraft’s autonomous systems successfully detected and locked on to Dimorphos, impacting its surface within 2 m of the center of the illuminated figure (Jensenius et al., 2023). No human intervention was required for a successful impact, demonstrating that humanity possesses the technology to perform a kinetic impact. Within 2 weeks of impact, it was clear that the orbit of Dimorphos had been significantly altered. On 11 October 2022, NASA Administrator Bill Nelson announced that the new orbital period of Dimorphos was shortened by approximately 32 ± 2 min, from 11 h and 55 min before impact to 11 h and 23 min after impact. With additional observations over the following months, the accuracy of this measurement improved to a –33.24 min ± 1.4 s orbital period change (Naidu et al., 2023; Scheirich et al., 2023), and Beta (β), the momentum transfer enhancement parameter, was reported to be 3.6 (Cheng et al., 2023). Subsequent studies examined the details of DART’s impact site, modeled the impact event, investigated the ejecta produced, and analyzed the dynamics of the Didymos system. These combined results clearly demonstrate that the project met all Level 1 mission requirements.

asteroid↗
NASA NTRSDate not supplied

Estimating Future Changes of Energy Demand for Heating and Cooling Buildings at NASA Centers GC23J-1198

With its unique and trusted earth observations, NASA is a critical source in informing decisions that will help achieve the U.S. goal of Net-Zero Greenhouse Gas (GHG) Emissions by 2050. NASA’s Prediction of Worldwide Energy Resource (POWER) project facilitates the use of NASA Earth Science data holdings within the energy, agricultural, and building heating/cooling design industries. POWER packages solar and meteorological data from several NASA projects in a user friendly GIS-enabled web services system (https://power.larc.nasa.gov). As part of the development of new data products to support the energy and building heating/cooling design communities, we estimate the changes in energy required to heat and cool buildings in the future climate at 14 different NASA site locations spread throughout the continental United States, as projected by CMIP6 climate models under different emissions scenarios. Bias-corrected downscaled time series of meteorological variables are taken from NASA Earth Exchange (NEX) Global Daily Downscaled Projections (GDDP-CMIP6) downscaled climate model data. The spread between the different model projections is accounted for by analyzing both the ensemble average of 22 CMIP6 models and 6 representative models with different climate sensitivities and different interannual variability. Changes in energy use are estimated in two ways. First, changes in the total annual heating and cooling degree days (HDD and CDD, respectively) are calculated relative to the current climate. This is done at all 14 sites. Second, the downscaled time series are used as inputs into RETScreen(R), a clean energy management decision tool, to give an estimate of heating/cooling energy use for a typical office building. We use this estimation method with model data at Langley Research Center. In the next 50 years, the annual total of HDD (CDD) is projected to decrease by 8-38% (increase by 5-28%) at all sites, with the increase in CDD typically a larger magnitude the decrease in HDD. For a typical small office building at Langley Research Center, the amount of energy needed to cool increases by 33-54% and the amount of energy to heat decreases by 29-40%. POWER is working to develop long term climate data services based on these results to include in future data products to provide to users.

Bradley M. Hegyi↗
NASA NTRS2024

Autonomy to Enable NASA Missions from Aeronautics to Space

2024 ASCEND Call for Sessions Session Format: Panel Session Topic: Space Exploration and Infrastructure: Exploring, Living, and Working in Space (The panel must map to one of six Session Topics - https://www.ascend.events/presenters/call-for-sessions/#sessiontopics) Title: Autonomy to Enable NASA Missions from Aeronautics to Space Short Session Description: In this panel discussion the National Aeronautics and Space Administration (NASA) will discuss the role that autonomy and Artificial Intelligence (AI) will play as humanity moves off-world. Recent advances in general autonomy tools are changing the way NASA and its partners leverage autonomy for its air and space initiatives, including Advanced Air Mobility (AAM) concepts and potential lunar and Martian operations. The panelists will consist of autonomy subject matter experts familiar with the current state of the art for autonomy across both aeronautical and space domains. They will discuss how those technologies could evolve as operations become more complex and which autonomy technologies can be used in both the space and aeronautical domains. For example, perhaps autonomy work originally developed for terrestrial applications, like Advanced Air Mobility (AAM), could be applied to off-world lunar and Martian applications and vice versa. Additionally, the panel will address common misconceptions of these technologies, obstacles to implementation, and possible solutions for overcoming those obstacles. Join NASA in exploring how research activities can align to streamline autonomy development efforts, advancing NASA's goals to expand humanity's reach beyond Earth for the benefit of all. Contact Information: • Dr. Adam Yingling • Office of Technology, Policy, and Strategy (OTPS) • Adam.j.yingling@nasa.gov, 703-416-9129 Session Length: 1.25 hours, 75 minutes Extended Description: Moderator: Dr. Adam Yingling, NASA, Office of Technology, Policy, and Strategy Panel Speakers: • Autonomy Forum Principals o Dr. Charles Norton, Deputy Chief Technologist, Jet Propulsion Laboratory (JPL) o Dr. Carolyn Mercer, Chief Technologist, Space Mission Directorate (SMD) o Dr. Parimal Kopardekar (PK), Advanced Air Mobility (AAM) Integration Manager o Danette Alan, NASA, Senior Leader for Autonomous Systems, Space Technology Mission Directorate (STMD) o Duane Armstrong, Intelligent Systems Lead, Autonomous Systems Laboratory (ASL) Panel Format: • Introduction (10 min): The panel moderator will provide a 10-minute session introduction that will include an overview NASA’s Moon to Mars architecture, AAM autonomy research, and an introduction of the principals as panel speakers. • Moderated Session Part 1 (30 min): There will be a 30-minute moderated session among the moderator and the five autonomy principals to discuss the current state of art for autonomy and how work developed in one domain may be applicable to other domains; including the merits and challenges for implementing those technologies. • Moderated Session Part 2 (25 min): The moderator will then ask the principals to consider how technologies developed across all the domains might be able to address the most salient challenges identified in the previous session. • Q&A (10 min): The session will conclude with 10-minutes of audience Q&A. Session Goals and Outcomes: The session goals are 1) to communicate the importance of autonomy for both aeronautical and space mission, 2) Investigate potential synergies across autonomy research efforts that will enable scalable operations, and 3) to receive community feedback as NASA leverages autonomy to evolve aviation on Earth and enable humanity to live and work off-world.

Aerospace↗
NASA NTRSDate not supplied

End-User Assessment of the NASA SPoRT Lightning AI Product

The NASA Short-term Prediction Research and Transition (SPoRT) Center has begun to develop products to address operational challenges and enhance safety during the lifecycle of lightning activity, and conduct evaluations in concentrated R2O/O2R efforts. The product evaluated for this study is Lightning Artificial Intelligence (A.I.), which predicts the probability of lightning out to 15 minutes in advance and spatially maps it using filled color contours. Lightning A.I. uses reflectivity, differential reflectivity, and correlation coefficient data from a subset of radars within the NEXRAD network to generate lightning probabilities at approximately 2 km resolution. The domains, spanning 145 x 145 km are centered over NASA-affiliated centers across the CONUS and use radar data which are closest in proximity. Lightning A.I. was developed with intended use by emergency managers at NASA centers. However, National Weather Service (NWS) offices are also often tasked with monitoring and forecasting the threat for lightning within their County Warning Areas for various impact-based decision support services. These forecasts are typically provided for aviation operations and large-scale, outdoor events, which may have varying safety requirements for decision-making based on lightning proximity and recency. The NASA SPoRT center conducted an assessment of the operational uses of Lightning A.I by various collaborative NWS Offices from late July into early September. This assessment included feedback from participants on both the product itself as well as its accessibility within the new, interactive NASA SPoRT Lightning Viewer. This presentation will include background information about Lightning A.I. and highlight results from this assessment. The feedback from the assessment will be used to inform research on any necessary modifications to this and future lightning products to assist end users.

Kelley Murphy↗
NASA NTRSDate not supplied

NASA’s Developments in Cryogenic Fluid Management Technology

NASA has been pursuing the development and demonstration of enabling and enhancing technologies for Cryogenic Fluid Management (CFM) in collaboration with the US industry. NASA’s vision for current and future space exploration requires high-performance chemical and nuclear propulsion solutions that utilize cryogens. The Agency will use cryogenic fluids for Earth-to-orbit transportation, human missions to the Moon and Mars, planetary exploration, and in-situ resource utilization (ISRU) production. All these architectures will require state-of-the-art long-duration storage on the surface and in-space transfer for refueling. This paper focuses on key CFM technology developments completed or ongoing by the Cryogenic Fluid Management Portfolio Office within NASA’s Space Technology Mission Directorate. The CFM Portfolio Office, partnered with US aerospace industry, has invested in CFM technology ground and flight demonstrations, focused on maturing CFM hardware and operations for Artemis and Moon to Mars activities. These demonstrations additionally provide NASA with data to inform numerical modeling activities for verification and validation of design tools and approaches for future missions. This paper includes discussion on remaining high-priority open CFM technology gaps for Mar-forward architectures and initiatives for closure.

Cryogenic Fluid Management↗
NASA NTRS2024

ISS Technology Demonstrations for Future Spaceflight Medical Systems

Throughout the history of human spaceflight, crewmembers have experienced various in-flight medical conditions including illness and injury. Planned missions to the Moon and Mars will require capabilities to maintain the health of future space travelers. Mass, power, and volume available in the vehicles and habitats for these missions will be severely constrained; resupply of resources will be limited or non-existent, as will opportunities for evacuation to Earth. Furthermore, ground-based support will be hampered by communication latencies and blackouts. These vehicle and mission constraints will necessitate a medical system that has been efficiently planned, providing on-board procedural guidance in addition to a variety of medical devices and consumable resources. Medical capabilities required for the diagnosis and treatment of potential medical conditions during future spaceflight missions may include real-time health monitoring, medical imaging, and biomarker analyses ( e.g., blood or urine). Terrestrial medicine shares these needs, thus many of these medical capabilities could likely be satisfied by Commercial-Off-The-Shelf (COTS) devices and methodologies; however, in some cases the unique space environment and increased mission duration will drive the need to modify technologies and the way care is provided. NASA’s Human Research Program (HRP) Exploration Medical Capability (ExMC) Element and Mars Campaign Office’s Exploration Medical Integrated Product Team (XMIPT) are working together to decrease medical risk during exploration missions. Flight-tested medical diagnostic and treatment technologies are necessary to effectively manage medical conditions relevant to exploration missions while meeting vehicle constraints, integrating with medical decision-support tools, and enabling increasingly Earth-independent operations. Several projects have leveraged the ISS as a testbed for exploration, including 1) i n- situ blood analysis, 2) medical inventory, 3) intravenous fluid generation, and 4) autonomous medical procedure guidance. Management of several in-flight medical conditions, such as bacterial and viral infections and acute radiation syndrome, is dramatically improved with ability to assess blood cell populations, electrolytes, and metabolites. I n December 2020 and January 2021 ExMC performed an ISS technology demonstration (Tech Demo) of the HemoCue® WBC DIFF analyzer (HemoCue, Brea, CA), a COTS device that was modified to enable functionality in a spaceflight environment. This Tech Demo marked the first time that hematology measurements were successfully performed real-time in microgravity. Also modified and demonstrated was the reusable Handheld Electrolytes and Lab Technology for Humans (rHEALTH) ONE analyzer (rHEALTH, Bedford, MA), which uses flow cytometry and sheath-based hydrodynamic focusing methodologies. The rHEALTH ONE ISS Tech Demo in May 2022 demonstrated test results obtained in-flight matched those on the ground. NASA currently relies on crew self-reporting to manage and maintain medical inventory on ISS.The ability to maintain an accurate inventory becomes more critical during long duration missions since the crew will need to be increasingly autonomous in finding and utilizing medical items, including those scenarios when alternative treatments need to be considered due to limited or no resupply. HRP’s Medical Consumables Tracking (MCT) project was developed by ZIN Technologies, Inc. (Cleveland, OH), and demonstrated real-time tracking of medical supplies aboard the ISS between December 2016 and July 2018. The MCT system design utilized Radio Frequency Identification Device (RFID) technology to perform automated inventory and was installed in the Crew Health Care System (CHeCS) Resupply Stowage Rack (RSR). The challenge of limited shelf life, exacerbated by the lack of resupply opportunities, affects a plethora of medical system components including consumables, pharmaceuticals, and intravenous (IV) fluid. In 2010, ExMC funded ZIN Technologies, Inc. (Cleveland, OH), to develop the Intravenous Fluid Generation (IVGEN) system. IV fluids were successfully generated with IVGEN using the potable water supply on ISS during ISS Expedition 23. The XMIPT is in the process of developing a miniaturized version of the original IVGEN hardware for a future Tech Demo aboard the ISS. Current ISS medical operations rely heavily on preflight training and real-time remote guidance, both of which become impractical or impossible for exploration missions. The primary goal of the Autonomous Medical Officer Support (AMOS) Software Tech Demos on ISS was to confirm telemedical proof-of-concept for autonomous medical imaging in an operational setting. This novel software tool shifts emphasis from preflight training and real-time remote guidance to in-flight just-in-time instruction, a new and necessary paradigm for crew medical autonomy. AMOS introduces a novel, streamlined skill management concept for exploration missions featuring comprehensive training and guidance modules for ultrasound examinations using the ISS Ultrasound 2 (a modified GE Vivid-q™; General Electric HealthCare, Chicago, IL). With no prior crew training or remote guidance, two Tech Demos on the ISS (April 2020 and June 2022) resulted in high quality, clinically useful image sets. We will provide a review of historical, current, and planned medical devices and technologies considered for inclusion within future spaceflight medical systems and summarize hardware development activities and medical device tech demos conducted on the ISS.

Astronaut health and performance↗
NASA NTRSDate not supplied

The Plankton, Aerosol, Cloud, Ocean Ecosystem (Pace) Mission Overview: From Concept to Launch

Abstract for Technical Review: The Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission is a strategic climate continuity mission that was defined in the 2010 document Responding to the Challenge of Climate and Environmental Change: NASA’s Plan for Climate-Centric Architecture for Earth Observations and Applications from Space (referred to as the “Climate Initiative”). Launched in February 2024, the PACE mission represents NASA’s next investment in ocean biology, clouds, and aerosol data records. PACE will extend the high quality ocean ecological, ocean biogeochemical, cloud, and aerosol particle data records begun by NASA in the 1990s, building on the exceptional heritages of the Sea-Viewing Wide Field-of-View Sensor (SeaWiFS), the Moderate Resolution Imaging Spectroradiometer (MODIS), the Multi-angle Imaging SpectroRadiometer (MISR), and the Visible Infrared Imaging Radiometer Suite (VIIRS). NASA Headquarters directed the mission development and implementation to the NASA Goddard Space Flight Center (GSFC) with guidance to utilize a Design-to-Cost (DTC) process. Mission studies were conducted to define appropriate approaches within and across elements while maximizing science capabilities at a high cost confidence. Mission baseline requirements development is also embedded within the DTC process, as these requirements were not established at the onset of the mission concept development. The PACE project office at NASA’s GSFC was responsible for the satellite development, launch and commissioning. The NASA Headquarters PACE Program Science office is responsible for supporting the science data processing system and assembling competed community science teams, which includes field-based vicarious calibration and data product validation efforts to support the PACE Project Science team. The PACE observatory is comprised of three instruments, the Ocean Color Instrument (OCI) and two polarimeters, the Hyper-Angular Rainbow Polarimeter 2 (HARP2) and the Spectro-Polarimeter for Exploration (SPEXone) and the PACE spacecraft. The observatory has been commissioned and is performing on-orbit science data collection operations. Summary for Program: The Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission is a strategic climate continuity mission that was defined in the 2010 document Responding to the Challenge of Climate and Environmental Change: NASA’s Plan for Climate-Centric Architecture for Earth Observations and Applications from Space (referred to as the “Climate Initiative”). Launched in February 2024 under the leadership of the NASA Goddard Space Flight Center (GSFC), the PACE mission represents NASA’s next investment in ocean biology, clouds, and aerosol data records. PACE will extend the high quality ocean ecological, ocean biogeochemical, cloud, and aerosol particle data records begun by NASA in the 1990s. The PACE observatory is comprised of the Ocean Color Instrument (OCI), the Hyper-Angular Rainbow Polarimeter 2 (HARP2) and the Spectro-Polarimeter for Exploration (SPEXone), along with the PACE spacecraft.

Robert H Estep, Jr↗
NASA NTRS2024

A Summary of the 2023 Joint High-Speed Boundary Layer Transition Workshop

A joint workshop between the Air Force Office of Scientific Research, the Office of Naval Research, and the NASA Hypersonic Technology Project was held in June 2023 on the topic of high-speed boundary-layer transition. The purpose of this workshop was to gather subject matter experts in the areas of supersonic and hypersonic boundary-layer transition in the areas of geometries of interest, computational methods, facilities and diagnostics, flight experiments, flow control, and new approaches and to discuss the current state of the art in the field. As gaps and accomplishments were identified, roadmaps were also created to guide future investments in these areas. The top recommendations are (1) to define relevant common geometries of interest that can be worked by multiple research groups; (2) improve modeling of high-enthalpy flows involving chemistry and ablation, studies of receptivity of freestream disturbances and atmospheric particulates into the boundary layer, surface feature characterization and modeling of changes to geometry; (3) design and determine viable flow control methods; and (4) move towards incorporating boundary layer transition prediction into a standard practice for design of high-speed vehicles. To execute this last recommendation successfully, investments beyond fundamental (basic and early applied) research are needed.

boundary layer transition↗
NASA NTRS2024

Independent Scientific Review of Biological Assumptions and Planned Ultraviolet Treatment for Mars Sample Return Backward Planetary Protection

The Backward Planetary Protection Study Team (“the Study Team”), assembled by the Office of the Chief Scientist (OCS) at the request of the Office of Planetary Protection (OPP), has conducted numerous detailed discussions on the potential use of an active ultraviolet (UV) approach for minimizing or eliminating biological contamination of the exterior of the planned Orbiting Sample container (OS) of the Mars Sample Return (MSR) mission. This review of the backward planetary protection (BPP) considerations for the MSR mission focused on two key parameters that are opportunities for further process development to support implementation of planetary protection practices in meeting mission requirements. These parameters include: 1) Sub-cellular biological assumptions – should Mars missions consider self-replicating organisms only or do they need to consider non-self-replicating entities without a cellular organization such as viruses, prions, etc. and macromolecules capable of genetic information transfer, as well? 2) UV biocidal impact – what is the UV fluence in the Mars atmosphere and its associated potential biocidal credit? The assembled subject matter experts (SMEs) in the Study Team are listed in Appendix A, with a brief description of each member’s relevant expertise.

Mamta Patel Nagaraja↗
NASA NTRSDate not supplied

Mission Overview and Status from Concept to Launch

The Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission is a strategic climate continuity mission that was defined in the 2010 document Responding to the Challenge of Climate and Environmental Change: NASA’s Plan for Climate-Centric Architecture for Earth Observations and Applications from Space (referred to as the “Climate Initiative”). Launched in February 2024, the PACE mission represents NASA’s next investment in ocean biology, clouds, and aerosol data records. PACE will extend the high quality ocean ecological, ocean biogeochemical, cloud, and aerosol particle data records begun by NASA in the 1990s, building on the exceptional heritages of the Sea-Viewing Wide Field-of-View Sensor (SeaWiFS), the Moderate Resolution Imaging Spectroradiometer (MODIS), the Multi-angle Imaging SpectroRadiometer (MISR), and the Visible Infrared Imaging Radiometer Suite (VIIRS). NASA Headquarters directed the mission development and implementation to the NASA Goddard Space Flight Center (GSFC) with guidance to utilize a Design-to-Cost (DTC) process. Mission studies were conducted to define appropriate approaches within and across elements while maximizing science capabilities at a high cost confidence. Mission baseline requirements development is also embedded within the DTC process, as these requirements were not established at the onset of the mission concept development. The PACE project office at NASA’s GSFC was responsible for the satellite development, launch and commissioning. The NASA Headquarters PACE Program Science office is responsible for supporting the science data processing system and assembling competed community science teams, which includes field-based vicarious calibration and data product validation efforts to support the PACE Project Science team. The PACE observatory is comprised of three instruments, the Ocean Color Instrument (OCI) and two polarimeters, the Hyper-Angular Rainbow Polarimeter 2 (HARP2) and the Spectro-Polarimeter for Exploration (SPEXone) and the PACE spacecraft. The observatory has been commissioned and is performing on-orbit science data collection operations. Summary for Program: The Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission is a strategic climate continuity mission that was defined in the 2010 document Responding to the Challenge of Climate and Environmental Change: NASA’s Plan for Climate-Centric Architecture for Earth Observations and Applications from Space (referred to as the “Climate Initiative”). Launched in February 2024 under the leadership of the NASA Goddard Space Flight Center (GSFC), the PACE mission represents NASA’s next investment in ocean biology, clouds, and aerosol data records. PACE will extend the high quality ocean ecological, ocean biogeochemical, cloud, and aerosol particle data records begun by NASA in the 1990s. The PACE observatory is comprised of the Ocean Color Instrument (OCI), the Hyper-Angular Rainbow Polarimeter 2 (HARP2) and the Spectro-Polarimeter for Exploration (SPEXone), along with the PACE spacecraft.

Robby Estep↗
NASA NTRS2024

NASA's Human Research Program: Evolving Collaborations to Enable the Future of Human Spaceflight

Since its formation in 2007, the NASA Human Research Program’s (HRP) mission has been to protect the health and performance of astronauts as they explore beyond low Earth orbit. The HRP helps enable exploration spaceflight through a focused program of research that leads to the development and delivery of solutions to protect human health and performance during and after these missions. This research is conducted primarily in ground analogs of the spaceflight environment and on the International Space Station (ISS). Over the last 3 years, NASA has undergone transformative changes with the flight of Artemis I, the formation of the Commercial Low Earth Orbit Destinations Program, commercial flights to the ISS, and collaboration with new international partners participating in human spaceflight. The HRP has embraced these new opportunities and is collaborating on all these fronts to collect biomedical research data. Artemis I marked the arrival of NASA’s new human spaceflight exploration missions. NASA established the Moon to Mars Program Office to design a roadmap for the exploration of the lunar surface and the journey beyond to Mars. The HRP has a critical role in conducting research and delivering technologies that will lead to solutions that protect human health and performance, and is working closely with the Moon to Mars Office to ensure these deliverables are ready in time to support their strategy. The HRP is also developing the partnership strategies required to support these deliverables. Commercial space flights, both free flyer and suborbital missions and private astronaut missions to the ISS, are providing broader opportunities and more subjects to characterize spaceflight-induced changes to the human system and to test countermeasures. To better use these opportunities to achieve its mission, the HRP has been working to understand the commercial spaceflight companies’ needs and then partnering with them on aspects of mutual interest. In addition, the HRP continues to engage in long-standing relationships with its international partners through the International Space Life Sciences Working Group and other joint international groups. The HRP is interested in sharing its knowledge and collaborating on projects of mutual interest with new countries that are developing capabilities for human spaceflight. The next 10 years will shape how humanity partners on exploration missions to Mars, and the HRP is committed to enabling and developing collaborative strategies with commercial and international partners to keep humans safe and productive as they explore longer and further into space.

Human research↗
NASA NTRS2006

Nuclear Thermal Propulsion Requirements Analysis of the ESAS Reference Human Mars Mission Architecture

The Nuclear Thermal Propulsion Mission and System Analysis (NTP MSA) Phase 2 Study was initiated by Marshall Space Flight Center’s (MSFC) Advanced Concepts Office (VP11) in December, 2005 in support of MSFC’s Nuclear Systems Office (VP31) NTP for Exploration Study. The Mission and Systems Analysis Study was task # 6 of a set of 14 tasks within the NTP for Exploration Study. The primary goal of the NTP MSA Phase 2 Study was to identify the range of potential NTP engine and vehicle requirements for NASA Exploration Systems Mission Directorate (ESMD) Mars human exploration reference mission.

mars↗
NASA NTRSDate not supplied

Transformation of the NASA Life Sciences Portal to a FAIR Data Point

The FAIR principles emphasize optimizing metadata, the vast majority of which are textual in nature, and often organized into attribute name-value pairs. This uniformity has led to the development of guidelines and best practices for providing programmatic access to scientific data through their metadata, yielding the first iteration of the FAIR Data Point Specifications (FDPS). A key feature of the FDPS is its support for automated agents seeking and fetching data without first needing to learn a plethora of different application programming interfaces. These software agents can interrogate metadata catalogs that adhere to FDPS in a uniform manner because each catalog describes itself and its metadata schema consistently. This approach enhances the sustainability of data retrieval support, allowing systems to refine and update their metadata schemas as needed and without requiring data-seeking software agents to change how they interrogate FDPS catalogs. An essential aspect of the FDPS is the standardization of data catalog semantics, which formalizes concepts such as “metadata” and “metadata service” and links them to other concepts specifications including the Data Catalog Vocabulary (DCAT), a W3C standard that is also the basis of NASA-STD-2831 “Metadata Standard for Data Discoverability,” authored by NASA’s Office of the Chief Information Officer. The FDPS references DCAT (version 2) elements which focus on the distribution of datasets and support the goal of stream-lined catalog integration across repositories for improved data discovery. Additionally, the FDPS also prescribe the use of Linked Data Platform elements for data catalog-metadata record containment descriptions, allowing users to ascertain which data and metadata belong to which catalogs. NASA’s Life Sciences Portal is implementing the FDPS while formalizing its metadata schema to support the accelerated synthesis of knowledge from space life sciences investigations.

platform↗