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At least 1,009 records · Page 56

Epigenetics Research on the International Space Station

The International Space Station (ISS) is a state-of-the orbiting laboratory focused on advancing science and technology research. Experiments being conducted on the ISS include investigations in the emerging field of Epigenetics. Epigenetics refers to stably heritable changes in gene expression or cellular phenotype (the transcriptional potential of a cell) resulting from changes in a chromosome without alterations to the underlying DNA nucleotide sequence (the genetic code), which are caused by external or environmental factors, such as spaceflight microgravity. Molecular mechanisms associated with epigenetic alterations regulating gene expression patterns include covalent chemical modifications of DNA (e.g., methylation) or histone proteins (e.g., acetylation, phorphorylation, or ubiquitination). For example, Epigenetics ("Epigenetics in Spaceflown C. elegans") is a recent JAXA investigation examining whether adaptations to microgravity transmit from one cell generation to another without changing the basic DNA of the organism. Mouse Epigenetics ("Transcriptome Analysis and Germ-Cell Development Analysis of Mice in Space") investigates molecular alterations in organ-specific gene expression patterns and epigenetic modifications, and analyzes murine germ cell development during long term spaceflight, as well as assessing changes in offspring DNA. NASA's first foray into human Omics research, the Twins Study ("Differential effects of homozygous twin astronauts associated with differences in exposure to spaceflight factors"), includes investigations evaluating differential epigenetic effects via comprehensive whole genome analysis, the landscape of DNA and RNA methylation, and biomolecular changes by means of longitudinal integrated multi-omics research. And the inaugural Genes in Space student challenge experiment (Genes in Space-1) is aimed at understanding how epigenetics plays a role in immune system dysregulation by assaying DNA methylation in immune cells directly in space using miniPCR technology. In addition, NASA's geneLAB campaign covers the epigenome as part of the "expressome", by employing an innovative open source science platform for multi-investigator high throughput utilization of the ISS. Earth benefits of Epigenetics research onboard the ISS range from contributions to the fundamental understanding of epigenetic phenomena with applications in countermeasure development for biomedical conditions, to the generation of integrated strategies for personalized medicine based on unique physiological responses.

Love, John↗

ASI's space automation and robotics programs: The second step

The strategic decisions taken by ASI in the last few years in building up the overall A&R program, represent the technological drivers for other applications (i.e., internal automation of the Columbus Orbital Facility in the ESA Manned Space program, applications to mobile robots both in space and non-space environments, etc...). In this context, the main area of application now emerging is the scientific missions domain. Due to the broad range of applications of the developed technologies, both in the in-orbit servicing and maintenance of space structures and scientific missions, ASI foresaw the need to have a common technological development path, mainly focusing on: (1) control; (2) manipulation; (3) on-board computing; (4) sensors; and (5) teleoperation. Before entering into new applications in the scientific missions field, a brief overview of the status of the SPIDER related projects is given, underlining also the possible new applications for the LEO/GEO space structures.

Dipippo, Simonetta↗

Cyrogenic Life Support Technology Development Project

KSC has used cryogenic life support (liquid air based) technology successfully for many years to support spaceflight operations. This technology has many benefits unique to cryogenics when compared to traditional compressed gas systems: passive cooling, lighter, longer duration, and lower operating pressure. However, there are also several limiting factors that have prevented the technology from being commercialized. The National Institute of Occupational Safety and Health, Office of Mine Safety and Health Research (NIOSH-OMSHR) has partnered with NASA to develop a complete liquid air based life support solution for emergency mine escape and rescue. The project will develop and demonstrate various prototype devices and incorporate new technological innovations that have to date prevented commercialization.

compressed gas systems: passive cooling↗

NASA Ames Arc Jets and Range, Capabilities for Planetary Entry

NASA is pursuing innovative technologies and concepts as part of America's Vision for Space Exploration. The rapidly emerging field of nanotechnology has led to new concepts for multipurpose shields to prevent catastrophic loss of vehicles and crew against the triple threats of aeroheating during atmospheric entry, radiation (Solar and galactic cosmic rays) and Micrometorid/Orbital Debris (MMOD) strikes. One proposed concept is the Thermal Radiation Impact Protection System (TRIPS) using carbon nanotubes, hydrogenated carbon nanotubes, and ceramic coatings as a multi-use TPS. The Thermophysics Facilities Branch of the Space Technology Division at NASA Ames Research Center provides testing services for the development and validation of the present and future concepts being developed by NASA and national and International research firms. The Branch operates two key facilities - the Range Complex and the Arc Jets. The Ranges include both the Ames Vertical Gun Range (AVGR) and the Hypervelocity Free Flight (HFF) gas guns best suited for MMOD investigations. Test coupons can be installed in the AVGR or HFF and subjected to particle impacts from glass or metal particles from micron to _ inch (6.35-mm) diameters and at velocities from 5 to 8 kilometers per second. The facility can record high-speed data on film and provide damage assessment for analysis by the Principle Investigator or Ames personnel. Damaged articles can be installed in the Arc Jet facility for further testing to quantify the effects of damage on the heat shield s performance upon entry into atmospheric environments.

Fretter, Ernest F.↗

The Emergence and Impact of Intelligent Machines

The following issues are addressed in this essay: a) Models of Technology Trends: A discussion of why nanotechnology and related advanced technologies are inevitable. The underlying technologies are deeply integrated into our society and are advancing on many diverse fronts; and b) The Economic Imperatives of the Law of Accelerating Returns: The exponential advance of technology, including the accelerating miniaturization of technology, is driven by economic imperative, and, in turn, has a pervasive impact on the economy.

Kurzweil, Raymond↗

Emerging Needs for Pervasive Passive Wireless Sensor Networks on Aerospace Vehicles

NASA is investigating passive wireless sensor technology to reduce instrumentation mass and volume in ground testing, air flight, and space exploration applications. Vehicle health monitoring systems (VHMS) are desired on all aerospace programs to ensure the safety of the crew and the vehicles. Pervasive passive wireless sensor networks facilitate VHMS on aerospace vehicles. Future wireless sensor networks on board aerospace vehicles will be heterogeneous and will require active and passive network systems. Since much has been published on active wireless sensor networks, this work will focus on the need for passive wireless sensor networks on aerospace vehicles. Several passive wireless technologies such as microelectromechanical systems MEMS, SAW, backscatter, and chipless RFID techniques, have all shown potential to meet the pervasive sensing needs for aerospace VHMS applications. A SAW VHMS application will be presented. In addition, application areas including ground testing, hypersonic aircraft and spacecraft will be explored along with some of the harsh environments found in aerospace applications.

Wilson, William C.↗

A Summary and Analysis of NASA's Strategic Astrophysics Technology PCOS/COR Investments Since Program Inception

The NASA Strategic Astrophysics Technology (SAT) Program was established in 2009 as a new technology maturation program to fill the gap in the Technology Readiness Level (TRL) range from 3 to 6. Since the inception of the program, 47 tasks have been awarded under the auspices of the NASA Physics of the Cosmos (PCOS) Program in the areas of optics and detectors as well as lasers, electronics, and micro-thruster subsystems. In addition, 31 tasks have been awarded under the auspices of the NASA Cosmic Origins (COR) Program to develop optics, coatings, cooling subsystems, and detectors from the Far-IR to the Far-UV. We present the PCOS/COR portfolio distribution in terms of specific technology areas addressed and show an analysis of the rate and cost of TRL advancements. We present highlights of the infusion success stories that have emerged from the SAT maturation program as it relates to enabling future NASA astrophysics strategic missions. Finally, we present an outlook for future technology priorities for investment by the SAT Program.

COR↗

You can't eat moon rocks

The effects produced by the aerospace program are investigated. The technology developed from aerospace-related research, development, and manufacturing has been made available to the public for its use through the NASA Technology Utilization Program. A description is presented of 'spinoffs' of NASA's aerospace programs which are used on a daily basis by the public. Attention is given to the liquid cooled garment technology, meal systems for the elderly, the zinc-rich coating, the emergency blanket, the flexible urethane foam Temper Foam, the 'Fog-Away Coating', and composite graphite equipment.

Kubokawa, C. C.↗

Strategic plan, 1985

The Lewis Strategic Plan was updated for 1985 and beyond. Major programs for the space station, the advanced turboprop, the Advanced Communications Technology Satellite (ACTS), and the Altitude Wind Tunnel were begun or greatly expanded during 1984. In parallel, The Lewis aeropropulsion research and technology program was extensively evaluated and reviewed; a reduced and reoriented program emerged. The thrusts and implementation plans for these programs are described as they pertain to the individual directorates. Other key accomplishments and plans are summarized.

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Aviation technology applicable to developing regions

This paper is an analysis of aviation technologies useful for formulation of development plans to the year 2000 for emerging nations. The Caribbean Basin was used as a specific application. This development promises to be so explosive over the next 15 years as to be virtually unpredictable.

Zuk, John↗

Silicon carbide, a semiconductor for space power electronics

After many years of promise as a high temperature semiconductor, silicon carbide (SiC) is finally emerging as a useful electronic material. Recent significant progress that has led to this emergence has been in the areas of crystal growth and device fabrication technology. High quality single-crystal SiC wafers, up to 25 mm in diameter, can now be produced routinely from boules grown by a high temperature (2700 K) sublimation process. Device fabrication processes, including chemical vapor deposition (CVD), in situ doping during CVD, reactive ion etching, oxidation, metallization, etc. have been used to fabricate p-n junction diodes and MOSFETs. The diode was operated to 870 K and the MOSFET to 770 K.

Powell, J. Anthony↗

Thermal protection systems manned spacecraft flight experience

Since the first U.S. manned entry, Mercury (May 5, 1961), seventy-five manned entries have been made resulting in significant progress in the understanding and development of Thermal Protection Systems (TPS) for manned rated spacecraft. The TPS materials and systems installed on these spacecraft are compared. The first three vehicles (Mercury, Gemini, Apollo) used ablative (single-use) systems while the Space Shuttle Orbiter TPS is a multimission system. A TPS figure of merit, unit weight lb/sq ft, illustrates the advances in TPS material performance from Mercury (10.2 lb/sq ft) to the Space Shuttle (1.7 lb/sq ft). Significant advances have been made in the design, fabrication, and certification of TPS on manned entry vehicles (Mercury through Shuttle Orbiter). Shuttle experience has identified some key design and operational issues. State-of-the-art ceramic insulation materials developed in the 1970's for the Space Shuttle Orbiter have been used in the initial designs of aerobrakes. This TPS material experience has identified the need to develop a technology base from which a new class of higher temperature materials will emerge for advanced space transportation vehicles.

Curry, Donald M.↗

Silicon carbide, a semiconductor for space power electronics

After many years of promise as a high temperature semiconductor, silicon carbide (SiC) is finally emerging as a useful electronic material. Recent significant progress that has led to this emergence has been in the area of crystal growth and device fabrication technology. High quality of single-crystal SiC wafers, up to 25 mm in diameter, can now be produced routinely from boules grown by a high temperature (2700 K) sublimation process. Device fabrication processes, including chemical vapor deposition (CVD), in situ doping during CVD, reactive ion etching, oxidation, metallization, etc. have been used to fabricate p-n junction diodes and MOSFETs. The diode was operated to 870 K and the MOSFET to 770 K.

Powell, J. A.↗

Managing the space sciences

In April 1994 the National Research Council received a request from NASA that the NRC's Space Studies Board provide guidance on questions relating to the management of NASA's programs in the space sciences. The issues raised in the request closely reflect questions posed in the agency's fiscal year 1994 Senate appropriations report. These questions included the following: Should all the NASA space science programs be gathered into a 'National Institute for Space Science'? What other organizational changes might be made to improve the coordination and oversight of NASA space science programs? What processes should be used for establishing interdisciplinary science priorities based on scientific merit and other criteria, while ensuring opportunities for newer fields and disciplines to emerge? And what steps could be taken to improve utilization of advanced technologies in future space scienc missions? This report details the findings of the Committee on the Future of Space Science (FOSS) and its three task groups: the Task Group on Alternative Organizations, Task Group on Research Prioritization, and the Task Group on Technology.

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Simulation Based Evaluation of Integrated Adaptive Control and Flight Planning Technologies

The objective of this work is to leverage NASA resources to enable effective evaluation of resilient aircraft technologies through simulation. This includes examining strengths and weaknesses of adaptive controllers, emergency flight planning algorithms, and flight envelope determination algorithms both individually and as an integrated package.

Campbell, Stefan Forrest↗

Namibian Flood Early Warning SensorWeb Pilot

The major goal of the Namibia SensorWeb Pilot Project is a scientifically sound, operational trans-boundary flood management decision support system for Southern African region to provide useful flood and waterborne disease forecasting tools for local decision makers. The Pilot Project established under the auspices of: Namibian Ministry of Agriculture Water and Forestry (MAWF), Department of Water Affairs; Committee on Earth Observing Satellites (CEOS), Working Group on Information Systems and Services (WGISS); and moderated by the United Nations Platform for Space-based Information for Disaster Management and Emergency Response (UN-SPIDER). The effort consists of identifying and prototyping technology which enables the rapid gathering and dissemination of both space-based and ground sensor data and data products for the purpose of flood disaster management and water-borne disease management.

Mandl, Daniel↗

Long-Term Preservation of NASA Heliophysics Data and Access: Where We Were and Where We're Going

The importance of ensuring preservation and useful access to the unique science potential of past, present and future NASA solar and space physics (i.e. heliophysics) data has been recognized since the inception of NASA but remains challenging. In this talk, I will briefly review the history of this topic and and then discuss the present NASA model for heliophysics science data management, including key current resources for finding and using data projects like the Space Physics Data Facility. I will highlight expected future directions, building on working elements of the present program and exploiting new technology, to further improve the data environment, address existing issues and anticipate emerging challenges.

McGuire, Robert E.↗