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At least 991 records · Page 55

Stimulation of serotonin-1A receptors in mammals to alleviate motion sickness and emesis induced by chemical agents

A method for the alleviation of both motion sickness and chemically-induced emesis is provided which includes the administration of a nontoxic, therapeutically effective amount of a composition which stimulates serotonin-1A receptors in a mammal in need of such treatment. The preferred compounds for use are buspirone and 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT).

Lucot, James B.↗

Measurement of Off-Body Velocity, Pressure, and Temperature in an Unseeded Supersonic Air Vortex by Stimulated Raman Scattering

A noninvasive optical method is used to make time-averaged (30 sec) off-body measurements in a supersonic airflow. Seeding of tracer particles is not required. One spatial component of velocity, static pressure, and static temperature are measured with stimulated Raman scattering. The three flow parameters are determined simultaneously from a common sample volume (0.3 by 0.3 by 15 mm) using concurrent measurements of the forward and backward scattered line shapes of a N2 vibrational Raman transition. The capability of this technique is illustrated with laboratory and large-scale wind tunnel testing that demonstrate 5-10% measurement uncertainties. Because the spatial resolution of the present work was improved to 1.5 cm (compared to 20 cm in previous work), it was possible to demonstrate a modest one-dimensional profiling of cross-flow velocity, pressure, and translational temperature through the low-density core of a stream-wise vortex (delta-wing model at Mach 2.8 in NASA Langley's Unitary Plan Wind Tunnel).

Herring, Gregory C.↗

Using Optically Stimulated Electron Emission as an Inspection Method to Monitor Surface Contamination

During redesign of the Space Shuttle reusable solid rocket motor (RSRM), NASA amended the contract with ATK Launch Systems (then Morton Thiokol Inc.) with Change Order 966 to implement a contamination control and cleanliness verification method. The change order required: (1) A quantitative inspection method (2) A written record of actual contamination levels versus a known reject level (3) A method that is more sensitive than existing methods of visual and black light inspection. Black light inspection is only useful for inspection of contaminants that fluoresce near the 365 nm spectral line and is not useful for inspection of most silicones that will not produce strong fluorescence. Black light inspection conducted by a qualified inspector under controlled light is capable of detecting Conoco HD-2 grease in gross amounts and is very subjective due to operator sensitivity. Optically stimulated electron emission (OSEE), developed at the Materials and Process Laboratory at Marshall Space Flight Center (MSFC), was selected to satisfy Change Order 966. OSEE offers several important advantages over existing laboratory methods with similar sensitivity, e.g., spectroscopy and nonvolatile residue sampling, which provide turn around time, real time capability, and full coverage inspection capability. Laboratory methods require sample gathering and in-lab analysis, which sometimes takes several days to get results. This is not practical in a production environment. In addition, these methods do not offer full coverage inspection of the large components

Lingbloom, Mike S.↗

Dynamic Foot Stimulation Attenuates Soleus Muscle Atrophy Induced by Hindlimb Unloading in Rats

Unloading-induced myofiber atrophy is a phenomenon that occurs in the aging population, bed-ridden patients and astronauts. The objective of this study was to determine whether or not dynamic foot stimulation (DFS) applied to the plantar surface of the rat foot can serve as a countermeasure to the soleus muscle atrophy normally observed in hindlimb unloaded (HU) rats. Thirty mature adult (6-month-old) male Wistar rats were randomly assigned into ambulatory control (AMB), hindlimb unloaded alone (HU), or hindlimb unloaded with the application of DFS (HU+DFS) groups. A dynamic pattern of pressure was applied to the right foot of each HU animal using a specially fabricated boot containing an inflatable air bladder connected to a solenoid air pump controlled by a laptop computer. The anti-atrophic effects of DFS were quantified morphometrically in frozen cross-sections of soleus muscle stained using the metachromatic-ATPase fiber typing technique. Application of DFS during HU significantly counteracted the atrophic response observed in the soleus by preventing approximately 85% of the reduction in Type I myofiber cross-sectional area (CSA) observed during HU. However, DFS did not protect type II fibers of the soleus from HU-induced atrophy or any fiber type in the soleus muscle of the contralateral control leg of the DFS-treated HU animals. These results illustrate that the application of DFS to the rat foot is an effective countermeasure to soleus muscle atrophy induced by HU.

Kyparos, Antonios↗

Estimation of an Optimal Stimulus Amplitude for Using Vestibular Stochastic Stimulation to Improve Balance Function

Sensorimotor changes such as postural and gait instabilities can affect the functional performance of astronauts when they transition across different gravity environments. We are developing a method, based on stochastic resonance (SR), to enhance information transfer by applying non-zero levels of external noise on the vestibular system (vestibular stochastic resonance, VSR). The goal of this project was to determine optimal levels of stimulation for SR applications by using a defined vestibular threshold of motion detection.

Goel, R.↗

Optical Sensors Using Stimulated Brillouin Scattering

A method for enhancing a sensitivity of an optical sensor having an optical cavity counter-propagates beams of pump light within the optical cavity to produce scattered light based on Stimulated Brillouin Scattering (SBS). The properties of the pump light are selected to generate fast-light conditions for the scattered light, such that the scattered light includes counter-propagating beams of fast light. The method prevents the pump light from resonating within the optical cavity, while allowing the scattered light to resonate within the optical cavity. At least portions of the scattered light are interfered outside of the optical cavity to produce a beat note for a measurement of the optical sensor. The disclosed method is particularly applicable to optical gyroscopes.

Christensen, Caleb A↗

Aerojet Engineering Corporation: Stimulation and Creation, 1935-1942

There are multiple published accounts of the stimulation and creation of the Aerojet Engineering Corporation that are inconsistent, incomplete, or erroneous in significant details, describing principals involved, timing, and funding of the creation process. This paper corrects the record and offers a well-documented and reliable history of the creation of the Aerojet Engineering Corporation. A small group of academic researchers and technicians, joined by an attorney, working at the California Institute of Technology (Caltech), accomplished the formation and creation of the corporation. The group of six men incorporated and served as initial officers of the Aerojet Engineering Corporation—Dr. Theodore von Karman; Dr. Frank Malina; Dr. Martin Summerfield; John Parsons; Edward Forman; and a Washington, DC, attorney, Andrew Haley. A government-funded program definition study at Caltech generated a proposal to produce a means of providing superior aircraft performance capabilities using rocketry, often referred to as jet propulsion, due to engineering disrepute of “rocketry" prior to WWII. Caltech successfully conducted flight demonstrations at March Field (Riverside, California) in the summer of 1941, leading Drs. von Karman and Malina to discuss and explore the best method to provide for production of jet-assisted takeoff (JATO) rockets with established industrial leaders, as well as industrial organizational alternatives. Von Karman, Malina, Summerfield, Parsons, and Forman continued these discussions until von Karman decided, in early 1942, to solicit the legal advice of Andrew Haley on how to proceed. After meetings at von Karman's home in Pasadena, on Haley's recommendation and using his volunteered initial corporate funding, it was agreed to incorporate the group. Articles of incorporation were drawn up by Haley and on 19 March 1942 were formally filed with the Delaware Secretary of State, establishing the Aerojet Engineering Corporation. Many accounts previously published have distorted or misreported many of the details of the process followed by the group that created the company. It is intended that this paper will be regarded as a fully researched historical account of the creation of the Aerojet Engineering Corporation. Included are the historical environment, the industrial motivations, descriptions of key players, the role of government, and the ultimate confluence of these factors with the motivation of a champion and the availability of the required resources.

Doyle, Stephen E.↗

Hyperspectral stimulated emission depletion microscopy and methods of use thereof

A hyperspectral stimulated emission depletion ("STED") microscope system for high-resolution imaging of samples labeled with multiple fluorophores (e.g., two to ten fluorophores). The hyperspectral STED microscope includes a light source, optical systems configured for generating an excitation light beam and a depletion light beam, optical systems configured for focusing the excitation and depletion light beams on a sample, and systems for collecting and processing data generated by interaction of the excitation and depletion light beams with the sample. Hyperspectral STED data may be analyzed using multivariate curve resolution analysis techniques to deconvolute emission from the multiple fluorophores. The hyperspectral STED microscope described herein can be used for multi-color, subdiffraction imaging of samples (e.g., materials and biological materials) and for analyzing a tissue by Forster Resonance Energy Transfer ("FRET").

47 OTHER INSTRUMENTATION↗

Recovery Act. Development and Validation of an Advanced Stimulation Prediction Model for Enhanced Geothermal Systems

This research project aims to develop and validate an advanced computer model that can be used in the planning and design of stimulation techniques to create engineered reservoirs for Enhanced Geothermal Systems. The specific objectives of the proposal are to; Develop a true three-dimensional hydro-thermal fracturing simulator that is particularly suited for EGS reservoir creation; Perform laboratory scale model tests of hydraulic fracturing and proppant flow/transport using a polyaxial loading device, and use the laboratory results to test and validate the 3D simulator; Perform discrete element/particulate modeling of proppant transport in hydraulic fractures, and use the results to improve understand of proppant flow and transport; Test and validate the 3D hydro-thermal fracturing simulator against case histories of EGS energy production; and Develop a plan to commercialize the 3D fracturing and proppant flow/transport simulator. The project is expected to yield several specific results and benefits. Major technical products from the proposal include; A true-3D hydro-thermal fracturing computer code that is particularly suited to EGS; Documented results of scale model tests on hydro-thermal fracturing and fracture propping in an analogue crystalline rock; Documented procedures and results of discrete element/particulate modeling of flow and transport of proppants for EGS applications; and Database of monitoring data, with focus of Acoustic Emissions (AE) from lab scale modeling and field case histories of EGS reservoir creation.

15 GEOTHERMAL ENERGY↗

Magnetically stimulated fluid flow patterns

Sandia National Laboratories' Jim Martin and Kyle Solis explain research on the effects of magnetic fields on fluid flows and how they stimulate vigorous flows. Fluid flow is a necessary phenomenon in everything from reactors to cooling engines in cars.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Extraction of solubles from plant biomass for use as microbial growth stimulant and methods related thereto

A method for producing a microbial growth stimulant (MGS) from a plant biomass is described. In one embodiment, an ammonium hydroxide solution is used to extract a solution of proteins and ammonia from the biomass. Some of the proteins and ammonia are separated from the extracted solution to provide the MGS solution. The removed ammonia can be recycled and the proteins are useful as animal feeds. In one embodiment, the method comprises extracting solubles from pretreated lignocellulosic biomass with a cellulase enzyme-producing growth medium (such T. reesei) in the presence of water and an aqueous extract.

09 BIOMASS FUELS↗

Recovery Act. Development and Validation of an Advanced Stimulation Prediction Model for Enhanced Geothermal System

The research project aims to develop and validate an advanced computer model that can be used in the planning and design of stimulation techniques to create engineered reservoirs for Enhanced Geothermal Systems. The specific objectives of the proposal are to: 1) Develop a true three-dimensional hydro-thermal fracturing simulator that is particularly suited for EGS reservoir creation. 2) Perform laboratory scale model tests of hydraulic fracturing and proppant flow/transport using a polyaxial loading device, and use the laboratory results to test and validate the 3D simulator. 3) Perform discrete element/particulate modeling of proppant transport in hydraulic fractures, and use the results to improve understand of proppant flow and transport. 4) Test and validate the 3D hydro-thermal fracturing simulator against case histories of EGS energy production. 5) Develop a plan to commercialize the 3D fracturing and proppant flow/transport simulator. The project is expected to yield several specific results and benefits. Major technical products from the proposal include: 1) A true-3D hydro-thermal fracturing computer code that is particularly suited to EGS, 2) Documented results of scale model tests on hydro-thermal fracturing and fracture propping in an analogue crystalline rock, 3) Documented procedures and results of discrete element/particulate modeling of flow and transport of proppants for EGS applications, and 4) Database of monitoring data, with focus of Acoustic Emissions (AE) from lab scale modeling and field case histories of EGS reservoir creation.

15 GEOTHERMAL ENERGY↗

Revisiting Fenton Hill Phase I reservoir creation and stimulation mechanisms through the GTO code comparison effort

A series of experiments performed at the Fenton Hill hot dry rock site after stage 2 drilling of Phase I reservoir provided intriguing field observations on the reservoir’s responses to injection and venting under various conditions. Two teams participating in the US DOE Geothermal Technologies Office (GTO)’s Code Comparison Study (CCS) used different numerical codes to model these five experiments with the objective of inferring the hydraulic stimulation mechanism involved. The codes used by the two teams are based on different numerical principles, and the assumptions made were also different, due to intrinsic limitations in the codes and the modelers’ personal interpretations of the field observations. Both sets of models were able to produce the most important field observations and both found that it was the combination of the vertical gradient of the fracture opening pressure, injection volume, and the use/absence of proppant that yielded the different outcomes of the five experiments.

Fu, Pengcheng↗

Cavitation-based hydro-fracturing technique for geothermal reservoir stimulation

A rotary shutter valve 500 is used for geothermal reservoir stimulation. The valve 500 includes a pressure chamber 520 for holding a working fluid (F) under pressure. A rotatable shutter 532 is turned with a powering device 544 to periodically align one or more windows 534 with one or more apertures 526 in a bulkhead 524. When aligned, the pressurized working fluid (F) flows through the bulkhead 524 and enters a pulse cavity 522, where it is discharged from the pulse cavity 522 as pressure waves 200. The pressure wave propagation 200 and eventual collapse of the bubbles 202 can be transmitted to a target rock surface 204 either in the form of a shock wave 206, or by micro jets 208, depending on the bubble-surface distance. Once cavitation at the rock face begins, fractures are initiated in the rock to create a network of micro-fissures for enhanced heat transfer.

15 GEOTHERMAL ENERGY↗

Evaluation of Stimulation by Shear Slip in Fractured Rock Using a 3D Coupled Thermo-Poro-Mechanical FEM

This paper presents a 3D finite element model for simulating shear slip on fractures in rock in response to coupled thermo-poro-mechanical processes. The modeling is part of a broader effort to investigate the role of pore pressure and cooling by cold water injection on shear slip and permeability increase in granitic rock using laboratory shearing experiments under triaxial conditions. In particular, 3D thermo-poro-mechanical finite element modeling and analysis of injection experiment in fractured rock has been carried out to analyze the role of pore pressure, temperature, fracture deformation and their interactions. 4-noded tetrahedral elements are employed for intact rock deformation and transport processes within the matrix. To represent the mechanical response of a fracture surface, zero thickness contact interface element is developed based on recently developed element partitioning algorithm and procedures for applying hydraulic pressure on the fracture surfaces. A Mohr-Coulomb type criterion is adapted to capture the slip on the fracture and to quantify its reversible and irreversible deformation. The numerical model has been calibrated using results from well controlled, advanced laboratory experiments. Excellent agreement between modeling and experimental observations is achieved. Simulation results illustrate that pore pressure increase and rock matrix/fracture surface cooling cause the fracture system to deform and slip. Fracture slip is promoted due to its normal stress reduction associated with cooling effect of cold fluid injection. The numerical model provides a physics-based understanding of the role of coupled processes on shear stimulation phenomenon and the resulting permeability enhancement.

58 GEOSCIENCES↗

High power laser hydraulic fracturing, stimulation, tools systems and methods

There are provided high power laser perforation, hydraulic fracturing systems, tools and methods for the stimulation and recovery of energy sources, such as hydrocarbons, from a formation. These systems, tools and methods provide predetermined laser beam energy patterns, to provide for the down hole volumetric removal of custom geometries of materials, sealing of perforations, reperforations, refractures and other downhole actives.

42 ENGINEERING↗

The EGS Collab Project: Stimulation and Simulation

Development of Enhanced Geothermal Systems (EGS) requires accurate predictions of flow rates and temperatures at production wells over time. The concept of EGS is simple; however, complications from heterogeneity and complexity of fracture pathways may lead to channeling, short-circuiting, and premature thermal breakthrough. In the EGS Collab project, we are establishing a suite of highly monitored and well characterized intermediate-scale (~10-20 m) field test beds along with fracture stimulation and interwell flow tests to better understand processes that control formation of effective subsurface heat exchangers. EGS Collab experiments will provide a means of testing tools and concepts that could later be employed under geothermal reservoir conditions at FORGE or elsewhere. Key to the project is using numerical simulations in the experiment design and interpretation of results. Our tests will be well-controlled, in situ experiments focused on rock fracture behavior and permeability enhancement. Our pre- and post-test modeling results of each field experiment compared with detailed measurements will allow for improved model prediction and validation. We will use comprehensive instrumentation to collect high-quality and high-resolution geophysical and other fracture characterization and fluid flow data. We will analyze these data and compare them with models and field observations to further elucidate the basic relationships between stress, induced seismicity, and permeability enhancement. We will also observe and quantify other key governing parameters that impact permeability, and will attempt to understand how these parameters might change throughout the development and operation of an EGS project with the ultimate goal of enabling commercial viability of EGS. Our first set of experiments will be performed at the Sanford Underground Research Facility (SURF) in South Dakota. Our team is well underway with building the first field experiment test bed planned for this project, which is supported by the US Department of Energy’s Geothermal Technologies Office.

EGS Collab↗

Stimulated Generation of Magnetrons powered below the Self-Excitation Threshold Voltage

Modern CW or pulsed superconducting accelerators of megawatts beams require efficient RF sources controllable in phase and power. It is desirable to have an individual RF power source with power up to hundreds of kW for each Superconductive RF (SRF) cavity. For pulsed accelerators the pulse duration in millisecond range is required. The efficiency of the traditional RF sources (klystrons, IOTs, solid-state amplifiers) in comparison to magnetrons is lower and the cost of unit of RF power is significantly higher. Typically, the cost of RF sources and their operation is a significant part of the total project cost and operation. The magnetron-based RF sources with a cost of power unit of 1-3 dollars per Watt would significantly reduce the capital and operation costs in comparison with the traditional RF sources. This arouses interest in magnetron RF sources for use in modern accelerators. A recently developed kinetic model describing the principle of magnetron operation and subsequent experiments resulted in an innovative technique producing the "stimulated" generation of magnetrons powered below the self-excitation threshold voltage. The magnetron operation in this regime is stable, low noise, controllable in phase and power, and provides higher efficiency than other types of RF power sources. It allows operation in CW and pulse modes (at large duty factor). For pulsed operation this technique does not require pulse modulators to form RF pulses. It also looks as a promising opportunity to extend magnetron life time. The developed technique, its experimental verification and a brief explanation of the kinetic model substantiating the technique are presented and discussed in this article.

43 PARTICLE ACCELERATORS↗