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At least 991 records · Page 55

A study of the biological effect of continuous inhalation exposure of 1, 1, 1-trichloroethene (methyl chloroform) on animals

The effects of continuous exposure to 1,1,1-trichloroethane on hepatic morphology and function are evaluated and compared with those produced by methylene chloride (dichloromethane) to determine environmental concentrations of each compound that would produce a similar biological response, i.e., a comparable increase in liver triglycerides over control levels. Experimental findings on mice, rats, dogs, and monkeys indicate that the pathological alternations observed with 1,1,1-trichloroethane are similar to those observed with dichloromethane except for different time courses of the effects and different degrees of recovery. A ten fold greater atmospheric concentration of 1,1,1-trichloroethane is required to produce the minimal liver changes found at 100 ppm dichloromethane.

Macewen, J. D.↗

Hepatic pathology in mice after continuous inhalation exposure to 1, 1, 1-trichloroethane

Mice exposed to either 250ppm or 1,000ppm 1,1,1-trichloroethane in air continuously for 14 weeks demonstrated significant changes in the centrilobular hepatocytes for the 1,000ppm group. Moderate liver triglyceride accumulation was evident in the 1,000ppm group and peaked at 40mg/gm of tissue after 7 weeks of exposure. Focal hepatocyte necrosis occurred in 40% of the mice exposed to 1,000ppm for 12 weeks. This necrosis was associated with an acute inflammatory infiltrate and hypertrophy of Kupffer cells. These findings indicate that the pathological alternations observed with 1,1,1-trichloroethane are similar to those observed with dichloromethane except for different time courses of the effects and different degrees of recovery. The toxic effects of 1,1,1-trichloroethane are of a similar type to those produced by carbon tetrachloride but appear much less severe.

Mcnutt, N. S.↗

Continued investigations in the NAAL low speed wind tunnel into the effects of the air breathing propulsion system on orbiter subsonic stability and control characteristics (OA62A)

Experimental aerodynamic investigations were conducted on a stingmounted 0.0405-scale representation (model 43-0) of the 140A/B Space Shuttle Orbiter in a Low Speed Wind Tunnel. The NASA designation for this test was 0A62A. The primary test objective was to continue studies, initiated on tests 0A16 and 0A71A and 0A71C, in optimizing the air breathing propulsion system (ABPS) and investigating the aerodynamic effects of various nacelle number/location configurations on the orbiter stability and control characteristics. Orbiter stability and control characteristics, both with and without ABPS, were investigated at elevon deflections of 0, + or -5, + or -19, + or -5, and -20 deg; aileron deflections of 0 and 10 deg (about 0 deg elevon); and rudder deflections of 0, -7.5, and -15 deg. Aerodynamic force and moment data was measured in the body axis system by a 2.5-inch task type internal balance. The model was sting supported through the base region with a nominal angle of attack range of -4 to 30 deg. Yaw polars were recorded over the beta range of -10 to 10 deg at fixed angles of attack of 0, 5, 10, and 15 deg.

Mennell, R.↗

Development of a method for fabricating metallic matrix composite shapes by a continuous mechanical process

Attempts made to develop processes capable of producing metal composites in structural shapes and sizes suitable for space applications are described. The processes must be continuous and promise to lower fabrication costs. Special attention was given to the aluminum boride (Al/b) composite system. Results show that despite adequate temperature control, the consolidation characteristics did not improve as expected. Inadequate binder removal was identified as the cause responsible. An Al/c (aluminum-graphite) composite was also examined.

Divecha, A. P.↗

Research study on stabilization and control: Modern sampled-data control theory. Continuous and discrete describing function analysis of the LST system

The dynamics of the Large Space Telescope (LST) control system were studied in order to arrive at a simplified model for computer simulation without loss of accuracy. The frictional nonlinearity of the Control Moment Gyroscope (CMG) Control Loop was analyzed in a model to obtain data for the following: (1) a continuous describing function for the gimbal friction nonlinearity; (2) a describing function of the CMG nonlinearity using an analytical torque equation; and (3) the discrete describing function and function plots for CMG functional linearity. Preliminary computer simulations are shown for the simplified LST system, first without, and then with analytical torque expressions. Transfer functions of the sampled-data LST system are also described. A final computer simulation is presented which uses elements of the simplified sampled-data LST system with analytical CMG frictional torque expressions.

Kuo, B. C.↗

Energy: A Continuing Bibliography with Indexes, May 1974

A bibliography on energy is reported, the bibliography, Energy: A Continuing Bibliography With Indexes, contains 232 reports, journal articles, and other documents originally announced in STAR, and IAA between Jan. 1, and Mar. 31, 1974. The coverage includes regional, national and international energy systems; research and development of fuels and other sources of energy, and energy conversion, transport, transmission, distribution and storage, with special emphasis on use of hydrogen and of solar energy. Also included are methods of locating or using new energy resources. Of special interest is energy for heating, lighting, for powering aircraft, surface vehicles, or other machinery.

Source record↗

A square-root data array solution of the continuous-discrete filtering problem

The Dyer-McReynolds (1969) discrete square-root filtering algorithm is extended to accommodate continuous dynamics. Differential equations are given to represent the time evolution of the filter data array. These equations are nonlinear, but it is shown that the nonlinearities act to enhance the stability of the solution.

Bierman, G. J.↗

Digital redesign of continuous systems by matching of states at multiple sampling periods

This paper presents a method of digital approximation of a continuous-data system by the matching of states at multiple sampling periods. Two alternate methods are presented; one method samples the states every sampling period, and alters the forward and feedback gains, so as to match the states of the two systems at the end of N sampling periods. The second method requires the sampling of the states every N sampling periods, with the change of gains at each sampling period. An illustrative example using the one-axis dynamics of the Skylab Satellite is presented.

Yackel, R. A.↗

Computer extension and analytic continuation of Stokes' expansion for gravity waves

Stokes' infinitesimal-wave expansion for steady progressive free-surface waves has been extended to high order using a computer to perform the coefficient arithmetic. Stokes' expansion has been found to be incapable of yielding the highest wave for any value of the water depth since convergence is limited by a square-root branch-point some distance short of the maximum. By reformulating the problem using a different independent parameter, the highest waves are obtained correctly. Series summation and analytic continuation are facilitated by the use of Pade approximants. The method is valid in principle for any finite value of the wavelength and solutions of high accuracy can be obtained for most values of the wave height and water depth.

Schwartz, L. W.↗

Digital approximation of continuous-data control systems by point-by-point state comparison

This paper presents a point-by-point state comparison method of approximating a continuous-data system by a sampled-data system. The problem is to attempt the matching of the states of the two systems at the sampling instants. A partial matching has to be conducted if the systems have more states than controls. A weighting matrix is used to regulate the partial matching and weights placed on each state. The digital approximation is affected by use of forward gain E(T) and feedback gain G(T) in the sampled-data system. It is shown that, in general, these gains can be approximated by truncated Taylor series expansions. An illustrative example is given using the one-axis dynamics of the Skylab satellite.

Kuo, B. C.↗

A guidance and navigation system for continuous low-thrust vehicles

A midcourse guidance and navigation system for continuous low thrust vehicles was developed. The equinoctial elements are the state variables. Uncertainties are modelled statistically by random vector and stochastic processes. The motion of the vehicle and the measurements are described by nonlinear stochastic differential and difference equations respectively. A minimum time trajectory is defined; equations of motion and measurements are linearized about this trajectory. An exponential cost criterion is constructed and a linear feedback quidance law is derived. An extended Kalman filter is used for state estimation. A short mission using this system is simulated. It is indicated that this system is efficient for short missions, but longer missions require accurate trajectory and ground based measurements.

Jack-Chingtse, C.↗

Continuous-output terminal-shock-position sensor for mixed-compression inlets evaluated in wind tunnel tests of YF-12 aircraft inlet

An electronic sensor was built to measure the position of the terminal shock in a supersonic inlet. The sensor uses several static-pressure taps in the inlet wall. The sensor output is continuously proportional to shock position. When the sensor was installed in a YF-12 aircraft flight inlet during wind tunnel tests, it indicated shock position within + or - 5 percent of the total distance covered by the static-pressure-tap region. The maximum error caused by an angle of attack change of 4 deg was less than 25 percent. In the region of normal inlet operation, the angle of attack error is negligible. Frequency-response tests show the amplitude ratio is constant out to 60 Hz, and decreases to about 50 percent at 100 Hz, with a phase lag of 50 deg.

Dustin, M. O.↗

Lymphoid cell kinetics under continuous low dose-rate gamma irradiation: A comparison study

The mechanism of cell proliferation is studied in the lymphoid tissue of the mouse spleen under the stress of continuous irradiation at a dose-rate of 10 roentgens per day for 105 days. Autoradiography and specific labeling with tritiated thymidine were utilized. It was found that at least four compensatory mechanisms maintained a near-steady state of cellular growth: (1) an increase in the proportion of PAS-positive cells which stimulate mitotic activity, (2) maturation arrest of proliferating and differentiating cells which tend to replenish the cells damaged or destroyed by irradiation, (3) an increase in the proportion of cells proliferating, and (4) an increase in the proportion of precursor cells. The results are compared to previous findings observed in the thymus.

Foster, B. R.↗