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Results for “binding”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts
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Arabidopsis C‐terminal binding protein ANGUSTIFOLIA modulates transcriptional co‐regulation of MYB46 and WRKY33
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Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca[superscript 2+] binding and cause misfolding
Abstract not provided
Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
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Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4
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Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization
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A defined structural unit enables de novo design of small-molecule-binding proteins
Abstract not provided
RNA stabilization by a poly(A) tail 3;#8242;-end binding pocket and other modes of poly(A)-RNA inter
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Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain
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Structural Basis and Binding Kinetics of Vaborbactam in Class A [beta]-Lactamase Inhibition
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Oxygen Generation via Water Splitting by a Novel Biogenic Metal Ion-Binding Compound
The discovery that MB will couple the oxidation of H 2 O to metal ion reduction and the release of O 2 suggests that methanotrophs expressing MB may be able to maintain their activity under hypoxic/anoxic conditions through the “self-generation” of dioxygen required for the initial oxidation of methane to methanol. Such an ability may be an important factor in enabling methanotrophs to not only colonize the oxic-anoxic interface where methane concentrations are highest but also tolerate significant temporal fluctuations of this interface.
Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin
Clostridioides difficile is a Gram-positive opportunistic human pathogen that causes 15,000 deaths annually in the United States, prompting a need for vaccine development. In addition to the important toxins TcdA and TcdB, binary toxin (CDT) plays a significant role in the pathogenesis of certain C. difficile ribotypes by catalyzing the ADP-ribosylation of actin in host cells. However, the mechanisms of CDT neutralization by antibodies have not been studied, limiting our understanding of key epitopes for CDT antigen design. Therefore, we isolated neutralizing monoclonal antibodies against CDT and characterized their mechanisms of neutralization structurally and biochemically. Here, 2.5-Å and 2.6-Å resolution X-ray crystal structures of the antibodies BINTOXB/22 and BINTOXB/9, respectively, in complex with CDTb—the CDT subunit that forms a heptameric pore for the delivery of toxic CDTa enzyme into the host cytosol—showed that both antibodies sterically clash with adjacent protomers in the assembled heptamer. Assessment of trypsin-induced oligomerization of the purified CDTb protoxin in vitro showed that BINTOXB/22 and BINTOXB/9 prevented the assembly of di-heptamers upon prodomain cleavage. This work suggests that the CDT oligomerization process can be effectively targeted by antibodies, which will aid in the development of C. difficile vaccines and therapeutics.
Structure, Immunogenicity, and Conformation-Dependent Receptor Binding of the Postfusion Human Metap
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Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural
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The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site
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A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specifi
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Gut Commensal Bacteroidetes Encode a Novel Class of Vitamin B 12 -Binding Proteins
The gut microbiome is a complex microbial community with important impacts on human health. One of the major groups within the gut microbiome, the Bacteroidetes , rely on their ability to capture vitamin B 12 and related molecules for fitness in the gut.