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At least 991 records · Page 55

Exploiting Cross-sensitivity by Bayesian Decoding of Mixed Potential Sensor Arrays

LANL mixed-potential electrochemical sensor (MPES) device arrays were coupled with advanced Bayesian inference treatment of the physical model of relevant sensor-analyte interactions. We demonstrated that our approach could be used to uniquely discriminate the composition of ternary gas sensors with three discreet MPES sensors with an average error of less than 2%. We also observed that the MPES exhibited excellent stability over a year of operation at elevated temperatures in the presence of test gases.

47 OTHER INSTRUMENTATION↗

A parameterized ray-tracing model for evaluation of hemispherical lensing of a uniform, telecentric object aperture -- performance improvement estimates for segmented scintillators with miniature lens arrays

A parametric model describing the collimation of radiation from a uniform circular aperture by a hemispherical lens of the same radius has been developed for rapid estimation of the potential benefit of miniature dielectric lens arrays in lens-coupled gamma ray cameras (GRCs) with segmented scintillators. A simplified ray-tracing approach is adopted that makes use of small angle approximations relevant to GRCs used in nuclear science at Los Alamos National Laboratory and elsewhere. Application of this analysis technique in a first-pass design optimization process results in the optimistic estimate that miniature lenses fabricated from typical optical quality glass might boost optical coupling by as much as a factor of 4 (6 dB gain). However, this is not likely to be economically attractive compared to other techniques, such as reduction of the GRC lens f-number.

47 OTHER INSTRUMENTATION↗

Parametric Studies for Plutonium Metal-Water Mixtures in Arrays of 6-Inch Columns

A parametric study for arrays of 6-inch diameter tank columns was performed in order to assist in the practical development of limits for plutonium solution operations. This technical document utilizes approaches taken in NCS-TECH-10-009 [Reference 1]. While this technical document expands on areas where the authors feel appropriate, it does not attempt to recreate all parts of the existing technical document. This technical document is intended to be used in conjunction with the previous technical document. The results reported in this technical document may be used to support facility-specific program documents or individual Criticality Safety Evaluation Documents (CSEDs). This technical document does not derive any specific requirements. Caution should be taken when applying these results; it is the criticality safety analyst's responsibility, if he/she chooses to utilize this technical document, to properly assess the applicability of the results presented herein for his/her application.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Pixelated scintillator array response to relativistic electrons

In order to make time resolved measurements of the gamma spectra on DARHT Axis 2 using the Compton Spectrometer (CS), the electron detector in the focal plane must be a scintillator that is optically coupled to a gated or streak camera. There are several issues we would like to address with experiments at Idaho Accelerator Center (IAC) before committing to a full size array (7”x2”), which would cost at least $100k. Two candidates for this application are organic (Bicron 422 or equivalent) or inorganic (LYSO) scintillator. Monte Carlo calculations were performed by Rachel Morneau, P-21, using MCNP to compare the two materials each 1.5mm thick for an energy range of 0.1 to 20MeV. The energy loss per particle in LYSO is much larger (100x) than in the plastic scintillator. We confirmed, by performing experiments with the CS on the Microton, that sensitivity of the LYSO was much larger (10x) than the plastic scintillator. Therefore, we have selected LYSO as the scintillator of choice. However, interest in the response of other organic and plastic scintillators prompted an increase in scope of the project. The goals of this experiment were as follows. First, we need to understand the optical response of the scintillators to electrons as a function of thickness, energy, and deposited charge. We also need to verify level of saturation in the scintillation process. Second, compare the scintillators’ response to an image plate (the current CS detector). Third, we need to quantify the effect of signal bleed through to adjacent pixels.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Development of Arrayed CRISPR-based Libraries for Functional Genomics Screening

Sandia National Laboratories and The Regents of the University of California, on Behalf of its Los Angeles Campus will collaboratively engage in the development of arrayed formatted genomic screening libraries based on CRISPR genome-editing technology. The effort will create libraries intended for use by the scientific community in research that includes therapeutic target discovery and comprehensive pathogen-host interaction analysis of agents of national security interest.

Childress, Amy↗

Arrayed Guide RNA Libraries for CRISPR-based Gene Knockout Screening

collaboration to develop arrayed formatted genomic screening libraries based on recently developed genome-editing technology termed CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). CRISPR-based screening allows for potent knockout of cellular genes with a genome-wide level scalability. With the development of CRISPR knockout libraries, comprehensive analysis of pathogen-host interaction and therapeutic target discovery can be performed against pathogens of biothreat concern and national security interest. Under this work, a CRISPR knockout screen was executed against the mosquito-borne pathogens Zika virus and Rift Valley fever virus. We identified existing as well as novel host genes involved in infection by these viruses. By discovering host genes essential for infection, we can design anti-viral treatments using those identified gene or gene products as targets. The scope of this partnership was within Sandia’s mission area and national security of reducing biological dangers from emerging infections or biodefense threats.

Negrete, Oscar↗

The Control of an Array of Micro-mirrors

The goal of this project is to develop an array of micro electromechanical systems (MEMS) mirrors with the following characteristics: three degrees of freedom (tip, tilt, piston); ±10° range of motion; and 40kHz closed-loop bandwidth. The combination of these characteristics will push the boundaries of devices currently in the literature, enabling a myriad of applications, from glasses-less stereo imagery to high-performance beam steering.

42 ENGINEERING↗

SPARR: Spiking/Processing Array for Wide Dynamic Range and High Resolution Photonic Sensing

The Spiking/Processing Array (spARR) is a novel photonic focal plane that uses pixels which generate electronic spikes autonomously and without a clock. These spikes feed into a network of digital asynchronous processing elements or DAPES. By building a useful assemblage of DAPES, and connecting them together in the correct way, sophisticated signal processing can be accomplished within the focal plane. Autonomous self-resetting pixels (AsP) enable SPARR to generate electronic response with very small signals--as little as a single photon in the case of Geiger mode avalanche photodiodes to as few as several hundred photons for in-cmos photodetectors. These spiking pixels enable fast detector response, but do not draw as much continuous power as synchronous clocked designs. The spikes emitted by the pixels all have the same magnitude, the information from the scene is effectively encoded into the rate of spikes and the time at which the spike is emitted. The spiking pixels, having converted incident light into electronic spikes, supply the spikes to a network of digital asynchronous processors. These are small state machines which respond to the spikes arriving at their input ports by either remaining unchanged or updating their internal state and possibly emitting a spike on one or more output ports. We show a design that accomplishes the sophisticated signal processing of a Haar spatial wavelet transform with spatial-spectral whitening. We furthermore show how this design results in a data streams which support imaging and transient optical source detection. Two simulators support this analysis: SPICE and sparrow. The CMOS SPICE simulator Cadence provides accurate CMOs design with accounting for effects of circuit parasitics throughout layout, accurate timing, and accurate energy consumption estimates. To more rapidly assess larger networks with more pixels, sparrow is a custom discrete event simulator that supports the non-homogeneous Poisson processes that lie behind photoelectric interaction. Sparrow is a photon-exact simulator that nevertheless performs SPARR system simulator for large-scale systems.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Energy Harvesting Remotely Monitored Sealing Array (RMSA) (Field Test Annual Report)

Sandia National Laboratories (SNL) is investigating photovoltaic (PV) cell configurations, integrating them with the battery-operated Remotely Monitored Sealing Array (RMSA), and testing and evaluating performance for enhanced battery life under various lighting conditions at a facility at the Savannah River Site (SRS) or Savannah River National Laboratory (SRNL). Unattended safeguards equipment (e.g. seals) incorporates many low-power electronic circuits, which are often powered by expensive and environmentally toxic lithium batteries. These batteries must periodically be replaced, adding a radiological hazard for both safeguards inspectors and operators. An extended field test of these prototype PV energy harvesting (EH) RMSAs at an operational nuclear facility will give additional data and allow for an analysis of this technology in a variety of realistic conditions, which will be documented in a final report. RMSAs are used for this testing, but SNL envisions energy harvesting technology may be applicable to additional safeguards equipment.

14 SOLAR ENERGY↗

Pixel Array Germanium Detectors for Nuclear Physics (Final Technical Report)

The Department of Energy (DOE) Office of Nuclear Physics supports the development and maintenance of germanium gamma-ray detector arrays at national laboratories and universities. Germanium gamma-ray detectors provide state-of-the-art gamma-ray energy resolution, making them critical for gamma-ray and x-ray spectroscopy in Nuclear Physics. Furthermore, detector segmentation and charge-signal waveform processing enables 3-dimensional (3D) measurement of gamma-ray interaction locations needed for the highest-fidelity Nuclear Physics experiments. Attaining and maintaining excellent gamma-ray energy resolution depends largely on the naturally excellent charge-collection properties of germanium crystals. However, the optimal method for achieving the best practical 3D spatial resolution within the detector volume at high counting rates is less clear.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Little Big Horn College Health and Wellness Center 45 kilo-Watt (kW) Solar Array (Final Report)

The report summarizes the activities completed, results, and lessons learned in installing at 45 kW photovoltaic solar array on the roof and as awnings at the 25,000 square foot Health and Wellness Center on the campus of the Little Big Horn College (LBHC) in Crow Agency, Montana. The installation is expected to displace greater than 16% of the current electricity requirements at the Health and Wellness Center and save LBHC more than $6,600 in operating costs annually.

14 SOLAR ENERGY↗

Non-visual analysis of miniaturized melt wire arrays for in-pile measurement of peak irradiation temperature

As a part of the in-pile instrumentation program, the Idaho National Laboratory (INL) has established in-house capabilities to fabricate and test new advanced manufactured printed sensors for measurement of peak temperature inside the harsh environment of a nuclear test reactor. Although nuclear test reactors may use standard methods that can provide real-time temperature information, such as thermocouples, the need for feedthroughs for real-time measurements greatly increases the cost of the experiment. Some experiments also present the problem of limited space available for instrumentation. To address this need, INL is working to improve temperature detection options for such applications. The lab is developing advanced manufactured melt wire arrays to determine peak temperatures in experiments with limited space. Furthermore, capabilities to print multiple melt wires with different melting properties on a single miniaturized unit is being established. Recent results and knowledge from this ongoing work have made it possible to develop unique temperature sensors that can accomplish user specific temperature ranges inside the harsh environments experienced during radiation testing.

36 MATERIALS SCIENCE↗

Evaluation of the Lawrence Livermore Microbal Detection Array at the Statens Serum Institut

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Statens Serum Institut to evaluate and transition the Lawrence Livermore Microarray Detection Array (LLMDA) analysis software package, the Composite Likelihood Maximization method (CLiMax) to the SSI. The SSI is a public enterprise under the Danish Ministry of Health that operates a microbiology reference laboratory for the Danish population and analyzes tens to thousands of human clinical samples annually. SSI has been collaborating with the LLNL team for several years to use the LLMDA to analyze viral and bacterial infections from human clinical samples. The collaboration has resulted in two joint publications thus far, describing improvements to LLMDA sample preparation, and the utility of the LLMDA for detecting emerging viruses in clinical samples.

59 BASIC BIOLOGICAL SCIENCES↗

Probing function in 3D neuronal cultures: a survey of 3D multielectrode array advances

Recent advances in microphysiological systems (MPS) have made significant strides to include design features that reconstruct key elements found in the brain, and in parallel advanced technologies to detect the activity of electrogenic cells that form neural networks. In particular, three-dimensional multielectrode arrays (3D MEAs) are being developed with the increasing levels of spatial and temporal precision, difficult to achieve with current 2D MEAs, insertable MEA probes, and/or optical imaging of calcium dynamics. Thus, providing a means to monitor the flow of neural network activity within all three dimensions (X, Y, and Z) of the engineered tissue. In the last 6 years, 3D MEAs, using either “bottom-up” or “top-down” designs, have been developed to overcome the current technical challenges in monitoring the functionality of the in vitro systems. Herein, we will report on the design and application of novel 3D MEA prototypes for probing neural activity throughout the 3D neural tissue.

59 BASIC BIOLOGICAL SCIENCES↗

Design Optimization for Printed Melt Wire Arrays Encapsulation

As part of the Nuclear Energy Enabling Technology (NEET) Advanced Sensor and Instrumentation (ASI) Program, Idaho National Laboratory (INL) has recently established in-house capabilities to fabricate and test new advanced-manufactured sensors for measuring peak irradiation temperature within a nuclear test reactor. Although methods of real-time temperature monitoring, such as thermocouples, may be used, the complexity of feedthroughs and attachments to collect real-time measurements greatly increases the cost of the experiment. Instead, passive monitoring techniques may be used for peak- temperature measurement that exploit the melting point of well-characterized materials (standard melt wires) to infer peak reactor temperatures. However, limited available space for instrumentation during experiments introduces an additional challenge. To accommodate this, INL has expanded its temperature- detection instrumentation capabilities to include advanced manufactured (AM) melt wires for peak irradiation temperature measurements. These melt wires can determine peak temperatures while also accommodate space limitations in irradiation experiments. In an effort to improve performance reliability of AM meltwire capabilities, a process was developed and tested to identify the significance of entrapping a high purity inert atmosphere within the packaging of printed melt wire arrays. The materials used in this study were aluminum, zinc, and tin encapsulated in high purity helium within a stainless steel (SS) 316 container. Tin, with a low melting point of approximately 230°C, Zn with a mid-melting point of approximately 420°C, and Al with a high melting point of approximately 660°C. This report describes the design, fabrication process, furnace testing and X-ray Computed Tomography (XCT) evaluation. Results show a successful outcome in creating an inert gas encapsulation and high-resolution evaluation methods.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Final Report for Tech-X Corporations’s contribution to Enhancing Understanding of High Energy Density Plasmas from Wire Array and Solid Liner Implosions Using Fluid Modeling with Kinetic Closures

Recent results from experiments and simulation of magnetically driven pulsed power liners have explored the role of the early-time electrothermal instability in the evolution of the magneto-Rayleigh-Taylor instability. Our focus will be on understanding the development of such instabilities and the potential stabilization mechanisms via electron thermal conduction, viscosity, and large magnetic fields which we expect could play a significant role in supporting the success of the MagLIF program. Experiments have shown that studies of high-energy density plasmas from wire-array implosions require physics modeling that goes well beyond simple models such as ideal magnetohydrodynamics. The goal of this work is to provide increased understanding of these experiments by employing simulations with a multi-fluid extended-MHD model which uses kinetic closures for thermal conduction, resistivity and viscosity. We will use codes easily available to the wider research community, including university students, with a secondary goal of providing the community with well-benchmarked tools capable of advanced modeling of high-energy-density plasmas.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Vector-Matrix Multiplication Engine for Neuromorphic Computation with a CBRAM Crossbar Array [Slides]

The core function of many neural network algorithms is the dot product, or vector matrix multiply (VMM) operation. Crossbar arrays utilizing resistive memory elements can reduce computational energy in neural algorithms by up to five orders of magnitude compared to conventional CPUs. Moving data between a processor, SRAM, and DRAM dominates energy consumption. By utilizing analog operations to reduce data movement, resistive memory crossbars can enable processing of large amounts of data at lower energy than conventional memory architectures.

97 MATHEMATICS AND COMPUTING↗