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At least 991 records · Page 55

COVID-19 vaccination status, side effects, and perceptions among breast cancer survivors: a cross-sectional study in China

Introduction Breast cancer is the most prevalent malignancy in patients with coronavirus disease 2019 (COVID-19). However, vaccination data of this population are limited. Methods A cross-sectional study of COVID-19 vaccination was conducted in China. Multivariate logistic regression models were used to assess factors associated with COVID-19 vaccination status. Results Of 2,904 participants, 50.2% were vaccinated with acceptable side effects. Most of the participants received inactivated virus vaccines. The most common reason for vaccination was “fear of infection” (56.2%) and “workplace/government requirement” (33.1%). While the most common reason for nonvaccination was “worry that vaccines cause breast cancer progression or interfere with treatment” (72.9%) and “have concerns about side effects or safety” (39.6%). Patients who were employed (odds ratio, OR = 1.783, p = 0.015), had stage I disease at diagnosis (OR = 2.008, p = 0.019), thought vaccines could provide protection (OR = 1.774, p = 0.007), thought COVID-19 vaccines were safe, very safe, not safe, and very unsafe (OR = 2.074, p < 0.001; OR = 4.251, p < 0.001; OR = 2.075, p = 0.011; OR = 5.609, p = 0.003, respectively) were more likely to receive vaccination. Patients who were 1–3 years, 3–5 years, and more than 5 years after surgery (OR = 0.277, p < 0.001; OR = 0.277, p < 0.001, OR = 0.282, p < 0.001, respectively), had a history of food or drug allergies (OR = 0.579, p = 0.001), had recently undergone endocrine therapy (OR = 0.531, p < 0.001) were less likely to receive vaccination. Conclusion COVID-19 vaccination gap exists in breast cancer survivors, which could be filled by raising awareness and increasing confidence in vaccine safety during cancer treatment, particularly for the unemployed individuals.

Xu, Yali↗

Bayesian Optimization of Non-Invariant Systems with Constraints Developed for Application to the ECR Ion Source VENUS

In this work, we consider the optimization of non-invariant systems with both safety and control constraints. We present a new approach based on Bayesian optimization for the dynamic, safe and controlled optimization of such systems. Although there are other possible use cases, we focus on the application to the electron cyclotron resonance ion source VENUS. From experimental data, we have observed that VENUS behaves to first order as a non-invariant dynamic system with moving areas of instability. Our novel approach aims at providing a tool that can maintain system optimization in a safe way. This is accomplished by making sure the objective function, the beam current in the case of VENUS, does not fall under an operational minimum, while simultaneously requiring the optimization to avoid areas where VENUS is unstable. We compare the result of our approach on synthetic data modeled to mimic the behavior of VENUS with two methods from the literature, a standard Bayesian optimizer and a safe Bayesian optimizer, both adapted to deal with dynamic systems. A cross Student T-test is conducted to show the significance of the improvement given by the new method we introduce here, regarding the two preexisting methods we compared to. The results of the tests conducted on synthetic data show that the proposed method succeeds at maintaining the system optimized and obeys the predefined constraints better than the literature methods explored.

Bayesian optimization↗

Fracture control methods for space vehicles. Volume 1: Fracture control design methods

A systematic approach for applying methods for fracture control in the structural components of space vehicles consists of four major steps. The first step is to define the primary load-carrying structural elements and the type of load, environment, and design stress levels acting upon them. The second step is to identify the potential fracture-critical parts by means of a selection logic flow diagram. The third step is to evaluate the safe-life and fail-safe capabilities of the specified part. The last step in the sequence is to apply the control procedures that will prevent damage to the fracture-critical parts. The fracture control methods discussed include fatigue design and analysis methods, methods for preventing crack-like defects, fracture mechanics analysis methods, and nondestructive evaluation methods. An example problem is presented for evaluation of the safe-crack-growth capability of the space shuttle crew compartment skin structure.

Liu, A. F.↗

MSFC Data Analysis of the SAFE/DAE Experiment

The Solar Array Flight Experiment (SAFE) on-orbit experiment for measurement of large structures dynamics consists of a dynamic sensing system designed to record and analyze the dynamic characteristics of the SAFE. The early availability of the SAFE and its basic large space structure characteristics made it a logical candidate for verification of the sensing system and evaluation technique. The characteristics of the solar array which place it well within the generic class of large space structures are: (1) Large size; (2) Low natural frequencies; (3) Mechanical complexity of its extendable/retractable mast; and (4) The inability to dynamic test in Earth atmosphere and one g.

Schock, R. W.↗

Optimal flight paths through microburst wind profiles

The problem of safe microburst wind shear encounter during the approach and climb-out flight phases is addressed using flight path optimization. The purpose was to investigate the physical limits of safe penetration and to determine control strategies that take full advantage of those limits. Optimal trajectories for both jet transport and general aviation aircraft were computed for encounters with idealized and actual microburst profiles. The results demonstrate that limits to control system design rather than to the aircraft's physical performance may be the deciding factor in an aircraft's capability for safe passage through a wide class of microbursts. The best control strategies responded to airspeed loss in an unconventional manner: by raising the nose to maintain lift.

Psiaki, M. L.↗

Qualification Motor no. 8 (QM-8), volume 1

All inspection and instrumentation data indicate that the QM-8 static test firing conducted 20 January 1989 was successful. Ambient temperature at T-0 was 28 F. With two flights successfully accomplished, this final test in the redesigned solid rocket motor (RSRM) program certified that the design meets motor performance requirements under extreme cold conditions. This test was a prerequisite to the third flight. The entire test article was cold conditioned at 20 to 25 F for approximately 31 days to assure a maximum propellant mean bulk temperature (PMBT) of 40 F, making it the lowest PMBT in the history of the program. This extreme condition also presented the opportunity to certify critical components at low temperatures. Certification of field joint and igniter heaters, adhesive bondline integrity, flex bearing performance, flight instrumentation performance, RSRM seal performance, and LSC and nozzle plug performance was accomplished. Prior to motor ignition, the field joints were maintained between 75 to 130 F, the igniter-to-case joint was maintained between 75 to 123 F, and the case-to-nozzle joint was maintained between 75 to 120 F. QM-8 was tested with induced side loads to simulate the strut loads experienced during ignition and maximum aerodynamic loading conditions. The ability of the safe and arm device to change position from safe-to-arm and arm-to-safe was certified. Ballistics performance was certified at the lower limits. Values were within specification requirements. Nozzle performance was nominal with typical erosion. The use of Fiberite carbon-cloth phenolic was certified. The water deluge system, CO2 quench, and other test equipment performed as planned during all required test operations.

Garecht, D. M.↗

Proposal for a lunar landing pod for SKITTER

The purpose of this project is to design a lunar landing module for the SKITTER vehicle. SKITTER is a three-legged mobile lunar transport and work platform. This lunar landing module must be able to bring SKITTER, with attached crane, from a lunar orbit to the surface of the Moon. This propulsion system is entirely self-contained and removable after touchdown. SKITTER is unmanned and must be able to touch down on the lunar surface and perform assigned tasks independently of other space or lunar vehicles. The propulsion system is designed to ensure that the vehicle will make a lunar landing within the expected velocity range. A landing gear configuration is presented to safely dissipate landing forces on lunar impact and be removed from the SKITTER structure after touchdown. The overall engineering analysis was conducted to determine an economical design to land SKITTER safely on the Moon. SKITTER will perform various tasks on the surface of the Moon. The completion of this project will determine the feasibility of landing SKITTER with the attached crane safely on the lunar surface.

Herman, David↗

A study of atmospheric optical scattering parameters at 1.5 and 2 micron region for solid state Doppler lidar applications

The increasing interest in the development of an eye-safe, solid state, Doppler lidar for avionic applications has created the need for a quantitative evaluation of atmospheric effects on performance. Theoretical calculations were completed for optical scattering parameters to be compared with the field measurements. Computer codes were developed for the required calculations and designed to be interactive and user friendly in order to support comparison with experimental results and, thus, provide the basis for evaluation of eye-safe Doppler lidar over a wide range of atmospheric conditions and geographical locations. A holmium Doppler lidar operating at 2.09 microns was constructed for atmospheric backscattering, attenuation, and wind velocity measurements. Theoretical calculations and field studies were performed for backscatter coefficients. The selected wavelengths correspond to Er:glass, Tm:YAG, and Tm,Ho:YAG solid state lasers that are suitable for use in an eye-safe Doppler lidar system.

Margalit, Eli↗

Pre-flight risk assessment in emergency medical service (EMS) helicopters

A preflight risk assessment system (SAFE) was developed at NASA-Ames Research Center for civil EMS operations to assist pilots in making a decision objectively to accept or decline a mission. The ability of the SAFE system to predict risk profiles was examined at an EMS operator. Results of this field study showed that the usefulness of SAFE was largely dependent on the type of mission flown.

Shively, Robert J.↗

Power system monitoring and source control of the Space Station Freedom DC power system testbed

Unlike a terrestrial electric utility which can purchase power from a neighboring utility, the Space Station Freedom (SSF) has strictly limited energy resources; as a result, source control, system monitoring, system protection, and load management are essential to the safe and efficient operation of the SSF Electric Power System (EPS). These functions are being evaluated in the DC Power Management and Distribution (PMAD) Testbed which NASA LeRC has developed at the Power System Facility (PSF) located in Cleveland, Ohio. The testbed is an ideal platform to develop, integrate, and verify power system monitoring and control algorithms. State Estimation (SE) is a monitoring tool used extensively in terrestrial electric utilities to ensure safe power system operation. It uses redundant system information to calculate the actual state of the EPS, to isolate faulty sensors, to determine source operating points, to verify faults detected by subsidiary controllers, and to identify high impedance faults. Source control and monitoring safeguard the power generation and storage subsystems and ensure that the power system operates within safe limits while satisfying user demands with minimal interruptions. System monitoring functions, in coordination with hardware implemented schemes, provide for a complete fault protection system. The objective of this paper is to overview the development and integration of the state estimator and the source control algorithms.

Kimnach, Greg L.↗

Fault detection and initial state verification by linear programming for a class of Petri nets

The authors present an algorithmic approach to determining when the marking of a LSMG (live safe marked graph) or a LSFC (live safe free choice) net is in the set of live safe markings M. Hence, once the marking of a net is determined to be in M, then if at some time thereafter the marking of this net is determined not to be in M, this indicates a fault. It is shown how linear programming can be used to determine if m is an element of M. The worst-case computational complexity of each algorithm is bounded by the number of linear programs necessary to compute.

Rachell, Traxon↗

Power system monitoring and source control of the Space Station Freedom dc-power system testbed

Unlike a terrestrial electric utility which can purchase power from a neighboring utility, the Space Station Freedom (SSF) has strictly limited energy resources; as a result, source control, system monitoring, system protection, and load management are essential to the safe and efficient operation of the SSF Electric Power System (EPS). These functions are being evaluated in the dc Power Management and Distribution (PMAD) Testbed which NASA LeRC has developed at the Power System Facility (PSF) located in Cleveland, Ohio. The testbed is an ideal platform to develop, integrate, and verify power system monitoring and control algorithms. State Estimation (SE) is a monitoring tool used extensively in terrestrial electric utilities to ensure safe power system operation. It uses redundant system information to calculate the actual state of the EPS, to isolate faulty sensors, to determine source operating points, to verify faults detected by subsidiary controllers, and to identify high impedance faults. Source control and monitoring safeguard the power generation and storage subsystems and ensure that the power system operates within safe limits while satisfying user demands with minimal interruptions. System monitoring functions, in coordination with hardware implemented schemes, provide for a complete fault protection system. The objective of this paper is to overview the development and integration of the state estimator and the source control algorithms.

Kimnach, Greg L.↗

Implementing Software Safety in the NASA Environment

Until recently, NASA did not consider allowing computers total control of flight systems. Human operators, via hardware, have constituted the ultimate safety control. In an attempt to reduce costs, NASA has come to rely more and more heavily on computers and software to control space missions. (For example. software is now planned to control most of the operational functions of the International Space Station.) Thus the need for systematic software safety programs has become crucial for mission success. Concurrent engineering principles dictate that safety should be designed into software up front, not tested into the software after the fact. 'Cost of Quality' studies have statistics and metrics to prove the value of building quality and safety into the development cycle. Unfortunately, most software engineers are not familiar with designing for safety, and most safety engineers are not software experts. Software written to specifications which have not been safety analyzed is a major source of computer related accidents. Safer software is achieved step by step throughout the system and software life cycle. It is a process that includes requirements definition, hazard analyses, formal software inspections, safety analyses, testing, and maintenance. The greatest emphasis is placed on clearly and completely defining system and software requirements, including safety and reliability requirements. Unfortunately, development and review of requirements are the weakest link in the process. While some of the more academic methods, e.g. mathematical models, may help bring about safer software, this paper proposes the use of currently approved software methodologies, and sound software and assurance practices to show how, to a large degree, safety can be designed into software from the start. NASA's approach today is to first conduct a preliminary system hazard analysis (PHA) during the concept and planning phase of a project. This determines the overall hazard potential of the system to be built. Shortly thereafter, as the system requirements are being defined, the second iteration of hazard analyses takes place, the systems hazard analysis (SHA). During the systems requirements phase, decisions are made as to what functions of the system will be the responsibility of software. This is the most critical time to affect the safety of the software. From this point, software safety analyses as well as software engineering practices are the main focus for assuring safe software. While many of the steps proposed in this paper seem like just sound engineering practices, they are the best technical and most cost effective means to assure safe software within a safe system.

Wetherholt, Martha S.↗

The Alpha-Proton-X-ray Spectrometer deployment mechanism: An anthropomorphic approach to sensor placement on Martian rocks and soil

On July 4,1997, the Mars Pathfinder spacecraft lands on Mars and starts conducting technological and scientific experiments. One experiment, the Alpha-Proton-X-ray Spectrometer, uses a sensor head placed against rocks and soil to determine their composition. To guarantee proper placement, a deployment mechanism mounted on the Mars Rover aligns the sensor head to within 20 deg of the rock and soil surfaces. In carrying out its task, the mechanism mimics the action of a human hand and arm. Consisting of a flexible wrist, a parallel link arm, a brush dc motor actuator, and a revolutionary non-pyrotechnic fail-safe release device, the mechanism correctly positions the sensor head on rocks as high as 0.29 m and on targets whose surfaces are tilted as much as 45 deg from the nominal orientation of the sensor head face. The mechanism weighs less than 0.5 kg, can withstand 100 g's, and requires less than 2.8 N x m of actuation torque. The fail-safe coupler utilizes Cerrobend, a metal alloy that melts at 60 C, to fuse the actuator and the rest of the mechanism together. A film heater wrapped around the coupler melts the metal, and Negator springs drive the mechanism into its stowed position. The fail-safe actuates using 6.75 Watts for 5 minutes in the event of an actuator failure.

Blomquist, Richard S.↗

Automated Testing Experience of the Linear Aerospike SR-71 Experiment (LASRE) Controller

System controllers must be fail-safe, low cost, flexible to software changes, able to output health and status words, and permit rapid retest qualification. The system controller designed and tested for the aerospike engine program was an attempt to meet these requirements. This paper describes (1) the aerospike controller design, (2) the automated simulation testing techniques, and (3) the real time monitoring data visualization structure. Controller cost was minimized by design of a single-string system that used an off-the-shelf 486 central processing unit (CPU). A linked-list architecture, with states (nodes) defined in a user-friendly state table, accomplished software changes to the controller. Proven to be fail-safe, this system reported the abort cause and automatically reverted to a safe condition for any first failure. A real time simulation and test system automated the software checkout and retest requirements. A program requirement to decode all abort causes in real time during all ground and flight tests assured the safety of flight decisions and the proper execution of mission rules. The design also included health and status words, and provided a real time analysis interpretation for all health and status data.

Larson, Richard R.↗

Test Results for the Automated Rendezvous and Capture System

The Automated Rendezvous and Capture (AR&C) system was designed and tested at NASA's Marshall Space Flight Center (MSFC) to demonstrate technologies and mission strategies for automated rendezvous and docking of spacecraft in Earth orbit, The system incorporates some of the latest innovations in Global Positioning, System space navigation, laser sensor technologies and automated mission sequencing algorithms. The system's initial design and integration was completed in 1998 and has undergone testing at MSFC. This paper describes the major components of the AR&C system and presents results from the official system tests performed in MSFC's Flight Robotics Laboratory with digital simulations and hardware in the loop tests. The results show that the AR&C system can safely and reliably perform automated rendezvous and docking missions in the absence of system failures with 100 percent success. When system failures are included, the system uses its automated collision avoidance maneuver logic to recover in a safe manner. The primary objective of the AR&C project is to prove that by designing a safe and robust automated system, mission operations cost can be reduced by decreasing the personnel required for mission design, preflight planning and training required for crewed rendezvous and docking missions.

Cruzen, Craig↗

First Generation Least Expensive Approach to Fission (FiGLEAF) Testing Results

Successful development of space fission systems will require an extensive program of affordable and realistic testing. In addition to tests related to design/development of the fission system, realistic testing of the actual flight unit must also be performed. Testing can be divided into two categories, non-nuclear tests and nuclear tests. Full power nuclear tests of space fission systems are expensive, time consuming, and of limited use, even in the best of programmatic environments. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system performance and lifetime can be attained through a series of non-nuclear tests. Non-nuclear tests are affordable and timely, and the cause of component and system failures can be quickly and accurately identified. MSFC is leading a Safe Affordable Fission Engine (SAFE) test series whose ultimate goal is the demonstration of a 300 kW flight configuration system using non-nuclear testing. This test series is carried out in collaboration with other NASA centers, other government agencies, industry, and universities. The paper describes the SAFE test series, which includes test article descriptions, test results and conclusions, and future test plans.

VanDyke, Melissa↗