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At least 991 records · Page 55

Comparing the effect on the AGS longitudinal emittance of gold ions from the BtA stripping foil with and without a Booster Bunch Merge

The aim of this note to better understand the effect of merging the Gold bunches in the Booster into one on the resulting AGS longitudinal emittance as compared to not merging them. The reason it matters whether they are merged or not is because they pass through a stripping foil in the BtA line. Data was taken last run (Run 17) for the case where the bunches are not merged, and it will be compared with data from cases where the bunches are merged. Previous data from Tandem operation will also be considered. There are two main pieces to this puzzle. The first is the ε growth associated with the energy spread due to ‘energy straggling’ in the BtA stripping foil and the second is the effective ε growth associated with the energy loss that occurs while passing through the foil. Both of these effects depend on whether or not the Booster bunches have been merged into one.

43 PARTICLE ACCELERATORS↗

The 2020 Low Energy Gold Run in the Injectors

During Run 20 the injectors provided Gold to RHIC at four different energies (3.85, 4.59, 5.75, and 7.3 GeV). The majority of the run was spent providing 4.59 and 5.75 GeV beams. The RHIC physics program using 5.75 GeV beam took place from Dec. 10, 2019 to Feb. 24, 2020, although there was a period of about 2 weeks (Jan. 27 th to Feb. 10 th ) where 7.3 and 4.59 GeV were used. The 4.59 GeV program took place from Feb. 24. 2020 to Sept.1 2020. Data taking for the 4.59 GeV program was interrupted by the COVID-19 shutdown which lasted about 3 months, from Mar. 20 to June 21. So, the 5.75 GeV program was about 2 months long and the 4.59 GeV program was about 3 months long. There were also other short periods where 7.3 GeV beam was provided to RHIC for CeC development and fixed target data taking. 3.85 GeV beam was also provided near the end of the run in preparation for next year (Sept. 2-11).

43 PARTICLE ACCELERATORS↗

FY2020-21 parameters for Gold ions in Booster, AGS, and RHIC

Sections 1 through 6 of this report give parameters for low-energy gold ions circulating in RHIC at injection and in AGS at extraction. Section 7 gives parameters for Au79+ ions circulating in RHIC at the standard injection magnetic rigidity of 81.11378003 Tm. Sections 8 through 10 give parameters for medium-energy Au79+ ions circulating in RHIC at 31.2, 26.5, 19.5, 13.5 GeV per nucleon. To reach these energies, acceleration in RHIC is required. The magnetic rigidity at RHIC injection for these setups is 60.3050632557 Tm. The corresponding ion energy is 7.30950517185 GeV per nucleon.

43 PARTICLE ACCELERATORS↗

An additional gold ion energy in RHIC for the FY2021 run

Parameters for an additional gold ion energy in RHIC between 7.3 and 9.8 GeV per nucleon are considered here. The critical factor driving the choice of an energy in this range is the need to be sufficiently far from transition at AGS extraction. The ion energy favored by STAR, 8.65 GeV per nucleon, is found to be a suitable choice. The parameters for this energy are given in Section 7 of the following

43 PARTICLE ACCELERATORS↗

The 2023 Gold Run in the Injectors

RHIC Run 23 used Gold beam from Tandem with an AGS extraction energy of 9.8 GeV. The same basic setup, 8 single bunch transfers from the Booster and a 12-6 merge in the AGS to provide 4 bunches at extraction, had been used before to deliver Tandem Au to RHIC. But in those cases, it was used for low energy runs (3.85 GeV in 2021 and 5.75 GeV in 2020) where extraction was below transition energy (7.9 GeV). Tandem beam was used for this run because the intensity and stability of EBIS Au did not meet the requirements for RHIC. Physics was first declared in RHIC on May 22 nd and on August 1 st the run was cut short by about 2 months due to a major failure in RHIC. Prior to the advent of EBIS as the preinjector in 2012, 9.8 GeV Tandem Au was regularly delivered to RHIC but the setup in the Booster and AGS was quite different: Four Booster transfers of 6 bunches each were merged into 4 bunches using a 24-12-4 merge scheme. The supercycle length was 6.0 sec before June 29 th when it was extended to 6.6 sec to accommodate EBIS commissioning. The Tandem, Booster, and AGS were on user 1 for the 9.8 GeV setup. Some work with EBIS Au 32+ took place on EBIS, Booster, and AGS user 5 using the standard 9.8 GeV injector setup with a 4 to 1 merge in Booster and a 6-3-1 type merge in AGS. The Siemens motor generator was used for the entire run. An intensity limit of 8.0e9 Au 77+ ions in the AGS was in effect during the run to protect the J7 plunging stripping foil and the Copper absorber of the AGS beam dump. This corresponds to a merged bunch intensity limit of 2.0e9 Au 77+ ions for 4 equal intensity bunches. The per bunch intensity limit can be increased to 2.67e9 by reducing the number of BtA transfers from 8 to 6. There was also a Booster Late intensity limit of 16e9 Au ions in effect to protect the BtA stripping foil from damage due to overheating. Lowering the number of transfers also makes this limit less of a constraint. BtA foil 5, which was installed in 2020 and had not been used regularly prior to this run was used all run and showed no obvious signs of deterioration. In May, a Tandem Au 3.85 GeV setup from 2021 was also re-established on AGS user 2. It was used for APEX on May 24 and July 26. Initial work with 3.85 GeV beam was on May 19. Proton beam was also set up during the run and extracted to W dump on July 10. It was used for APEX on July 12. Although the OPPIS source was used the AGS setup was without snakes.

43 PARTICLE ACCELERATORS↗

Gold Catalyzed Polymerization Reactions of Unsaturated Substrates: Towards New Functional, Recyclable, and Upcycled Aromatic Polymers (Final Report)

The overarching goal of this project lied in the translation of gold (Au) catalyzed small molecule synthetic transformations to the field of polymer science, the generation of new macromolecular structures, and the application of the materials and methodologies produced toward sustainable polymer development and chemical upcycling. Specifically, this project aimed to polymerize monomers based on unsaturated precursors and access novel polymeric materials through the extension of Au catalyzed intermolecular processes. The specific objectives of this project comprised: (1) the extension of Au-catalyzed intermolecular reactions to bifunctional monomers and the polycondensation of diverse nucleophiles; (2) to gain fundamental mechanistic insight into Au-catalyzed polymerizations; (3) the application of these reactions to the synthesis of new classes of aromatic polymers that can be readily and/or selectively deconstructed; and (4) to apply these chemistries to post-polymerization modification (PPM) of commercially relevant polyaromatic substrates, including post-industrial plastics and post-consumer waste.

36 MATERIALS SCIENCE↗

Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress

Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on progesterone and estradiol-17b accumulation by rat ovaries ex vivo and (2) to identify the locus/loci whereby GNPs modulate steroidogenesis via multiple-reference gene quantitative real-time RT-PCR. Regression analyses indicated a positive relationship between both Star (p < 0.05, r2 = 0.278) and Cyp11a1 (p < 0.001, r2 = 0.366) expression and P4 accumulation. upon exposure to 1.43 * 106 GNPs/mL. Additional analyses showed that E2 accumulation was positively associated with Hsd3b1 (p < 0.05, r2 = 0.181) and Cyp17a1 (p < 0.01, r2 = 0.301) expression upon exposure to 1.43 * 13 and 1.43 * 109 GNPs/mL, respectively. These results suggest a subtle treatmentdependent impact of low-dose GNPs on the relationship between progesterone or estradiol-17b and specific steroidogenic target genes, independent of oxidative stress or inhibin.

Larson, Jeremy K.↗

Development of a colloidal gold immunochromatographic assay strip using monoclonal antibody for rapid detection of porcine deltacoronavirus

Porcine deltacoronavirus (PDCoV) cause diarrhea and dehydration in newborn piglets and has the potential for cross-species transmission. Rapid and early diagnosis is important for preventing and controlling infectious disease. In this study, two monoclonal antibodies (mAbs) were generated, which could specifically recognize recombinant PDCoV nucleocapsid (rPDCoV-N) protein. A colloidal gold immunochromatographic assay (GICA) strip using these mAbs was developed to detect PDCoV antigens within 15 min. Results showed that the detection limit of the GICA strip developed in this study was 10 3 TCID 50 /ml for the suspension of virus-infected cell culture and 0.125 μg/ml for rPDCoV-N protein, respectively. Besides, the GICA strip showed high specificity with no cross-reactivity with other porcine pathogenic viruses. Three hundred and twenty-five fecal samples were detected for PDCoV using the GICA strip and reverse transcription-quantitative real-time PCR (RT-qPCR). The coincidence rate of the GICA strip and RT-qPCR was 96.9%. The GICA strip had a diagnostic sensitivity of 88.9% and diagnostic specificity of 98.5%. The specific and efficient detection by the strip provides a convenient, rapid, easy to use and valuable diagnostic tool for PDCoV under laboratory and field conditions.

Wang, Wei↗

Efficacy of Hair Total Mercury Content as a Biomarker of Methylmercury Exposure to Communities in the Area of Artisanal and Small-Scale Gold Mining in Madre de Dios, Peru

Total mercury content (THg) in hair is an accepted biomarker for chronic dietary methylmercury (MeHg) exposure. In artisanal and small-scale gold mining (ASGM) communities, the validity of this biomarker is questioned because of the potential for contamination from inorganic mercury. As mining communities may have both inorganic and organic mercury exposures, the efficacy of the hair-THg biomarker needs to be evaluated, particularly as nations begin population exposure assessments under their commitments to the Minamata Convention. We sought to validate the efficacy of hair THg for public health monitoring of MeHg exposures for populations living in ASGM communities. We quantified both THg and MeHg contents in hair from a representative subset of participants (N = 287) in a large, population-level mercury exposure assessment in the ASGM region in Madre de Dios (MDD), Peru. We compared population MeHg-THg correlations and %MeHg values with demographic variables including community location, sex, occupation, and nativity. We observed that hair MeHg-THg correlations were high (r > 0.7) for all communities, regardless of location or nativity. Specifically, for individuals within ASGM communities, 81% (121 of 150 total) had hair THg predominantly in the form of MeHg (i.e., >66% of THg) and reflective of dietary exposure to mercury. Furthermore, for individuals with hair THg exceeding the U.S. EPA threshold (1.0 μg/g), 88 out of 106 (83%) had MeHg as the predominant form. As a result, had urine THg solely been used for mercury exposure monitoring, approximately 59% of the ASGM population would have been misclassified as having low mercury exposure. Our results support the use of hair THg for monitoring of MeHg exposure of populations in ASGM settings where alternative biomarkers of MeHg exposure are not feasible.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗