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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 991 records · Page 55

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NASA NTRS2011

Intake of Fish and Omega-3 (n-3) Fatty Acids: Effect on Humans During Actual and Simulated Weightlessness

Space flight has many negative effects on human physiology, including bone and muscle loss. Bone and muscle are two systems that are positively affected by dietary intake of fish and n-3 fatty acids. The mechanism is likely to be related to inhibition by n-3 fatty acids of inflammatory cytokines (such as TNF) and thus inhibition of downstream NF-kB activation. We have documented this effect in a 3-dimensional cell culture model, where NF-kB activation in osteoclasts was inhibited by eicosapentaenoic acid, an n-3 fatty acid. We have also indentified that NF-kB activation in peripheral blood mononuclear cells of Space Shuttle crews. We found that after Shuttle flights of ~2 wk, expression of the protein p65 (evidence of NF-kB activation) was increased at landing (P less than 0.001). When evaluating the effects of n-3 fatty acid intake on bone breakdown after 60 d of bed rest (a weightlessness analog). We found that after 60 d of bed rest, greater intake of n-3 fatty acids was associated with less N-telopeptide excretion (Pearson r = -0.62, P less than 0.05). We also evaluated the relationship of fish intake and bone loss in astronauts after 4 to 6 mo missions on the International Space Station. Higher consumption of fish during flight was associated with higher bone mineral density (Pearson r = 0.46, P less than 0.05). Together, these findings provide evidence of the cellular mechanism by which n-3 fatty acids can inhibit bone loss, and preliminary human evidence of the potential for n-3 fatty acids to counteract bone loss associated with space flight. This study was supported by the NASA Human Research Program.

Smith, S. M.↗

DOE OSTI2021

Characterisation of a laser plasma betatron source for high resolution x-ray imaging

Abstract We report on the characterisation of an x-ray source, generated by a laser-driven plasma wakefield accelerator. The spectrum of the optimised source was consistent with an on-axis synchrotron spectrum with a critical energy of 13.8 − 1.9 + 2.2 keV and the number of photons per pulse generated above 1 keV was calculated to be 6 − 0.9 + 1.2 × 10 9 . The x-ray beam was used to image a resolution grid placed 37 cm from the source, which gave a measured spatial resolution of 4 µ m × 5 µ m. The inferred emission region had a radius and length of 0.5 ± 0.2 µ m and 3.2 ± 0.9 mm respectively. It was also observed that laser damage to the exit aperture of the gas cell led to a reduction in the accelerated electron beam charge and a corresponding reduction in x-ray flux due to the change in the plasma density profile.

plasma acceleration↗

NASA NTRS1972

Investigation of superconducting interactions and amorphous semiconductors

Research papers on superconducting interactions and properties and on amorphous materials are presented. The search for new superconductors with improved properties was largely concentrated on the study of properties of thin films. An experimental investigation of interaction mechanisms revealed no new superconductivity mechanism. The properties of high transition temperature, type 2 materials prepared in thin film form were studied. A pulsed field solenoid capable of providing fields in excess of 300 k0e was developed. Preliminary X-ray measurements were made of V3Si to determine the behavior of cell constant deformation versus pressure up to 98 kilobars. The electrical properties of amorphous semiconducting materials and bulk and thin film devices, and of amorphous magnetic materials were investigated for developing radiation hard, inexpensive switches and memory elements.

Janocko, M. A.↗

NASA NTRS1974

Correlation of hippocampal theta rhythm with changes in cutaneous temperature

A possible role for the hippocampus in alerting an animal to changes in cutaneous temperature was examined. Following local warming or cooling of the ears of unanesthetized, loosely restrained rabbits, theta waves (4-7 Hz EEG waves) were recorded from electrodes straddling the hippocampus. The onset of the hippocampal theta rhythm was correlated with changes in cutaneous temperature, an observation consistent with studies indicating that the theta rhythm is a nonspecific response evoked by stimulation of several sensory modalities. Additional data from cats and rabbits were correlated with specific neurons within the hippocampus, namely pyramidal cells. Post stimulus time histograms obtained by excitation of the dorsal fornix were interpreted in terms of excitatory and inhibitory inputs to pyramidal cells. Thus, the theta rhythm, which appears to be evoked by changes in cutaneous temperature, can be related to a specific type of hippocampal neuron which is in turn connected with other areas of the brain involved in temperature regulation.

Horowitz, J. M.↗

NASA NTRS1984

Prediction Model for the Life of Nickel-cadmium Batteries in Geosynchronous Orbit Satellites

A mathematical model is described which predicts the service life of nickel-cadmium batteries designed for geosynchronous orbit satellites. Regression analysis technique is used to analyze orbital data on second generation trickle charged batteries. The model gives average cell voltage as a function of design parameters, operating parameters and time. The voltage model has the properties of providing a good fit to the data, good predictive capability, and agreement with known battery performance characteristics. Average cell voltage can be predicted to within 0.02 volts for up to 8 years. This modeling shows that these batteries will operate reliably for 10 years. Third-generation batteries are expected to operate even longer.

Engleman, J. H.↗

NASA NTRS1984

Simple collimator for use with diamond-anvil cells in a synchrotron beam

A simple double-slit system is described which allows a synchrotron beam to be collimated onto a small sample (approximately 150-micron diameter) in a diamond-anvil cell using remote control. The apparatus can be constructed easily and inexpensively, and allows the shutter positions to be monitored accurately using readily available electronic equipment. A desirable feature of the collimator is the relatively small time needed for adjustment.

Spain, I. L.↗

NASA NTRS1985

Properties of electrophoretic fractions of human embryonic kidney cells separated on space shuttle flight STS-8

Suspensions of cultured primary human embryonic kidney cells were subjected to continuous flow electrophoresis on Space Shuttle flight STS-8. The objectives of the experiments were to obtain electrophoretically separated fractions of the original cell populations and to test these fractions for the amount and kind of urokinase (a kidney plasminogen activator that is used medically for digesting blood clots), the morphologies of cells in the individual fractions, and their cellular electrophoretic mobilities after separation and subsequent proliferation. Individual fractions were successfully cultured after return from orbit, and they were found to differ substantially from one another and from the starting sample with respect to all of these properties.

Morrison, D. R.↗

NASA NTRS1986

Regulation of hematopoiesis in rats exposed to antiorthostatic hypokinetic/hypodynamia. II - Mechanisms of the 'anemia'

The cause of the red cell mass (RCM) deficit, which occurs in rats during suspenion, is investigated. The experimental conditions and procedures, in which male Sprague-Dawley rats are subjected to antiorthostatic hyypokinetic/hypodynamia and changes in RCM are monitored, are described. The influences of stress, reduced food and water consumption, and antiorhostatic posture on RCM are analyzed. Changes in body weight, RCM, radioiron incorporation, red blood cells (RBC), and reticulocytes, for the rats after head-down suspension are graphically presented; only the changes in RBC are related to the antiorthostatic posture. The data reveal that anemia is primarily caused by reduced food and water consumption and secondly by restricted movements.

Dunn, C. D. R.↗

NASA NTRS1993

The 5-6 December 1991 FIRE IFO 2 jet stream cirrus case study: The influence of volcanic aerosols

In presenting an overview of the cirrus clouds comprehensively studied by ground-based and airborne sensors from Coffeyville, KS, during the 5-6 Dec. 1992 Project FIRE (First International Satellite Cloud Climatology Project Regional Experiment) IFO II case study period, evidence is provided that volcanic aerosols from the June 1991 Pinatubo eruptions significantly influenced the formation and maintenance of the cirrus. Following the local appearance of a spur of stratospheric volcanic debris from the subtropics, a series of jet streaks subsequently conditioned the troposphere through tropopause foldings with sulfur-based particles that became effective cirrus cloud-forming nuclei. Aerosol and ozone measurements suggest a complicated history of stratospheric-tropospheric exchanges embedded within the upper level flow, and cirrus cloud formation was noted to occur locally at the boundaries of stratospheric aerosol-enriched layers that became humidified through diffusion, precipitation, or advective processes. Apparent cirrus cloud alterations include abnormally high ice crystal concentrations (up to approximately 600 l(sup -1), small but complex radial ice crystal types, and relatively large haze particles in cirrus uncinus cell heads at temperatures between -40 to -50 C. Implications for volcanic-cirrus cloud climate effects, and usual (non-volcanic aerosol) jet stream cirrus cloud formation are discussed.

Sassen, Kenneth↗

NASA NTRS1995

The 5-6 December 1991 FIRE IFO II jet stream cirrus case study: Possible influences of Volcanic Aerosols

In presenting an overview of the cirus clouds comprehensively studied by ground-based and airborne sensors from Coffeyville, Kansas, during the 5-6 December 1992 Project First ISCCP Region Experiment (FIRE) Intensive Fields Observation (IFO) II case study period, evidence is provided that volcanic aerosols friom the June 1991 Pinatubo eruptions may have significantly influenced the formation and maintenance of the cirrus. Following the local appearance of a spur of stratospheric volcanic debris from the subtropics, a series of jet streaks subsequently conditioned the troposphere through tropopause foldings with sulfur-based particles that became effective cloud-forming nuclei in cirrus clouds. Aerosol and ozone measurements suggest a complicated history of stratospheric-tropospheric exchanges embedded within the upper-level flow, and cirrus cloud formation was noted to occur locally at the boundaries of stratospheric aerosol-enriched layers that became humidified through diffusion, precipitation, or advective processes. Apparent cirrus cloud alterations include abnormally high ice crystal concentrations (up to approximately 600/L), complex radial ice crystal types, and relatively large haze particles in cirrus uncinus cell heads at temperatures between -40 and -50 C. Implications for volcanic-cirrus cloud climate effects and usual (nonvolcanic aerosol) jet stream cirrus cloud formation are discussed.

Sassen, Kenneth↗

NASA NTRS1994

Induction of carcinoembryonic antigen expression in a three-dimensional culture system

MIP-101 is a poorly differentiated human colon carcinoma cell line established from ascites that produces minimal amounts of carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, and nonspecific cross-reacting antigen (NCA), a related protein that has 50 and 90 kDa isoforms, in vitro in monolayer culture. MIP-101 produces CEA when implanted into the peritoneum of nude mice but not when implanted into subcutaneous tissue. We tested whether MIP-101 cells may be induced to express CEA when cultured on microcarrier beads in three-dimensional cultures, either in static cultures as non-adherent aggregates or under dynamic conditions in a NASA-designed low shear stress bioreactor. MIP- 101 cells proliferated well under all three conditions and increased CEA and NCA production 3 - 4 fold when grown in three-dimensional cultures compared to MIP-101 cells growing logarithmically in monolayers. These results suggest that three-dimensional growth in vitro simulates tumor function in vivo and that three-dimensional growth by itself may enhance production of molecules that are associated with the metastatic process.

Jessup, J. M.↗

NASA NTRS1996

The 5-6 December 1991 FIRE IFO 2 Jet Stream Cirrus Case Study: Possible Influences of Volcanic Aerosols

In presenting an overview of the cirrus clouds comprehensively studied by ground based and airborne sensors from Coffeyville, Kansas, during the 5-6 December 1992 First ISCCP Regional Experiment (FIRE) intensive field observation (IFO) case study period, evidence is provided that volcanic aerosols from the June 1991 Pinatubo eruptions may have significantly influenced the formation and maintenance of the cirrus. Following the local appearance of a spur of stratospheric volcanic debris from the subtropics, a series of jet streaks subsequently conditioned the troposphere through tropopause foldings with sulfur based particles that became effective cloud forming nuclei in cirrus clouds. Aerosol and ozone measurements suggest a complicated history of stratospheric-tropospheric exchanges embedded with the upper level flow, and cirrus cloud formation was noted to occur locally at the boundaries of stratospheric aerosol enriched layers that became humidified through diffusion, precipitation, or advective processes. Apparent cirrus cloud alterations include abnormally high ice crystal concentrations (up to approximately 600 L(exp. 1)), complex radial ice crystal types, and relatively large haze particles in cirrus uncinus cell heads at temperatures between -40 and -50 degrees C. Implications for volcanic-cirrus cloud climate effects and unusual (nonvolcanic) aerosol jet stream cirrus cloud formation are discussed.

Sassen, Kenneth↗

NASA NTRS1987

The locations and amounts of endogenous ions and elements in the cap and elongating zone of horizontally oriented roots of Zea mays L.: an electron-probe EDS study

We used quantitative electron-probe energy-dispersive x-ray microanalysis to localize endogenous Na, Cl, K, P, S, Mg and Ca in cryofixed and freeze-dried cryosections of the cap (i.e. the putative site of graviperception) and elongating zone (i.e. site of gravicurvature) of horizontally oriented roots of Zea mays. Ca, Na, Cl, K and Mg accumulate along the lower side of caps of horizontally oriented roots. The most dramatic asymmetries of these ions occur in the apoplast, especially the mucilage. We could not detect any significant differences in the concentrations of these ions in the central cytoplasm of columella cells along the upper and lower sides of caps of horizontally-oriented roots. However, the increased amounts of Na, Cl, K and Mg in the longitudinal walls of columella cells along the lower side of the cap suggest that these ions may move down through the columella tissue of horizontally-oriented roots. Ca also accumulates (largely in the mucilage) along the lower side of the elongating zone of horizontally-oriented roots, while Na, P, Cl and K tend to accumulate along the upper side of the elongating zone. Of these ions, only K increases in concentration in the cytoplasm and longitudinal walls of cortical cells in the upper vs lower sides of the elongating zone. These results indicate that (1) gravity-induced asymmetries of ions differ significantly in the cap and elongating zone of graviresponding roots, (2) Ca accumulates along the lower side of the cap and elongating zone of graviresponding roots, (3) increased growth of the upper side of the elongating zone of horizontally-oriented roots correlates positively with increased amounts of K in the cytoplasm and longitudinal walls of cortical cells, and (4) the apoplast (especially the mucilage) may be an important component of the pathway via which ions move in graviresponding rots of Zea mays. These results are discussed relative to mechanisms for graviperception and gravicurvature of roots.

NASA Program Space Biology↗

NASA NTRS2006

Three-Dimensional Human Bronchial-Tracheal Epithelial Tissue-Like Assemblies (TLAs) as Hosts for Severe Acute Respiratory Syndrome (SARS)-CoV Infection

A three-dimensional (3-D) tissue-like assembly (TLA) of human bronchial-tracheal mesenchymal (HBTC) cells with an overlay of human bronchial epithelial (BEAS-2B) cells was constructed using a NASA Bioreactor to survey the infectivity of SARS-CoV. This TLA was inoculated with a low passage number Urbani strain of SARS-CoV. At selected intervals over a 10-day period, media and cell aliquots of the 3-D TLA were harvested for viral titer assay and for light and electron microscopy examination. All viral titer assays were negative in both BEAS-2B two-dimensional monolayer and TLA. Light microscopy immunohistochemistry demonstrated antigen-antibody reactivity with anti-SARS-CoV polyclonal antibody to spike and nuclear proteins on cell membranes and cytoplasm. Coronavirus Group 2 cross-reactivity was demonstrated by positive reaction to anti-FIPV 1 and anti-FIPV 1 and 2 antibodies. TLA examination by transmission electron microscopy indicated increasing cytoplasmic vacuolation with numerous electron-dense bodies measuring 45 to 270 nm from days 4 through 10. There was no evidence of membrane blebbing, membrane duplication, or fragmentation of organelles in the TLAs. However, progressive disruption of endoplasmic reticulum was observed throughout the cells. Antibody response to SARS-CoV specific spike and nucleocapsid glycoproteins, cross-reactivity with FIPV antibodies, and the cytoplasmic pathology suggests this HBTE TLA model is permissive to SARS-CoV infection.

Suderman, M. T.↗

DOE OSTI2021

The PRad windowless gas flow target

In this work, we report on a windowless, high-density, gas flow target at Jefferson Lab that was used to measure $r_p$, the root-mean-square charge radius of the proton. To our knowledge, this is the first such system used in a fixed-target experiment at a (non-storage ring) electron accelerator. The target achieved its design goal of an areal density of 2$\times$10$^{18}$ atoms/cm$^2$, with the gas uniformly distributed over the 4 cm length of the cell and less than 1% residual gas outside the cell. This design eliminated scattering from the end caps of the target cell, a problem endemic to previous measurements of the proton charge radius in electron scattering experiments, and permitted a precise, model-independent extraction of $r_p$ by reaching unprecedentedly low values of $Q^2$, the square of the electron's transfer of four-momentum to the proton.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

DOE OSTI2020

Cobalt-stabilized lithium metal oxide electrodes for lithium batteries

An electrode material comprising a composite lithium metal oxide, which in an initial state has the formula: y[xLi2MO3.(1−x)LiM′O2].(1−y)Li1+dMn2−z−dM″zO4; wherein 0≤x≤1; 0.75≤y<1; 0<z≤2; 0≤d≤0.2; and z−d≤2. M comprises one or more metal ions that together have an average oxidation state of +4; M′ comprises one or more metal ions that together have an average oxidation state of +3; and M″ comprises one or more metal ions that together with the Mn and any excess proportion of lithium, “d”, have a combined average oxidation state between +3.5 and +4. The Li1+dMn2−z−dM″zO4 component comprises a spinel structure, each of the Li2MO3 and the LiM′O2 components comprise layered structures, and at least one of M, M′, and M″ comprises Co. Cells and batteries comprising the electrode material also are described.

25 ENERGY STORAGE↗

DOE OSTI2020

Single Shot Characterization of High Transformer Ratio Wakefields in Nonlinear Plasma Acceleration

We report that plasma wakefields can enable very high accelerating gradients for frontier high energy particle accelerators, in excess of 10 GeV/m. To overcome limits on single stage acceleration, specially shaped drive beams can be used in both linear and nonlinear plasma wakefield accelerators (PWFA), to increase the transformer ratio, implying that the drive beam deceleration is minimized relative to acceleration obtained in the wake. In this Letter, we report the results of a nonlinear PWFA, high transformer ratio experiment using high-charge, longitudinally asymmetric drive beams in a plasma cell. An emittance exchange process is used to generate variable drive current profiles, in conjunction with a long (multiple plasma wavelength) witness beam. The witness beam is energy modulated by the wakefield, yielding a response that contains detailed spectral information in a single-shot measurement. Using these methods, we generate a variety of beam profiles and characterize the wakefields, directly observing transformer ratios up to R=7.8. Lastly, a spectrally based reconstruction technique, validated by 3D particle-in-cell simulations, is introduced to obtain the drive beam current profile from the decelerating wake data.

43 PARTICLE ACCELERATORS↗

NASA NTRS1977

Technology advancement of the electrochemical CO2 concentrating process

A five-cell, liquid-cooled advanced electrochemical depolarized carbon dioxide concentrator module was fabricated. The cells utilized the advanced, lightweight, plated anode current collector concept and internal liquid-cooling. The five cell module was designed to meet the carbon dioxide removal requirements of one man and was assembled using plexiglass endplates. This one-man module was tested as part of an integrated oxygen generation and recovery subsystem.

Schubert, F. H.↗