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At least 973 records · Page 54

Information-theoretic astrophysical uncertainties in the effective theory of dark matter direct detection

The impact of astrophysical uncertainties in direct detection searches can vary significantly across particle dark matter models and detector targets, due to the different velocity and momentum dependencies of the scattering cross section. We address these uncertainties for all operators of the nonrelativistic effective field theory of dark-matter/nucleon interactions, making use of the Kullback-Leibler (KL) information divergence to measure the deviation of the true dark matter velocity distribution from the Maxwell-Boltzmann form. This approach quantifies how astrophysical uncertainties affect each operator in the effective theory, without assuming any specific functional form for the velocity distribution. While for some operators the uncertainties are smaller than 1 order of magnitude for entropically motivated deviations from the Maxwell-Boltzmann form, for other operators, these uncertainties can be as large as three orders of magnitude near threshold. Furthermore, we identify the dependence of the scattering rate for various operators of the effective theory with different velocity-weighted moments of the velocity distribution, functionally analogous to the mean, variance, or skewness. This provides new analytic insight into which features of the velocity distribution are most relevant to detect a given particle dark matter model. Our technique is general and could be applied to a broader class of physics problems where a physical observable depends on the statistical moments of an uncertain theoretical distribution.

Herrera, Gonzalo [MIT, MKI; Harvard U.; Virginia T↗

SARS-CoV-2 RNA in Wastewater Settled Solids Is Associated with COVID-19 Cases in a Large Urban Sewershed

Wastewater-based epidemiology may be useful for informing public health response to viral diseases like COVID-19 caused by SARS-CoV-2. Here, we quantified SARS-CoV-2 RNA in wastewater influent and primary settled solids in two wastewater treatment plants to inform the preanalytical and analytical approaches and to assess whether influent or solids harbored more viral targets. The primary settled solids samples resulted in higher SARS-CoV-2 detection frequencies than the corresponding influent samples. Likewise, SARS-CoV-2 RNA was more readily detected in solids using one-step digital droplet (dd)RT-PCR than with two-step RT-QPCR and two-step ddRT-PCR, likely owing to reduced inhibition with the one-step ddRT-PCR assay. We subsequently analyzed a longitudinal time series of 89 settled solids samples from a single plant for SARS-CoV-2 RNA as well as coronavirus recovery (bovine coronavirus) and fecal strength (pepper mild mottle virus) controls. SARS-CoV-2 RNA targets N1 and N2 concentrations correlated positively and significantly with COVID-19 clinically confirmed case counts in the sewershed. Together, the results demonstrate that measuring SARS-CoV-2 RNA concentrations in settled solids may be a more sensitive approach than measuring SARS-CoV-2 in influent.

54 ENVIRONMENTAL SCIENCES↗

Double-Pulsed 2-Micrometer Lidar Validation for Atmospheric CO2 Measurements

A double-pulsed, 2-micron Integrated Path Differential Absorption (IPDA) lidar instrument for atmospheric carbon dioxide (CO2) measurements is successfully developed at NASA Langley Research Center (LaRC). Based on direct detection technique, the instrument can be operated on ground or onboard a small aircraft. Key features of this compact, rugged and reliable IPDA lidar includes high transmitted laser energy, wavelength tuning, switching and locking, and sensitive detection. As a proof of concept, the IPDA ground and airborne CO2 measurement and validation will be presented. IPDA lidar CO2 measurements ground validation were conducted at NASA LaRC using hard targets and a calibrated in-situ sensor. Airborne validation, conducted onboard the NASA B-200 aircraft, included CO2 plum detection from power stations incinerators, comparison to in-flight CO2 in-situ sensor and comparison to air sampling at different altitude conducted by NOAA at the same site. Airborne measurements, spanning for 20 hours, were obtained from different target conditions. Ground targets included soil, vegetation, sand, snow and ocean. In addition, cloud slicing was examined over the ocean. These flight validations were conducted at different altitudes, up to 7 km, with different wavelength controlled weighing functions. CO2 measurement results agree with modeling conducted through the different sensors, as will be discussed.

Singh, Upendra N.↗

Development of a Lateral Flow Strip-Based Recombinase-Aided Amplification for Active Chlamydia psittaci Infection

Chlamydia psittaci is the causative agent of psittacosis, a worldwide zoonotic disease. A rapid, specific, and sensitive diagnostic assay would be benefit for C. psittaci infection control. In this study, an assay combining recombinase-aided amplification and a lateral flow strip (RAA-LF) for the detection of active C. psittaci infection was developed. The RAA-LF assay targeted the CPSIT_RS02830 gene of C. psittaci and could be accomplished in 15 min at a single temperature (39°C). The analytical sensitivity of the assay was as low as 1 × 10 0 copies/μl and no cross-reaction with some other intracellular pathogens was observed. Moreover, all feces samples from mice infected with C. psittaci at day-1 post-infection were positive in the RAA-LF assay. In conclusion, the RAA-LF assay provides a convenient, rapid, specific and sensitive method for detection of active C. psittaci infection and it is also suitable for C. psittaci detection in field.

Jiao, Jun↗

Processing Motion Signals in Complex Environments

Motion information is critical for human locomotion and scene segmentation. Currently we have excellent neurophysiological models that are able to predict human detection and discrimination of local signals. Local motion signals are insufficient by themselves to guide human locomotion and to provide information about depth, object boundaries and surface structure. My research is aimed at understanding the mechanisms underlying the combination of motion signals across space and time. A target moving on an extended trajectory amidst noise dots in Brownian motion is much more detectable than the sum of signals generated by independent motion energy units responding to the trajectory segments. This result suggests that facilitation occurs between motion units tuned to similar directions, lying along the trajectory path. We investigated whether the interaction between local motion units along the motion direction is mediated by contrast. One possibility is that contrast-driven signals from motion units early in the trajectory sequence are added to signals in subsequent units. If this were the case, then units later in the sequence would have a larger signal than those earlier in the sequence. To test this possibility, we compared contrast discrimination thresholds for the first and third patches of a triplet of sequentially presented Gabor patches, aligned along the motion direction. According to this simple additive model, contrast increment thresholds for the third patch should be higher than thresholds for the first patch.The lack of a measurable effect on contrast thresholds for these various manipulations suggests that the pooling of signals along a trajectory is not mediated by contrast-driven signals. Instead, these results are consistent with models that propose that the facilitation of trajectory signals is achieved by a second-level network that chooses the strongest local motion signals and combines them if they occur in a spatio-temporal sequence consistent with a trajectory. These results parallel the lack of increased apparent contrast along a static contour made up of similarly oriented elements.

Verghese, Preeti↗

Ultraviolet detection of very low-surface-brightness objects

The night-sky surface brightness at excellent ground-based sites is compared to the sky background in space. In directions typical of extragalactic pointings, the background in the space ultraviolet reaches 26 mag/sq arcsec for the wavelength 2000 A, which is a factor of 40 darker than at any wavelength on the ground. This represents an important new 'window' for the study of extragalactic systems with low surface brightness. Taking into account the UV/V energy distributions of potential targets, it is found that in certain favorable circumstances UV photometry may permit the detection of regions with equivalent V band surface brightness as low as 35 mag/sq arcsec, or over 100,000 times fainter than the ground-based sky.

O'Connell, Robert W.↗

Direct detection of dark baryons naturally suppressed by ℋ-parity

We identify symmetries in a broad class of vectorlike confining dark sectors that forbid the leading electromagnetic moments that would ordinarily mediate dark baryon scattering with the Standard Model. The absence of these operators implies dark baryon dark matter has much smaller cross sections for elastic scattering off nuclei, leading to suppressed direct detection signals. In the confined description, we identify an “ℋ-parity” symmetry that exists in any dark sector with dark quarks transforming under a vectorlike representation of a new confining SU(𝑁 𝑐 ) gauge theory as well as a vectorlike representation of the electroweak group SU⁡(2) 𝐿 . The parity is independent of 𝑁 𝑐 and 𝑁 𝑓 , though it is essential that the dark quarks are neutral under hypercharge. This parity forbids dark hadron electric and magnetic dipole moments, charge radius, and anapole moment, while permitting dimension-7 operators that include polarizability, electroweak loop-induced interactions, and lower-dimensional electromagnetic transition moments between different neutral dark baryon states. We work out an explicit example, 𝑁 𝑐 = 𝑁 𝑓 = 3, that is the most minimal theory with fermionic dark baryons. In this specific model, we use the nonrelativistic quark model to show the magnetic dipole moment and charge radius vanish, while the transition moments are nonzero, consistent with ℋ-parity. We discuss the implications of a suppressed direct detection signal, emphasizing that this broad class of models provide a well-motivated target for future colliders.

composite models↗

Adaptive Neuro Fuzzy Inference System for Cyber-Intrusion Detection in a Smart Grid

The evolution of the power grid has brought increasing deployment of advance metering infrastructure, penetration of intelligent electronic devices, and integration of physical power system components with information and communications technologies. With the fast-expanding connectivity, cyber vulnerabilities arise due to the use of internet-based communication systems. These systems are targets of cyber-intrusions which attempt to disturb the normal power system functions. Traditional intrusion detection algorithms have been developed without an explicit model of the cyber components. In this paper, an algorithm to detect false data injections in the power system is proposed considering both cyber and physical models of the power system. The algorithm is based on an Adaptive Neuro Fuzzy Inference System (ANFIS) which collects information from state variables of the cyber-physical system to meet the performance requirements of the grid. Simulations of the proposed approach using the IEEE 13-bus test system validate the effectiveness of this artificial intelligence-based algorithm.

Adaptive Neuro Fuzzy Inference System (ANFIS), cyb↗

A Sensitive Quantitative Analysis of Abiotically Synthesized Short Homopeptides using Ultraperformance Liquid Chromatography and Time-of-Flight Mass Spectrometry

In the origins of life field understanding the abiotic polymerization of simple organic monomers (e.g., amino acids) into larger biomolecules (e.g., oligopeptides), remains a seminal challenge. Recently, preliminary observations showed a limited set of peptides formed in the presence of the plausible prebiotic phosphorylating agent, diamidophosphate (DAP), highlighting the need for an analytical tool to critically evaluate the ability of DAP to induce oligomerization of simple organics under aqueous conditions. However, performing accurate and precise, targeted analyses of short oligopeptides remains a distinct challenge in the analytical chemistry field. Here, we developed a new technique to detect and quantitate amino acids and their homopeptides in a single run using ultraperformance liquid chromatography-fluorescence detection/time of flight mass spectrometry. Over an 8-minute retention time window, 18 target analytes were identified and quantitated, 16 of which were chromatographically separated at, or near baseline resolution. Compound identity was confirmed by accurate mass analysis using a 10 ppm mass tolerance window. This method featured limits of detection < 5 nM (< 1 fmol on column) and limits of quantitation (LOQs) <15 nM (< 3 fmol on column). The LODs and LOQs were upwards of ∼28x and ∼788x lower, respectively, than previous methods for the same analytes, highlighting the quantifiable advantages of this new method. Both detectors provided good quantitative linearity (R(exp 2) > 0.985) for all analytes spanning concentration ranges ∼3 - 4 orders of magnitude. We performed a series of laboratory experiments to investigate DAP-mediated oligomerization of amino acids and peptides and analyzed experimental products with the new method. DAP readily polymerized amino acids and peptides under a range of simulated environmental conditions. This research underscores the potential of DAP to have generated oligopeptides on the primordial Earth, enhancing prebiotic chemical diversity and complexity at or near the origin of life.

Prebiotic Chemistry and Analytical Chemistry↗

Analytic Guided-Search Model of Human Performance Accuracy in Target- Localization Search Tasks

Current models of human visual search have extended the traditional serial/parallel search dichotomy. Two successful models for predicting human visual search are the Guided Search model and the Signal Detection Theory model. Although these models are inherently different, it has been difficult to compare them because the Guided Search model is designed to predict response time, while Signal Detection Theory models are designed to predict performance accuracy. Moreover, current implementations of the Guided Search model require the use of Monte-Carlo simulations, a method that makes fitting the model's performance quantitatively to human data more computationally time consuming. We have extended the Guided Search model to predict human accuracy in target-localization search tasks. We have also developed analytic expressions that simplify simulation of the model to the evaluation of a small set of equations using only three free parameters. This new implementation and extension of the Guided Search model will enable direct quantitative comparisons with human performance in target-localization search experiments and with the predictions of Signal Detection Theory and other search accuracy models.

Eckstein, Miguel P.↗

Process Anomaly Detection for Sparsely Labeled Events in Nuclear Power Plants

An essential aspect of online monitoring, subtle anomaly detection increases the detection lead time for equipment failure and enables a nuclear power plant (NPP) to mitigate unexpected partial or full outages, resulting in significant cost saving to the plant. Once an anomaly is detected by plant staff, its cause and severity are investigated. Because the vast majority of anomalies require some level of investigation, including some that require time-consuming examination, before they are passed over to the engineering organization for further analysis, plants are often equipped with tools to assist the staff in performing anomaly detection. Those tools operate as a black box and are often based on statistical methods that establish sensor correlations using preconfigured mathematical models and flag correlation deviations as anomalies. Due to the number of anomalies detected at a given NPP on a daily basis, a significant number of flagged anomalies usually await examination for days or weeks. A primary cause of this backlog is that the methods used by the tools generate many false positives. Though this is usually attributed to oversensitive model settings due to very narrow normal operation bands, it can also be associated with the model development being inadequate for the process being monitored, or with missing model inputs that could have explained misclassified positives. The performance of anomaly detection tools impacts their plant acceptance and utilization, especially when the effort to address false positives generated by the tool depletes the value or cost saved by using that tool. Thus, means to advance anomaly detection performance have been investigated by the Department of Energy’s Light Water Reactor Sustainability program. Previous and ongoing efforts have targeted unsupervised machine-learning (ML) methods, which do not require the labeling of any data fed into the ML model. By contrast, in supervised anomaly detection methods, every data point is labeled as either a normal or abnormal process condition, and the model is trained to replicate the classification process. Supervised methods usually outperform unsupervised methods, due to the added value in differentiating normal from anomalous states of the monitored process. An NPP’s corrective action program requires it to track and document, via a dedicated report, the resolution of any issues that occur within the plant. Once created, each report is reviewed by a plant screening committee, and several classifications and decisions are made. Recently, a collaborating NPP developed an artificial intelligence and ML-based classifier to categorize a condition report (CR) into classes that can serve to label the data as normal or anomalous. Applying CRs as labels represents a semi-supervised use case. Semi-supervised ML assumes that labels exist for some data points (i.e., labeled anomalies, in this case) but not for the rest. In this effort, semi-supervised ML methods were used to fuse data from CRs with anomaly detection methods in order to test the hypothesis that partially labeled anomalies would improve the accuracy of the anomaly detection methods. Specifically, two methods were used. The first is the deep Semi-supervised Anomaly Detection (deep SAD) method, which can handle labels ranging from fully unsupervised to fully supervised cases. The second is a newly designed ML method developed specifically for this effort and referred to as the high-order feature (HOF)-based method. To evaluate these two methods in controlled environments, synthetic data generators were developed and used. The first datasets used a spring-mass-damper (SMD) system simulator commonly found in mechanical engineering references. This was used to create two use cases: a one- and a three-mass system. Anomalies were introduced by changing the spring and damper coefficients while the system was actuated by random forces. The second datasets used the commercial Dymola-Modelica software to build a simplified nuclear reactor model. Anomalies were added in the form of corrupted sensor readings and/or control commands. The deep SAD method was tested using the SMD system, while the HOF method was tested using both datasets. Application of the deep SAD semi-supervised ML method demonstrated that labels can generate increased confidence in detecting true anomalies. This helped increase the number of true positives and decrease the number of false negatives—something that would aid in addressing the backlog of possible anomalies. Application of the HOF method demonstrated that labels can aid in down selecting from a candidate set of features to a more optimal subset in order to better differentiate between normal and anomalous conditions.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Two-Step Procedure to Detect Cosmological Gravitational Wave Backgrounds with Next-Generation Terrestrial Gravitational-Wave Detectors

Cosmological gravitational-wave backgrounds are an exciting science target for next-generation ground-based detectors, as they encode invaluable information about the primordial Universe. However, any such background is expected to be obscured by the astrophysical foreground from compact-binary coalescences. We propose a novel framework to detect a cosmological gravitational-wave background in the presence of binary black holes and binary neutron star signals with next-generation ground-based detectors, including Cosmic Explorer and the Einstein Telescope. Our procedure involves first removing all the individually resolved binary black hole signals by notching them out in the time-frequency domain. Then, we perform joint Bayesian inference on the individually resolved binary neutron star signals, the unresolved binary neutron star foreground, and the cosmological background. For a flat cosmological background, we find that we can claim detection at 5⁢𝜎 level when Ω ref ≥ 2.7 × 10 −12 /$\sqrt{𝑇_{obs}/yr}$, where 𝑇 obs is the observation time (in years), which is within a factor of ≲ 2 from the sensitivity reached in the absence of these astrophysical foregrounds.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

The LHS 1678 System: Two Small Planets and a Likely Brown Dwarf Orbiting a Nearby M Dwarf in Unconventional Circumstances

We present the LHS 1678 (TOI-696) exoplanet system: two nearly Earth-sized transiting planets detected by TESS and a likely brown dwarf orbiting a bright M2 dwarf at 19.9 pc. The ultra-short-period LHS 1678 b (0.70 Earth radii, 0.9-day orbit) is a captivating target for emission spectroscopy observations with the JWST. LHS 1678 c (0.98 Earth radii, 3.7- day orbit) is in the Venus-zone and may be Venus density: a promising target for greenhouse effect studies. Both planets are favorable targets for EPRV mass measurements and for JWST transmission spectroscopy observations to study their atmospheres. The substellar companion, detected via CTIO/SMARTS 0.9m astrometry, is on a decades-long orbit and may someday eclipse the host star, revealing a rare system architecture in which more and less massive objects orbit in the same plane. There is also a candidate third planet detected in TESS multi-cycle data in near 4:3 resonance with LHS 1678 c. The host star is associated with an observed gap in the HR diagram tied to a change in M dwarf energy transport mechanisms. The effect of the associated stellar astrophysics on exoplanet evolution is currently unknown. In aggregate, LHS 1678 an exciting playground for comparative exoplanet science and understanding the formation and evolution of small, short-period exoplanets orbiting low-mass stars.

Michele L Silverstein↗

Space vehicle approach velocity judgments under simulated visual space conditions

There were 35 volunteers who responded when they first perceived an increase in apparent size of a collimated, two-dimensional perspective image of an Orbiter vehicle. The variables of interest included the presence (or absence) of a fixed reticle within the field of view (FOV), background starfield velocity, initial range to the vehicle and vehicle closure velocity. It was found that: 1) increasing vehicle approach velocity yielded a very small (but significant) effect of faster detection of vehicle movement, nevertheless, response variability was relatively large; 2) including the fixed reticle in the FOV produced significantly slower detection of vehicle radial movement, however this occurred only at the largest range and the magnitude of the effect was only about 15% of the one sigma value; and 3) increasing background star velocity during this judgment led to slower detection of vehicle movement. While statistically significant, this effect was small and occurred primarily at the largest range. A possible explanation for the last two findings is that other static and dynamic objects within the visual field may compete for available attention which otherwise would be available for judging image expansion; thus, the target's retinal image has to expand more than otherwise for its movement to be detected. This study also showed that the Proximity Operations Research Mockup at NASA/Ames can be used effectively to investigate a variety of visual judgment questions related to future space operations. These findings are discussed in relation to previous research and possible underlying mechanisms.

Space Flight↗

Snowmass white paper: Light dark matter direct detection at the interface with condensed matter physics

Direct detection experiments for light (sub-GeV) dark matter are making enormous leaps in reaching previously unexplored theory space. The need for accurate characterizations of target responses has led to a growing interplay between particle and condensed matter physics. This white paper summarizes recent progress on direct detection calculations that utilize state-of-the-art numerical tools in condensed matter physics and effective field theory techniques. These new results provide the theoretical framework for interpreting ongoing and planned experiments using electronic and collective excitations, and for optimizing future searches.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Microbial detection with low molecular weight RNA

The need to monitor microorganisms in the environment has increased interest in assays based on hybridization probes that target nucleic acids (e.g., rRNA). We report the development of liquid-phase assays for specific bacterial 5S rRNA sequences or similarly sized artificial RNAs (aRNAs) using molecular beacon technology. These beacons fluoresce only in the presence of specific target sequences, rendering as much as a 27-fold fluorescence enhancement. The assays can be used with both crude cell lysates and purified total RNA preparations. Minimal sample preparation (e.g., heating to promote leakage from cells) is sufficient to detect many Gram-negative bacteria. Using this approach it was possible to detect an aRNA-labeled Escherichia coli strain in the presence of a large background of an otherwise identical E. coli strain. Finally, by using a longer wavelength carboxytetramethylrhodamine beacon it was possible to reduce the fraction of the signal due to cellular autofluorescence to below 0.5%.

NASA Discipline Life Sciences Technologies↗

Biochemical Detection and Identification False Alarm Rate Dependence on Wavelength Using Laser Induced Fluorescence

Most organic and many inorganic materials absorb strongly in specific wavelength ranges in the deep UV between about 220nm and 300nm. Excitation within these absorption bands results in native fluorescence emission. Each compound or composite material, such as a bacterial spore, has a unique excitation-emission fingerprint that can be used to provide information about the material. The sensitivity and specificity with which these materials can be detected and identified depends on the excitation wavelength and the number and location of observation wavelengths.We will present data on our deep ultraviolet Targeted Ultraviolet Chemical Sensors that demonstrate the sensitivity and specificity of the sensors. In particular, we will demonstrate the ability to quantitatively differentiate a wide range of biochemical agent targets against a wide range of background materials. We will describe the relationship between spectral resolution and specificity in target identification, as well as simple, fast, algorithms to identify materials.Hand-held, battery operated instruments using a deep UV laser and multi-band detection have been developed and deployed on missions to the Antarctic, the Arctic, and the deep ocean with the capability of detecting a single bacterial spore and to differentiate a wide range of organic and biological compounds.

native flourescence↗

Large Interferometer for Exoplanets (Life) I. Improved Exoplanet Detection Yield Estimates for A Large Mid-Infrared Space-Interferometer Mission

Context. One of the long-term goals of exoplanet science is the atmospheric characterization of dozens of small exoplanets in order to understand their diversity and search for habitable worlds and potential biosignatures. Achieving this goal requires a space mission of sufficient scale that can spatially separate the signals from exoplanets and their host stars and thus directly scrutinize the exoplanets and their atmospheres. Aims. We seek to quantify the exoplanet detection performance of a space-based mid-infrared (MIR) nulling interferometer that measures the thermal emission of exoplanets. We study the impact of various parameters and compare the performance with that of large single-aperture mission concepts detecting exoplanets in reflected light. Methods. We have developed an instrument simulator that considers all major astrophysical noise sources and coupled it with Monte Carlo of a synthetic exoplanet population around main-sequence stars within 20 pc. This allows us to quantify the number (and types) of exoplanets that our mission concept could detect over a certain time period. Two different scenarios to distribute the observing time among the stellar targets are discussed and different apertures sizes and wavelength ranges are considered. Results. An interferometer consisting of four 2 m apertures working in the 4–18.5 μ.m wavelength range with a total instrument throughput of 5% could detect up to ≈550 exoplanets with radii between 0.5 and 6 R ⊕ with an integrated S/N ≥ 7. At least ≈160 of the detected exoplanets have radii ≤1.5 R ⊕ . Depending on the observing scenario, ≈25–45 rocky exoplanets (objects with radii between 0.5 and 1.5 R ⊕ ) orbiting within the empirical habitable zone (eHZ) of their host stars are among the detections. With four 3.5 m apertures, the total number of detections can increase to up to ≈770, including ≈60–80 rocky eHZ planets. With four times 1 m apertures, the maximum detection yield is ≈315 exoplanets, including ≤20 rocky eHZ planets. The vast majority of small, temperate exoplanets are detected around M dwarfs. The impact of changing the wavelength range to 3–20 μm or 6–17 μm on the detection yield is negligible. Conclusions. A large space-based MIR nulling interferometer will be able to directly detect hundreds of small, nearby exoplanets, tens of which would be habitable world candidates. In terms of predicted detection yield, such a mission can compete with large single-aperture reflected light missions. Given that we assumed only 2.5 years for the search phase, a significant sub-set of the detected exoplanets can be followed-up in a second mission phase to obtain high SNR thermal emission spectra, leveraging the superior diagnostic power of the MIR wavelength regime compared to shorter wavelengths.

planets and satellites: terrestrial planets↗