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At least 973 records · Page 54

SU-F-T-538: CyberKnife with MLC for Treatment of Large Volume Tumors: A Feasibility Study

Purpose: CyberKnife is a well-documented modality for SRS and SBRT treatments. Typical tumors are small and 1–5 fractions are usually used. We determined the feasibility of using CyberKnife, with an InCise multileaf collimator option, for larger tumors undergoing standard dose and fractionation. The intent was to understand the limitation of using this modality for other external beam radiation treatments. Methods: Five tumors from different anatomical sites with volumes from 127.8 cc to 1,320.5 cc were contoured and planned on a Multiplan V5.1 workstation. The target average diameter ranged from 7 cm to 13 cm. The dose fractionation was 1.8–2.0 Gy/fraction and 25–45 fractions for total doses of 45–81 Gy. The sites planned were: pancreas, head and neck, prostate, anal, and esophagus. The plans were optimized to meet conventional dose constraints based on various RTOG protocols for conventional fractionation. Results: The Multiplan treatment planning system successfully generated clinically acceptable plans for all sites studied. The resulting dose distributions achieved reasonable target coverage, all greater than 95%, and satisfactory normal tissue sparing. Treatment times ranged from 9 minutes to 38 minutes, the longest being a head and neck plan with dual targets receiving different doses and with multiple adjacent critical structures. Conclusion: CyberKnife, with the InCise multileaf collimation option, can achieve acceptable dose distributions in large volume tumors treated with conventional dose and fractionation. Although treatment times are greater than conventional accelerator time; target coverage and dose to critical structures can be kept within a clinically acceptable range. While time limitations exist, when necessary CyberKnife can provide an alternative to traditional treatment modalities for large volume tumors.

60 APPLIED LIFE SCIENCES↗

SU-G-BRC-08: Evaluation of Dose Mass Histogram as a More Representative Dose Description Method Than Dose Volume Histogram in Lung Cancer Patients

Purpose: Dose-volume-histogram (DVH) is widely used for plan evaluation in radiation treatment. The concept of dose-mass-histogram (DMH) is expected to provide a more representative description as it accounts for heterogeneity in tissue density. This study is intended to assess the difference between DVH and DMH for evaluating treatment planning quality. Methods: 12 lung cancer treatment plans were exported from the treatment planning system. DVHs for the planning target volume (PTV), the normal lung and other structures of interest were calculated. DMHs were calculated in a similar way as DVHs expect that the voxel density converted from the CT number was used in tallying the dose histogram bins. The equivalent uniform dose (EUD) was calculated based on voxel volume and mass, respectively. The normal tissue complication probability (NTCP) in relation to the EUD was calculated for the normal lung to provide quantitative comparison of DVHs and DMHs for evaluating the radiobiological effect. Results: Large differences were observed between DVHs and DMHs for lungs and PTVs. For PTVs with dense tumor cores, DMHs are higher than DVHs due to larger mass weighing in the high dose conformal core regions. For the normal lungs, DMHs can either be higher or lower than DVHs depending on the target location within the lung. When the target is close to the lower lung, DMHs show higher values than DVHs because the lower lung has higher density than the central portion or the upper lung. DMHs are lower than DVHs for targets in the upper lung. The calculated NTCPs showed a large range of difference between DVHs and DMHs. Conclusion: The heterogeneity of lung can be well considered using DMH for evaluating target coverage and normal lung pneumonitis. Further studies are warranted to quantify the benefits of DMH over DVH for plan quality evaluation.

60 APPLIED LIFE SCIENCES↗

WE-H-207A-05: Spatial Co-Localization of F-18 NaF Vs. F-18 FDG Defined Disease Volumes

Purpose: Both [F-18]NaF and [F-18]FDG show promise for quantitative PET/CT assessment in metastatic prostate cancer to bone. Broad agreement between the tracers has been shown but voxel-wise correspondence has not been explored in depth. This study evaluates the spatial co-localization of [F-18]NaF PET and [F-18]FDG PET in bone lesions. Methods: Seventy-three lesion contours were identified in six patients receiving dynamic NaF PET/CT and FDG PET/CT scans two hours apart using identical fields-of-view. Tracer uptake (SUV) reflecting 60 minutes post-injection was modeled from kinetic parameters. Lesions were segmented by a physician separately on NaF PET and FDG PET. PET images were rigidly aligned using skeletal references on CT images. Lesion size, degree of overlap, voxel-wise tracer uptake values (SUV), and CT density distributions were compared using Dice coefficient, Positive Predictive Value (PPV), and Spearman rank correlation tests. Results: Across all patients, 42 lesions were identified on NaF PET (median 1.4 cm{sup 3}, range <1–204 cm{sup 3}) compared to 31 using FDG PET (median 1.8 cm{sup 3}, range <1–244 cm{sup 3}). Spatial cooccurrence was found in 25 lesion pairs. Lesions on NaF PET had PPV of 0.91 and on FDG a PPV of 0.65. Overall, NaF-defined lesions were 47% (±24%) larger by volume with moderate overlap to FDG, resulting in mean Dice coefficient of 34% (±22%). In areas of overlap, voxel-wise correlation of NaF and FDG SUV was moderate (ρ=0.56). Expanding to regions of non-spatial overlap, voxels contained in FDG-only contours were almost exclusively low HU (median 118), compared to dense regions of NaF-only voxels (median 250). In sclerotic sub-volumes (HU > 300) NaF-defined contours encompassed 83% of total FDG volume. Conclusion: Moderate voxel-wise correlation of FDG and NaF PET/CT uptake was observed. Spatial discrepancies in FDG and NaF PET/CT imaging of boney metastases could be influenced by poor sensitivity of FDG PET/CT in sclerotic regions. Funded by Prostate Cancer Foundation.

60 APPLIED LIFE SCIENCES↗

Formation of Vortex Flows in Liquid Crystal Phases Encapsulated in Microliter Volumes under the Action of Focused Laser Radiation

A theoretical description of the process of formation of vortex flows v(t, r) and the evolution of the director field n̂ in microliter liquid crystal (LC) volumes with a free surface under the influence of a temperature gradient ∇T(t, r), which is initiated by focused laser radiation, has been proposed. Thermomechanical contributions to both the stress tensor and viscous moment which are acting per unit volume of the LC phase were taken into account in the framework of the nonlinear generalization of the classical Ericksen−Leslie theory, which allowed describing the origin and formation of vortex flows in nematics formed by 4-n-pentyl- 4'-cyanobiphenyl molecules. Various hydrodynamic modes of vortex formation in microsized LC volumes under the action of focused laser radiation have been investigated by numerical methods.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

FCC Physics Opportunities

This volume of the Conceptual Design Report is dedicated to an overview of the FCC physics potential. It focuses on the most significant targets of the potential FCC research programme but, for the sake of space, not covering a large body of science that will nevertheless be accessible (and which is documented in various other reports, listed in the Appendix). The studies presented here, in addition to setting plausible targets for the FCC achievements, have helped in making the choice of the colliders’ parameters (energy, luminosity) and their operation plans. Furthermore, these studies contributed to the deinition of the critical detector features and parameters, as described in Volumes 2 and 3 of the CDR. While at first discussing the targets of each collider separately, the second part of this volume puts their synergy and complementarity in perspective, underscoring the added benefit to science brought by the unity and coherence of the whole programme. In addition to summarising the outcome of the work done during this CDR phase of the FCC physics studies, for the benefit of the whole particle physics community, this document is intended to stimulate an expert discussion of the FCC physics potential, in the context of the forthcoming review of the European Strategy for Particle Physics.

43 PARTICLE ACCELERATORS↗

FCC-ee: The Lepton Collider

Particle physics has arrived at an important moment of its history. The discovery of the Higgs boson, with a mass of 125 GeV, completes the matrix of particles and interactions that has constituted the “Standard Model” for several decades. This model is a consistent and predictive theory, which has so far proven successful at describing all phenomena accessible to collider experiments. On the other hand, several experimental facts do require the extension of the Standard Model and explanations are needed for observations such as the domination of matter over antimatter, the evidence for dark matter and the non-zero neutrino masses. Theoretical issues that need to be addressed include the hierarchy problem, the neutrality of the Universe, the stability of the Higgs boson mass upon quantum corrections and the strong CP problem. This report contains the description of a novel research infrastructure based on a highest-luminosity energy frontier electron-positron collider (FCC-ee) to address the open questions of modern physics. It will be a general precision instrument for the continued in-depth exploration of nature at the smallest scales, optimised to measure precisely the properties of the Higgs boson at the per-cent level, the Z and W bosons, the top quark and the Higgs coupling to the Z at the per-mil level. FCC-ee will provide unprecedented sensitivity to signs of new physics appearing either in the form of small deviations from the Standard Model or as rare decay processes. This collider will be implemented in stages, successively spanning the entire energy range from the Z pole over the WW threshold and H production peak to the t"t" ̅ threshold. Most of the infrastructure (e.g. underground structures, surface sites, electrical distribution, cooling & ventilation, RF systems) can be directly re-used for a subsequent highest-energy hadron collider (described in the FCC conceptual design report volume 3), serving the world-wide particle-physics community in a highly synergetic and cost-effective manner throughout the 21st century. The European Strategy for Particle Physics (ESPP) update 2013 stated “To stay at the forefront of particle physics, Europe needs to be in a position to propose an ambitious post-LHC accelerator project at CERN by the time of the next Strategy update”. The FCC study has implemented the ESPP recommendation by developing a long-term vision for an “accelerator project in a global context”. This document describes the detailed design and preparation of a construction project for a post-LHC circular lepton collider “in collaboration with national institutes, laboratories and universities worldwide”, and enhanced by a strong participation of industrial partners. Now, a coordinated preparation effort can be based on a core of an ever-growing consortium of already more than 135 institutes worldwide. The technology for constructing a high-energy, highest-luminosity circular lepton collider exists today. The FCC-ee concept comprises a power-saving twin-aperture magnet system, a continuous top-up injection scheme for stable operation and maximum integrated luminosity. Combined with an energy staging scheme, the FCC-ee represents the most efficient and most sustainable route for executing the research required to discover signs of new physics beyond the Standard Model. The step-wise energy increase of the FCC-ee does not require any additional civil engineering activities. Strategic R&D for FCC-ee aims at minimising construction cost and energy consumption, while maximising the socio-economic impact. It will mitigate residual technology-related risks and ensure that industry can benefit from an acceptable economic utility. Concerning the implementation, a preparatory phase of about eight years is both necessary and adequate to establish the project governance and organisation structures, building the international machine and experiment consortia, developing a territorial implementation plan in agreement with the host-states’ requirements, optimising the disposal of land and underground volumes and preparing the civil engineering project. Such a large-scale, international fundamental research infrastructure, tightly involving industrial partners and providing training at all education levels, will be a strong motor of economic and societal development in all participating nations. The FCC study has implemented a set of actions towards a coherent vision for the world-wide high-energy and particle physics community, providing a collaborative framework for topically complementary and geographically well-balanced contributions. This conceptual design report lays the foundation for a subsequent infrastructure preparatory and technical design phase.

43 PARTICLE ACCELERATORS↗

FCC-hh: The Hadron Collider

Particle physics has arrived at an important moment of its history. The discovery of the Higgs boson, with a mass of 125 GeV, completes the matrix of particles and interactions that has constituted the “Standard Model” for several decades. This model is a consistent and predictive theory, which has so far proven successful at describing all phenomena accessible to collider experiments. However, several experimental facts do require the extension of the Standard Model and explanations are needed for observations such as the abundance of matter over antimatter, the striking evidence for dark matter and the non-zero neutrino masses. Theoretical issues such as the hierarchy problem, and, more in general, the dynamical origin of the Higgs mechanism, do likewise point to the existence of physics beyond the Standard Model. This report contains the description of a novel research infrastructure based on a highest-energy hadron collider with a centre-of-mass collision energy of 100 TeV and an integrated luminosity of at least a factor of 5 larger than the HL-LHC. It will extend the current energy frontier by almost an order of magnitude. The mass reach for direct discovery will reach several tens of TeV, and allow, for example, to produce new particles whose existence could be indirectly exposed by precision measurements during the earlier preceding e+e– collider phase. This collider will also precisely measure the Higgs self-coupling and thoroughly explore the dynamics of electroweak symmetry breaking at the TeV scale, to elucidate the nature of the electroweak phase transition. WIMPs as thermal dark matter candidates will be discovered, or ruled out. As a single project, this particle collider infrastructure will serve the world-wide physics community for about 25 years and, in combination with a lepton collider (see FCC conceptual design report volume 2), will provide a research tool until the end of the 21st century. Collision energies beyond 100 TeV can be considered when using high-temperature superconductors. The European Strategy for Particle Physics (ESPP) update 2013 stated “To stay at the forefront of particle physics, Europe needs to be in a position to propose an ambitious post-LHC accelerator project at CERN by the time of the next Strategy update”. The FCC study has implemented the ESPP recommendation by developing a long-term vision for an “accelerator project in a global context”. This document describes the detailed design and preparation of a construction project for a post-LHC circular energy frontier collider “in collaboration with national institutes, laboratories and universities worldwide”, and enhanced by a strong participation of industrial partners. Now, a coordinated preparation effort can be based on a core of an ever-growing consortium of already more than 135 institutes worldwide. The technology for constructing a high-energy circular hadron collider can be brought to the technology readiness level required for constructing within the coming ten years through a focused R&D programme. The FCC-hh concept comprises in the baseline scenario a power-saving, low-temperature superconducting magnet system based on an evolution of the Nb3Sn technology pioneered at the HL-LHC, an energy-efficient cryogenic refrigeration infrastructure based on a neon-helium (Nelium) light gas mixture, a high-reliability and low loss cryogen distribution infrastructure based on Invar, high-power distributed beam transfer using superconducting elements and local magnet energy recovery and re-use technologies that are already gradually introduced at other CERN accelerators. On a longer timescale, high-temperature superconductors can be developed together with industrial partners to achieve an even more energy efficient particle collider or to reach even higher collision energies.The re-use of the LHC and its injector chain, which also serve for a concurrently running physics programme, is an essential lever to come to an overall sustainable research infrastructure at the energy frontier. Strategic R&D for FCC-hh aims at minimising construction cost and energy consumption, while maximising the socio-economic impact. It will mitigate technology-related risks and ensure that industry can benefit from an acceptable utility. Concerning the implementation, a preparatory phase of about eight years is both necessary and adequate to establish the project governance and organisation structures, to build the international machine and experiment consortia, to develop a territorial implantation plan in agreement with the host-states’ requirements, to optimise the disposal of land and underground volumes, and to prepare the civil engineering project. Such a large-scale, international fundamental research infrastructure, tightly involving industrial partners and providing training at all education levels, will be a strong motor of economic and societal development in all participating nations. The FCC study has implemented a set of actions towards a coherent vision for the world-wide high-energy and particle physics community, providing a collaborative framework for topically complementary and geographically well-balanced contributions. This conceptual design report lays the foundation for a subsequent infrastructure preparatory and technical design phase.

43 PARTICLE ACCELERATORS↗

CAM-SE–CSLAM: Consistent Coupling of a Conservative Semi-Lagrangian Finite-Volume Method with Spectral Element Dynamics

An algorithm to consistently couple a conservative semi-Lagrangian finite-volume transport scheme with a spectral element (SE) dynamical core is presented. The semi-Lagrangian finite-volume scheme is the Conservative Semi-Lagrangian Multitracer (CSLAM), and the SE dynamical core is the National Center for Atmospheric Research (NCAR)’s Community Atmosphere Model–Spectral Elements (CAM-SE). The primary motivation for coupling CSLAM with CAM-SE is to accelerate tracer transport for multitracer applications. The coupling algorithm result is an inherently mass-conservative, shape-preserving, and consistent (for a constant mixing ratio, the CSLAM solution reduces to the SE solution for air mass) transport that is efficient and accurate. This is achieved by first deriving formulas for diagnosing SE airmass flux through the CSLAM control volume faces. Thereafter, the upstream Lagrangian CSLAM areas are iteratively perturbed to match the diagnosed SE airmass flux, resulting in an equivalent upstream Lagrangian grid that spans the sphere without gaps or overlaps (without using an expensive search algorithm). This new CSLAM algorithm is not specific to airmass fluxes provided by CAM-SE but applies to any airmass fluxes that satisfy the Lipshitz criterion and for which the Courant number is less than one.

Lauritzen, Peter Hjort↗

Mineral density volume gradients in normal and diseased human tissues

Clinical computed tomography provides a single mineral density (MD) value for heterogeneous calcified tissues containing early and late stage pathologic formations. The novel aspect of this study is that, it extends current quantitative methods of mapping mineral density gradients to three dimensions, discretizes early and late mineralized stages, identifies elemental distribution in discretized volumes, and correlates measured MD with respective calcium (Ca) to phosphorus (P) and Ca to zinc (Zn) elemental ratios. To accomplish this, MD variations identified using polychromatic radiation from a high resolution micro-computed tomography (micro-CT) benchtop unit were correlated with elemental mapping obtained from a microprobe X-ray fluorescence (XRF) using synchrotron monochromatic radiation. Digital segmentation of tomograms from normal and diseased tissues (N=5 per group; 40-60 year old males) contained significant mineral density variations (enamel: 2820-3095mg/cc, bone: 570-1415mg/cc, cementum: 1240-1340mg/cc, dentin: 1480-1590mg/cc, cementum affected by periodontitis: 1100-1220mg/cc, hypomineralized carious dentin: 345-1450mg/cc, hypermineralized carious dentin: 1815-2740mg/cc, and dental calculus: 1290-1770mg/cc). A plausible linear correlation between segmented MD volumes and elemental ratios within these volumes was established, and Ca/P ratios for dentin (1.49), hypomineralized dentin (0.32-0.46), cementum (1.51), and bone (1.68) were observed. Furthermore, varying Ca/Zn ratios were distinguished in adapted compared to normal tissues, such as in bone (855-2765) and in cementum (595-990), highlighting Zn as an influential element in prompting observed adaptive properties. Hence, results provide insights on mineral density gradients with elemental concentrations and elemental footprints that in turn could aid in elucidating mechanistic processes for pathologic formations.

59 BASIC BIOLOGICAL SCIENCES↗

Control volume finite element method with multidimensional edge element Scharfetter-Gummel upwinding. Part 1, formulation.

We develop a new formulation of the Control Volume Finite Element Method (CVFEM) with a multidimensional Scharfetter-Gummel (SG) upwinding for the drift-diffusion equations. The formulation uses standard nodal elements for the concentrations and expands the flux in terms of the lowest-order Nedelec H(curl; {Omega})-compatible finite element basis. The SG formula is applied to the edges of the elements to express the Nedelec element degree of freedom on this edge in terms of the nodal degrees of freedom associated with the endpoints of the edge. The resulting upwind flux incorporates the upwind effects from all edges and is defined at the interior of the element. This allows for accurate evaluation of integrals on the boundaries of the control volumes for arbitrary quadrilateral elements. The new formulation admits efficient implementation through a standard loop over the elements in the mesh followed by loops over the element nodes (associated with control volume fractions in the element) and element edges (associated with flux degrees of freedom). The quantities required for the SG formula can be precomputed and stored for each edge in the mesh for additional efficiency gains. For clarity the details are presented for two-dimensional quadrilateral grids. Extension to other element shapes and three dimensions is straightforward.

99 GENERAL AND MISCELLANEOUS↗

Site Environmental Report for 2011, Volumes 1 & 2

The Site Environmental Report for 2011 summarizes Berkeley Lab’s environmental management performance, presents environmental monitoring results, and describes significant programs for calendar year (CY) 2011. Throughout this report, “Berkeley Lab” or “LBNL” refers both to (1) the multiprogram scientific facility the UC manages and operates on the 202-acre university-owned site located in the hills above the UC Berkeley campus, and the site itself, and (2) the UC as managing and operating contractor for Ernest Orlando Lawrence Berkeley National Laboratory. The report is separated into two volumes. Volume I is organized into an executive summary followed by six chapters that include an overview of LBNL, a discussion of its Environmental Management System (EMS), the status of environmental programs, summarized results from surveillance and monitoring activities, and quality assurance (QA) measures. Volume II contains individual data results from surveillance and monitoring activities.

54 ENVIRONMENTAL SCIENCES↗

Photogrammetry and Laser Imagery Tests for Tank Waste Volume Estimates: Summary Report

Feasibility tests were conducted using photogrammetry and laser technologies to estimate the volume of waste in a tank. These technologies were compared with video Camera/CAD Modeling System (CCMS) estimates; the current method used for post-retrieval waste volume estimates. This report summarizes test results and presents recommendations for further development and deployment of technologies to provide more accurate and faster waste volume estimates in support of tank retrieval and closure.

Photogrammetry↗

Probabilistic Characterization of Partial Volume Effects in Imaging of Rectangular Objects

In imaging, a partial volume effect refers to the problem that arises when the system resolution is low relative to the size of the object being imaged. In this setting, it is likely that most voxels occupied by the object are only partially covered, and that the fraction covered in each voxel is low. This makes the problem of object detection and image segmentation very difficult because the algorithms designed for these purposes rely on pixel summary statistics. If the area covered by the object is very low in relatively many of the total number of the voxels the object occupies, these summary statistics may not reach the thresholds required to detect this object. It is thus important to understand the extent of partial volume effect for a given object size and resolution. This technical report focuses on rectangular objects and derives the probability distributions for three quantities for such objects: 1) the number of fully covered voxels, 2) the number of partially covered voxels, and 3) the fractions of the total volume covered in the partially covered voxels. The derivations are first shown for 2-D settings and are then extended to 3-D settings.

97 MATHEMATICS AND COMPUTING↗

Proceedings of RIKEN BNL Research Center Workshop: Multi-Hadron and Nonlocal Matrix Elements in Lattice QCD (Volume 120)

Nonperturbative QCD calculations of hadronic matrix elements are needed to understand the structure of the matter in our universe and to search for physics beyond the Standard Model. Numerical lattice gauge theory is uniquely suited for this task and has reached a remarkable level of precision. However, the types of observables that are accessible in a straightforward way are limited because lattice calculations are performed with imaginary time. Traditionally, lattice QCD determinations of hadronic matrix elements have been restricted to situations with at most one stable hadron in the initial and final states, and with a single insertion of a local current. This situation has been changing recently thanks to theoretical breakthroughs and pioneering numerical studies of new observables. At this workshop, the latest developments concerning multi-hadron systems and nonlocal matrix elements in lattice QCD were discussed: • Liischer's quantization condition relates the energy spectrum of two interacting particles in a finite volume to the scattering phase shifts. At this workshop, generalizations of Liischer's quantization condition to three-particle systems, and to two-particle systems with long-range QED interactions were presented. • Advanced numerical lattice QCD studies of hadronic resonances using the Liischer method were shown, including coupled-channel scattering and near-threshold resonances. • The Lellouch-Liischer formula relates two-hadron matrix elements computed in a finite volume to the infinite-volume matrix elements. This workshop included presentations of the latest numerical lattice QCD calculations ofthe nonleptonic weak decay K ® tl tl, as well as new theoretical results extending the Lellouch-Liischer formula to general multichannel 1 ® 2 transition matrix elements. • Novel methods allowing the direct calculation of parton distribution functions in lattice QCD were discussed, and a one-loop calculation of the lattice-to-continuum matching required for these methods was presented. • Lattice QCD calculations of nonlocal matrix elements relevant for rare kaon decays and for the Kl-Ks mass difference were shown. The inclusion of QED corrections in weak decays was discussed. Results from a new method for computing the hadronic light-by-light contribution to the muon anomalous magnetic moment were shown. • • Calculations of the binding energies and magnetic moments of light nuclei directly from lattice QCD were presented. The theoretical foundations of a potential-based method for studying multihadron interactions on the lattice were discussed, and an application of this method to charmed tetraquarks was shown.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

SOP--Determining the Volume of a Container

The purpose of this Standard Operating Procedure (SOP) is to give guidelines on how to measure the volume of a container for use in radiography studies. This SOP gives details on a recommended method of how exactly to measure the volume of containers used for specimens for Micro CT and EDS measurements. This volume is important in determining accurate densities of the specimens. This SOP is referred to in TP 48 - Preparation of Hydrogen Peroxide/Icing Sugar Specimens for X-ray Measurements by J.G. Reynolds and H.E. Martz

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Modeling the Effect of Glass Microballoon (GMB) Volume Fraction on Behavior of Sylgard/GMB Composites.

This work was done to support customer questions about whether a Sylgard/Glass Microballoon (GMB) potting material in current use could be replaced with pure Sylgard and if this would significantly change stresses imparted to internal components under thermal cycling conditions. To address these questions, we provide micromechanics analysis of Sylgard/GMB materials using both analytic composite theory and finite element simulations to better understand the role of the GMB volume fraction in determining thermal expansion coefficient, elastic constants, and behavior in both confined and unconfined compression boundary value problems. A key finding is that damage accumulation in the material from breakage of GMBs significantly limits the global stress magnitude and results in a plateau stress behavior over large ranges of compressive strain. The magnitude of this plateau stress is reduced with higher volume fractions of GMBs. This effect is particularly pronounced in confined compression, which we estimate bears the most similarity to the application of interest. This stress-limiting damage mechanism is not present in pure Sylgard, however, and the result is much higher stresses under confined compression. Thus, we recommend that some volume fraction greater than 10% GMBs be used for confined deformation applications.

36 MATERIALS SCIENCE↗

2017 Project Peer Review: U.S. Department of Energy Wind Energy Technologies Office: Volume I

This report details the results of the 2017 Peer Review for the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy Wind Energy Technologies Office (WETO). The purpose of the review was to evaluate projects funded by DOE from fiscal year 2014 through fiscal year 2016 for their contribution to the mission and goals of the office, assess progress against stated objectives, and appraise WETO’s overall management and performance. This volume (Volume I) includes Sections 1–5 of the report: the executive summary, synopses of the program and project-level evaluation results, and WETO’s response to the 2017 Peer Review findings. Volume II includes Sections 6 and 7—the complete program-level and project-level evaluation results—as well as the report appendices.

17 WIND ENERGY↗

The DUNE Far Detector Interim Design Report Volume 1: Physics, Technology and Strategies

The DUNE IDR describes the proposed physics program and technical designs of the DUNE Far Detector modules in preparation for the full TDR to be published in 2019. It is intended as an intermediate milestone on the path to a full TDR, justifying the technical choices that flow down from the high-level physics goals through requirements at all levels of the Project. These design choices will enable the DUNE experiment to make the ground-breaking discoveries that will help to answer fundamental physics questions. Volume 1 contains an executive summary that describes the general aims of this document. The remainder of this first volume provides a more detailed description of the DUNE physics program that drives the choice of detector technologies. It also includes concise outlines of two overarching systems that have not yet evolved to consortium structures: computing and calibration. Volumes 2 and 3 of this IDR describe, for the single-phase and dual-phase technologies, respectively, each detector module's subsystems, the technical coordination required for its design, construction, installation, and integration, and its organizational structure.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗