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Probing the Conical Intersection Dynamics of the RNA Base Uracil by UV-Pump Stimulated-Raman-Probe Signals; Ab Initio Simulations
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Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position
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Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H
Abstract not provided
Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication
Abstract not provided
Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2;#8242;-Fluoro RNA
Abstract not provided
Defining the functional determinants for RNA surveillance by RIG-I
Abstract not provided
In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation
Purely in vitro ribosome synthesis could provide a critical step towards unraveling the systems biology of ribosome biogenesis, constructing minimal cells from defined components, and engineering ribosomes with new functions. Here, as an initial step towards this goal, we report a method for constructing Escherichia coli ribosomes in crude S150 E. coli extracts. While conventional methods for E. coli ribosome reconstitution are non-physiological, our approach attempts to mimic chemical conditions in the cytoplasm, thus permitting several biological processes to occur simultaneously. Specifically, our integrated synthesis, assembly, and translation (iSAT) technology enables one-step co-activation of rRNA transcription, assembly of transcribed rRNA with native ribosomal proteins into functional ribosomes, and synthesis of active protein by these ribosomes in the same compartment. We show that iSAT makes possible the in vitro construction of modified ribosomes by introducing a 23S rRNA mutation that mediates resistance against clindamycin. We anticipate that iSAT will aid studies of ribosome assembly and open new avenues for making ribosomes with altered properties.
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1
Abstract not provided
Initiation of translation in bacteria by a structured eukaryotic IRES RNA
Abstract not provided
RNA degradation paths in a 12-subunit nuclear exosome complex
Abstract not provided
Structural basis for high-affinity fluorophore binding and activation by RNA Mango
Abstract not provided
Structural basis for RNA recognition by a dimeric PPR-protein complex
Abstract not provided