Increased Risk of Exposure Induced Death Associated with Clonal Hematopoiesis of Indeterminate Potential for Mars Mission Scenarios
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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The increase in automated capabilities of small Uncrewed Aerial Systems (sUAS) has enabled the human operators to manage larger numbers of vehicles simultaneously. As this happens, the operational paradigm shifts to an m:N configuration where multiple operators (m) are managing multiple vehicles (N) together. However, many questions about how operators will interact with each other and share interaction across the vehicle pool are yet unanswered. Therefore, stakeholders from government and industry have partnered to develop ground control station concepts for such operations. The work presented in this paper aims to identify factors that contribute to operator workload. A supervised machine learning-based method built using Support Vector Machines and K-fold cross-validation was used to create workload prediction models for various NASA TLX subscales by leveraging features related to interactions and their relative timings during m:N operations. Results show that the models yielded fairly high predictive accuracies ranging from ~60-75%.
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New concepts in aviation system safety thinking have emerged to consider not only what may go wrong, but also what can be learned when things go right. This approach forms a more comprehensive approach to system safety thinking. A need exists for methods to enable a better understanding of human contributions to aviation safety and how they may inform Safety Management Systems (SMS). A high-fidelity 737-800 simulation study was conducted to study how current type-rated commercial airline flight crews anticipate, monitor, respond to, and learn from expected and unexpected disturbances during line operations. A number of dependent measures were collected that included traditional SMS data types, but also non-traditional safety data to include multiple psychophysiological metrics. This paper describes the psychophysiological measures results that evinced the capability of measures to help identify resilient flight crews. Implications for future research and design of future In-time Aviation Safety Management Systems are discussed.
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New concepts in aviation system safety thinking have emerged to consider not only what may go wrong, but also what can be learned when things go right. This approach forms a more comprehensive approach to system safety thinking. A need exists for methods to enable a better understanding of human contributions to aviation safety and how they may inform Safety Management Systems (SMS). A high-fidelity 737-800 simulation study was conducted to study how current type-rated commercial airline flight crews anticipate, monitor, respond to, and learn from expected and unexpected disturbances during line operations. A number of dependent measures were collected that included traditional SMS data types, but also non-traditional safety data to include multiple psychophysiological metrics. This paper describes the psychophysiological measures results that evinced the capability of measures to help identify resilient flight crews. Implications for future research and design of future In-time Aviation Safety Management Systems are discussed.
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Globally, we are facing an emerging climate crisis, with impacts to be notably felt in semiarid regions across the world. Cultivation of drought-adapted succulent plants has been suggested as a nature-based solution that could: (i) reduce land degradation, (ii) increase agricultural diversification and provide both economic and environmentally sustainable income through derived bioproducts and bioenergy, (iii) help mitigate atmospheric CO 2 emissions and (iv) increase soil sequestration of CO 2 . Identifying where succulents can grow and thrive is an important prerequisite for the advent of a sustainable alternative ‘bioeconomy’. Here, we first explore the viability of succulent cultivation in Africa under future climate projections to 2100 using species distribution modelling to identify climatic parameters of greatest importance and regions of environmental suitability. Minimum temperatures and temperature variability are shown to be key controls in defining the theoretical distribution of three succulent species explored, and under both current and future SSP5 8.5 projections, the conditions required for the growth of at least one of the species are met in most parts of sub-Saharan Africa. These results are supplemented with an analysis of potentially available land for alternative succulent crop cultivation. In total, up to 1.5 billion ha could be considered ecophysiologically suitable and available for succulent cultivation due to projected declines in rangeland biomass and yields of traditional crops. These findings may serve to highlight new opportunities for farmers, governments and key stakeholders in the agriculture and energy sectors to invest in sustainable bioeconomic alternatives that deliver on environmental, social and economic goals.
This paper describes the rationale and the protocol of the first component of the third simulation round of the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP3a, http://www.isimip.org, last access: 2 November 2023) and the associated set of climate-related and direct human forcing data (CRF and DHF, respectively). The observation-based climate-related forcings for the first time include high-resolution observational climate forcings derived by orographic downscaling, monthly to hourly coastal water levels, and wind fields associated with historical tropical cyclones. The DHFs include land use patterns, population densities, information about water and agricultural management, and fishing intensities. The ISIMIP3a impact model simulations driven by these observation-based climate-related and direct human forcings are designed to test to what degree the impact models can explain observed changes in natural and human systems. In a second set of ISIMIP3a experiments the participating impact models are forced by the same DHFs but a counterfactual set of atmospheric forcings and coastal water levels where observed trends have been removed. These experiments are designed to allow for the attribution of observed changes in natural, human, and managed systems to climate change, rising CH 4 and CO 2 concentrations, and sea level rise according to the definition of the Working Group II contribution to the IPCC AR6.
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X-ray and MeV polarization can be powerful diagnostics for leptonic and hadronic blazar models. Previous predictions are mostly based on a one-zone framework. However, recent IXPE observations of Mrk 421 and 501 strongly favor a multizone framework. Thus, the leptonic and hadronic polarization predictions need to be revisited. Here we identify two generic radiation transfer effects, namely, double depolarization and energy stratification, that can have an impact on the leptonic and hadronic polarization. We show how they are generalized from previously known multizone effects of the primary electron synchrotron radiation. Under our generic multizone model, the leptonic polarization degree is expected to be much lower than the one-zone prediction, unlikely detectable in most cases. The hadronic polarization degree can reach a value as high as the primary electron synchrotron polarization during simultaneous multiwavelength flares, consistent with the one-zone prediction. Therefore, IXPE and future X-ray and MeV polarimeters such as eXTP, COSI, and AMEGO-X, have good chances to detect hadronic polarization during flares. However, the hadronic polarization cannot be well constrained during the quiescent state. Nonetheless, if some blazar jets possess relatively stable large-scale magnetic structures, as suggested by radio observations, a nontrivial polarization degree may show up for the hadronic model after a very long exposure time (≳1 yr).