Interband Cascade Optical Frequency Comb Spectroscopy of C-H bonds
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The transboundary Pumqu/Arun River basin spreads across Nepal and Tibet. Nearly 95% of the basin lies in Tibet through which the Pumqu River flows forming the Arun River once it enters Nepal. The Arun River valley has about 3,163 MW in five large hydropower projects undergoing construction or planned for the future. Rainfall and earthquake-induced landslides, landslide dammed lakes and landslide-induced glacial lake outburst floods pose major risks to smooth operation of these projects. To safeguard upcoming hydropower projects, areas susceptible to landslides in the Arun River valley must be identified. We generated a multitemporal landslide inventory (2010-2020), modeled landslide susceptibility and runouts around the hydropower sites using Earth Observation (EO) techniques. We used high-resolution satellite imagery from Planet and open-source tool to establish a detailed and comprehensive multitemporal landslide inventory for the basin. The rigorous quality-controlled inventory represents yearly record of landslides from 2010 to 2020. To our knowledge this is one of the most comprehensive landslide inventories for the basin with yearly records of landslides.A data-driven approach was used to map areas susceptible to landslides within the Pumqu/Arun River basin. The multitemporal landslide inventory combined with other readily available EO-based variables were used to create a landslide susceptibility map. The highly susceptible areas delineated from the map was further used to characterize runouts near the hydropower sites. The susceptibility and runout analysis provide a valuable initial estimate of where landslides are likely to trigger and where the mobilized material is likely to end up.
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A cascade of three protein kinases known as a mitogen-activated protein kinase (MAPK) cascade is commonly found as part of the signaling pathways in eukaryotic cells. Almost two decades of genetic and biochemical experimentation plus the recently completed DNA sequence of the Saccharomyces cerevisiae genome have revealed just five functionally distinct MAPK cascades in this yeast. Sexual conjugation, cell growth, and adaptation to stress, for example, all require MAPK-mediated cellular responses. A primary function of these cascades appears to be the regulation of gene expression in response to extracellular signals or as part of specific developmental processes. In addition, the MAPK cascades often appear to regulate the cell cycle and vice versa. Despite the success of the gene hunter era in revealing these pathways, there are still many significant gaps in our knowledge of the molecular mechanisms for activation of these cascades and how the cascades regulate cell function. For example, comparison of different yeast signaling pathways reveals a surprising variety of different types of upstream signaling proteins that function to activate a MAPK cascade, yet how the upstream proteins actually activate the cascade remains unclear. We also know that the yeast MAPK pathways regulate each other and interact with other signaling pathways to produce a coordinated pattern of gene expression, but the molecular mechanisms of this cross talk are poorly understood. This review is therefore an attempt to present the current knowledge of MAPK pathways in yeast and some directions for future research in this area.
We recently proposed that a magnetohydrodynamic (MHD) turbulent cascade produces the bulk energization of electrons to approximately 25 keV in the impulsive phase of solar flares (LaRosa & Moore 1993). In that scenario, (1) the cascading MHD turbulence is fed by shear-unstable Alfvenic outflows from sites of strongly driven reconnection in the low corona, and (2) the electrons are energized by absorbing the energy that flows down through the cascade. We did not specify the physical mechanism by which the cascading energy is ultimately transferred to the electrons. Here we propose that Fermi acceleration is this mechanism, the process by which the electrons are energized and by which the cascading MHD turbulence is dissipated. We point out that in the expected cascade MHD fluctuations of scale 1 km can Fermi-accelerate electrons from 0.1 keV to approximately 25 keV on the subsecond timescales observed in impulsive flares, provided there is sufficient trapping and scattering of electrons in the MHD turbulence. We show that these same fluctuations provide the required trapping; they confine the electrons within the turbulent region until the turbulence eis dissipated. This results in the energization of all of the lectrons in each large-scale (5 x 10(exp 7)cm) turbulent eddy to 25 keV. The Fermi process also requires efficient scattering so that the pitch-angle distribution of the accelerating electrons remains isotropic. We propose that the electrons undergo resonant scattering by high-frequency plasma R-waves that, as suggested by others (Hamilton & Petrosian 1992), are generated by the reconnection. Ions are not scattered by R-waves. Provided that there is negligible generation of ion-scattering plasma turbulence (e.g., L-waves) by the reconnection or the MHD turbulence, the ions will not Fermi-accelerate and the cascading energy is transferred only to the electrons. We conclude that, given this situation, electron Fermi acceleration can plausibly account for the electron bulk energization in impulsive solar flares.
Various methods for the study of muon spectrum are presented. The direct ones include the muon energy measurements by magnetic spectrometers. The indirect ones deal with the reconstruction of the muon spectrum from the spectrum of secondary particles obtained by burst or calorimeter technique. The burst technique is based on the measurement of the number of cascade particles, mainly in the cascade maximum, by the detectors of small thickness T sub 0. The calorimeter method consist in determination of the cascade energy with help of the cascade curve shape. The multilayer detectors are used for this purpose. They are usually comprised of proportional counters, X-ray emulsion chambers or scintillation counters with the target material placed between them. The scintillation detectors of a large thickness measures the total cascade energy directly and the detector works as a true calorimeter. When the total energy is detected, the cascade spectrum differs from the muon one.