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Developing an Active Learning algorithm for learning Bayesian classifiers under the Multiple Instance Learning scenario

In the Multiple Instance Learning scenario, the training data consists of instances grouped into bags, and each bag is labelled with whether it is positive, i.e. contains at least one positive instance. First, Active Learning, in which additional labels can be iteratively requested, has the potential to allow more accurate classifiers to be learned with less labels. Active Learning has been applied to the Multiple Instance Learning under two settings: when bag labels of unlabelled bags can be requested, and when instance labels within bags known to be positive can be requested. Second, Bayesian Active learning methods have the potential to learn accurate classifiers with few labels, because they explicitly track the classifier uncertainty and can thus address its knowledge gaps. Yet, there does not exist any Bayesian Active Learning method for the Multiple Instance Learning Scenario. In this work, we develop the first such method. We develop a Bayesian classifier for the Multiple Instance Learning scenario, show how it can be efficiently used for Bayesian Active Learning, and perform experiments assessing its performance. While its performance exceeds that when no Active Learning is used, it is sometimes better, sometimes worse than the naive baseline of uncertainty sampling, depending on the situation. This suggests future work: building more customizable Bayesian Active Learning methods for the Multiple Instance Scenario, customizable to whether bag or instance label accuracy is targeted, and the labeling budget.

97 MATHEMATICS AND COMPUTING↗

High-Energy Laser Direct Strike Assessment for NIF CryoXNBS Snout and Naiad SNM Container

An experimental IPT performed two NIF shots as an assessment of the effect of a direct laser beam strike impact on the NIF CryoXNBS snout and Naiad container. Four aligned NIF outer cone beams at best focus, 42 kJ total, struck a four millimeter thick stainless plate. In the first shot, the struck plate was followed by a 1.75 mm gap and a 2.0 millimeter stainless plate to create a surrogate geometry for the current CryoXNBS snout and Naiad container. There was minor plastic deformation of the rear plate rear surface with no evidence of bulk failure. The second shot tested a layered glass-filled polycarbonate and titanium shield placed in the gap. Nondestructive assay was sufficient to metrologize the beam strike area and the damage induced to the NIF target assemblies.

36 MATERIALS SCIENCE↗

Plant Design for a Developing Bioeconomy Workshop Report: Frontier Science for the Bioeconomy Workshop Series

Recent advances in fundamental plant biology research, synthetic biology, and artificial intelligence (AI) are unlocking powerful new capabilities in plant biodesign, offering unprecedented potential to reimagine plants as programmable platforms for resource-efficient production of bioenergy, biomaterials, chemicals, and more. The U.S. Department of Energy (DOE) convened the Plant Design for a Developing Bioeconomy virtual workshop on March 12 through 14, 2025, to bring together leaders across plant science, engineering, and computation to assess the current landscape and define a bold vision for future research. Discussions during the workshop built upon findings included in DOE’s Biological and Environmental Research (BER) workshop report Overcoming Barriers in Plant Transformation: A Focus on Bioenergy Crops (U.S. DOE 2024; genomicscience. energy.gov/plant-transformation). Participants identified critical knowledge gaps, technical barriers, and emerging opportunities in the design and engineering of plant systems to support a robust, resilient domestic bioeconomy aligned with DOE’s mission.

09 BIOMASS FUELS↗

Improving the Transition of Earth Satellite Observations from Research to Operations

There are significant gaps between the observations, models, and decision support tools that make use of new data. These challenges include: 1) Decreasing the time to incorporate new satellite data into operational forecast assimilation systems, 2) Blending in-situ and satellite observing systems to produce the most accurate and comprehensive data products and assessments, 3) Accelerating the transition from research to applications through national test beds, field campaigns, and pilot demonstrations, and 4) Developing the partnerships and organizational structures to effectively transition new technology into operations. At the Short-term Prediction Research and Transition (SPORT) Center in Huntsville, Alabama, a NASA-NOAA-University collaboration has been developed to accelerate the infusion of NASA Earth science observations, data assimilation and modeling research into NWS forecast operations and decision-making. The SPoRT Center research focus is to improve forecasts through new observation capability and the regional prediction objectives of the US Weather Research Program dealing with 0-1 day forecast issues such as convective initiation and 24-hr quantitative precipitation forecasting. The near real-time availability of high-resolution experimental products of the atmosphere, land, and ocean from the Moderate Resolution Imaging Spectroradiometer (MODIS), the Advanced Infrared Spectroradiometer (AIRS), and lightning mapping systems provide an opportunity for science and algorithm risk reduction, and for application assessment prior to planned observations from the next generation of operational low Earth orbiting and geostationary Earth orbiting satellites. This paper describes the process for the transition of experimental products into forecast operations, current products undergoing assessment by forecasters, and plans for the future. The SPoRT Web page is at (http://www.ghcc.msfc.nasa.gov/sport).

Goodman, Steven J.↗

Screening of Potential Landing Gear Noise Control Devices at Virginia Tech For QTD II Flight Test

In support of the QTD II (Quiet Technology Demonstrator) program, aeroacoustic measurements of a 26%-scale, Boeing 777 main landing gear model were conducted in the Virginia Tech Stability Tunnel. The objective of these measurements was to perform risk mitigation studies on noise control devices for a flight test performed at Glasgow, Montana in 2005. The noise control devices were designed to target the primary main gear noise sources as observed in several previous tests. To accomplish this task, devices to reduce noise were built using stereo lithography for landing gear components such as the brakes, the forward cable harness, the shock strut, the door/strut gap and the lower truck. The most promising device was down selected from test results. In subsequent stages, the initial design of the selected lower truck fairing was improved to account for all the implementation constraints encountered in the full-scale airplane. The redesigned truck fairing was then retested to assess the impact of the modifications on the noise reduction potential. From extensive acoustic measurements obtained using a 63-element microphone phased array, acoustic source maps and integrated spectra were generated in order to estimate the noise reduction achievable with each device.

Ravetta, Patricio A.↗

Why Income Comparison is Rational

A major factor affecting a person s happiness is the gap between their income and their neighbors , independent of their own income. This effect is strongest when the neighbor has moderately higher income. In addition a person s lifetime happiness often follows a "U" shape. Previous models have explained subsets of these phenomena, typically assuming the person has limited ability to assess their own (hedonic) utility. Here I present a model that explains all the phenomena, without such assumptions. In this model greater income of your neighbor is statistical data that, if carefully analyzed, would recommend that you explore for a new income-generating strategy. This explains unhappiness that your neighbor has greater income, as an emotional "prod" that induces you to explore, in accord with careful statistical analysis. It explains the "U" shape of happiness similarly. Another benefit of this model is that it makes many falsifiable predictions.

Wolpert, David H.↗

Improved Determination of Europa's Long-Wavelength Topography Using Stellar Occultations

Europa Clipper will arrive at Jupiter at the end of this decade and will explore Europa through a series of flybys. One of its many goals is to characterize Europa's topography and global shape using the Europa Imaging System and Radar for Europa Assessment and Sounding: Ocean to Near-surface (REASON) instruments. In addition, Europa Clipper's UV Spectrograph will observe stars pass behind (be occulted by) Europa. The spectrograph has sufficiently precise timing, corresponding to a topographic precision of order meters, that these occultations can also serve as altimetric measurements. Because of gaps in the REASON radar altimeter coverage imposed by the flyby geometries, the addition of ∼100 occultations results in a substantial improvement in the recovery of Europa's long-wavelength shape. Typically, five extra spherical harmonic degrees of topography can be recovered by combining occultations with radar altimetry.

Jacob N. H. Abrahams↗

NASA Advanced Explorations Systems: Advancements in Life Support Systems

The NASA Advanced Exploration Systems (AES) Life Support Systems (LSS) project strives to develop reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support systems (ECLSS) critical to enabling long duration human missions beyond low Earth orbit (LEO). Highly reliable, closed-loop life support systems are among the capabilities required for the longer duration human space exploration missions assessed by NASA's Habitability Architecture Team (HAT). The LSS project is focused on four areas: architecture and systems engineering for life support systems, environmental monitoring, air revitalization, and wastewater processing and water management. Starting with the international space station (ISS) LSS systems as a point of departure (where applicable), the mission of the LSS project is three-fold: 1. Address discrete LSS technology gaps 2. Improve the reliability of LSS systems 3. Advance LSS systems towards integrated testing on the ISS. This paper summarized the work being done in the four areas listed above to meet these objectives. Details will be given on the following focus areas: Systems Engineering and Architecture- With so many complex systems comprising life support in space, it is important to understand the overall system requirements to define life support system architectures for different space mission classes, ensure that all the components integrate well together and verify that testing is as representative of destination environments as possible. Environmental Monitoring- In an enclosed spacecraft that is constantly operating complex machinery for its own basic functionality as well as science experiments and technology demonstrations, it's possible for the environment to become compromised. While current environmental monitors aboard the ISS will alert crew members and mission control if there is an emergency, long-duration environmental monitoring cannot be done in-orbit as current methodologies rely largely on sending environmental samples back to Earth. The LSS project is developing onboard analysis capabilities that will replace the need to return air and water samples from space for ground analysis. Air Revitalization- The air revitalization task is comprised of work in carbon dioxide removal, oxygen generation and recovery and trace contamination and particulate control. The CO2 Removal and associated air drying development efforts under the LSS project are focused both on improving the current SOA technology on the ISS and assessing and examining the viability of other sorbents and technologies available in academia and industry. The Oxygen Generation and Recovery technology development area encompasses several sub-tasks in an effort to supply O2 to the crew at the required conditions, to recover O2 from metabolic CO2, and to recycle recovered O2 back to the cabin environment. Current state-of-the-art oxygen generation systems aboard space station are capable of generating or recovering approximately 40% of required oxygen; for exploration missions this percentage needs to be greatly increased. A spacecraft cabin trace contaminant and particulate control system serves to keep the environment below the spacecraft maximum allowable concentration (SMAC) for chemicals and particulates. Both passive (filters) and active (scrubbers) methods contribute to the overall TC & PC design. Work in the area of trace contamination and particulate control under the LSS project is focused on making improvements to the SOA TC & PC systems on ISS to improve performance and reduce consumables. Wastewater Processing and Water Management- A major goal of the LSS project is the development of water recovery systems to support long duration human exploration beyond LEO. Current space station wastewater processing and water management systems distill urine and wastewater to recover water from urine and humidity condensate in the spacecraft at a approximately 74% recovery rate. For longer, farther missions into deep space, that recovery rate must be greatly increased so that astronauts can journey for months without resupply cargo ships from Earth.

Shull, Sarah A.↗

Electronic structure of intrinsic defects in c -gallium nitride: Density functional theory study without the jellium approximation

Here, we report the first nonjellium, systematic, density functional theory (DFT) study of intrinsic and extrinsic defects and defect levels in zinc-blende (cubic) gallium nitride. We use the local moment counter charge (LMCC) method, the standard Perdew-Becke-Ernzerhoff (PBE) exchange-correlation potential, and two pseudopotentials, where the Ga 3$\textit{d}$ orbitals are either in the core ($d^0$) or explicitly in the valence set ($d^{10}$). We studied 64, 216, 512, and 1000 atom supercells, and demonstrated convergence to the infinite limit, crucial for delineating deep from shallow states near band edges, and for demonstrating the elimination of finite cell-size errors. Contrary to common claims, we find that exact exchange is not required to obtain defect levels across the experimental band gap. As was true in silicon, silicon carbide, and gallium arsenide, the extremal LMCC defect levels of the aggregate of defects yield an effective LMCC defect band gap that is within 10% of the experimental gap (3.3 eV) for both pseudopotentials. We demonstrate that the gallium vacancy is more complicated than previously reported. There is dramatic metastability–a nearest-neighbor nitrogen atom shifts into the gallium site, forming an antisite, nitrogen vacancy pair, which is more stable than the simple vacancy for positive charge states. Our assessment of the $d^0$ and $d^{10}$ pseudopotentials yields minimal differences in defect structures and defect levels. The better agreement of the $d^0$ lattice constant with experiment suggests that the more computationally economical $d^0$ pseudopotentials are sufficient to achieve the fidelity possible within the physical accuracy of DFT, and thereby enable calculations in larger supercells necessary to demonstrate convergence with respect to finite size supercell errors.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

A roadmap to understanding and anticipating microbial gene transfer in soil communities

Engineered microbes are being programmed using synthetic DNA for applications in soil to overcome global challenges related to climate change, energy, food security, and pollution. However, we cannot yet predict gene transfer processes in soil to assess the frequency of unintentional transfer of engineered DNA to environmental microbes when applying synthetic biology technologies at scale. This challenge exists because of the complex and heterogeneous characteristics of soils, which contribute to the fitness and transport of cells and the exchange of genetic material within communities. Here, we describe knowledge gaps about gene transfer across soil microbiomes. Here, we propose strategies to improve our understanding of gene transfer across soil communities, highlight the need to benchmark the performance of biocontainment measures in situ, and discuss responsibly engaging community stakeholders. We highlight opportunities to address knowledge gaps, such as creating a set of soil standards for studying gene transfer across diverse soil types and measuring gene transfer host range across microbiomes using emerging technologies. By comparing gene transfer rates, host range, and persistence of engineered microbes across different soils, we posit that community-scale, environment-specific models can be built that anticipate biotechnology risks. Such studies will enable the design of safer biotechnologies that allow us to realize the benefits of synthetic biology and mitigate risks associated with the release of such technologies.

bioccontainment↗

Tidal Resource Gaps Analysis Technical Report

The tidal resource gaps project was created to address a growing body of evidence that models underpredict tidal current speeds compared to measurements at a number of the top-ranking tidal energy sites. In response, this project compared opportunistic tidal power density measurements from 16 tidal energy hot spot sites with estimates from resource assessment data to identify discrepancies. To improve the accuracy of resource estimates from model data, updated data from eight improved model simulations were obtained. Model improvements included grid refinement, domain coupling, and the use of unstructured or nested grids. New resource estimates were calculated from the updated models, and these data were used to update the tidal hot spots-a list of promising tidal energy sites around the United States.

16 TIDAL AND WAVE POWER↗

Check-Up of Planet Earth at the Turn of the Millennium: Anticipated New Phase in Earth Sciences

Langley's remarkable solar and lunar spectra collected from Mt. Whitney inspired Arrhenius to develop the first quantitative climate model in 1896. In 1999, NASA's Earth Observing AM Satellite (EOS-AM) will repeat Langley's experiment, but for the entire planet, thus pioneering calibrated spectral observations from space. Conceived in response to real environmental problems, EOS-AM, in conjunction with other international satellite efforts, will fill a major gap in current efforts by providing quantitative global data sets with a resolution of few kilometers on the physical, chemical and biological elements of the earth system. Thus, like Langley's data, EOS-AM can revolutionize climate research by inspiring a new generation of climate system models and enable us to assess the human impact on the environment.

Kaufman, Y. J.↗

Check-Up of Planet Earth at the Turn of the Millennium Anticipated New Phase in Earth Sciences

Langley's remarkable solar and lunar spectra collected from mt. Whitney inspired Arrhenius to develop the first quantitative climate model in 1896. In 1999, NASA's Earth Observing AM Satellite named recently "Terra" (by Ms. Sasha Jones, a 17 year old student in St. Louis, MO) will repeat Langley's experiment, but for the entire planet, thus pioneering calibrated spectral observations from space. Conceived in response to real environmental problems, EOS-AM, in conjunction with other international satellite efforts, will fill a major gap in current efforts by providing quantitative global data sets with a resolution of few kilometers on the physical, chemical and biological elements of the earth system. Thus, like Langley's data, EOS-AM can revolutionize climate research by inspiring a new generation of climate system models and enable us to assess the human impact on the environment. In this talk I shall a give a historical perspective for the need for this expensive mission, give examples of the science that we anticipate to achieve using Terra measurements and describe this exciting mission.

Kaufman, Yoram↗

Check-Up of Planet Earth at the Turn of the Millennium: Contribution of EOS-Terra to a New Phase in Earth Sciences

Langley's remarkable solar and lunar spectra collected from Mt. Whitney inspired Arrhenius to develop the first quantitative climate model in 1896. In 1999, NASA's Earth Observing AM Satellite (EOS-Terra) will repeat Langley's experiment, but for the entire planet, thus pioneering a wide array of calibrated spectral observations from space of the Earth System. Conceived in response to real environmental problems, EOS-Terra, in conjunction with other international satellite efforts, will fill a major gap in current efforts by providing quantitative global data sets with a resolution of few kilometers on the physical, chemical and biological elements of the earth system. Thus, like Langley's data, EOS-Terra can revolutionize climate research by inspiring a new generation of climate system models and enable us to assess the human impact on the environment. In the talk I shall review the historical developments that brought to the Terra mission, its objectives and example of application to biomass burning.

Kaufman, Yoram↗

Experimental Investigation of a One-Sided Ejector Nozzle

A fundamental exploratory experiment is conducted assessing the performance of a one-sided ejector with the eventual goal of noise reduction for jet engines. The hardware is comprised of an 8:1 rectangular nozzle together with an ejector box whose lower surface is flush with the lower lip of the nozzle. Secondary flow is allowed through a gap between the upper lip of the nozzle and a flap that constitutes the upper surface of the ejector. Wall static pressures and Pitot probe surveys are conducted to evaluate the performance of the ejector with variation of geometric parameters. It is found that addition of vortex generating tabs at the upper lip of the nozzle significantly increases secondary flow entrainment. The entrainment is further enhanced by a divergence of the ejector up-per surface. Limited noise measurements are done. The baseline ejector (without tabs) often encounters flow resonance with accompanying tones. The tabs have the additional benefit of eliminating those tones in all cases. However, for the tabbed case, addition of the ejector produces insignificant further noise reduction. This is due to the fact that the flow remains unmixed on the lower half of the ejector. The focus of ongoing and future efforts is to achieve sufficient mixing of the flow so that the exhaust velocities are uniformly low, while keeping the ejector hardware short and light-weight.

Zaman, K. B. M. Q.↗

Experimental Investigation of a One-Sided Ejector Nozzle

A fundamental exploratory experiment is conducted assessing the performance of a one-sided ejector with the eventual goal of noise reduction for jet engines. The hardware is comprised of an 8:1 rectangular nozzle together with an ejector box whose lower surface is flush with the lower lip of the nozzle. Secondary flow is allowed through a gap between the upper lip of the nozzle and a flap that constitutes the upper surface of the ejector. Wall static pressures and Pitot probe surveys are conducted to evaluate the performance of the ejector with variation of geometric parameters. It is found that addition of vortex generating tabs at the upper lip of the nozzle significantly increases secondary flow entrainment. The entrainment is further enhanced by a divergence of the ejector upper surface. Limited noise measurements are done. The baseline ejector (without tabs) often encounters flow resonance with accompanying tones. The tabs have the additional benefit of eliminating those tones in all cases. However, for the tabbed case, addition of the ejector produces insignificant further noise reduction. This is due to the fact that the flow remains unmixed on the lower half of the ejector. The focus of ongoing and future efforts is to achieve sufficient mixing of the flow so that the exhaust velocities are uniformly low, while keeping the ejector hardware short and lightweight.

Ejectors↗

Assessing Compatibility of Natural Gas Pipeline Materials with Hydrogen, CO 2 , and Ammonia

Here, in this study, we examine the efficacy of repurposing natural gas (NG) pipelines for transporting hydrogen blends (with NG), ammonia, and CO 2 (gaseous and supercritical) from the standpoint of materials compatibility. Some information pertaining to component performance is also included, especially those components critical for pressurization and monitoring of flow. A listing of critical pipeline components and materials was developed, and their compatibilities was assessed for each fluid or gas type based on known compatibilities. Results indicate that pipeline materials should be suitable for gaseous CO 2 and anhydrous ammonia, but hydrogen blends greater than 12% may be problematic. Current compressor/regulator stations will not be suitable for use with either supercritical CO 2 or ammonia. Important knowledge gaps were identified, including (1) polymer performance with hydrogen/NG blends at low pressures, (2) compressor/regulator station polymers and epoxy coating materials with supercritical CO 2 , and (3) metal performances of hydrogen/NG blends at low pressures.

03 NATURAL GAS↗

Windowed Fourier transform and cross-correlation algorithms for molecular tagging velocimetry

In this study, simulated and experimental molecular tagging velocimetry (MTV) images have been analyzed with a technique commonly used to process grid images on surfaces, the windowed Fourier transform with local spectrum analysis (WFT-LSA). A systematic synthetic image study of the modulation transfer function (MTF) and error tendencies of the WFT-LSA was performed and compared with a PIV-style cross-correlation algorithm to see if advanced strategies such as iterative image deformation can improve analysis of gridded images with high noise levels. Testing of single-pass algorithms showed that in typical MTV images, the WFT-LSA yields significantly lower bias errors than cross-correlation (CC) at displacements greater than 1 pixel but slightly higher random error at all displacements and image conditions. Analysis of the MTF shows that CC provided better resolution of spatial fluctuations than the WFT-LSA in many combinations of grid size and interrogation window. Tests of image deformation algorithms showed that the gap in performance between CC and WFT-LSA is maintained even as both methods improve. Additionally, WFT-LSA and CC methods are applied to real MTV experiments in high-speed gas jet flows. A preliminary analysis of phosphorescence lifetime provided by acetone vapor excited at 266 nm is used for assessing the required gas speeds for making MTV application feasible. The application of WFT-LSA to real MTV images demonstrates the ability of the algorithm to handle further real-world effects that could not be considered in the synthetic image analysis, like reduced signal-to-noise ratio and non-uniform intensity of the tagging grid across the image introduced by the actual laser beam energy distribution. With experimental images, CC is more accurate with shear flows but less robust to high noise levels than WFT-LSA, as predicted by the synthetic image analysis.

42 ENGINEERING↗