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At least 937 records · Page 52

Testing the Common Platform LLRF with a 197 MHz NCRF Cavity

The Common Platform is the hardware that will support the new LLRF platform to be used for the Electron-Ion Collider. The Common Platform features a carrier board that is used to interface with a variety of daughter for different applications. This paper details the testing that was done using the Common Platform and an RF Digitizer Daugther Board. Firstly, the firmware and software development is discussed followed by a description of the controls algorithms used in the testing. Then, testing and verification of the platform with a 197 MHz NCRF cavity is discussed. The paper concludes with results from the testing and the path forward.

42 ENGINEERING↗

TU-C-12A-07: Characterization of Longitudinal Reproducibility of Quantitative Diffusion Imaging Data Acquired with Four Different Protocols Using a Phantom

Purpose: To characterize and compare the longitudinal reproducibility of diffusion imaging data acquired with four different protocols using a phantom. Methods: The Diffusive Quantitative Imaging Phantom (DQIP) was constructed using fifteen cylindrical compartments within a larger compartment, filled with deionized water doped with CuSO4 and NaCl. The smaller compartments contained arrays of hexagonal or cylindrical glass capillaries of varying inner diameters, for differing restraint of water diffusion. The sensitivity of diffusion imaging metrics to signal-to-noise ratio (SNR) was probed by doping compartments with differing ratios of deuterium oxide to H2O. A cork phantom enclosure was constructed to increase thermal stability during scanning and a cork holder was made to reproduce scanner positioning. Four different protocols of DWI (diffusion weighted imaging) and DTI (Diffusion tensor imaging) imaging were assembled on a GE Excite HDx 3.0T MRI scanner to collect imaging data over 9-10 days. Data was processed with in-house software created in Matlab to obtain fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values. Results: All DTI and DWI sequences showed good longitudinal stability of mean FA and ADC values per compartment, exhibiting low standard deviation ∼9%. A t-test was performed to compare mean FA values from the DTI clinical protocol to those of the DTI special protocol, indicating significantly different values in the majority of compartments. ANOVA performed on ADC values for all DTI and DWI sequences also showed significantly different values in a majority of compartments. Conclusion: This work has the potential for quantifying systemic variations between diffusion imaging sequences from different platforms. Characterization of DWI and DTI performance were done over four sequences with predictable results. This data suggests that the DQIP phantom may be a reliable method of monitoring day-to-day and scan-to-scan variation in diffusion imaging sequences from different platforms. Schott Glass North America and The Phantom Laboratory have donated materials and personnel time to this project.

60 APPLIED LIFE SCIENCES↗

Combining biophysical methods for the analysis of protein complex stoichiometry and affinity in SEDPHAT

Global multi-method analysis for protein interactions (GMMA) can increase the precision and complexity of binding studies for the determination of the stoichiometry, affinity and cooperativity of multi-site interactions. The principles and recent developments of biophysical solution methods implemented for GMMA in the software SEDPHAT are reviewed, their complementarity in GMMA is described and a new GMMA simulation tool set in SEDPHAT is presented. Reversible macromolecular interactions are ubiquitous in signal transduction pathways, often forming dynamic multi-protein complexes with three or more components. Multivalent binding and cooperativity in these complexes are often key motifs of their biological mechanisms. Traditional solution biophysical techniques for characterizing the binding and cooperativity are very limited in the number of states that can be resolved. A global multi-method analysis (GMMA) approach has recently been introduced that can leverage the strengths and the different observables of different techniques to improve the accuracy of the resulting binding parameters and to facilitate the study of multi-component systems and multi-site interactions. Here, GMMA is described in the software SEDPHAT for the analysis of data from isothermal titration calorimetry, surface plasmon resonance or other biosensing, analytical ultracentrifugation, fluorescence anisotropy and various other spectroscopic and thermodynamic techniques. The basic principles of these techniques are reviewed and recent advances in view of their particular strengths in the context of GMMA are described. Furthermore, a new feature in SEDPHAT is introduced for the simulation of multi-method data. In combination with specific statistical tools for GMMA in SEDPHAT, simulations can be a valuable step in the experimental design.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

TRACC: An open source software for processing sap flux data from thermal dissipation probes

Here, thermal dissipation probes (TDPs) have become a widely used method of monitoring plant water use in recent years. The use of TDPs requires calibration to a theoretical zero-flow value (ΔT0); usually based upon the assumption that at least some nighttime measurements represent zero-flow conditions. Fully automating the processing of data from TDPs is made exceedingly difficult due to errors arising from many sources. However, it is desirable to minimize variation arising from different researchers’ processing data, and thus, a common platform for processing data, including editing raw data and determination of ΔT0, is useful and increases the transparency and replicability of TDP-based research. Here, we present the TDP data processing software TRACC (Thermal dissipation Review Assessment Cleaning and Conversion) to serve this purpose. TRACC is an open-source software written in the language R, using graphical presentation of data and on screen prompts with yes/no or simple numerical responses. It allows the user to select several important options, such as calibration coefficients and the exclusion of nights when vapor pressure deficit does not approach zero. Although it is designed for users with no coding experience, the outputs of TRACC could be easily incorporated into more complex models or software.

60 APPLIED LIFE SCIENCES↗

The sequence of intermetallic formation and solidification pathway of an Al–13Mg–7Si–2Cu in-situ composite

The phase transformation sequence and solidification behaviour of an Al–13Mg–7Si–2Cu in-situ composite was examined using a combination of computer-aided cooling curve thermal analysis and interrupted quenching techniques. Five different phases were identified by analysing the derivative cooling curves, the X-ray diffraction profile, optical and scanning electron microscopy images and the corresponding energy dispersive spectroscopy. It has been found that the solidification of this alloy begins with primary Mg{sub 2}Si precipitation and continues with the formation of eutectic Al–Mg{sub 2}Si, followed by Al{sub 5}FeSi and simultaneous precipitation of Al{sub 5}Cu{sub 2}Mg{sub 8}Si{sub 6} and Al{sub 2}Cu complex intermetallic phases. The formation of the last three intermetallic compounds changes the solidification behaviour of these composites remarkably due to their complex eutectic formation reactions. The solidification of the alloy, calculated using the Factsage thermochemical analysis software, has demonstrated a good agreement with the experiments in terms of compound prediction, their weight fractions and reaction temperatures. - Highlights: • Solidification path of a commercial Al-13Mg-7Si-2Cu composite was characterized. • Five different phases were identified and then confirmed with EDS and XRD results. • Mg{sub 2}Si, Al-Mg{sub 2}Si,Al{sub 5}FeSi (β),Al{sub 5}Cu{sub 2}Mg{sub 8}Si{sub 6} (Q) and Al{sub 2}Cu(θ) precipitated respectively. • Solidification was predicted using the Factsage thermochemical analysis software.

36 MATERIALS SCIENCE↗

Stand-Alone and Hybrid Electric Thermal Energy Storage in the System Advisor Model

This project developed stand-alone electric-thermal energy storage (ETES), stand-alone pumped thermal energy storage (PTES), and hybrid molten-salt power tower (MSPT)-ETES performance and dispatch optimization techno-economic models. The models are available to the public through the System Advisor Model (SAM) software, scripting, and as open-source code. We compared results of the dispatch model to PLEXOS dispatch of a similar generator using the same initial grid pricing signal and found our dispatch model performed well, but closer agreement between the models was limited by the inherent differences between price-taker and unit commitment models. Nevertheless, the price-taker models developed in this project are useful to analyze proposed ETES and PTES technologies because they provide more detailed system and component models, solve several orders of magnitude faster, and are available as free open-source software. The model results represent the most optimistic returns considering grid arbitrage from the input electricity pricing, so the financial results can be applied as a feasibility stage-gate. We also submitted a journal draft paper that describes the ETES dispatch model methodology and demonstrates model functionality. An accepted journal article will serve as peer-reviewed documentation for the models, along with the open-source code, SAM help-menu content, and eventually this final project report.

14 SOLAR ENERGY↗

SU-E-T-126: Application of PIPSpro and EPID for Quality Assurance of Medical Accelerators

Purpose: The purpose is to study applying PIPSpro and EPID for routine quality assurance of medical accelerators. Methods: (1) The coincidence of Light field and radiation field: Placed the FC-2 phantom on the treatment couch at the 100cm SSD. Using jaw set 10×10 cm{sup 2} or 15×15 cm{sup 2} field. Verified that the light field aligns with the engraved squares on the phantom. Placed the Crosshair Marker phantom on the top of the FC-2 phantom with the cross-hair and spherical marker aligned to the center of the light field. Acquired images with EPID and the images should be exported preferably in DICOM format. Analyzed Follow the recommended procedures in the radiation light field module of PIPSpro software.(2)MLC QA:Set up the MLC phantom on the treatment couch at isocenter. Positioned the EPID imager at the highest possible position without colliding with either the couch or the phantom. Created and delivered four different patterns for testing the MLC leaf position, leaf width, multi-port and leaf transmission. (3)Radiation isocenter test: Included the isocenter of collimator rotation, gantry rotation and couch rotation. Set the jaws of the collimator to create a thin field as 0.4cm x 20cm.Irradiated film or EPID using an equidistant 15° spacing angles with rotating collimator, gantry and couch respectively. Results: We analyzed imagers from EPID and film with PIPSPro software. As a Result, we acquired the specifications of medical accelerators quickly. In the meantime, the results were saved to database for trending and future analysis. Conclusion: Quality assurance of medical accelerator is very important. We used PIPSpro and EPID for routine detection, not only improved our efficiency, but also saved the cost. It is an good method.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

SU-E-J-102: Performance Variations Among Clinically Available Deformable Image Registration Tools in Adaptive Radiotherapy: How Should We Evaluate and Interpret the Result?

Purpose: To evaluate the performance variations in commercial deformable image registration (DIR) tools for adaptive radiation therapy. Methods: Representative plans from three different anatomical sites, prostate, head-and-neck (HN) and cranial spinal irradiation (CSI) with L-spine boost, were included. Computerized deformed CT images were first generated using virtual DIR QA software (ImSimQA) for each case. The corresponding transformations served as the “reference”. Three commercial software packages MIMVista v5.5 and MIMMaestro v6.0, VelocityAI v2.6.2, and OnQ rts v2.1.15 were tested. The warped contours and doses were compared with the “reference” and among each other. Results: The performance in transferring contours was comparable among all three tools with an average DICE coefficient of 0.81 for all the organs. However, the performance of dose warping accuracy appeared to rely on the evaluation end points. Volume based DVH comparisons were not sensitive enough to illustrate all the detailed variations while isodose assessment on a slice-by-slice basis could be tedious. Point-based evaluation was over-sensitive by having up to 30% hot/cold-spot differences. If adapting the 3mm/3% gamma analysis into the evaluation of dose warping, all three algorithms presented a reasonable level of equivalency. One algorithm had over 10% of the voxels not meeting this criterion for the HN case while another showed disagreement for the CSI case. Conclusion: Overall, our results demonstrated that evaluation based only on the performance of contour transformation could not guarantee the accuracy in dose warping. However, the performance of dose warping accuracy relied on the evaluation methodologies. Nevertheless, as more DIR tools are available for clinical use, the performance could vary at certain degrees. A standard quality assurance criterion with clinical meaning should be established for DIR QA, similar to the gamma index concept, in the near future.

60 APPLIED LIFE SCIENCES↗

Deterministically estimated fission source distributions for Monte Carlo k-eigenvalue problems

The standard Monte Carlo (MC) k-eigenvalue algorithm involves iteratively converging the fission source distribution using a series of potentially time-consuming inactive cycles before quantities of interest can be tallied. One strategy for reducing the computational time requirements of these inactive cycles is the Sourcerer method, in which a deterministic eigenvalue calculation is performed to obtain an improved initial guess for the fission source distribution. This method has been implemented in the Exnihilo software suite within SCALE using the SPNSPN or SNSN solvers in Denovo and the Shift MC code. The efficacy of this method is assessed with different Denovo solution parameters for a series of typical k-eigenvalue problems including small criticality benchmarks, full-core reactors, and a fuel cask. Here it is found that, in most cases, when a large number of histories per cycle are required to obtain a detailed flux distribution, the Sourcerer method can be used to reduce the computational time requirements of the inactive cycles.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Cost and Efficiency Analysis for Hybrid AC/DC Distribution System Planning with PV and Battery

Distribution system planning is one of the main tasks for the electric utilities. Cost and energy efficiency are two main concerns in the distribution planning process. In this work, cost and efficiency analyses are conducted for the hybrid AC and DC distribution grids for the planning purposes. The IEEE 34-bus feeder has been applied for the case studies. The investment cost, operation and maintenance cost, replacement cost, etc., have been considered in the life cycle cost analysis. Power losses of both the AC and DC section are calculated with an open source simulation tool, the Open Distribution Simulator Software (OpenDSS). The proposed framework can be applied to quantitatively evaluate the cost and efficiency of hybrid AC and DC distribution grids and help comparing different planning options.

AC/DC hybrid system planning↗

Exploring the mobility and energy implications of shared versus private autonomous vehicles

The prevailing trend toward greater automation and connectivity requires modeling and analysis tools to explore connectivity, automation, decision science and other future mobility issues at multiple scales. This paper describes various modeling efforts in order to model the mobility and energy impact of autonomous and connected technologies; design of scenarios under different technological, behavioral, and socioeconomic assumptions; and finally, key findings from the scenario runs enabled by the advanced models developed. The integrated ABM-DTA software POLARIS has been extended to include transit, intra-household vehicle sharing, transportation network company (TNC) operations along with updates to the mesoscopic traffic models and value of time adjustments due to new technologies affecting the mode, destination, and route choice. The three scenarios are summarized as high sharing - low automation, high sharing - high automation, and low sharing - high automation, with VMT changes ranging from -13% to 42%.

Multi-autonomous Vehicle Studies, Models, Techniqu↗

SU-E-I-10: Automatic Monitoring of Accumulated Dose Indices From DICOM RDSR to Improve Radiation Safety in X-Ray Angiography

Purpose: To investigate the potential benefits of automatic monitoring of accumulated patient and staff dose indicators, i.e., CAK and KAP, from DICOM Radiation Dose Structured Reports (RDSR) in x-ray angiography (XA). Methods: Recently RDSR has enabled the convenient aggregation of dose indices and technique parameters for XA procedures. The information contained in RDSR objects for three XA systems, dedicated to different types of clinical procedures, has been collected and aggregated in a database for over one year using a system developed with open-source software at the Karolinska University Hospital. Patient weight was complemented to the RDSR data via an interface with the Hospital Information System (HIS). Results: The linearly approximated trend in KAP over a time period of a year for cerebrovascular, pelvic/peripheral vascular, and cardiovascular procedures showed a decrease of 12%, 20%, and 14%, respectively. The decrease was mainly due to hardware/software upgrades and new low-dose imaging protocols, and partially due to ongoing systematic radiation safety education of the clinical staff. The CAK was in excess of 3 Gy for 15 procedures, and exceeded 5 Gy for 3 procedures. The dose indices have also shown a significant dependence on patient weight for cardiovascular and pelvic/peripheral vascular procedures; a 10 kg shift in mean patient weight can result in a dose index increase of 25%. Conclusion: Automatic monitoring of accumulated dose indices can be utilized to notify the clinical staff and medical physicists when the dose index has exceeded a predetermined action level. This allows for convenient and systematic follow-up of patients in risk of developing deterministic skin injuries. Furthermore, trend analyses of dose indices over time is a valuable resource for the identification of potential positive or negative effects (dose increase/decrease) from changes in hardware, software, and clinical work habits.

60 APPLIED LIFE SCIENCES↗

SU-F-BRF-04: Evaluation of Five Commercially-Available Algorithms for Deformable Image Registration

Purpose: Deformable image registration (DIR) is increasingly being used in various clinical applications. Although there are several DIR packages all making successful attempts at modeling complex anatomical changes using even more complex mathematical approximations, they are all subject to various uncertainties. Many studies have attempted to quantify the spatial uncertainty with DIR. This is the first study to compare the uncertainty for interfraction DIR for 5 different commercially-available algorithms. The aim of this study was to benchmark the performance of the most commonlyused DIR algorithms offered through these 5 software packages: Eclipse, MIM, Pinnacle, RaySearch, and Velocity. Methods: A set of 10 virtual H'N phantoms [Pukala et al. MedPhys. 40(11) 2013] with known deformations were used to determine the spatial errors that might be seen when performing DIR. The “ground-truth” deformation vector field (DVF) was compared to the DVF output of the 5 commercially-available algorithms in order to evaluate spatial errors for six regions of interest (ROIs): brainstem, cord, mandible, left parotid, right parotid, and the external body contour. Results: We found that each software package had varying uncertainties with the various ROIs, but were generally all comparable to one another – with mean spatial errors for each algorithm below 3.5 mm for each ROI (averaged across all phantoms). We also found that no single algorithm was the clear winner over the other 4 algorithms. However, at times, we found huge maximum errors in our results (e.g. phantom #9 maximum errors: right parotid = 22.9 mm, external contour = 30.5mm) with the varying DIR algorithms. Conclusion: Although our evaluation was limited to H'N patients, we show that our methods are a single-assessment analysis tool that could be used by any physicist, within any type of facility, to compare their DIR software before initiating widespread use within their daily radiotherapy practice.

60 APPLIED LIFE SCIENCES↗

TU-G-BRA-05: Predicting Volume Change of the Tumor and Critical Structures Throughout Radiation Therapy by CT-CBCT Registration with Local Intensity Correction

Purpose: The purpose of this study is to develop an accurate and effective technique to predict and monitor volume changes of the tumor and organs at risk (OARs) from daily cone-beam CTs (CBCTs). Methods: While CBCT is typically used to minimize the patient setup error, its poor image quality impedes accurate monitoring of daily anatomical changes in radiotherapy. Reconstruction artifacts in CBCT often cause undesirable errors in registration-based contour propagation from the planning CT, a conventional way to estimate anatomical changes. To improve the registration and segmentation accuracy, we developed a new deformable image registration (DIR) that iteratively corrects CBCT intensities using slice-based histogram matching during the registration process. Three popular DIR algorithms (hierarchical B-spline, demons, optical flow) augmented by the intensity correction were implemented on a graphics processing unit for efficient computation, and their performances were evaluated on six head and neck (HN) cancer cases. Four trained scientists manually contoured nodal gross tumor volume (GTV) on the planning CT and every other fraction CBCTs for each case, to which the propagated GTV contours by DIR were compared. The performance was also compared with commercial software, VelocityAI (Varian Medical Systems Inc.). Results: Manual contouring showed significant variations, [-76, +141]% from the mean of all four sets of contours. The volume differences (mean±std in cc) between the average manual segmentation and four automatic segmentations are 3.70±2.30(B-spline), 1.25±1.78(demons), 0.93±1.14(optical flow), and 4.39±3.86 (VelocityAI). In comparison to the average volume of the manual segmentations, the proposed approach significantly reduced the estimation error by 9%(B-spline), 38%(demons), and 51%(optical flow) over the conventional mutual information based method (VelocityAI). Conclusion: The proposed CT-CBCT registration with local CBCT intensity correction can accurately predict the tumor volume change with reduced errors. Although demonstrated only on HN nodal GTVs, the results imply improved accuracy for other critical structures. This work was supported by NIH/NCI under grant R42CA137886.

60 APPLIED LIFE SCIENCES↗

Study of the distribution profile of iron ions implanted into silicon

Iron ions with energies of 90 and 250 keV and a dose of 10{sup 16} cm{sup –2} are implanted into a silicon single crystal with the (110) orientation. The method of Rutherford backscattering in combination with channeling is used to study the distribution profiles of the introduced impurity and also the profiles of the distribution of radiation-induced defects in the crystal lattice. Experimental data are compared with the results of simulation performed using the TRIM software package. It is shown that, at an energy of 4.6 keV/nucleon, the average projected ranges coincide; however, at an energy of 1.6 keV/nucleon, the difference amounts to 35%. In addition, it is shown that the calculation incorrectly takes into account the dose dependence at energies of 1.6–4.6 keV/nucleon.

36 MATERIALS SCIENCE↗

Energy Storage Sizing, Placement and Valuation for Distribution Networks

SAND2023-05682O The Energy Storage Sizing, Placement, and Valuation for Distribution software allows a user to simulate sizing, placement, and operation of one or more storage assets on a distribution grid. Among its features are measuring differences to determine the best combinations, and options for configuring and comparing results. This new simulation capability leverages the Open Distribution System Simulator and the Hierarchical Engine for Large-scale Infrastructure Co-Simulation (HELICS). Sandia National Laboratories is a multimission laboratory managed and operated by National Technology & Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-NA0003525.

Tamrakar, Ujjwol↗

ESnet SmartNIC v1.0

The ESnet SmartNIC is a collection of Verilog based FPGA design software, as well as drivers to interact with the FPGA. It provides an infrastructure framework for FPGA based hardware acceleration of network packet use cases. Different research and production applications can be easily written for the SmartNIC. Its advantage is that it reduces the development time for new applications by providing a pre-existing shell library for common functions.

Mah, Bruce↗

Petascale Hierarchical Modeling VIA Parallel Execution

The research allows more effective model building. By allowing researchers to fit complex models to large datasets in a scalable manner, our algorithms and software enable more effective scientific research. In the new area of “big data,” it is often necessary to fit “big models” to adjust for systematic differences between sample and population. For this task, scalable and efficient model-fitting tools are needed, and these have been achieved with our new Hamiltonian Monte Carlo algorithm, the no-U-turn sampler, and our new C++ program, Stan. In layman’s terms, our research enables researchers to create improved mathematical modes for large and complex systems.

97 MATHEMATICS AND COMPUTING↗