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All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

The Michigan New Technology Training and Research (MNTR) Translational Program in Nuclear Medicine (Final Report)

The Michigan New Technology Training and Research (MNTR) Translational Program in Nuclear Medicine and Molecular Imaging This project established the Michigan New Technology Training and Research (MNTR) translational program, focused on the acceleration of new clinical molecular imaging methods. Molecular imaging approaches to imaging are a very flexible and powerful development, with many recent examples advancing the diagnosis and guiding the management of human disease. These methods depend on the design, synthesis and testing of new radiotracers (molecules designed to target specific cells or tissues in the body), labeled with short-lived radioactive atoms (positron emitters). The new radiotracers are imaged in the human body using positron emission tomography (PET) imaging. The University of Michigan PET Center has considerable experience in the discovery, development, refinement and initial human applications of new PET radiotracers. An emerging impediment to efficient availability of new PET radiotracers, however, involves the regulatory environment at multiple levels. Many potentially successful ideas are delayed or even prevented from entering human use by these barriers. In the current grant, we provided hands-on experience for the next generation of young scientists working in molecular imaging so that they are equipped to effectively move new ideas and radiotracers from the research laboratory to the nuclear medicine clinic (bench-to-bedside). For new radiotracer development, oversight by the Food and Drug Administration (FDA), the Nuclear Regulatory Commission (NRC), and local institutional committees and reviews are required. These aspects of translation from laboratory to clinic are often omitted from the formal training of new scientists, but were provided to three trainees via direct mentorship in the MNTR program. The MNTR training program built on the translational successes of the University of Michigan Division of Nuclear Medicine and capitalized on our strengths (facilities, faculty, a wide-ranging selection of projects, and the experience and commitment to bring new radiotracers into human studies) to systematically train three fellows in radiochemistry and nuclear medicine. Integrated training in development, validation and clinical translation of new PET radiotracers occurred through practical involvement in multiple research projects, each at a different stage along the pathway from bench-to-bedside. Each trainee obtained experience of the entire process over about 2 years. Projects involved development of new radiotracers for neurodegenerative disorders (e.g. Alzheimer disease), movement disorders (e.g. Parkinson disease, progressive supranuclear palsy) and neurodevelopmental syndromes (e.g. Tourette syndrome) as well as new radiochemistry methods for synthesizing radiotracers. Each project was pursued in a close collaboration between the fellow trainee and both the clinical and basic science faculty at the University of Michigan PET Center, and provided an unprecedented opportunity for the highest-level training in academic radiochemistry and nuclear medicine research. The project has resulted in 17 peer-reviewed publications to date, and at least 4 more are in preparation. Additionally, 1 book chapter and 26 conference presentations have resulted from this grant. Upon completion of the MNTR Program, the trainees have emerged as translational scientists wielding the necessary skill-set (practical research experience, multidisciplinary training, regulatory know-how) to embark on successful careers in translational molecular imaging, bringing continued advances in the field to bear on important human disorders. As a metric of the Program’s success, one fellow has already secured employment in the field, while the other two are finishing writing papers; they wish to also stay in the radiochemistry and nuclear medicine community, and are currently applying for jobs.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
DOE OSTI2020

Implications of a regional resource adequacy program on utility integrated resource planning: Study for the Western United States

LBNL collaborated with the Western Interstate Energy Board and the University of Texas, Austin to investigate the implications of a regional resource adequacy (RA) program on utility integrated resource planning. This report is focused on an active policy discussion to develop a novel voluntary program to share capacity resource and improve RA in the Western Interconnection. This report identifies two RA components of IRP that will be highly impacted by a regional RA program: resource capacity accreditation and RA targets. There are at least four resources that will require specific attention for their capacity credit calculation: (1) variable renewable resources, (2) demand-side resources, (3) hydropower, and (4) contracts. It will then be necessary to decide on a RA target reliability metric (e.g., a planning reserve margin) that is at least the minimum requirement in IRPs to ensure consistency in RA requirement calculations. The report finds that load forecasting and transmission expansion analyses will be moderately impacted, but that most of IRP components will not be significantly impacted. The report includes (i) a review of traditional resource adequacy practices in IRP; (ii) a case study of an existing regional RA program that interacts with IRP (Southwest Power Pool) and (iii) an overview of the NWPP regional resource adequacy proposal that is the object of this work. This paper does not (1) advocate for or against a regional RA program for the NWPP, (2) make detailed design recommendations for this program, or (3) assess its benefits and costs.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2022

California Energy Systems for the 21st Century (CES-21) Program, CRADA TC02200 (Final Report)

The following report representsthe culmination of a five-year Cybersecurity Research and Development (R&D) program performed by California’s Investor-Owned Utilities (IOUs) and Lawrence Livermore National Laboratory (LLNL) and funded by the IOUs’ electricity ratepayers as authorized by California Legislation and the California Public Utilities Commission (CPUC). The cybersecurity R&D, which was intensely technical in nature, was broken into three major workstreams: 1. The development of a modeling & simulation platform, to explore the potential effects of various threat and response scenarios at grid scale; 2. The establishment of a physical testbed with separate substation instances from each of the IOUs, to evaluate threats and responses on actual substation equipment; 3. The development of a research package consisting of several capabilities to support the industry’s evolution towards automated threat response and other next-generation cybersecurity techniques Throughout the program, there was extensive collaboration between the program team and national laboratories, federal departments, academic institutions and industry organizations. Several of the tools developed through the program have been made available to the open source community, to enable faster adoption and continued development of important cybersecurity capabilities. While this program began to develop much of the foundation for automated threat response, much work remains to be done, and this report recommends a series of next steps. While the Executive Summary below has been simplified as much as possible, the very technical nature of the subject matter would make further reduction difficult without causing meaning to be lost. Due to the sensitive nature of the research, some topics are intentionally covered at a high level to protect the research and therefore the electric grid and customers of California and the Nation. For further detail, clarification or questions we suggest discussion with the program team.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2023

Laboratory Directed Research and Development Program FY 2020 Annual Summary of Completed Projects

ORNL has established a program with four complementary subprograms to meet its LDRD objectives and to fulfill the particular needs of the laboratory. A provision for multiple routes of access to ORNL LDRD funds maximizes the likelihood that novel ideas with scientific and technological merit will be recognized and supported. The ORNL LDRD Program comprises the following four subprograms: 1) The Director’s R&D Program supports projects that advance research frontiers, capabilities, and expertise at ORNL in key strategic areas. 2) The Seed Program supports innovative high-risk/high-reward research to the proof-of-principle stage. 3) The Strategic Hire Program supports the research of key new staff whose expertise and capabilities address a critical strategic need for the laboratory. 4) The Distinguished Staff Fellowships assist the laboratory in bringing in exceptional early-career scientists to refresh and expand its scientific and technical expertise. The total ORNL LDRD Program budget authorized by DOE for FY 2020 was $\$$55 million. FY 2020 allocations totaled $\$$52.5 million and supported 153 projects. An additional $\$$95,827 was allocated to administrative costs for conducting proposal reviews. Overall, 96.4% of the allocated funds were spent. The expenditure of $\$$50.6 million was about 3.2% of the laboratory’s total budget of $\$$1,572 million for operating and capital expenses, which is well below the maximum of 6% allowed by DOE Order 413.2C and is in accordance with Section 309 of Division D of the Consolidated Appropriations Act.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2023

LDRD 2022 Annual Report: Laboratory Directed Research and Development Program Activities

Each year, Brookhaven National Laboratory (BNL) is required to provide a report of its completed Laboratory Directed Research and Development Program (LDRD) projects to the Department of Energy (DOE) Office of Scientific and Technical Information in accordance with DOE Order 413.2C Chg1 (MinChg) dated August 2, 2018. This report provides a detailed look at the scientific and technical activities for each of the LDRD projects funded by BNL in FY 2022, in fulfillment of that requirement. In FY 2022, the BNL LDRD Program funded 70 projects, 30 of which were new starts, at a total cost of $17.2M. The investments that BNL makes in its LDRD program support the Laboratory’s strategic goals. BNL has identified seven scientific initiatives that define the Laboratory’s scientific future and that will enable it to realize its overall vision. This requires simultaneous excellence in all aspects of BNL’s work – from science and operations, to external partnerships with the local, state, and national communities, and beyond. This is enabled by safe, efficient, and secure operations; by an unwavering commitment to a diverse, equitable, and inclusive environment, including workforce development, both with staff and reaching out to the community; and by a strong focus on renewed infrastructure. The seven scientific initiatives are: 1) Nuclear Physics: uncover the structure of visible matter by constructing and operating the Electron-Ion Collider at BNL to maintain international leadership in nuclear physics for decades; 2) Clean Energy and Climate: support a net-zero U.S. economy through fundamental research in basic energy and climate sciences to revolutionize grid-scale storage, renewable integration, and the study of atmospheric processes with a new facility to improve climate predictability; 3) Quantum Information Science and Technology: discover new quantum materials to enhance quantum computers and develop an entanglement sharing quantum network as a prototype for the first quantum internet; 4) Discovery Science Driven by the Human-AI Facility Integration: revolutionize the operation of experiments across the sciences at user facilities and in core programs; 5) High Energy Physics: understand the origin of space and time with the ATLAS high luminosity upgrade at CERN and the future Long Baseline Neutrino Facility/Deep Underground Neutrino Experiment; 6) Isotope Production: accelerate and expand isotope production to ensure the security of the Nation’s supply; 7) Accelerator Science and Technology: harness the cross-cutting accelerator science expertise at BNL to develop new facilities, improve and expand its user facilities, and promote the use of accelerators in industry. The funded projects support BNL’s seven scientific initiatives and priority programs as well as new areas of research and competencies at the Laboratory that are consistent with the Laboratory’s vision and mission. In total, these LDRD investments supported 43 postdoctoral researchers in whole or in part and resulted in 138 publications and 7 awards. This Program Activities Report represents the future of BNL science; it is an impressive body of exploratory work that investigates many scientific and technical directions in support of the DOE and BNL missions.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2017

Overview of the Jefferson Lab 12 GeV Experimental Program in Halls A,B, and C

The 11 GeV beam energy available in experimental Halls A, B, and C as part of the Jefferson Lab 12 GeV Upgrade, combined with the new equipment in those halls will provide a rich and diverse physics program. This program includes inclusive measurements used to constrain polarized and unpolarized quark distributions in nucleons, exclusive reactions to access nucleon and meson form factors and GPDs, semi-inclusive measurements aimed at constraining TMDs, as well as measurements from nuclei to provide further insight into the origins of Short Range Correlations and the EMC Effect. The experimental equipment was designed with the above program in mind and the three halls provide complementary capabilities. Magnetic focusing spectrometers in Hall C (the new SHMS and existing HMS) will provide precision separated and unseparated cross section measurements and ratios. The new large acceptance CLAS12 spectrometer in Hall B enables measurements over broad regions of phase space. In Hall A, the new SBS spectrometer, used in conjunction with the existing HRS or Big Bite spectrometers will provide access to very large Q2 and allow for measurements requiring both high luminosity and large acceptance. This talk will give an overview of the upcoming experimental program in Halls A,B, and C, in particular highlighting synergies between the hall programs, which will allow Jefferson Lab to maximize the science output its 12 GeV program.

Gaskell, David↗
DOE OSTI2025

LANL Meteorology Program Self-Assessment 2025 Update

The LANL Meteorological (Met) Program has been subject to several external reviews over the past 19 years. The DOE Meteorological Coordinating Council (DMCC) conducted an initial Met Program Site Assist Visit (SAV) in August 2006 (DMCC 2006). A follow-up SAV in August 2015 assessed progress (DMCC 2015), and in June 2023, the DOE Meteorological Subcommittee (DMSC), successor to the DMCC, conducted a second follow-up SAV (DMSC 2023), in which the Met Program was evaluated relative to the following 8 high-level questions: • What is the state of the meteorological services provided to its customers? • What is the quality of meteorological data provided to its customers and is it adequate and available to meet all customer needs? • What is the quality of atmospheric transport and diffusion modeling provided to its customers and is it applicable to complex wind flow patterns at LANL? • Are the current and future meteorological service customers being serviced appropriately? • Are there adequate human resources to meet present and future program customer needs and are they being appropriately leveraged? • Are existing instrumentation, facilities, and systems adequate to meet present and future customer needs? • Are LANL meteorological services conducted in an efficient, cost-effective manner? • Is meteorological data used to ensure safety & health of LANL personnel? More specific evaluations were performed relative to 23 performance objectives extracted from the ANSI/ANS-3.11- 2024 national standard and 14 separate performance objectives associated with consequence assessment and atmospheric transport and diffusion modeling in the consequence assessment element of DOE G 151.1-1B. In 2023, the DMSC SAV Team also reviewed the status of each of the 18 remaining recommendations from its 2015 SAV. Based on this review, DMSC stated in its Exit Briefing that the LANL meteorological program has gotten much stronger and more robust since 2015 and now represents one of the better managed programs within the DOE complex.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

The role of international collaboration in the United States geologic disposal research program

Abstract. More than a decade ago, the United States disposal program discontinued all research activities focused on the unsaturated fractured tuff formation at Yucca Mountain as the geologic disposal site for spent fuel and high-level radioactive waste. A new research and development (R&D) program was initiated to provide a sound technical basis for alternative disposal options across clay, crystalline, and salt rocks. The goals of this broad program were (and still are) to (1) increase confidence in the robustness of generic disposal concepts, (2) develop the science and engineering tools needed to support disposal concept implementation, and (3) conduct R&D on the direct disposal of existing dual-purpose (storage and transportation) canisters. Recognizing the benefits of international collaboration toward the common goal of safely and efficiently managing the back end of the nuclear fuel cycle, the program emphasized international cooperation as an effective strategy for sharing information and knowledge. In a multi-laboratory effort coordinated by Lawrence Berkeley National Laboratory, the United States Department of Energy (DOE) program established formal and informal cooperation partnerships with several international initiatives and institutions and developed a number of collaborative R&D activities in important research areas, such as engineered barrier integrity, near-field perturbations, radionuclide transport, performance assessment, and methods for characterization and monitoring of engineered and natural barriers. This presentation gives an overview of these R&D activities, with a specific focus on activities that improve our current understanding of the coupled thermal–hydrological–mechanical–chemical (THMC) processes occurring in engineered and natural barriers. We start with a brief review of selected international collaboration initiatives and then describe a few specific collaboration projects. We focus specifically on such studies that use experimental data sets provided by international research cooperation for joint modeling work to increase confidence in performance-relevant predictions of coupled processes. Overall, the focus on international collaboration has allowed deep engagement of US researchers with the international waste management R&D community in terms of best practices, new scientific advances, state-of-the-art simulation tools, new monitoring and performance confirmation approaches, and lessons learned. The joint R&D with international researchers, worldwide sharing of knowledge and experience, and access to relevant data and experiments from a variety of host rocks have helped our researchers to significantly improve their understanding of the current technical basis for disposal in a range of potential host rock environments. International collaboration also provides ample opportunity for training and educating junior staff that are well suited to move the United States disposal research program forward into the next decades, a promising avenue for developing a next-generation workforce of disposal scientists.

Birkholzer, Jens T.↗
DOE OSTI2026

Estimating Return on Investment for Energy Technical Assistance Programs

The U.S. Department of Energy's Office of State and Community Energy Programs engaged the National Laboratory of the Rockies to assess the return on investment (ROI) of technical assistance (TA) programs that support state, local, and Tribal energy planning. Although TA delivers value through capacity building, stakeholder engagement, and knowledge transfer, these benefits are often intangible and challenging to monetize. This study reviews existing ROI frameworks and synthesizes the most relevant elements into a hybrid approach tailored to energy TA programs. The proposed framework integrates monetary and non-monetary outcomes through early logic model development, baseline data collection, and the use of proxies for intangible benefits. As a case study, this paper applies this approach to the Communities Local Energy Action Program (Communities LEAP), demonstrating how ROI can inform program design, data strategy, and performance assessment. Findings underscore that ROI should be applied selectively and planned from the outset to ensure data alignment and attribution accuracy. The framework offers TA practitioners a structured approach that can be leveraged for future programs to evaluate and communicate the multifaceted value of TA investments.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
NASA NTRS1971

Methodologies for optimal resource allocation to the national space program and new space utilizations. Volume 1: Technical description

The optimal allocation of resources to the national space program over an extended time period requires the solution of a large combinatorial problem in which the program elements are interdependent. The computer model uses an accelerated search technique to solve this problem. The model contains a large number of options selectable by the user to provide flexible input and a broad range of output for use in sensitivity analyses of all entering elements. Examples of these options are budget smoothing under varied appropriation levels, entry of inflation and discount effects, and probabilistic output which provides quantified degrees of certainty that program costs will remain within planned budget. Criteria and related analytic procedures were established for identifying potential new space program directions. Used in combination with the optimal resource allocation model, new space applications can be analyzed in realistic perspective, including the advantage gain from existing space program plant and on-going programs such as the space transportation system.

Source record↗
NASA NTRS1972

Automated testing data reduction computer program

The capability of a computer program which can be part of a larger computer program for a fully automated multiaxial testing facility is described. The program was designed to process test data from tubular or flat specimens made from isotropic or anistropic materials, including high modulus fiber composites. Data from a large number of strain gages and combinations of applied loads can be used. Options are provided for single element, 90-degree, rectangular or Delta rosettes, or any combinations of these types of strain gages. Options are provided for strain gage transverse sensitivities. The program outputs include: structural axes strains and stresses, initial and strain-dependent elastic constants, shift of principal strain direction with load, and local curvatures from back-to-back strain gages, and either Calcomp or microfilm plots. The computer program is described with respect to its flow chart, input/output, embedding or linking with other programs.

Chamis, C. C.↗
NASA NTRS1971

Integrated operations/payloads/fleet analysis. Volume 3: System costs. Appendix A: Program direct costs

Individualized program direct costs for each satellite program are presented. This breakdown provides the activity level dependent costs for each satellite program. The activity level dependent costs, or, more simply, program direct costs, are comprised of the total payload costs (as these costs are strictly program dependent) and the direct launch vehicle costs. Only those incremental launch vehicle costs associated directly with the satellite program are considered. For expendable launch vehicles the direct costs include the vehicle investment hardware costs and the launch operations costs. For the reusable STS vehicles the direct costs include only the launch operations, recovery operations, command and control, vehicle maintenance, and propellant support. The costs associated with amortization of reusable vehicle investment, RDT&E range support, etc., are not included.

Source record↗
NASA NTRS1972

A computer program for the calculation of laminar and turbulent boundary layer flows

The results are presented of a study to produce a computer program to calculate laminar and turbulent boundary layer flows. The program is capable of calculating the following types of flow: (1) incompressible or compressible, (2) two dimensional or axisymmetric, and (3) flows with significant transverse curvature. Also, the program can handle a large variety of boundary conditions, such as blowing or suction, arbitrary temperature distributions and arbitrary wall heat fluxes. The program has been specialized to the calculation of equilibrium air flows and all of the thermodynamic and transport properties used are for air. For the turbulent transport properties, the eddy viscosity approach has been used. Although the eddy viscosity models are semi-empirical, the model employed in the program has corrections for pressure gradients, suction and blowing and compressibility. The basic method of approach is to put the equations of motion into a finite difference form and then solve them by use of a digital computer. The program is written in FORTRAN 4 and requires small amounts of computer time on most scientific machines. For example, most laminar flows can be calculated in less than one minute of machine time, while turbulent flows usually require three or four minutes.

Dwyer, H. A.↗
NASA NTRS1972

Viscel: A general purpose computer program for analysis of linear viscoelastic structures, volume 2

The VISCEL program is a general purpose computer program developed for equilibrium analysis of linear viscoelastic structures. The program is written in FORTRAN 5 language to operate on the Univac 1108 computer under the EXEC 8 operating system. The program, an extension of the linear equilibrium problem solver ELAS, is an updated and extended version of its earlier form written for the IBM 7094 computer. Finite element matrix displacement approach coupled with the synchronized material property concept, utilizing incremental time steps, was adopted for the solution presented. The step-by-step procedure involves solution of recursive equations in the time domain, which takes into account the memory of material properties. Incremental and accumulative displacements and stresses are obtained at the end of each time step. In order to minimize the extent of computations resulting from accumulative effects of material memory, the program provides an option which enables the employment of constant time steps in the logarithmic scale. Program documentation is presented.

Gupta, K. K.↗
NASA NTRS1972

Formulation of an effective safety design review for the Skylab Program.

The Skylab Program is presenting a unique set of requirements by extending the capabilities of both men and equipment to withstand extended periods of time in space. The progression of space programs which preceded Skylab have provided a set of building blocks of knowledge and experience coupled with an extensive ground test program which makes it possible to plan its flight program without earlier, unmanned test flights. This approach, however, makes it mandatory that to the maximum extent possible, we factor into the design review process all the 'lessons learned' which are applicable. It is this conscious review of the Skylab design, based on checklists prepared from design criteria, gleaned from a variety of sources and experiences, which is the subject of this paper. A brief description of the Skylab Program, its objectives, and the missions planned for it are presented briefly to better understand the degree of extrapolation of hardware development from previous programs.

Cohen, H.↗
NASA NTRS1971

DORCA computer program. Volume 1: User's guide

The Dynamic Operational Requirements and Cost Analysis Program (DORCA) was written to provide a top level analysis tool for NASA. DORCA relies on a man-machine interaction to optimize results based on external criteria. DORCA relies heavily on outside sources to provide cost information and vehicle performance parameters as the program does not determine these quantities but rather uses them. Given data describing missions, vehicles, payloads, containers, space facilities, schedules, cost values and costing procedures, the program computes flight schedules, cargo manifests, vehicle fleet requirements, acquisition schedules and cost summaries. The program is designed to consider the Earth Orbit, Lunar, Interplanetary and Automated Satellite Programs. A general outline of the capabilities of the program are provided.

Wray, S. T., Jr.↗
NASA NTRS1972

Analysis of advanced programs (Study 2.3). Volume 1: Executive summary

An analysis of advanced programs for space missions is presented. The subjects discussed are (1) alternate space shuttle configurations, (2) space transportation systems, (3) computer programs and methodology to estimate program cost implications of space vehicle program uncertainties, (4) vehicle synthesis program, (5) relative effectiveness of various proposals for space vehicles, and (6) cost analysis of solid propellant rocket engine program to support space shuttle vehicle.

Source record↗
NASA NTRS1973

Cost estimation for unmanned lunar and planetary programs

A basic model is presented for estimating the cost of unmanned lunar and planetary programs. Cost data were collected and analyzed for eight lunar and planetary programs. Total cost was separated into the following components: labor, overhead, materials, and technical support. The study determined that direct labor cost of unmanned lunar and planetary programs comprises 30 percent of the total program cost. Twelve program categories were defined for modeling: six spacecraft subsystem categories (science, structure, propulsion, electrical power, communications, and guidance and integration, test and quality assurance, launch and flight operations, ground equipment, systems analysis and engineering, and program management). An analysis showed that on a percentage basis, direct labor cost and direct labor manhours compare on a one-to-one ratio. Therefore, direct labor hours is used as the parameter for predicting cost, with the advantage of eliminating the effect of inflation on the analysis.

Dunkin, J. H.↗