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At least 937 records · Page 52

Dose-response relationship between sleep duration and human psychomotor vigilance and subjective alertness

Although it has been well documented that sleep is required for human performance and alertness to recover from low levels after prolonged periods of wakefulness, it remains unclear whether they increase in a linear or asymptotic manner during sleep. It has been postulated that there is a relation between the rate of improvement in neurobehavioral functioning and rate of decline of slow-wave sleep and/or slow-wave activity (SWS/SWA) during sleep, but this has not been verified. Thus, a cross-study comparison was conducted in which dose-response curves (DRCs) were constructed for Stanford Sleepiness Scale (SSS) and Psychomotor Vigilance Task (PVT) tests taken at 1000 hours by subjects who had been allowed to sleep 0 hours, 2 hours, 5 hours or 8 hours the previous night. We found that the DRCs to each PVT metric improved in a saturating exponential manner, with recovery rates that were similar [time constant (T) approximately 2.14 hours] for all the metrics. This recovery rate was slightly faster than, though not statistically significantly different from, the reported rate of SWS/SWA decline (T approximately 2.7 hours). The DRC to the SSS improved much more slowly than psychomotor vigilance, so that it could be fit equally well by a linear function (slope = -0.26) or a saturating exponential function (T = 9.09 hours). We conclude that although SWS/SWA, subjective alertness, and a wide variety of psychomotor vigilance metrics may all change asymptotically during sleep, it remains to be determined whether the underlying physiologic processes governing their expression are different.

Non-NASA Center↗

Cracking Behavior of Irradiated Ex-Plant Materials

The cracking behavior of reactor core internal materials is a key factor for the long-term safety and availability of light water reactors. Subject to high-temperature coolant, thermal and mechanical loading, and neutron irradiation, reactor core internal materials are susceptible to several degradation mechanisms during power operation. To understand the long-term effects of neutron irradiation, irradiated materials harvested from a decommissioned reactor were studied for their cracking susceptibility and fracture resistance. Small compact-tension specimens were machined from different locations on the baffle plates with irradiation doses ranging from 0.06 to 48.5 dpa. Crack growth rate and fracture toughness J-resistance (J-R) curve tests were performed on these specimens in a simulated light water reactor environment, and the fracture morphologies of the tested samples were examined with a scanning electron microscope. All samples behaved similarly under cyclic loading, and no deteriorated corrosion-fatigue behavior was observed in the test environments. Under constant load, no elevated cracking susceptibility was observed either in these samples at low stress intensity factors. However, a rapid cracking behavior featuring very high crack growth rates was observed in several high-dose samples. This rapid crack growth behavior was activated when the applied stress intensity factor, K, was sufficiently high. Once activated, the rapid crack growth remained steady even when the K was lowered to the pre-activation level and stopped only when the K was reduced drastically. Yet, the rapid crack growth could be re-activated repeatedly in these samples by raising the K above the initial activation level. This rapid cracking response may be related to the severe irradiation embrittlement experienced by these samples. The J-R curve tests performed with these samples showed a significant decline in fracture toughness with increasing neutron irradiation. Local cracking at the crack tip facilitated by the severe irradiation embrittlement of this material may be responsible for the rapid crack growth behavior demonstrated by this decommissioned material.

36 MATERIALS SCIENCE↗

LDEF radiation measurements: preliminary results

The Long Duration Exposure Facility (LDEF), retrieved by the Space Shuttle mission STS-32 after nearly 6 yr in orbit, is the focus of a broad-based study of the radiation environment in low Earth orbit (LEO) and its effects on materials. A combination of passive techniques has been used to study this environment via detectors which were contained in experiments aboard the LDEF spacecraft and through analysis of induced radioactivities. Preliminary results for absorbed dose measurements and for induced activities in various materials are presented. A number of effects have been observed which reflect the anisotropy of the charged particle flux in low Earth orbit. Quantitative results from these measurements should provide an accurate means of confirming environmental flux models and techniques for predicting radiation encountered in future LEO missions, particularly those of extended duration.

NASA Discipline Number 00-00↗

Dose, LET, time and strain dependence of radiation-induced 53BP1 foci in 15 mouse strains ex vivo and associations to in vivo radiation susceptibility

We present a comparative analysis on the repair of radiation-induced DNA damage ex vivo in 15 strains of mice, including 5 inbred reference strains and 10 collaborative-cross strains, of both sexes. Non-immortalized primary skin fibroblasts derived from 76 mice were subjected to both low- and high-LET radiation (0.1, 1 and 4 Gy of X rays; 1.1 and 3 particles/100μm2 of 350 MeV/n 40Ar and 600 MeV/n 56Fe). Automated image quantification of 53BP1 radiation-induced foci (RIF) during the first 4-48 h post-irradiation was performed as a function of dose and LET. Similarly to what we had previously reported for immortalized human cell lines [1], we observed a saturation of RIF number with dose at 4h post-irradiation, with more RIF/Gy for lower LET (X rays and 40Ar) compared to 56Fe. However at later time points (24h and above), the trend was inverted with more RIF/Gy for higher LET. Our data suggest that multiple DSBs cluster into RIF: as the linear density of DSBs increases with LET, so does the probability of having more DSBs per RIF, which makes it more difficult for cells to fully resolve high-LET-induced RIF, explaining the hypersensitivity to high-LET radiation despite a low number of RIF. Taking into account the amount of clustering at a given dose and LET, but also the kinetics of DNA damage repair, we introduced a novel mathematical formalism to evaluate the number of remaining RIF over time. We showed that the newly introduced kinetic metrics can be used as surrogate biomarkers for in vivo radiation toxicity, with potential applications in radiotherapy and human space exploration. In particular, we observed an association between the repairable fraction of RIF measured in vitro and survival levels of immune cells collected from irradiated mice. Moreover, the speed of DNA damage repair correlated with spontaneous cancer incidence data collected from the Mouse Tumor Biology database, suggesting a relationship between the efficiency of DSB repair after irradiation and cancer risk. In addition to the efficacy of repair and persistent RIF levels, even the amount of spontaneous foci without irradiation was shown to be strain dependent, indicating that these phenotypes are at least partially driven by genetics, and supporting their potential as indicators of individual radiation sensitivity. [1] Neumaier, T., et al., PNAS, 2012 (8) 109:443

Radiation, DNA damage, repair kinetics↗

Radiation tolerance of the PNI RM3100 magnetometer for a Europa lander mission

The results of two radiation test campaigns on a low-cost commercial off-the-shelf magnetometer are presented. The test setup and the total ionization dose (TID) levels studied were designed to meet the requirements of a mission to land on Europa. Based on the Europa Lander Science Definition Team report, instruments inside an aluminum vault at the surface of Europa would need to withstand TID of up to 300 krad(SI). In order to evaluate the performance of the PNI RM3100 magnetometer, nine separate sensors were irradiated at two different facilities during two separate campaigns and under different configurations, including passive and active tests. Of the nine sensors, seven survived the TID of 300 krad(SI) while the other two sensors started presenting failures after reaching 150 krad(SI). Post-irradiation tests showed that eight of the nine sensors continued to work without appreciable degradation after stopping exposure, while one sensor stopped working altogether.

58 GEOSCIENCES↗

Biomedical support of man in space

In its broadest sense, biomedical support of man in space must not be limited to assisting spacecraft crew during the mission; such support should also ensure that flight personnel be able to perform properly during landing and after leaving the craft. Man has developed mechanisms that allow him to cope with specific stresses in his normal habitat; there is indisputable evidence that, in some cases, the space environment, by relieving these stresses, has also allowed the adaptive mechanisms to lapse, causing serious problems after re-entry. Inflight biomedical support must therefore include means to simulate some of the normal stresses of the Earth environment. In the area of cardiovascular performance, we have come to rely heavily on complex feedback mechanisms to cope with two stresses, often combined: postural changes, which alter the body axis along which gravitational acceleration acts, and physical exercise, which increases the total load on the system. Unless the appropriate responses are reinforced continuously during flight, crew members may be incapacitated upon return. The first step in the support process must be a study of the way in which changes in g, even of short duration, affect these responses. In particular we should learn more about effects of g on the "on" and "off" dynamics, using a variety of approaches: increased acceleration on one hand at recumbency, immersion, lower body positive pressure, and other means of simulating some of the effects of low g, on the other. Once we understand this, we will have to determine the minimal exposure dose required to maintain the response mechanisms. Finally, we shall have to design stresses that simulate Earth environment and can be imposed in the space vehicle. Some of the information is already at hand; we know that several aspects of the response to exercise are affected by posture. Results from a current series of studies on the kinetics of tilt and on the dynamics of readjustment to exercise in different postures will be presented and discussed.

NASA Discipline Cardiopulmonary↗

Status of the MARS code

This report describes major features of the most recent version of the MARS code as well as ongoing developments. The list of features includes various options for geometry models, a beam line builder based on MADX code, import of geometry models in GDML format, use of structured and unstructured meshes for scoring purposes, an update to the recent TENDL library for a number of projectiles at low energies (up to 250 MeV), and a recently implemented method to calculate spatial distribution of residual dose in a single computer run without an intermediate source. Examples of the code application to various projects are presented as well.

Rakhno, Igor [Fermilab] (ORCID:0000000265828058)↗

Void swelling of conventional and composition engineered HT9 alloys after high-dose self-ion irradiation

Ferritic/martensitic (F/M) steels are being considered as potential structural materials for next generation nuclear reactors, and variants of the alloy HT9 are some of the most promising candidates. In this study, two conventional and two composition engineered HT9 alloys were irradiated using 3.5 MeV Fe 2+ up to 600 peak displacement-per-atom (dpa) at 450 °C. Void swelling and microstructure evolution were characterized for each alloy and compared. The two conventional HT9 alloys (INL and ACO3) showed similar void swelling behavior due to their similar elemental composition and processing conditions. The INL HT9 exhibited a maximum of 2.4% swelling and the ACO3 HT9 showed a maximum of 2.8% swelling at 342 and 393 average local dpa, respectively. On the other hand, the two-composition engineered HT9 alloys with varying N contents (10 ppm for low N and 440 ppm for high N) showed disparate swelling behavior. The low N HT9 exhibited a maximum of 4.6% swelling, while the high N HT9 showed a maximum of 0.7% swelling at 342 average local dpa. Changes in the N content also affected Ni/Si rich G-phase formation. The low N HT9 showed a larger size and lower density of G-phase precipitates compared with the high N HT9 after 600 peak dpa irradiation. This study compares the void swelling behavior of the ion irradiated four current HT9 alloys to extremely high doses, with the void swelling data from neutron irradiated HT9 alloys. Furthermore, the comparison lends critical insights into how well these current alloys can withstand high neutron fluxes in future reactors, especially since the low N and high N HT9 alloys have never been exposed to such high doses before.

36 MATERIALS SCIENCE↗

Tea consumption and risk of bladder cancer in the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) Study: Pooled analysis of 12 international cohort studies

Tea has been shown to be associated with reduced risk of several diseases including cardiovascular diseases, stroke, metabolic syndrome, and obesity. However, the results on the relationship between tea consumption and bladder cancer are conflicting. This research aimed to assess the association between tea consumption and risk of bladder cancer using a pooled analysis of prospective cohort data. Individual data from 532,949 participants in 12 cohort studies, were pooled for analyses. Cox regression models stratified by study centre was used to estimate hazard ratios (HR) and corresponding 95% CIs. Fractional polynomial regression models were used to examine the dose–response relationship. A higher level of tea consumption was associated with lower risk of bladder cancer incidence (compared with no tea consumption: HR = 0.87, 95% C.I. = 0.77–0.98 for low consumption; HR = 0.86, 95% C.I. = 0.77–0.96 for moderate consumption; HR = 0.84, 95% C.I. = 0.75–0.95 for high consumption). When stratified by sex and smoking status, this reduced risk was statistically significant among men and current and former smokers. In addition, dose–response analyses showed a lower bladder cancer risk with increment of 100 ml of tea consumption per day (HR-increment = 0.97; 95% CI = 0.96–0.98). A similar inverse association was found among males, current and former smokers while never smokers and females showed non-significant results, suggesting potential sex-dependent effect. Higher consumption of tea is associated with reduced risk of bladder cancer with potential interaction with sex and smoking status. Further studies are needed to clarify the mechanisms for a protective effect of tea (e.g. inhibition of the survival and proliferation of cancer cells and anti-inflammatory mechanisms) and its interaction with smoking and sex.

60 APPLIED LIFE SCIENCES↗

Design and "As Flown" Radiation Environments for Materials in Low Earth Orbits

The design estimate for the materials for the International Space Station (ISS) specified in SSP 30512 was a conservative estimate. The environment dose was over estimated. The materials originally qualified for approximately 10-15 years are anticipated to be acceptable for periods of up to 20-30 years based on SSP-30512 or 40-60 years based on 2x SSP-30512. This viewgraph presentation shows charts and graphs that review the altitude, the solar minimum and maximum, and the radiation exposure of other satellite, among other graphics.

Minow, Joseph I.↗

X-ray characterization of fully-depleted p-channel Skipper-CCDs for the DarkNESS mission

The Dark matter Nanosatellite Equipped with Skipper Sensors (DarkNESS) mission is a 6U CubeSat designed to search for X-ray lines from decaying dark matter using Skipper-CCDs. Thick, fully-depleted p-channel Skipper-CCDs provide low readout noise and high quantum efficiency for 1-10 keV X-rays, but their X-ray performance has not yet been demonstrated in the space environment. DarkNESS will operate in low-Earth orbit, where trapped protons induce displacement damage in the sensor that increases charge-transfer inefficiency and degrades the X-ray energy resolution. This work measures the X-ray line response of Skipper-CCDs before and after proton irradiation and quantifies the associated degradation. A sensor was exposed to 217 MeV protons at a fluence of 8.4 x 10^10 protons cm^-2, corresponding to a displacement-damage dose more than an order of magnitude above the three-year expectation for representative mid-inclination and Sun-synchronous low-Earth orbits. A 55Fe source was used to compare the energy resolution of the beam-exposed quadrant to adjacent unexposed quadrants and a non-irradiated reference sensor. These measurements provide a quantitative assessment of radiation-induced spectral degradation in Skipper-CCDs and enable an estimate of the end-of-life X-ray energy resolution expected for DarkNESS operation in low-Earth orbit.

Alpine, Phoenix [Illinois U., Urbana] (ORCID:00090↗

Radiation dose prediction for Space Station

A detailed examination is conducted of the basis for the significant differences in Space Station radiation dose predictions that result from magnetic field model extrapolations into the future, with attention to the radiation attenuation effects of the residual atmospheric layer at altitudes of less than 1000 km. A model adjustment is proposed to supplant the arbitrary procedure of magnetic field extrapolation into the future. At altitudes below 500 km and low inclination, and with nominal module wall thicknesses, the new predictions for a 90-day Space Station tour are found to be well within current radiation dose limit guidelines.

Mccormack, Percival D.↗

Radiation hardness characterization of LKH-5 scintillating glass

Radiation hardness is an important property to examine in scintillators to help determine their expected lifetime in application cases where significant radiation dose is expected. Industrial imaging systems using 9 MV linear accelerators for x-ray radiography are one such application where significant radiation doses are expected to the scintillators used. Cadmium tungstate scintillators (CWO) and Thallium doped Cesium Iodide scintillators (CsI(Tl)) are used in some high energy cargo x-ray radiography systems. However, CWO has a high manufacturing cost for adequately uniform crystals and CsI(Tl) does not have sufficient radiation hardness. LKH-5 glass is being investigated as a potential low cost replacement for CWO and CsI(Tl). In this experiment 36 samples of a terbium doped silicate glass called LKH-5 were irradiated at doses up to 5 MRad using a 9 MV linear accelerator, and the change in their transmission properties was observed. Additionally, the glass was discovered to be a radiation hard glass due to the relatively small change in the transmission of the glass: less than 3% per cm at its emission peak of 550 nm and 5 MRad. This is similar to CWO which has a reported reduction in transmitted light of 2% per cm at 5 MRad and the emission peak of 475 nm and better than CsI(Tl) which is reported to have a reduction in transmitted light of 5% per cm at the emission peak of 550 nm and 4.2 MRad dose. Furthermore, an annealing procedure is described that returned the transmission of the glass to pre-irradiation values.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Application of electron beam technology to decompose persistent emerging drinking water contaminants: poly- and perfluoroalkyl substances (PFAS) and 1,4-Dioxane

Poly- and perfluoroalkyl substances (PFAS) and 1,4-dioxane are persistent emerging contaminants that are currently under consideration for federal and state-specific regulations in drinking water. Both PFAS and 1,4-dioxane are highly resistant to degradation and are not effectively removed by conventional drinking water treatment systems. Results from the Unregulated Contaminant Monitoring Rule 3 survey showed that >540 sites across the nation are contaminated with both PFAS and 1,4-dioxane. Hence, there is a need to identify technologies that can effectively remove both these contaminants. Water treatment via electron beam (e-beam) has been proven effective at treating a wide range of contaminants, including perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), polychlorinated biphenyls, and trichloroethylene. While the e-beam process is often considered similar to advanced oxidation processes (AOPs), e-beam technology is unique in that it produces both highly oxidizing and reducing species at the same time. The specific objectives of this study were to: (i) determine the effectiveness of 9 MeV electrons provided by the Fermilab’s Accelerator Application Development and Demonstration (A2D2) tool to decompose PFAS and 1,4-dioxane; (ii) assess the formation of byproducts during water treatment; (iii) apply the optimized treatment to field groundwater samples contaminated with PFAS and 1,4-dioxane, and (iv) assess the energy demands for the treatment of these contaminants using e-beam. Results from this study showed that e-beam is effective in treating both 1,4-dioxane and PFAS. Complete degradation of 1,4-dioxane was observed at a dose of 5 kGy for an initial concentration of up to 1 ppm without the need for any sample modification. The electrical energy per order (EEo) for treatment of 1,4-dioxane ranged from 0.46 to 0.72 kWh/m 3 /order and was comparable and even lower, in some cases, than other AOP technologies. Alkaline conditions (pH 13) and low dissolved oxygen concentration (2 mg/L) highly favored the treatment of PFAS by e-beam. Greater than 90% removal of PFOA and PFOS from an initial concentration of 100 to 500 ppb was achieved at a dose of 250 kGy and 500 kGy, respectively, under optimized conditions. The degradation efficiency was not significantly changed when treating other PFAS of fluorinated carbon chain length of 5 to 7 individually at 250 kGy with a removal ranging from 85¬–99% for different compounds. Short chain PFAS (perfluorobutanoate: PFBA and perfluorobutane sulfonate: PFBS) did not degrade under the same conditions at 250 kGy, but 70 to 99% degradation was observed at a higher dose of 1000 kGy. Short chain PFAS (perfluorohexanoate: PFHxA (C5) and perfluoroheptanoate: PFHpA (C6)) were detected after treatment of PFOA, but not after PFOS treatment. Inability to close the mass balance through targeted analysis suggests the presence of other intermediates not detectable by available analytical methods. When treating PFAS mixture containing ten compounds at equimolar concentration of 0.05 µM each, preferential degradation of polyfluorinated compound (6:2 fluorotelomer sulfonate or 6:2 FTS) followed by C8 and C7 compounds was observed as a function of increasing e-beam dose. About 30% degradation of ΣPFAS was observed at 250 kGy and no further removal was observed up to a dose of 1000 kGy. C4 to C6 PFASs showed no degradation, while C3 PFAS (PFBS) showed an increase in concentration by 34% at 1000 kGy due to formation from the breakdown of other long chain PFAS. These results suggested that (a) the reaction kinetics is likely different for different PFAS based on chain length, functional group, and the degree of fluorination of the carbon chain, and (b) there may be intermediates generated from the degradation of 6:2 FTS and C7/C8 compounds that can potentially scavenge hydrated electrons needed for reaction with the untreated PFAS molecules. Treatment of three PFAS-contaminated groundwater samples from two US states showed similar trends as observed in the treatment of equimolar PFAS mixtures. Up to 71% removal of ΣPFAS was achieved in real groundwater samples at 750 kGy and data trend suggested that higher degradation is feasible if higher doses (>1MGy) are applied to treat field samples to overcome matrix effects and competing species. Calculated EEo for PFAS ranged from as low as ~48 to 1081 kWh/m 3 /order depending on the type of PFAS treated. These values are comparable and even lower, in some cases, than other destructive technologies employed for PFAS treatment such as ultrasound, plasma, and photochemical treatment. The results from this study indicate e-beam is a promising approach under favorable conditions and should be explored further as an end-of-train treatment option for PFAS destruction.

1,4-Dioxane↗

Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials

In the antibody mediated prevention (AMP) trials, the broadly neutralizing antibody (bNAb) VRC01 demonstrated protective efficacy against susceptible HIV strains. To understand how VRC01 shaped breakthrough infections, deep sequencing was performed on 172 participants (>100,000 gag-Δpol and rev-env-Δnef sequences), at diagnosis and over time, in the placebo and treatment arms of the African (HVTN703/HPTN081; NCT02568215) and Americas/Europe (HVTN704/HPTN085; NCT02716675) cohorts. A high frequency of multilineage infections was detected (38%), including co-infection with both VRC01 sensitive and resistant viruses. This high frequency is largely accounted for by low-abundance lineages. Although VRC01 does not significantly affect the genetic transmission bottleneck compared to placebo, higher VRC01 doses trend towards greater VRC01 neutralization differences among co-infecting lineages. Two-thirds of multilineage infections showed evidence of recombination at the diagnostic timepoint. In the treatment group there is evidence of recombinant viruses preferentially inheriting resistance-associated mutations. This study provides critical insights into viral genetic and antigenic diversity that needs to be targeted to achieve protection, and highlights the role of recombination in facilitating escape.

59 BASIC BIOLOGICAL SCIENCES↗

Radiation dosimetry for the Gemini program

The principal source of radiation for low-earth-orbit, low inclination space flights is in the area of the South Atlantic magnetic anomaly. None of the Gemini dose measurements reported in the paper are of high enough intensity to be considered hazardous. There is a trend toward larger doses as missions are flown higher and longer. Extended orbital operations between 1400 and 4400 kilometers would encounter high interior radiation levels. Pronounced spacecraft geometry effects have been measured in manned spacecraft. Instrumentation for radiation measurements on Gemini spacecraft is described.

Richmond, R. G.↗

Experiment K-6-24, K-6-25, K-6-26. Radiation dosimetry and spectrometry

Radiation experiments flown by the University of San Francisco on the Cosmos 1887 spacecraft were designed to measure the depth dependence of both total dose and heavy particle flux, dose and dose equivalent, down to very thin shielding. Three experiments were flown and were located both inside and outside the Cosmos 1887 spacecraft. Tissue absorbed dose rates of 264 to 0.028 rad d(-1) under shielding of 0.013 to 3.4 g/sq cm of (7)LiF were found outside the spacecraft and 0.025 rad d(-1) inside. Heavy particle fluxes of 3.43 to 1.03 x 10 to the minus 3rd power cm -2 sub s -1 sub sr -1 under shielding of 0.195 to 1.33 g/sq cm plastic were found outside the spacecraft and 4.25 times 10 to the minus 4th power cm -2 sub s -1 sub sr -1 inside (LET infinity H2O greater than or equal to 4 keV/micron m). The corresponding heavy particle dose equivalent rates outside the spacecraft were 30.8 to 19.8 mrem d(-1) and 11.4 mrem d(-1) inside. The large dose and particle fluxes found at small shielding thicknesses emphasize the importance of these and future measurements at low shielding, for predicting radiation effects on space materials and experiments where shielding is minimal and on astronauts during EVA. The Cosmos 1887 mission contained a variety of international radiobiological investigations to which the measurements apply. The high inclination orbit (62 degrees) of this mission provided a radiation environment which is seldom available to U.S. investigators. The radiation measurements will be compared with those of other research groups and also with those performed on the Shuttle, and will be used to refine computer models employed to calculate radiation exposures on other spacecraft, including the Space Station.

Benton, E. V.↗

Radiation Protection for Lunar Mission Scenarios

Preliminary analyses of shielding requirements to protect astronauts from the harmful effects of radiation on both short-term and long-term lunar missions have been performed. Shielding needs for both solar particle events (SPEs) and galactic cosmic ray (GCR) exposure are discussed for transit vehicles and surface habitats. This work was performed under the aegis of two NASA initiatives. The first study was an architecture trade study led by Langley Research Center (LaRC) in which a broad range of vehicle types and mission scenarios were compared. The radiation analysis for this study primarily focused on the additional shielding mass required to protect astronauts from the rare occurrence of a large SPE. The second study, led by Johnson Space Center (JSC), involved the design of lunar habitats. Researchers at LaRC were asked to evaluate the changes to mission architecture that would be needed if the surface stay were lengthened from a shorter mission duration of 30 to 90 days to a longer stay of 500 days. Here, the primary radiation concern was GCR exposure. The methods used for these studies as well as the resulting shielding recommendations are discussed. Recommendations are also made for more detailed analyses to minimize shielding mass, once preliminary vehicle and habitat designs have been completed. Here, methodologies are mapped out and available radiation analysis tools are described. Since, as yet, no dosimetric limits have been adopted for missions beyond low earth orbit (LEO), radiation exposures are compared to LEO limits. Uncertainties associated with the LEO career effective dose limits and the effects of lowering these limits on shielding mass are also discussed.

Clowdsley, Martha S.↗