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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 937 records · Page 52
All sourcesNASA NTRSDOE OSTI
NASA NTRS1993

Evolution of catalytic function

An RNA-based evolution system was constructed in the laboratory and used to develop RNA enzymes with novel catalytic function. By controlling the nature of the catalytic task that the molecules must perform in order to survive, it is possible to direct the evolving population toward the expression of some desired catalytic behavior. More recently, this system has been coupled to an in vitro translation procedure, raising the possibility of evolving protein enzymes in the laboratory to produce novel proteins with desired catalytic properties. The aim of this line of research is to reduce darwinian evolution, the fundamental process of biology, to a laboratory procedure that can be made to operate in the service of organic synthesis.

NASA Program Exobiology↗
NASA NTRS1993

The C-terminal region of alpha-crystallin: involvement in protection against heat-induced denaturation

Recent studies have demonstrated that the alpha-crystallins can protect other proteins against heat-induced denaturation and aggregation. To determine the possible involvement of the C-terminal region in this activity, the alpha-crystallins were subjected to limited tryptic digestion, and the amount of cleavage from the N-terminal and C-terminal regions of the alpha-A and alpha-B crystallin chains was assessed using antisera specific for these regions. Limited tryptic digestion resulted in cleavage only from the C-terminal region of alpha-A crystallin. This trypsin-treated alpha-A crystallin preparation showed a decreased ability to protect proteins from heat-induced aggregation using an in vitro assay. Together, these results demonstrate that the C-terminal region of alpha-A crystallin is important for its ability to protect against heat-induced aggregation, which is consistent with the hypothesis that post-translational changes that are known to occur at the C-terminal region may have significant effects on the ability of alpha-A crystallin to protect against protein denaturation in vivo.

NASA Discipline Cell Biology↗
NASA NTRS1993

An intron within the 16S ribosomal RNA gene of the archaeon Pyrobaculum aerophilum

The 16S rRNA genes of Pyrobaculum aerophilum and Pyrobaculum islandicum were amplified by the polymerase chain reaction, and the resulting products were sequenced directly. The two organisms are closely related by this measure (over 98% similar). However, they differ in that the (lone) 16S rRNA gene of Pyrobaculum aerophilum contains a 713-bp intron not seen in the corresponding gene of Pyrobaculum islandicum. To our knowledge, this is the only intron so far reported in the small subunit rRNA gene of a prokaryote. Upon excision the intron is circularized. A secondary structure model of the intron-containing rRNA suggests a splicing mechanism of the same type as that invoked for the tRNA introns of the Archaea and Eucarya and 23S rRNAs of the Archaea. The intron contains an open reading frame whose protein translation shows no certain homology with any known protein sequence.

NASA Discipline Exobiology↗
NASA NTRS1993

HSP86 and HSP84 exhibit cellular specificity of expression and co-precipitate with an HSP70 family member in the murine testis

This study extends to the protein level our previous observations, which had established the stage and cellular specificity of expression of hsp86 and hsp84 in the murine testis in the absence of exogenous stress. Immunoblot analysis was used to demonstrate that HSP86 protein was present throughout testicular development and that its levels increased with the appearance of differentiating germ cells. HSP86 was most abundant in the germ cell population and was present at significantly lower levels in the somatic cells. By contrast, the HSP84 protein was detected in the somatic cells of the testis rather than in germ cells. The steady-state levels of HSP86 and HSP84 paralleled the pattern of the expression of their respective mRNAs, suggesting that regulation at the level of translation was not a major mechanism controlling hsp90 gene expression in testicular cells. Immunoprecipitation analysis revealed that a 70-kDa protein coprecipitated with the HSP86/HSP84 proteins in testicular homogenates. This protein was identified as an HSP70 family member by immunoblot analysis, suggesting that HSP70 and HSP90 family members interact in testicular cells.

NASA Discipline Number 40-20↗
NASA NTRS2003

The HiVy toolset

The HiVy toolset provides model checking for statecharts. This is achieved by translating statechart specifications into the input language of the spin model checker.

model checking statechart translation validation↗
NASA NTRS2020

Solar Cruiser Technology Maturation Plans

The NASA Marshall Space Flight Center (MSFC) developed the Solar Cruiser mission concept to mature solar sail technology for use in future Heliophysics missions, as well as missions of interest across a broad user community (e.g., space weather and Earth polar observatories). Solar Cruiser will serve as a pathfinder for missions that observe the solar environment from unique vantage points such as a high inclination solar mission opening a fundamentally new range of observational capabilities for the Heliophysics Program and for space weather monitoring. Sustained observations away from the Sun-Earth line (SEL) present unique opportunities for answering the outstanding science questions of Heliophysics, improving space-weather monitoring and prediction, and revealing new information about our Sun and solar system. Propellantless solar sails can be used to create artificial equilibria and maintain indefinite station-keeping at locations sunward of L1 along the SEL, or at any desired offset from the SEL leading or trailing the Earth in its orbit. They can change the heliocentric inclination of a spacecraft from the ecliptic to as high as solar polar, stopping and remaining at any intermediate inclination orbit in between. Sails can be used to hover over the Earth’s poles, using solar photon pressure to offset the Earth’s gravitational attraction, creating functional equivalents of geostationary earth orbits. The Solar Cruiser mission would fly a small spacecraft with a large (>1,600 square meter) solar sail containing embedded reflectivity control devices (RCDs) and photovoltaic cells. The mission concept includes successful deployment of the solar sail, validation of all sail subsystems, controlled station-keeping inside of the Sun-Earth L1 point, attitude control of the sail with the RCDs (including spinning and de-spinning), demonstration of pointing performance for science imaging, and an increase in heliocentric inclination (out of the ecliptic). To demonstrate the requisite sail technology, the Solar Cruiser project will design, fabricate, deploy, and fly the Solar Sail Propulsion Element (SSPE). The SSPE incorporates the following three systems: • The Solar Sail System (SSS) provides the large propulsive surface required for acceleration and smaller reflectivity-changing surfaces for roll control. • The Active Mass Translator System (AMT) provides SSPE motion with respect to the sailcraft bus for pitch and yaw control. • The Solar Sail Attitude Determination and Control System (SSADCS) consists of embedded software to 1) provide autonomous sailcraft attitude estimation, attitude pointing control, and reaction wheel momentum management following sail deployment and 2) execute the uplinked inertial attitude pointing commands to maintain the desired sailcraft trajectory. The plans for maturing each of these technology systems to TRL 5 and beyond are described herein.

Solar Sail↗
NASA NTRS1962

Estimated Viscosities and Thermal Conductivities of Gases at High Temperatures

Viscosities and thermal conductivities, suitable for heat-transfer calculations, were estimated for about 200 gases in the ground state from 100 to 5000 K and 1-atmosphere pressure. Free radicals were included, but excited states and ions were not. Calculations for the transport coefficients were based upon the Lennard-Jones (12-6) potential for all gases. This potential was selected because: (1) It is one of the most realistic models available and (2) intermolecular force constants can be estimated from physical properties or by other techniques when experimental data are not available; such methods for estimating force constants are not as readily available for other potentials. When experimental viscosity data were available, they were used to obtain the force constants; otherwise the constants were estimated. These constants were then used to calculate both the viscosities and thermal conductivities tabulated in this report. For thermal conductivities of polyatomic gases an Eucken-type correction was made to correct for exchange between internal and translational energies. Though this correction may be rather poor at low temperatures, it becomes more satisfactory with increasing temperature. It was not possible to obtain force constants from experimental thermal conductivity data except for the inert atoms, because most conductivity data are available at low temperatures only (200 to 400 K), the temperature range where the Eucken correction is probably most in error. However, if the same set of force constants is used for both viscosity and thermal conductivity, there is a large degree of cancellation of error when these properties are used in heat-transfer equations such as the Dittus-Boelter equation. It is therefore concluded that the properties tabulated in this report are suitable for heat-transfer calculations of gaseous systems.

HEAT TRANSFER↗
NASA NTRS1960

Aerospace medicine and biology. an annotated bibliography, 1954 literature, volume iii

While this third volume of the bibliography was in preparation, a number of changes and new developments took place which, it is hoped, will be instrumental in furthering the bibliography's main objective: to provide as rapidly as possible comprehensive coverage of the aerospace-medical and bio-astronautical literature. To begin with, it will be noted that the title of the compilation has been changed from Aviation Medicine to Aerospace Medicine and Biology. This will bring into relief the fact that the general subject scope of the bibliography has been expanded to include new areas of interest in space-medical and space-biological research. Thus, to the subject fields heretofore covered by the bibliography (a full listing of which may be found in the Preface to Volume 2) new ones have been added, such as Biological Rhythms, Biological Orientation, Closed Ecological Systems, Physiological and Psychological Effects of Heat, Cold, Isolation, Restraint, and many others. Another important change was administrative in nature. Sponsorship of the bibliography for the fiscal year 1959/60 was taken over by the U. S. Advanced Research Project Agency (ARPA), the U. S. Aeronautics and Space Administration (NASA), and the Defense Research Board of Canada. Under a substantially increased budget, the Library of Congress was enabled to produce two volumes during the fiscal year. The Library also agreed to prepare selected abstracts from the current aerospace and bio-astronautic literature, which are published monthly in Aerospace Medicine, the official organ of the Aerospace Medical Association.*) If the present rate of production can be maintained, it will be possible to bring the bibliography up to date within about three years. In format, style, and arrangement, this volume follows closely the preceding ones. References are arranged alphabetically by author; abstracts are informative; and full bibliographic information is provided, including foreign and translated titles, volume and issue numbers, place of publication (if foreign), inclusive paging, full dates, and library call numbers or other location symbols. While the bulk of the publication is devoted to journal articles, reports, and monographs published during the year 1954, items published in 1952 or 1953 not included in the preceding volumes have been incorporated in this volume. For quick identification, the publication years of these off-year references have been printed next to the first author's name. As before, cumulated corporate and secondary author and subject indexes are included, the latter being revised and enlarged considerably, in keeping with the over-all expansion of subject scope.

Aerospace medicine↗