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At least 919 records · Page 51

Magnetic switching in Weyl semimetal-superconductor heterostructures

Here, we present a switching mechanism that utilizes the proximity coupling between the surface spin texture of a Weyl semimetal and a superconductor in a Weyl semimetal-superconductor Weyl semimetal trilayer heterostructure. We show that the superconductivity in the middle layer can be fully suppressed by the surface spin texture of the Weyl semimetals in the presence of an external magnetic field, but it can be recovered again by only changing the field direction. The restoration of the middle-layer superconductivity indicates a sharp transition to a low-resistance state. This sharp switching effect, realizable using a Weyl semimetal because of its strong spin-momentum locking and surface spin polarization, is a promising avenue for novel superconducting spin-valve applications.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Spacecraft rendezvous operational considerations affecting vehicle systems design and configuration

One lesson learned from Orbiting Maneuvering Vehicle (OMV) program experience is that Design Reference Missions must include an appropriate balance of operations and performance inputs to effectively drive vehicle systems design and configuration. Rendezvous trajectory design is based on vehicle characteristics (e.g., mass, propellant tank size, and mission duration capability) and operational requirements, which have evolved through the Gemini, Apollo, and STS programs. Operational constraints affecting the rendezvous final approach are summarized. The two major objectives of operational rendezvous design are vehicle/crew safety and mission success. Operational requirements on the final approach which support these objectives include: tracking/targeting/communications; trajectory dispersion and navigation uncertainty handling; contingency protection; favorable sunlight conditions; acceptable relative state for proximity operations handover; and compliance with target vehicle constraints. A discussion of the ways each of these requirements may constrain the rendezvous trajectory follows. Although the constraints discussed apply to all rendezvous, the trajectory presented in 'Cargo Transfer Vehicle Preliminary Reference Definition' (MSFC, May 1991) was used as the basis for the comments below.

Prust, Ellen E.↗

Computational Fluid Dynamics Methods Used in the Development of the Space Launch System Liftoff and Transition Lineloads Databases

The objective of this paper is to document the reasoning and trade studies that supported the selection of appropriate tools for constructing aerodynamic lineload databases for the Liftoff and Transition phases of flight for launch vehicles. These decisions were made amid the maturation of an evolving workflow for generating databases on variants of the Space Launch System launch vehicle, with most being based on results from brief developmental studies performed in response to specific, unforeseen challenges that were encountered in analyzing a given configuration. This report is intended to provide a summary of the results and the decision-making processes chronologically over the design cycles of various configurations, starting with isolated free-air bodies for the Block 1 Crew, then the Block 1B Crew and Cargo configurations, and most recently the Block 1B Crew configuration in proximity to the launch tower. The results from these analyses led to the selection of the CREATE-AV Kestrel flowsolver for simulating these problems. The need to accurately capture the expected leeward-wake flow field characteristics required the use of Delayed Detached Eddy Simulation (DDES) method, for which the vorticity magnitude was employed as the solution Adaptive Mesh Refinement (AMR) function over the off-body Cartesian grid region. In addition, the Spalart-Allmaras (SA) model is used to account for the flow turbulence effects.

Ratnayake, Nalin A.↗

A 2K Design for the Low Beta Quadrupoles Q1ApF/Q1BpF for the Interaction Region of the Electron-Ion Collider (EIC)

The forward hadron magnets of the planned electron-ion collider (EIC) at Brookhaven National Laboratory (BNL) present a set of unique challenges. In addition to the typical magnet requirements in terms of aperture, gradient, and field quality, the field leakage from the hadron magnets to the electron apertures must be negligible. Due to the close proximity of the two apertures the shielding solution for the electron beam can affect the field quality of the hadron magnets. Here, in this paper, a design for the Q1ApF/Q1BpF low beta quadrupoles based on NbTi Rutherford cable operating at 2K is presented. In this design the electron beam shielding and the required field quality in the hadron magnets are achieved using a set of cutouts in the iron yoke solely without resorting to active shielding. The chosen layout along with the key parameters are presented and their effect on hadron magnets in term of field quality and operational margins are also discussed.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Storms Are an Important Driver of Change in Tropical Forests

Tropical forest dynamics and composition have changed over recent decades, but the proximate drivers of these changes remain unclear. Investigations into these trends have focused on increasing drought stress, CO 2 , temperature, and fires, whereas convective storms are generally overlooked. We argue that existing literature provides clear support for the importance of storms as drivers of forest change. We reanalyze the largest plot-based study of tropical forest carbon dynamics to show that lightning frequency—an indicator of storm activity—strongly predicts forest carbon storage and residence time, and its inclusion improves model fit and weakens evidence for the effects of high temperatures. Convective storm activity has increased 5%–25% per decade over the past half century. Extrapolating from historic trends, we estimate that storms likely contribute ca. 50% of the reported increases in biomass mortality across Amazonia, with all realistic combinations of assumptions indicating a possible range of 12%–118%. Spatial variation in storm activity shows weak relationships with drought, demonstrating that forests can experience high drought stress, high storm activity, or both. Accordingly, we hypothesise that convective storms are among the most important drivers of tropical forest change, and as such, they require significant research investment to avoid misguiding science, policy, and management.

biomass carbon↗

Results of magnetospheric barium ion cloud experiment of 1971

The barium ion cloud experiment involved the release of about 2 kg of barium at an altitude of 31 482 km, a latitude of 6.926 N., and a longitude of 74.395 W. Significant erosion of plasma from the main ion core occurred during the initial phase of the ion cloud expansion. From the motion of the outermost striational filaments, the electric field components were determined to be 0.19 mV/m in the westerly direction and 0.68 mV/m in the inward direction. The differences between these components and those measured from balloons flown in the proximity of the extremity of the field line through the release point implied the existence of potential gradients along the magnetic field lines. The deceleration of the main core was greater than theoretically predicted. This was attributed to the formation of a polarization wake, resulting in an increase of the area of interaction and resistive dissipation at ionospheric levels. The actual orientation of the magnetic field line through the release point differed by about 10.5 deg from that predicted by magnetic field models that did not include the effect of ring current.

Adamson, D.↗

The interactive role of subsynoptic scale jet streak and planetary boundary layer processes in organizing an isolated convective complex

Surface analyses and numerical simulation sensitivity studies are compared in order to determine the role played by deep, well-mixed, and well-heated boundary layers in perturbing a weak jet streak in proximity to the development of an isolated but intense convective complex associated with the Grand Island, Nebraska tornado outbreak of June 3-4, 1980. A brief description of the case is first presented, emphasizing three-hourly surface analyses, radar, and satellite data. The results of numerical experiments comparing differences in the runs with and without diurnal surface sensible heating are discussed and related to observations. The dynamical processes responsible for these simulation differences are discussed, and the significance of these differences are considered in terms of their effect on the preconvective environment.

Kaplan, M. L.↗

Beat-to-Beat Blood Pressure Monitor

This device provides non-invasive beat-to-beat blood pressure measurements and can be worn over the upper arm for prolonged durations. Phase and waveform analyses are performed on filtered proximal and distal photoplethysmographic (PPG) waveforms obtained from the brachial artery. The phase analysis is used primarily for the computation of the mean arterial pressure, while the waveform analysis is used primarily to obtain the pulse pressure. Real-time compliance estimate is used to refine both the mean arterial and pulse pressures to provide the beat-to-beat blood pressure measurement. This wearable physiological monitor can be used to continuously observe the beat-to-beat blood pressure (B3P). It can be used to monitor the effect of prolonged exposures to reduced gravitational environments and the effectiveness of various countermeasures. A number of researchers have used pulse wave velocity (PWV) of blood in the arteries to infer the beat-to-beat blood pressure. There has been documentation of relative success, but a device that is able to provide the required accuracy and repeatability has not yet been developed. It has been demonstrated that an accurate and repeatable blood pressure measurement can be obtained by measuring the phase change (e.g., phase velocity), amplitude change, and distortion of the PPG waveforms along the brachial artery. The approach is based on comparing the full PPG waveform between two points along the artery rather than measuring the time-of-flight. Minimizing the measurement separation and confining the measurement area to a single, well-defined artery allows the waveform to retain the general shape between the two measurement points. This allows signal processing of waveforms to determine the phase and amplitude changes. Photoplethysmography, which measures changes in arterial blood volume, is commonly used to obtain heart rate and blood oxygen saturation. The digitized PPG signals are used as inputs into the beat-to-beat blood pressure measurement algorithm.

Lee, Yong Jin↗

Beat-to-Beat Blood Pressure Monitor

This device provides non-invasive beat-to-beat blood pressure measurements and can be worn over the upper arm for prolonged durations. Phase and waveform analyses are performed on filtered proximal and distal photoplethysmographic (PPG) waveforms obtained from the brachial artery. The phase analysis is used primarily for the computation of the mean arterial pressure, while the waveform analysis is used primarily to obtain the pulse pressure. Real-time compliance estimate is used to refine both the mean arterial and pulse pressures to provide the beat-to-beat blood pressure measurement. This wearable physiological monitor can be used to continuously observe the beat-to-beat blood pressure (B3P). It can be used to monitor the effect of prolonged exposures to reduced gravitational environments and the effectiveness of various countermeasures. A number of researchers have used pulse wave velocity (PWV) of blood in the arteries to infer the beat-to-beat blood pressure. There has been documentation of relative success, but a device that is able to provide the required accuracy and repeatability has not yet been developed. It has been demonstrated that an accurate and repeatable blood pressure measurement can be obtained by measuring the phase change (e.g., phase velocity), amplitude change, and distortion of the PPG waveforms along the brachial artery. The approach is based on comparing the full PPG waveform between two points along the artery rather than measuring the time-of-flight. Minimizing the measurement separation and confining the measurement area to a single, well-defined artery allows the waveform to retain the general shape between the two measurement points. This allows signal processing of waveforms to determine the phase and amplitude changes.

Lee, Yong Jin↗

Restoring the Dunes: Using Satellite Imagery to Help Restore Turtle Nesting Grounds In Puerto Rico After Hurricane Maria

The North coast of Puerto Rico sustained heavy damage from Hurricane Maria and other subsequent tropical storms. This damage included erosion of beaches and foredunes. The foredunes are a delicate ecological environment, which provides important nesting grounds for endangered turtles. Local ecologists have been working to restore these dunes with mixed results. Presented here is an evaluation of dune restoration sites, and strategies to improve the success of subsequent restoration efforts. This involves both historical satellite image analysis and field work to evaluate sediment migration pathways. Local ecologists use a technique called Biomimicry to restore dunes. This involves inserting sticks or plants into the ground, simulating the effects of natural vegetation to slow wind speeds and deposit wind-blown sand. Manually planted vegetation can follow to stabilize the trapped sand. While often successful, this technique occasionally fails to accumulate significant amounts of sand. Satellite imagery shows that one of the controlling factors is the orientation of the dune and beach to the prevailing wind. Dunes that are oriented parallel to the prevailing wind are relatively slower-growing due to sediment bypass. Satellite imagery also indicates that the fastest growing dunes are in close proximity to major sediment sources. This is complicated by large dams, which limit the amount of sediment delivered to the coast. Field observation shows that biomimicry matrices are occasionally located too close to the swash zone, where storms over-top the dunes, poisoning stabilizing vegetation with salt water. Another common observation was that many dunes were starting to form behind fallen trees, suggesting that a different type of biomimicry might be successful. Satellite and field observation suggest that strategies to protect nearshore environments and improve dune restoration biomimicry efforts include: 1) orient biomimicry matrices at a higher angle to prevailing winds. 2) Prioritize sites near river mouths, particularly those without upstream dams. 3) Test other orientations of biomimicry, such as horizontal boards to mimic fallen trees. 4) Improve sediment supply by preventing further dam development, and releasing trapped sediment.

Paul Bremner↗

Evaluation of IMERG Satellite Precipitation Over the Land-Coast-Ocean Continuum – Part Ii: Quantification

To understand and manage water systems under a changing climate and meet an increasing demand for water, a quantitative understanding of precipitation is most important in coastal regions. The capabilities of the Integrated Multi-satellitE Retrievals for Global Precipitation Measurement (IMERG) V06B product for precipitation quantification are examined over three coastal regions of the United States: the West Coast, the Gulf of Mexico, and the East Coast, all of which are characterized by different topographies and precipitation climatologies. A novel uncertainty analysis of IMERG is proposed that considers environmental and physical parameters such as elevation and distance to the coastline. The IMERG performance is traced back to its components, i.e., passive microwave (PMW), infrared (IR), and morphing-based estimates. The analysis is performed using high-resolution, high-quality Ground Validation Multi-Radar/Multi-Sensor (GV-MRMS) rainfall estimates as ground reference at the native resolution of IMERG of 30 min and 0.1°. IMERG Final (IM-F) quantification performance heavily depends on the respective contribution of PMW, IR, and morph components. IM-F and its components overestimate the contribution of light rainfall (<1 mm h−1) and underestimate the contribution of high rainfall rates (>10 mm h−1) to the total rainfall volume. Strong regional dependencies are highlighted, especially over the West Coast, where the proximity of complex terrain to the coastline challenges precipitation estimates. Other major drivers are the distance from the coastline, elevation, and precipitation types, especially over the land and coast surface types, that highlight the impact of precipitation regimes.

Atmosphere↗

Visible-Light-Driven Triplet Sensitization of Polycyclic Aromatic Hydrocarbons Using Thionated Perinones

Metal-free chromophores that efficiently generate triplet excited states represent enticing alternatives with respect to transition metal-containing photosensitizers, such as those featuring metal-to-ligand charge transfer excited states. Yet, such molecular constructs have remained underexplored due to the unclear relationship(s) between molecular structure and efficient/rapid intersystem crossing. In this regard, we present a series of three thionated perinone chromophores serving as a newly conceived class of heavy metal-free triplet photosensitizers. We demonstrate that thionation of the lone C=O substituent in each highly fluorescent perinone imparts red-shifted absorbance bands that maintain intense extinction coefficients across the visible spectrum, as well as unusually efficient triplet excited state formation as inferred from the measured singlet O 2 quantum yields at 1270 nm (Φ Δ = 0.78–1.0). Electronic structure calculations revealed the emergence of a low energy S 1 (n → π*) excited state in the proximity of a slightly higher energy S 2 (π → π*) excited state. The distinct character in each of the two lowest-lying singlet state manifolds resulted in the energetic inversion of the corresponding triplet excited states due to differences in electron exchange interactions. Rapid S 1 → T 1 intersystem crossing was thereby facilitated in this manner through spin–orbit coupling as predicted by the El Sayed rules. The lifetimes of the resultant triplet excited states persisted into the microsecond time regime, as measured by transient absorbance spectroscopy, enabling effective bimolecular triplet sensitization of some common polycyclic aromatic hydrocarbons. The synthetically facile interchange of a single O atom to an S atom in the investigated perinones resulted in marked changes to their photophysical properties, namely, conversion of dominant singlet state fluorescence in the former to long-lived triplet excited states in the latter. The combined results suggest a general strategy for accessing long-lived triplet excited states in organic chromophores featuring a lone C=O moiety residing within its structure, valuable for the design of metal-free triplet photosensitizers.

14 SOLAR ENERGY↗

Aerodynamic Performance of a 0.27-Scale Model of an AH-64 Helicopter with Baseline and Alternate Rotor Blade Sets

Performance of a 27 percent scale model rotor designed for the AH-64 helicopter (alternate rotor) was measured in hover and forward flight and compared against and AH-64 baseline rotor model. Thrust, rotor tip Mach number, advance ratio, and ground proximity were varied. In hover, at a nominal thrust coefficient of 0.0064, the power savings was about 6.4 percent for the alternate rotor compared to the baseline. The corresponding thrust increase at this condition was approx. 4.5 percent which represents an equivalent full scale increase in lift capability of about 660 lbs. Comparable results were noted in forward flight except for the high thrust, high speed cases investigated where the baseline rotor was slightly superior. Reduced performance at the higher thrusts and speeds was likely due to Reynolds number effects and blade elasticity differences.

Kelley, Henry L.↗

Microtubule distribution in gravitropic protonemata of the moss Ceratodon

Tip cells of dark-grown protonemata of the moss Ceratodon purpureus are negatively gravitropic (grow upward). They possess a unique longitudinal zonation: (1) a tip group of amylochloroplasts in the apical dome, (2) a plastid-free zone, (3) a zone of significant plastid sedimentation, and (4) a zone of mostly non-sedimenting plastids. Immunofluorescence of vertical cells showed microtubules distributed throughout the cytoplasm in a mostly axial orientation extending through all zones. Optical sectioning revealed a close spatial association between microtubules and plastids. A majority (two thirds) of protonemata gravistimulated for > 20 min had a higher density of microtubules near the lower flank compared to the upper flank in the plastid-free zone. This apparent enrichment of microtubules occurred just proximal to sedimented plastids and near the part of the tip that presumably elongates more to produce curvature. Fewer than 5% of gravistimulated protonemata had an enrichment in microtubules near the upper flank, whereas 14% of vertical protonemata were enriched near one of the side walls. Oryzalin and amiprophos-methyl (APM) disrupted microtubules, gravitropism, and normal tip growth and zonation, but did not prevent plastid sedimentation. We hypothesize that a microtubule redistribution plays a role in gravitropism in this protonema. This appears to be the first report of an effect of gravity on microtubule distribution in plants.

NASA Program Space Biology↗

Electrolyte and Cutoff Potential Effects on Cycle Life of Li4Ti5O12/LiNi0.9Mn0.1O2 Batteries for Behind-the-Meter Storage Applications

Behind-the-Meter Storage (BTMS) is a stationary battery energy storage system that is connected to the electrical distribution system on the customer's side of the utility's service meter. BTMS systems are used to store electrical energy from the grid as well as inconstant, renewable energy, such as local solar and wind generation. A successful BTMS system will allow the customer to pair their energy generation and storage to optimize electrical consumption from the grid, improving reliability and minimizing cost. For BTMS applications, batteries must be designed and optimized with different set of criteria from other leading segments of the Li-ion battery market, like transportation, due the system being stationary and proximal to the residential or commercial building it's benefitting. BTMS applications prioritize safety, cost (low/no-critical materials), reliability (20-year calendar life), and durability (10,000 cycle life), while having the ability to (minimally) compromise energy density and rate capability. Lithium titanate (Li4Ti5O12-, LTO) is a promising anode candidate for BTMS applications due to its high safety and capacity retention, while maintaining a reasonable 160 mAhg-1 reversable capacity and composition of relatively abundant materials. (1) Specifically, LTO has a high working voltage which helps to prevent Li dendrite formation, improving safety. Furthermore, LTO also has negligible lithiation-based volume change, leading to less mechanical pulverization, or loss of active material, upon cycling. For the cathode, materials with little or no Co are of high interest due to the high cost and low abundance of Co. LiMn2O4 (LMO) has been paired with LTO for BTMS applications in the past due to its safety, low cost (abundancy), and reasonably high operating voltage. (2-4) However, the low capacity of LMO limits energy density and specific energy. While not the highest priority for BTMS applications, increasing energy density will enable deployment in space constrained BTMS applications and decrease total cost. LiNi0.9Mn0.1O2 (LN-MO) is a recently developed material with promise due to its high operating voltage and relatively low price. (5) However, Ni-rich layered oxides, including LNMO, tend to struggle with capacity retention during high-voltage cycling due to mechanical pulverization, irreversible phase transitions, and unstable solid-electrolyte interphase. The study presented here focuses on building an understanding of how electrolyte solvent and varied cutoff potentials will impact the cycle life of LTO/LN-MO cells. Specifically, a comparison is provided between ethylene carbonate (EC), ethyl methyl carbonate (EMC), fluoroethylene carbonate (FEC), and Gen2 electrolyte solvents with 1M Lithium hexafluorophosphate (LiPF6) salt, cycling to two upper termination potentials, 2.6V and 2.7V. Electrochemical testing and diagnostics (e.g., differential capacity analysis, area specific impedance, constant voltage hold, and rate capability) and post-mortem characterization will be used to understand the aging behavior and failure mechanisms of the 8 cell combinations (four electrolytes and two voltage cutoffs). Cells with FEC electrolyte showed a lower initial capacity compared to cells with Gen2, EMC, and EC cycling at both voltages; however, the cells with FEC showed consistent trends in capacity retention with 2.6V and 2.7V termination potentials, while the cells with the other electrolytes showed much higher rates of capacity loss when cycling to the higher voltage. These results indicate that FEC may play a role in improving durability of high-voltage, Ni-rich electrode systems for use in high-cycle applications, such as BTMS.

electrolyte↗

Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer

Abstract New therapeutics and combination regimens have led to marked clinical improvements for the treatment of a subset of colorectal cancer. Immune checkpoint inhibitors have shown clinical efficacy in patients with mismatch-repair–deficient or microsatellite instability–high (MSI-H) metastatic colorectal cancer (mCRC). However, patients with microsatellite-stable (MSS) or low levels of microsatellite instable (MSI-L) colorectal cancer have not benefited from these immune modulators, and the survival outcome remains poor for the majority of patients diagnosed with mCRC. In this article, we describe the discovery of a novel T-cell–dependent bispecific antibody (TDB) targeting tumor-associated antigen LY6G6D, LY6G6D-TDB, for the treatment of colorectal cancer. RNAseq analysis showed that LY6G6D was differentially expressed in colorectal cancer with high prevalence in MSS and MSI-L subsets, whereas LY6G6D expression in normal tissues was limited. IHC confirmed the elevated expression of LY6G6D in primary and metastatic colorectal tumors, whereas minimal or no expression was observed in most normal tissue samples. The optimized LY6G6D-TDB, which targets a membrane-proximal epitope of LY6G6D and binds to CD3 with high affinity, exhibits potent antitumor activity both in vitro and in vivo. In vitro functional assays show that LY6G6D-TDB–mediated T-cell activation and cytotoxicity are conditional and target dependent. In mouse xenograft tumor models, LY6G6D-TDB demonstrates antitumor efficacy as a single agent against established colorectal tumors, and enhanced efficacy can be achieved when LY6G6D-TDB is combined with PD-1 blockade. Our studies provide evidence for the therapeutic potential of LY6G6D-TDB as an effective treatment option for patients with colorectal cancer.

60 APPLIED LIFE SCIENCES↗

Electronic Structure of TlBa2CaCu2O(7-Delta)

The core levels of TlBa2CaCu2O(7-delta) (Tl-1212) epitaxial films have been measured with X-ray photoelectron spectroscopy (XPS). The valence electronic structure has been determined using the full-potential linear muffin-tin-orbital band-structure method and measured with XPS. The calculations show that a van Hove singularity (VHS) lies above the Fermi level (E(sub F)) for the stoichiometric compound (delta = 0.5), while for 50% oxygen vacancies in the Tl-O layer (delta = 0.5) E(sub F) is in close proximity to the VHS. Samples annealed in nitrogen (to reduce the hole overdoping by the removal of oxygen) exhibit higher core-level binding energies and a higher T(sub c), consistent with a shift of E(sub F) closer to the VHS. Comparisons are made to the core levels and valence bands of Tl2Ba2CaCu2O(8 + delta)(Tl-2212) and HgBa2CaCu2O)6 + delta) (Hg- 1212). The similarity of the Cu 2p(sub 3/2) spectra for Tl-1212 and Tl-2212 indicates that the number of Tl-O layers has little effect on the Cu-O bonding. However, the Tl-1212 and Hg-1212 Cu 2p(sub 3/2) signals exhibit differences which suggest that the replacement of T(sup 3+) with Hg(sup 2+) results in a decrease in the O 2p right arrow Cu 3d charge-transfer energy and differences in the probabilities of planar vs apical oxygen charge transfer and/or Zhang-Rice singlet-state formation. Differences between the Tl-1212 and the Tl-2212 and Hg-1212 measured valence bands are consistent with the calculated Cu 3d and (Tl,Hg) 6s/5d partial densities of states.

Vasquez, R. P.↗

Spaceflight has compartment- and gene-specific effects on mRNA levels for bone matrix proteins in rat femur

In the present study, we evaluated the possibility that the abnormal bone matrix produced during spaceflight may be associated with reduced expression of bone matrix protein genes. To test this possibility, we investigated the effects of a 14-day spaceflight (SLS-2 experiment) on steady-state mRNA levels for glyceraldehyde-3-phosphate dehydrogenase (GAPDH), osteocalcin, osteonectin, and prepro-alpha(1) subunit of type I collagen in the major bone compartments of rat femur. There were pronounced site-specific differences in the steady-state levels of expression of the mRNAs for the three bone matrix proteins and GAPDH in normal weight-bearing rats, and these relationships were altered after spaceflight. Specifically, spaceflight resulted in decreases in mRNA levels for GAPDH (decreased in proximal metaphysis), osteocalcin (decreased in proximal metaphysis), osteonectin (decreased in proximal and distal metaphysis), and collagen (decreased in proximal and distal metaphysis) compared with ground controls. There were no changes in mRNA levels for matrix proteins or GAPDH in the shaft and distal epiphysis. These results demonstrate that spaceflight leads to site- and gene-specific decreases in mRNA levels for bone matrix proteins. These findings are consistent with the hypothesis that spaceflight-induced decreases in bone formation are caused by concomitant decreases in expression of genes for bone matrix proteins.

short duration↗