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Results for “PRODUCTIVITY”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Ethylene production by direct conversion of methane over isolated single active centers
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Utilizing a highly responsive gene, yhjX, in E. coli based production of 1,4-butanediol
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The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70
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Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols
Here, the terminal reductase (R) domain from the non-ribosomal peptide synthetase (NRPS) module MxaA in Stigmatella aurantiaca Sga15 catalyzes a non-processive four-electron reduction to produce the myxalamide family of secondary metabolites. Despite widespread use in nature, a lack of structural and mechanistic information concerning reductive release from polyketide synthase (PKS) and NRPS assembly lines principally limits our ability to redesign R domains with altered or improved activity. We report crystal structures for MxaA R, both in the absence and, for the first time, in the presence of the NADPH cofactor. Molecular dynamics simulations were employed to provide a deeper understanding of this domain and further identify residues critical for structural integrity, substrate binding, and catalysis. Aggregate computational and structural findings provided a basis for mechanistic investigations and, in the process, delivered a rationally altered variant with improved activity toward highly reduced substrates.
Process flowsheet optimization of chemicals production from biomass derived glucose solutions
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Comparison of PdII vs RhI-catalyzed catalytic cycle for single step styrene production
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Integrating production scheduling and process control using latent variable dynamic models
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Tracing metabolism from lignocellulosic biomass and gaseous substrates to products with stable-isotopes
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Recent applications of metabolomics to advance microbial biofuel production
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