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At least 919 records · Page 51

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NASA NTRS1986

Increased response to insulin of glucose metabolism in the 6-day unloaded rat soleus muscle

Hind leg muscles of female rats were unloaded by tail cast suspension for 6 days. In the fresh-frozen unloaded soleus, the significantly greater concentration of glycogen correlated with a lower activity ratio of glycogen phosphorylase (p less than 0.02). The activity ratio of glycogen synthase also was lower (p less than 0.001), possibly due to the higher concentration of glycogen. In isolated unloaded soleus, insulin (0.1 milliunit/ml) increased the oxidation of D(U-C-14) glucose, release of lactate and pyruvate, incorporation of D-(U-C-14) glucose into glycogen, and the concentration of glucose 6-phosphate more (p less than 0.05) than in the weight-bearing soleus. At physiological doses of insulin, the percent of maximal uptake of 2-deoxy-D-(1,2-H-3) glucose/muscle also was greater in the unloaded soleus. Unloading of the soleus increased, by 50 percent the concentration of insuling receptors, due to no decrease in total receptor number during muscle atrophy. This increase may account for the greater response of glucose metabolism to insulin in this muscle. The extensor digitorum longus, which generally shows little response to unloading, displayed no differential response of glucose metabolism to insulin.

Henriksen, Erik J.↗

NASA NTRS1987

Variation in the thickness of ejecta cover on Mars with increasing crater density

Even relatively young surfaces on Mars have superposed craters and must carry a dusting of impact debris. For increasingly more ancient surfaces, deposits of ejecta generally increase in thickness, and the signatures of the geology beneath become more obscured. Although nothing can be done about this obscuration, these newer deposits can be described, temporally and spatially, and thereby avoid falsely interpreting the geology beneath. The task of temporal and spatial characterization was begun by considering the areal variability of ejecta cover with increasing exposure to meteorite bombardment. This study establishes a baseline for evaluating the quality and distribution of exposures of strata lying temporally beneath the ejecta. Of special interest is the distribution of ejecta overlying surfaces that have never sustained a direct impact by a large meteorite, for these retain the volcanic and sedimentary stratigraphy in its most pristine state.

Woronow, A.↗

NASA NTRS1988

Infrared measurements of increased CF2Cl2 (CFC-12) absorption above the South Pole

An increase in the CF2Cl2 total vertical column above the South pole of 1.24 + or - 0.15 over a 6-year period from 1980 to 1986, corresponding to an average increase of 3.6 + or - 2.1 percent, is found by high-resolution, ground-based solar spectra analyzed in the nu(8) band Q branches at 1161/cm of CF2Cl. This rate of increase is lower than indicated by in situ measurements at the South Pole over the same period, but substantial agreement results when the rather large error margins of the spectral analysis results are considered.

Rinsland, Curtis P.↗

NASA NTRS1988

Continuing worldwide increase in tropospheric methane, 1978 to 1987

The average worldwide tropospheric mixing ratio of methane has increased by 11 percent from 1.52 parts per million by volume (ppmv) in January 1978 to 1.684 ppmv in September 1987, for an increment of 0.016 + or - 0.001 ppmv per year. Within the limits of the present measurements, the global tropospheric mixing ratio for methane over the past decade is consistent either with a linear growth rate of 0.016 + or - 0.001 ppmv per year or with a slight lessening of the rate of growth over the past 5 years. No indications were found of an effect of the El Nino-Southern Oscillation-El Chichon events of 1982-83 on total global methane, although severe reductions were reported in the Pacific Northwest during that time period.The growth in tropospheric methane may have increased the water concentration in the stratosphere by as much as 28 percent since the 1940s and 45 percent over the past two centuries and thus could have increased the mass of precipitable water available for the formation of polar stratospheric clouds.

Blake, Donald R.↗

NASA NTRS1988

Carbon monoxide in the earth's atmosphere - Indications of a global increase

Systematic measurements of CO have been taken over the past six to eight years at sites ranging from within the Arctic Circle to the South Pole, and the results are discussed. The rates of increase of the globally averaged concentration are between 0.8 percent and 1.4 percent per year depending on the statistical method used for estimating the trends. These increases may have gone on for much longer because more than half of the atmospheric CO now comes from anthropogenic sources. The rates of increase are largest at midnorthern and tropical latitudes, where most of the sources are located.

Khalil, M. A. K.↗

NASA NTRS1989

Operational efficiency increase in a copper vapor laser due to the replacement of vacuum jacket brewster windows with flat windows

The vacuum integrity of the discharge tube of a copper vapor laser (CVL) is normally protected by Brewster angled windows. In an attempt to increase the operating efficiency of the CVL, flat windows were used to replace the Brewster windows. Experimental data confirm that the overall efficiency of the CVL does increase when such windows are used. The experimental results are discussed in terms of a computer model found in the literature. The cause of the efficiency increase appears due to a double optical cavity set up by the flat windows. However, the variation of the efficiency due to changes in the pulse repetition frequency (PRF) and buffer gas pressure are less well understood.

Estep, Lee↗

NASA NTRS1989

Effect of reduced aft diameter and increased blade number on high-speed counterrotation propeller performance

Performance data of 0.17-scale model counterrotation pusher propeller configurations were taken in the NASA Lewis 8- by 6-Foot Supersonic Wind Tunnel at Mach numbers of 0.66, 0.71, 0.75, and 0.79. These tests investigated the aerodynamic performance of the unducted fan (UDF) demonstrator propeller engine developed in a joint program by General Electric and NASA. Data were recorded to show the effect on counterrotation propeller cruise efficiency of two takeoff noise-reduction concepts. These two concepts are reduced aft blade diameter and increased forward blade number. The four configurations tested were a baseline (F1/A1 8/8) configuration, a reduced aft diameter (F1/A3 8/8) configuration, an increase forward blade number (F1/A1 9/8) configuration, and a combination of the latter two (F1/A3 9/8) configurations. Data were collected with a complex counterrotation propeller test rig via rotating thrust and torque balances and pressure instrumentation. Data comparisons documented the power differences between the baseline and the reduced aft diameter concepts. Performance comparisons to the baseline configuration showed that reducing the aft blade diameter reduced the net efficiency, and adding a blade to the front rotor increased the net efficiency. The combination of the two concepts showed only slightly lower net efficiency than the baseline configuration. It was also found that the counterrotation demonstrator propeller model (F7/A7 8/8) configuration outperformed the baseline (F1/A1 8/8) configuration.

Rose, Gayle E.↗

NASA NTRS1989

Conservation of body calcium by increased dietary intake of potassium: A potential measure to reduce the osteoporosis process during prolonged exposure to microgravity

During the 1988 NASA Summer Faculty Fellowship Program, it was proposed that the loss of skeletal calcium upon prolonged exposure to microgravity could be explained, in part, by a renal maladjustment characterized by an increased urinary excretion of calcium. It was theorized that because the conservation of body fluids and electrolytes depends upon the energy of adenosine triphosphate and enzymes that control the use of its energy for renal ion transport, an induction of renal sodium and potassium-dependent adenosine triphosphatase (Na + K ATPase) by oral loading with potassium would increase the reabsorption of sodium directly and that of calcium indirectly, leading to improved hydration and to reduced calcium loss. Preliminary studies showed the following. Rats drinking water containing 0.2 M potassium chloride for six to 13 days excreted in urine 22 muEq of calcium and 135 muEq of sodium per 100 grams of body weight per day. The corresponding values for control rats drinking tap water were 43 muEq and 269 muEq respectively. Renal Na + K ATPase activity in potassium loaded rats was higher than in controls. Thus, oral potassium loading resulted in increased Na + K ATPase activity and diminished urinary excretion of calcium and of sodium as predicted by the hypothesis. An extension of these studies to humans has the potential of resulting in development of harmless, non-invasive, drug-free, convenient measures to reduce bone loss and other electrolyte and fluid problems in space travelers exposed to prolonged periods of microgravity.

Nechay, Bohdan R.↗

NASA NTRS1989

Effect of reduced aft diameter and increased blade number of high-speed counterrotation propeller performance

Gayle, E. Rose↗

NASA NTRS1992

Increased heat transfer to elliptical leading edges due to spanwise variations in the freestream momentum: Numerical and experimental results

A study of the effect of spanwise variation in momentum on leading edge heat transfer is discussed. Numerical and experimental results are presented for both a circular leading edge and a 3:1 elliptical leading edge. Reynolds numbers in the range of 10,000 to 240,000 based on leading edge diameter are investigated. The surface of the body is held at a constant uniform temperature. Numerical and experimental results with and without spanwise variations are presented. Direct comparison of the two-dimensional results, that is, with no spanwise variations, to the analytical results of Frossling is very good. The numerical calculation, which uses the PARC3D code, solves the three-dimensional Navier-Stokes equations, assuming steady laminar flow on the leading edge region. Experimentally, increases in the spanwise-averaged heat transfer coefficient as high as 50 percent above the two-dimensional value were observed. Numerically, the heat transfer coefficient was seen to increase by as much as 25 percent. In general, under the same flow conditions, the circular leading edge produced a higher heat transfer rate than the elliptical leading edge. As a percentage of the respective two-dimensional values, the circular and elliptical leading edges showed similar sensitivity to span wise variations in momentum. By equating the root mean square of the amplitude of the spanwise variation in momentum to the turbulence intensity, a qualitative comparison between the present work and turbulent results was possible. It is shown that increases in leading edge heat transfer due to spanwise variations in freestream momentum are comparable to those due to freestream turbulence.

Rigby, D. L.↗

NASA NTRS1993

Increase in stagnation pressure and enthalpy in shock tunnels

A new technique based on the insertion of a converging section in the driven tube is described which is capable of producing substantial increases in both reservoir pressure and enthalpy. A 1D inviscid full kinetics code is used to study a number of different locations and shapes for the converging driven tube section. For driven tube diameter reductions of factors of 2 and 3, the reservoir pressure is found to increase by factors of 2.1 and 3.2, respectively, and the enthalpy is found to simultaneously increase by factors of 1.5 and 2.1, respectively.

Bogdanoff, David W.↗

NASA NTRS1924

Increasing the compression pressure in an engine by using a long intake pipe

During some tests of a one-cylinder engine, using gas oil (diesel engine oil, specific gravity 0.86 at 60 F) with solid injection and compression ignition, it was found to be necessary to increase either the jacket water temperature or the compression pressure in order to start the engine. It was found that a sufficient increase in compression pressure could be obtained simply by attaching a long pipe to the inlet flange of the cylinder. However, since no data were available giving the values of the increase in compression pressure that might be expected from such a step-up, an investigation was made covering some engine speeds between 500 r.p.m. and 1800 r.p.m. The data obtained are included here in the form of curves. Although this data is not strictly applicable to another engine, it should give indications of what might be expected with such a set-up on an engine operating at similar speeds. The engine used was a single cylinder Liberty, 5-inch bore and 7-inch stroke, having standard cylinder, cams, valves, and valve timing and operating on a four-stroke cycle.

Mathews, Robertson↗

NASA NTRS1934

Increasing the Air Charge and Scavenging the Clearance Volume of a Compression-Ignition Engine

The object of the investigation presented in this report was to determine the effects of increasing the air charge and scavenging the clearance volume of a 4-stroke-cycle compression-ignition engine having a vertical-disk form combustion chamber. Boosting the inlet-air pressure with normal valve timing increased the indicated engine power in proportion to the additional air inducted and resulted in smoother engine operation with less combustion shock. Scavenging the clearance volume by using a valve overlap of 145 degrees and an inlet-air boost pressure of approximately 2 1/2 inches of mercury produced a net increase in performance for clear exhaust operation of 33 percent over that obtained with normal valve timing and the same boost pressure. The improved combustion characteristics result in lower specific fuel consumption, and a clearer exhaust.

Spanogle, J A↗

NASA NTRS1994

Increasing the yield of Ar((sup 3)P(sub 2, 0)) and Ne((sub 3)P(sub 2, 0)) effusing from a glow discharge by using a longitudinal magnetic field

It is demonstrated that a longitudinal magnetic field applied to a low-pressure, low-voltage, hot cathode glow discharge will substantially increase the intensity of metastable atoms effusing from a central anode slit. For an argon discharge there is a fourfold increase in the effusing Ar((sup 3)P(sub 2, 0)) atom intensity and for neon there is a 14-fold increase in Ne((sup 3)P(sub 2, 0)) intensity.

Barrios, A.↗

NASA NTRS1996

Evidence for Increased Beta-Adrenoreceptor Responsiveness Induced by 14 Days of Simulated Microgravity in Humans

We studied hemodynamic responses to alpha and beta receptor agonists in 8 healthy men ( 38+- 2 yrs) before and after 14 days of 6 degree head-down tilt (HDT) to test the hypothesis that increased adrenergic responsiveness is induced by prolonged exposure to microgravity. Immediately following a 30-min baseline period, a steady-state infusion of isoproterenol (ISO) was used to assess beta 1- and beta 2-adrenergic responsiveness. ISO was infused at three graded constant rates of 0.005, 0.01 and 0.02 ug/kg/min. After heart rate and blood pressure had been allowed to return to baseline levels following ISO infusion graded infusion of phenylephrine (PE) was used to assess responsiveness of alpha I-vascular receptors. PE was infused at three graded constant rates of 0.25, 0.50 and 1.00 ug/kg/min. Each infusion interval for both drugs was 9 min. During the infusions, constant monitoring of beat-to-beat blood pressure and heart rate was performed and leg blood flow was measured with occlusion plethysmography at each infusion level. The slopes calculated from linear regressions between ISO and PE doses and changes in heart rate, blood pressure, and leg vascular resistance for each subject were used to represent alpha- and beta- adrenoreceptor responsiveness. Fourteen days HDT increased the slopes of heart rate (1056 +- 107 to 1553 +- 83 beats/ug/kg/min; P= 0.014) and vasodilation (-469ft +- 111 to -l446 +- 309 PRU/ug/kg/min; P =0.0224) to ISO infusion. There was no alteration in blood pressure or vascular resistance responses to PE infusion after HDT. Our results provide evidence that microgravity causes selective increases in beta 1- and beta 2-adrenergic responsiveness without affecting alpha 1-vascular responses.

CARDIOVASCULAR SYSTEM↗

NASA NTRS1998

Effect of Increased Cyclic AMP Concentration on Muscle Protein Synthesis and Beta-Adrenergic Receptor Expression in Chicken Skeletal Muscle Cells in Culture

Analogies of epinephrine are known to cause hypertrophy of skeletal muscle when fed to animals. These compounds presumably exert their physiological action through interaction with the P-adrenergic receptor. Since the intracellular signal generated by the Beta-adrenergic receptor is cyclic AMP (cAMP), experiments were initiated in cell culture to determine if artificial elevation of cAMP by treatment with forskolin would alter muscle protein metabolism and P-adrenergic receptor expression. Chicken skeletal muscle cells after 7 days in culture were treated with 0.2-30 micrometers forskolin for a total of three days. At the end of the treatment period, both the concentration of cAMP and the quantity of myosin heavy chain (MHC) were measured. Concentration of cAMP in forskolin-treated cells increased up to 10-fold in a dose dependent manner. In contrast, the quantity of MHC was increased approximately 50% above control cells at 0.2 micrometers forskolin, but exhibited a gradual decline at higher levels of forskolin so that the quantity of MHC in cells treated with 30 micrometers forskolin was not significantly different from controls. Curiously, the intracellular concentration of cAMP which elicited the maximum increase in the quantity of MHC was only 40% higher than cAMP concentration in control cells.

Young, R. B.↗

NASA NTRS1994

Effects of Increased CO2 Level on the Well-Being, Growth and Renal Function of Rats

On the Space Shuttle the mean CO2 levels have been 0.3% which is ten times normal air, while there have been extended periods with mean levels of 0.7% and peak concentrations of 2%. On the Space Station the projected mean concentration of CO2 is 0.7% and not to exceed 1.0%. To ensure that high level of CO2 does not compromise the integrity of the science on the Space Station, the effects of chronic exposure to high levels of CO2 were investigated. Following 7 days of cage adaptation animals exposed to 2% CO2 for 30 days were compared to control (ambient air) animals and the effects on the well-being, growth and renal function analyzed. Ten male rats per group were placed in individual metabolic cages which allowed monitoring of daily food and water consumption, as well as feces and urine to be collected. Cages were placed in a plexiglass chamber with internal environment controlled by a computer in conjunction with gas sensors. The elevated CO2 was held constant at 2.0 +/- 0.03% and the O2 at 20.9 +/- 0.15%. Body weight and food and water intake were measured daily for the first ten days of exposure and then every three to four days for the remaining three weeks. Urine was measured for pH, CO2 (as an indicator for bicarbonate) and ammonia (as an indicator for ammonium). During 2% CO2 exposure, animal growth, weight, food and water consumption were within normal ranges suggesting that their well-being was not affected. Urine pH decreased from 7.12 to 6.77 over the first 6 days of exposure and increased the following 24 days returning to pre-exposure levels. Urine NH4+ increased 68% the first 6 days then dropped to and remained at 29% higher than pre-exposure level. Urine bicarbonate concentration did not change the first 6 days, but significantly increased by day 30. These results of chronic exposure to 2% C02 are consistent with renal compensation for respiratory acidosis which may impact science conducted on the Space Shuttle or the Space Station if CO2 levels reach 2%.

Lang, C.↗

NASA NTRS2002

Coronal Heating and the Increase of Coronal Luminosity with Magnetic Flux

We present the observed scaling of coronal luminosity with magnetic flux in a set of quiet regions. Comparison of this with the observed scaling found for active regions suggests an underlying difference between coronal heating in active regions and quiet regions. From SOHO/EIT coronal images and SOHO/MDI magnetograms of four similar large quiet regions, we measure L(sub corona) and Phi(sub total) in random subregions ranging in area from about four supergranules [(70,000 km)(exp 2)] to about 100 supergranules [(0.5 R(sub sun))(exp 2)], where L(sub corona) is the luminosity of the corona in a subregion and Phi(sub total) is the flux content of the magnetic network in the subregion. This sampling of our quiet regions yields a correlation plot of Log L(sub corona) vs Log Phi(sub total) appropriate for comparison with the corresponding plot for active regions. For our quiet regions, the mean values of L(sub corona) and Phi(sub total) both increase linearly with area (simply because each set of subregions of the same area has very nearly the same mean coronal luminosity per unit area and mean magnetic flux per unit area), and in each constant-area set the values of L(sub corona) and Phi(sub total) 'scatter' about their means for that area. This results in the linear least-squares fit to the Log ((L (sub corona)), vs Log ((Phi (sub total)) plot having a slope somewhat less than one. If active regions mimicked our quiet regions in that all large sets of same-area active regions had the same mean coronal luminosity per unit area and same mean magnetic flux per unit area, then the least-squares fit to their Log((L (sub corona)) vs Log((Phi (sub total)) plot would also have a slope of less than one. Instead, the slope for active regions is 1.2. Given the observed factor of three scatter about the least-squares linear fit, this slope is consistent with Phi(sub total) on average increasing linearly with area (A) as in quiet regions, but L(sub corona) on average increasing as the volume (A(exp 1.5)) of the active region instead of as the area. This possibility is reasonable if the heating in active regions is a burning down of previously-stored coronal magnetic energy rather than a steady dissipation of energy flux from below as expected in quiet regions.

Moore, R. L.↗