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SU-D-201-07: Exploring the Utility of 4D FDG-PET/CT Scans in Design of Radiation Therapy Planning Compared with 3D PET/CT: A Prospective Study

Purpose: A method using four-dimensional(4D) PET/CT in design of radiation treatment planning was proposed and the target volume and radiation dose distribution changes relative to standard three-dimensional (3D) PET/CT were examined. Methods: A target deformable registration method was used by which the whole patient’s respiration process was considered and the effect of respiration motion was minimized when designing radiotherapy planning. The gross tumor volume of a non-small-cell lung cancer was contoured on the 4D FDG-PET/CT and 3D PET/CT scans by use of two different techniques: manual contouring by an experienced radiation oncologist using a predetermined protocol; another technique using a constant threshold of standardized uptake value (SUV) greater than 2.5. The target volume and radiotherapy dose distribution between VOL3D and VOL4D were analyzed. Results: For all phases, the average automatic and manually GTV volume was 18.61 cm3 (range, 16.39–22.03 cm3) and 31.29 cm3 (range, 30.11–35.55 cm3), respectively. The automatic and manually volume of merged IGTV were 27.82 cm3 and 49.37 cm3, respectively. For the manual contour, compared to 3D plan the mean dose for the left, right, and total lung of 4D plan have an average decrease 21.55%, 15.17% and 15.86%, respectively. The maximum dose of spinal cord has an average decrease 2.35%. For the automatic contour, the mean dose for the left, right, and total lung have an average decrease 23.48%, 16.84% and 17.44%, respectively. The maximum dose of spinal cord has an average decrease 1.68%. Conclusion: In comparison to 3D PET/CT, 4D PET/CT may better define the extent of moving tumors and reduce the contouring tumor volume thereby optimize radiation treatment planning for lung tumors.

60 APPLIED LIFE SCIENCES↗

Performance Assurance Planning: Continuous Design-Level Performance of Each Energy Conservation Measure in a Utility Energy Service Contract is Fundamental to Achieving Projected Results

An energy savings performance contract energy sales agreement (ESPC ESA) is a project structure, similar to a power purchase agreement, that uses the multiyear ESPC authority to implement renewable energy projects (referred to as ESA energy conservation measures [ECMs]) on federal buildings or land. The ESA ECM is initially privately owned for tax-incentive purposes, and the federal agency purchases the electricity it produces. An ESPC ESA is one of the most cost-effective methods for implementing on-site distributed energy projects at civilian federal agency sites.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Electric Utility Distribution Costs: Scoping Study on Trends, Drivers, and Possible Response Strategies [Slides]

This scoping study synthesizes information that will help stakeholders understand the scope, scale, and drivers of recent increases in investor-owned utility (IOU) expenditures on local distribution power grids, while providing regulators and other decision-makers with potential strategies to keep electricity bills down. The study includes five distinct components. Drawing first on data from FERC Form 1, it summarizes key trends in past and recent IOU distribution costs. Next, through a review of a sample of distribution-system plans, it characterizes material drivers of planned distribution expenditures. Ultimately, regulators must approve cost recovery for IOU expenditures, including those for the distribution system. The study therefore also: examines trends in utility requests and regulatory approvals related to changes in retail rates and return on equity; identifies areas where utility shareholder and customer incentives may be misaligned; and develops a menu of options that state regulators might consider to optimize distribution system expenditures. Some of the key findings include: - IOU distribution spending at a national level has grown by 6%/yr since 2014 in real dollar terms, 4x faster than in the prior 20 years and consisting mostly of capital (not operating) expenditure. - On a per-kWh basis, increases in IOU distribution costs since 2014 represent over 30% of the overall national-average increase in retail electricity rates. - Regional spending growth has ranged from 2-8%/yr, with larger estimated rate impacts in CAISO, then NYISO & ISO-NE, and then the Southeast, MISO & PJM (see figure). - Some utilities are planning for significantly increased distribution system spending. Planned spending on managing the existing system (asset replacement, safety & reliability, and resilience are all important drivers) exceeds that for capacity expansion. - IOU rate increase requests ($18 billion in 2025) and public utility commission (PUC) approval levels (average of 64% of requested amounts from 2021-2025) have recently hit multi-decadal highs. - PUCs in New England and the Southeast have recently approved a greater fraction of rate requests (>75%, on average) than in ther regions, while PUCs in California and the Southeast have generally authorized higher equity returns than in other regions. - Regulators have many tools to tackle potential misalignments between utility and customer interests and, more specifically, to optimize and reduce distribution costs. Shorter-term options include those related to return on equity, capital structure, depreciation, trackers, construction work in progress, and securitization. Longer-term options include performance-based regulation and a wide variety of planning-related requirements. All options embed important tradeoffs.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Reinforcement Learning for Spacecraft Navigation & Environment Characterization in the Planar-Restricted Two-Body Problem

As science, exploration, and commercial space missions become increasingly complex, so does the need for efficient, autonomous, and integrated spacecraft navigation and operations techniques. Key operational functions, including data collection and transmission, environment characterization, systems constraints, human factors, and navigation, often are intertwined and conflicted. Deep Reinforcement Learning (DRL) offers a framework for addressing integrated spacecraft navigation and planning in an uncertain dynamical environment. The goal of this study is to evaluate the utility of DRL for integrated spacecraft navigation and planning. This is achieved by developing a simple environmental characterization training environment in the Planar-Restricted 2-Body Problem (PR2BP), establishing benchmarks and heuristic baselines, and designing a previously unstudied Markov Decision Process (MDP) formulation. This MDP formulation enables the spacecraft DRL agents to appropriately balance navigation and actuation capabilities. The resulting DRL-derived policy exceeds a random or untrained policy and meets or exceeds the level of performance of a heuristic without actuation. In the process, valuable intuition is gained about the problem with insight into how DRL methods could scale to increasingly more realistic scenarios, including net-work design and training architectures, efficient state space representations, and methods for encouraging exploration in a parametric action space, among others.

navigation↗

Annual Report for Structure-Aware Unsupervised, Transformational Machine Learning for Drug Discovery

The major goal of this project is to develop machine learning (ML) methods to enable improved predictive power on real drug discovery for novel targets. More specifically, we plan to demonstrate the capability and effectiveness of ML tools utilizing unlabeled large-volume protein-ligand datasets. We also plan to demonstrate the capability and effectiveness of the developed methods by testing on a realistic drug discovery task to identify pan-coronavirus protease inhibitors such as SARS-CoV-2. While the overall goals and milestones remain consistent with the original proposal, certain technical details have been modified, which we will describe in this report.

97 MATHEMATICS AND COMPUTING↗

Residential Electrification Roadmapping - Technical and Messaging Review (CRADA Final Report)

This work is to be conducted in support of the American Made Challenges EAS-E Prize. The intent is to connect competitor teams with national laboratories that can help accelerate the development of innovative solutions and products. National Renewable Energy Laboratory (NREL) and Pacific Northwest National Laboratory (PNNL) will help accelerate QuitCarbon’s automated home electrification planning model development.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Coordinated Natural Gas and Electric Planning: Case Studies of Current Approaches and Practices

This paper examines how natural gas and electric utilities across eight U.S. states and two Canadian provinces are beginning to coordinate historically separate planning processes in response to growing system interdependencies, policy mandates, aging infrastructure, and changing customer energy choices. Electricity planning has long relied on robust integrated resource planning frameworks that weigh numerous objectives, risks, and costs. Natural gas planning, on the other hand, is typically less transparent and more narrowly focused on safety and system integrity. As economic, reliability, and policy drivers place new and shared demands on both systems, jurisdictions and utilities are experimenting with approaches such as coordinated forecasting, non pipeline alternatives, and combined planning pilots. A few have issued regulatory or statutory directives for greater data sharing and methodological alignment. Case studies from British Columbia, California, Colorado, Illinois, Massachusetts, Minnesota, New York, Québec, Rhode Island, and Washington illustrate a wide range of approaches to rethinking siloed planning. The paper identifies several common themes across the jurisdictions examined. It provides observations on the methods, processes, and organizational steps that may be needed in the future to address the challenges being faced by states and utilities. Lastly, it identifies some initial steps that states and utilities can consider if they would like to pursue more integrated, cost-effective, policy-aligned energy system planning.

03 NATURAL GAS↗

High-Penetration Photovoltaic Planning Methodologies

The main objective of this report is to provide an overview of select U.S. utility methodologies for performing high-penetration photovoltaic (HPPV) system planning and impact studies. This report covers the Federal Energy Regulatory Commission's orders related to photovoltaic (PV) power system interconnection, particularly the interconnection processes for the Large Generation Interconnection Procedures and Small Generation Interconnection Procedures. In addition, it includes U.S. state interconnection standards and procedures. The procedures used by these regulatory bodies consider the impacts of HPPV power plants on the networks. Technical interconnection requirements for HPPV voltage regulation include aspects of power monitoring, grounding, synchronization, connection to the overall distribution system, back-feeds, disconnecting means, abnormal operating conditions, and power quality. This report provides a summary of mitigation strategies to minimize the impact of HPPV. Recommendations and revisions to the standards may take place as the penetration level of renewables on the grid increases and new technologies develop in future years.

14 SOLAR ENERGY↗

SU-E-T-199: Comparison Between Acuros XB and AAA in Homogeneous Phantoms for Volumetric Modulated Arc Therapy Plans

Purpose: To investigate the differences among Acuros XB (AXB) with dose-to-water report mode (AXBw), AXB with dose-to-medium report mode (AXBm) and Anisotropic Analytical Algorithm (AAA), in homogeneous phantoms and for volumetric modulated arc therapy (VMAT) plans. Methods: Nineteen clinically applied VMAT plans were transplanted to a Delta4 phantom and an I’mRT phantom to generate phantom plans, respectively. Each plan was calculated using AXBw, AXBm and AAA, respectively, utilizing the distributed calculation framework (DCF), and the calculation times were recorded. Each plan was delivered by the TrueBeam linear accelerator and measured using the Delta4 phantom and ionization chamber, respectively. The 3D gamma pass rates and point dose deviations were compared among AXBw, AXBm and AAA. Results: In terms of the gamma pass rates with both the criteria of 3 mm/3% (3 mm distance-to-agreement, 3% dose difference) and 2 mm/2%, AXBm demonstrated the significantly worst results, and no significant difference was found between AXBw and AAA. In terms of the point dose, AXBw was slightly closer to the measured dose compared with AAA, and AXBm demonstrated the maximum dose deviation from the measured dose. Moreover, AXB calculation consumed comparable time when the DCF was not busy, and consumed significantly less time when the DCF was busy. Conclusion: In the homogeneous phantoms and for the VMAT plans, AXBw has the best dose accuracy, and AAA is comparable to or slightly worse than AXBw, wheras AXBm has the worst dose accuracy. Furthermore, AXB has higher calculation efficiency than AAA.

60 APPLIED LIFE SCIENCES↗

MO-H-19A-02: Investigation of Modulated Electron Arc (MeArc) Therapy for the Treatment of Scalp Tumors

Purpose: Electron arc therapy has long been proposed as the most suitable technique for the treatment of superficial tumors that follow circularly curved surfaces. However it was challenged by unsuitability of the conventional applicators and the lack of adequate 3-D dose calculation tools for arc electron beams in the treatment planning systems (TPS). Now with the availability of an electron specific multi-leaf collimator (eMLC) and an in-house Monte Carlo (MC) based TPS, we were motivated to investigate more advanced modulated electron arc (MeARC) therapy and its beneficial outcome. Methods: We initiated the study by a film measurement conducted in a head and neck phantom, where we delivered electron arcs in a step and shoot manner using the light field as a guide to avoid fields abutments. This step was done to insure enough clearance for the arcs with eMLC. MCBEAM and MCPLAN MC codes were used for the treatment head simulation and phantom dose calculation, respectively. Treatment plans were generated for targets drawn in real patient CTs and head and neck phantom. We utilized beams eye view available from a commercial planning system to create beamlets having same isocenter and adjoined at the scalp surface. Then dose-deposition coefficients from those beamlets were calculated for all electron energies using MCPLAN. An in-house optimization code was then used to find the optimum weights needed from individual beamlets. Results: MeARC showed a nicely tailored dose distribution around the circular curved target on the scalp. Some hot spots were noticed and could be attributed to fields abutment problem owing to the bulging nature of electron profiles. Brain dose was shown to be at lower levels compared to photon treatment. Conclusion: MeARC was shown to be a promising modality for treating scalp cases and could be beneficial to all superficial tumors with a circular curvature.

60 APPLIED LIFE SCIENCES↗

SU-E-T-01: 2-D Characterization of DLG Among All MLC Leaf Pairs

Purpose: The aim of this study is to evaluate the variation of dosimetric leaf-gap (DLG) along the travel path of each MLC leaf pair. This study evaluates whether the spatial variations in DLG could cause dose differences between TPS-calculated and measured dose. Methods: The 6MV DLG values were measured for all leaf pairs in the direction of leaf motion using a 2-D diode array and 0.6cc ion chamber. These measurements were performed on two Varian Linacs, employing the Millennium 120-leaf MLC and a 2-D-DLG variation map was created via in-house software. Several test plans were created with sweeping MLC fields using constant gaps from 2mm to 10mm and corrected for 2-D variation utilizing in-house software. Measurements were performed utilizing the MapCHECK at 5.0cm depth for plans with and without the 2-D DLG correction and compared to the TPS calculated dose via gamma analysis (3%/3mm). Results: The measured DLGs for the middle 40 MLC leaf pairs (0.5cm width) were very similar along the central superior-inferior axis, with maximum variation of 0.2mm. The outer 20 MLC leaf pairs (1.0cm width) have DLG values from 0.32mm (mean) to 0.65mm (maximum) lower than the central leaf-pair, depending on off-axis distance. Gamma pass rates for the 2mm, 4mm, and 6mm sweep plans increased by 23.2%, 28.7%, and 26.0% respectively using the 2-D-DLG correction. The most improved dose points occur in areas modulated by the 1.0cm leaf-pairs. The gamma pass rate for the 10mm sweep plan increased by only 7.7%, indicating that the 2D variation becomes less significant for dynamic plans with larger MLC gaps. Conclusion: Fluences residing significantly off-axis with narrow sweeping gaps may exhibit significant variations from planned dose due to large differences between the true DLG exhibited by the 1.0cm leaf-pairs versus the constant DLG value utilized by the TPS for dose calculation.

60 APPLIED LIFE SCIENCES↗

Advanced Metering Infrastructure for Distribution Planning and Operation: Closing the Loop on Grid-Edge Visibility

In the recent history of electric utilities, the potential to have visibility of the grid edge is gaining significance for the reliable planning and operation of a clean energy smart grid. Before the recent large-scale customer adoption of distributed energy resources (DERs), distribution networks were planned with a simpler fit-and-forget philosophy. The importance of customer-sited DERs to achieve climate change goals marks a major shift for utility operations. Changes to traditional fit-and-forget planning paradigms require better availability of grid-edge data. Smart metering is an enterprise-wide tool that is enabling visibility when and where it has been most needed. As of 2020, the rollout of smart metering, or advanced metering infrastructure (AMI), had reached more than 100 million meters in the United States, and nearly half of all electricity customers are now equipped with a smart meter (Figure 1). Smart meters are quickly becoming a ubiquitous data capture feature of smart grids. AMI enables utilities to record and measure electricity usage and power-flow metrics at a minimum of hourly intervals and at least once a day. At a minimum, AMI enables interval metering, automatic meter reading enabling accurate and time-interval billing, and the ability to provide feedback on customer energy consumption.

advanced metering infrastructure↗

Final Technical Report for Contract No. DE-EE0006332, "Integrated Simulation Development and Decision Support Tool-Set for Utility Market and Distributed Solar Power Generation"

This project will enable utilities to develop long-term strategic plans that integrate high levels of renewable energy generation, and to better plan power system operations under high renewable penetration. The program developed forecast data streams for decision support and effective integration of centralized and distributed solar power generation in utility operations. This toolset focused on real time simulation of distributed power generation within utility grids with the emphasis on potential applications in day ahead (market) and real time (reliability) utility operations. The project team developed and demonstrated methodologies for quantifying the impact of distributed solar generation on core utility operations, identified protocols for internal data communication requirements, and worked with utility personnel to adapt the new distributed generation (DG) forecasts seamlessly within existing Load and Generation procedures through a sophisticated DMS. This project supported the objectives of the SunShot Initiative and SUNRISE by enabling core utility operations to enhance their simulation capability to analyze and prepare for the impacts of high penetrations of solar on the power grid. The impact of high penetration solar PV on utility operations is not only limited to control centers, but across many core operations. Benefits of an enhanced DMS using state-of-the-art solar forecast data were demonstrated within this project and have had an immediate direct operational cost savings for Energy Marketing for Day Ahead generation commitments, Real Time Operations, Load Forecasting (at an aggregate system level for Day Ahead), Demand Response, Long term Planning (asset management), Distribution Operations, and core ancillary services as required for balancing and reliability. This provided power system operators with the necessary tools and processes to operate the grid in a reliable manner under high renewable penetration.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Cybersecurity in Photovoltaic Plant Operations

This paper provides practical information for PV plant operators regarding cybersecurity. Plans to integrate photovoltaic generation into utility systems requires that cybersecurity be considered in every aspect- from customer data to business information to plant monitoring and control operations. This paper describes the types of threats encountered in operation of PV plants; challenges faced by photovoltaic plant operators in implementing cybersecurity; cybersecurity standards that apply to photovoltaic plant operations; cybersecurity response plans and recommended best practices to ensure photovoltaic plant cybersecurity.

14 SOLAR ENERGY↗

The BREKTRIA 500 – A Breakthrough in Technology and Power Density for an Advanced 500kW Utility-Scale String Inverter (Final Technical Report)

The primary goal of this development project, planned to be 36 months in duration, was to create a 500kW utility-scale string inverter, demonstrating an advanced hybrid architecture that would achieve unprecedented high power density, and bring the inverter to the stage of production readiness. Specific key objectives for the 500kW utility-scale string inverter were: Create a 500kW 3-phase 600Vac inverter that was similar in overall size to the existing 250kW string inverters in the market, thereby demonstrating dramatically increased power density; Achieve a cost of goods, including all manufacturing-related costs and overheads, at or below 2.5¢/Wac ($12,500); Demonstrate full-power operation at a 45-50C ambient temperature with no power de-rating; Accommodate a PV array DC input of up to 1MWdc, aka a DC/AC Ratio of 2.0; Demonstrate peak efficiency greater than 99% at any operating dc voltage, and a CEC weighted average efficiency greater than or equal to 98.5%. The motivation for this project was to leapfrog the competition by creating the world’s most powerful string inverter, utilizing an innovative topology and achieving a step change increase in power density. Achieving the goals of the project would have enabled Yaskawa Solectria Solar to demonstrate its technology leadership, manufacture the utility-scale string inverter in the company’s facilities in Illinois, and bring to the market a highly-differentiated and compelling product to help the company grow its share in the large and growing utility market segment. During the course of this project, BREK Electronics’ hybrid architecture inverter was taken from an early-stage 125kW prototype, to a more mature and successfully demonstrated power stage at twice the power. Two 250kW power stages were planned to build the 500kW inverter. Significant progress was made in the inverter controls, achieving a clean AC sinewave and closed-loop operation into the grid, and improved efficiency by control of the high-speed switching. Further, the updated 250kW power stage was on track to achieve full power operation at an ambient temperature of 50C. At the time of the project’s closure in September 2022, global semiconductor supply remained limited, with shortages creating dramatic swings in both availability and price. Given this situation, our ability to predict cost-of-goods two years out with any accuracy or confidence was limited. As a result, the probability of attaining the target cost of 2.5¢/Wac for the 500kW inverter remained uncertain at the closure of the project. This project successfully demonstrated the potential for the advanced hybrid architecture inverter that emerged from a decade of university research on Si IGBTs and SiC mosfets, leading to this unique inverter topology. The team has taken the first steps toward an evolutionary advancement in inverter technology that remains to be fully realized.

14 SOLAR ENERGY↗

Estimating Power System Interruption Costs: A Guidebook for Electric Utilities

Utilities are constantly making improvements to their infrastructure and operating protocols to maintain or enhance the reliability and resilience of the electric grid. Customer interruption cost (CIC) estimates are useful in assessing and monetizing the economic benefits customers receive from these improvements. This Guidebook for electric utilities explains how to conduct customer interruption cost studies and describes commonly-used, value-based planning methods. The authors intend that this Guidebook will serve as a reference for utility personnel, policymakers and experts in survey design and administration who may be planning to implement CIC studies. It brings the utility industry up-to-date using modern survey technologies, practices, and data analytics to estimate CICs and, ultimately, use the estimates to address both traditional and emerging planning needs.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Model-based interface design for smart field-device integration

Operational complexity is ever-increasing for electric utilities that face challenges including integration of DERs, customer expectation of energy choices, the proliferation of non-utility-owned resources, new business models with energy service providers, and new technology with IT/OT convergence. To maintain and improve the quality of operations, planning, and decision-making in general, utilities need to manage and navigate the complexity. Managing complexity requires a modular, scalable, and flexible solution. Connecting large amounts of DERs and introducing new services requires increased grid control and evolving applications. In this paper, we show an approach utilizing model-based standardized interfaces that simplifies integration and deployment of new algorithms and smart field devices for interoperability across legacy or new systems. A modular design is presented for a reference implementation of widely used DNP3 and IEEE 2030.5 interfaces within an open-source, standards-based data integration platform for integration of smart field devices with independently developed, best-of-breed applications.

Model-driven development, system integration, smar↗

Integration of Local Knowledge is a Key for the Remediation Success of Legacy Uranium Mine Sites - 19564

A key to success, during all aspects of the remediation process on legacy uranium sites, and easily transferable between countries and projects, is the integration of local knowledge. However, before this knowledge can be integrated, local trust and project understanding must be developed. Local trust and project understanding can only be developed through a principle-centred approach to a shared project vision, two-way communication of knowledge, alignment of project goals, and understanding the local needs early in the remediation process. Once public confidence is obtained, local trust and project understanding must be maintained throughout the entirety of the remediation process. Project understanding is an ongoing endeavor that needs continuous communication and varied methods to succeed. During the management of assessment, remediation, and post remediation monitoring on the Saskatchewan Research Council's CLEANS project (remediation of 37 legacy uranium mine sites in Northern Saskatchewan, Canada), integration of local knowledge has been an instrumental tool attributing to success. During site assessment, integration of local knowledge has included the development and implementation of land use surveys to determine realistic travel and occupancy on and adjacent to these legacy sites, and site specific traditional knowledge and land use studies that have contributed to the development of a detailed knowledge of local land use, resource utilization, country food intake, and human history of the sites. The local knowledge gained during the assessment process is invaluable as it provides information required to support remediation planning, such as: valued ecosystem components, human trophic utilization, length of site occupancy, cultural value assessment, and future land use considerations. During remediation planning, local and traditional knowledge can also be incorporated through determination of plant species suitability for revegetation, development and selection of remediation options, and setting realistic sustainable development targets for local project inclusion. During site remediation operations, local involvement can be utilized through direct labour and equipment, cultural resource monitoring (i.e. archaeological and heritage protection), local logistics and historic information transfer, and stakeholder communications and engagement support. Post remediation, local involvement is an efficient mechanism for long-term monitoring, and care and maintenance activities. Although there may be differences between countries, regions and sites, the remediation process on legacy uranium mines can universally be more successful through the integration of local knowledge; while developing rights/stakeholder engagement and capacity building. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗