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Technical Note: A novel leaf sequencing optimization algorithm which considers previous underdose and overdose events for MLC tracking radiotherapy

Purpose: Multileaf collimator (MLC) tracking radiotherapy is complex as the beam pattern needs to be modified due to the planned intensity modulation as well as the real-time target motion. The target motion cannot be planned; therefore, the modified beam pattern differs from the original plan and the MLC sequence needs to be recomputed online. Current MLC tracking algorithms use a greedy heuristic in that they optimize for a given time, but ignore past errors. To overcome this problem, the authors have developed and improved an algorithm that minimizes large underdose and overdose regions. Additionally, previous underdose and overdose events are taken into account to avoid regions with high quantity of dose events. Methods: The authors improved the existing MLC motion control algorithm by introducing a cumulative underdose/overdose map. This map represents the actual projection of the planned tumor shape and logs occurring dose events at each specific regions. These events have an impact on the dose cost calculation and reduce recurrence of dose events at each region. The authors studied the improvement of the new temporal optimization algorithm in terms of the L1-norm minimization of the sum of overdose and underdose compared to not accounting for previous dose events. For evaluation, the authors simulated the delivery of 5 conformal and 14 intensity-modulated radiotherapy (IMRT)-plans with 7 3D patient measured tumor motion traces. Results: Simulations with conformal shapes showed an improvement of L1-norm up to 8.5% after 100 MLC modification steps. Experiments showed comparable improvements with the same type of treatment plans. Conclusions: A novel leaf sequencing optimization algorithm which considers previous dose events for MLC tracking radiotherapy has been developed and investigated. Reductions in underdose/overdose are observed for conformal and IMRT delivery.

61 RADIATION PROTECTION AND DOSIMETRY↗

Tumor Tracking Method Based on a Deformable 4D CT Breathing Motion Model Driven by an External Surface Surrogate

Purpose: To develop a tumor tracking method based on a surrogate-driven motion model, which provides noninvasive dynamic localization of extracranial targets for the compensation of respiration-induced intrafraction motion in high-precision radiation therapy. Methods and Materials: The proposed approach is based on a patient-specific breathing motion model, derived a priori from 4-dimensional planning computed tomography (CT) images. Model parameters (respiratory baseline, amplitude, and phase) are retrieved and updated at each treatment fraction according to in-room radiography acquisition and optical surface imaging. The baseline parameter is adapted to the interfraction variations obtained from the daily cone beam (CB) CT scan. The respiratory amplitude and phase are extracted from an external breathing surrogate, estimated from the displacement of the patient thoracoabdominal surface, acquired with a noninvasive surface imaging device. The developed method was tested on a database of 7 lung cancer patients, including the synchronized information on internal and external respiratory motion during a CBCT scan. Results: About 30 seconds of simultaneous acquisition of CBCT and optical surface images were analyzed for each patient. The tumor trajectories identified in CBCT projections were used as reference and compared with the target trajectories estimated from surface displacement with the a priori motion model. The resulting absolute differences between the reference and estimated tumor motion along the 2 image dimensions ranged between 0.7 and 2.4 mm; the measured phase shifts did not exceed 7% of the breathing cycle length. Conclusions: We investigated a tumor tracking method that integrates breathing motion information provided by the 4-dimensional planning CT with surface imaging at the time of treatment, representing an alternative approach to point-based external–internal correlation models. Although an in-room radiograph-based assessment of the reliability of the motion model is envisaged, the developed technique does not involve the estimation and continuous update of correlation parameters, thus requiring a less intense use of invasive imaging.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Multivariate analysis for the estimation of target localization errors in fiducial marker-based radiotherapy

Purpose: To assess the target localization error (TLE) in terms of the distance between the target and the localization point estimated from the surrogates (|TMD|), the average of respiratory motion for the surrogates and the target (|aRM|), and the number of fiducial markers used for estimating the target (n). Methods: This study enrolled 17 lung cancer patients who subsequently underwent four fractions of real-time tumor tracking irradiation. Four or five fiducial markers were implanted around the lung tumor. The three-dimensional (3D) distance between the tumor and markers was at maximum 58.7 mm. One of the markers was used as the target (P{sub t}), and those markers with a 3D |TMD{sub n}| ≤ 58.7 mm at end-exhalation were then selected. The estimated target position (P{sub e}) was calculated from a localization point consisting of one to three markers except P{sub t}. Respiratory motion for P{sub t} and P{sub e} was defined as the root mean square of each displacement, and |aRM| was calculated from the mean value. TLE was defined as the root mean square of each difference between P{sub t} and P{sub e} during the monitoring of each fraction. These procedures were performed repeatedly using the remaining markers. To provide the best guidance on the answer with n and |TMD|, fiducial markers with a 3D |aRM ≥ 10 mm were selected. Finally, a total of 205, 282, and 76 TLEs that fulfilled the 3D |TMD| and 3D |aRM| criteria were obtained for n = 1, 2, and 3, respectively. Multiple regression analysis (MRA) was used to evaluate TLE as a function of |TMD| and |aRM| in each n. Results: |TMD| for n = 1 was larger than that for n = 3. Moreover, |aRM| was almost constant for all n, indicating a similar scale for the marker’s motion near the lung tumor. MRA showed that |aRM| in the left–right direction was the major cause of TLE; however, the contribution made little difference to the 3D TLE because of the small amount of motion in the left–right direction. The TLE calculated from the MRA ({sup MRA}TLE) increased as |TMD| and |aRM| increased and adversely decreased with each increment of n. The median 3D {sup MRA}TLE was 2.0 mm (range, 0.6–4.3 mm) for n = 1, 1.8 mm (range, 0.4–4.0 mm) for n = 2, and 1.6 mm (range, 0.3–3.7 mm) for n = 3. Although statistical significance between n = 1 and n = 3 was observed in all directions, the absolute average difference and the standard deviation of the {sup MRA}TLE between n = 1 and n = 3 were 0.5 and 0.2 mm, respectively. Conclusions: A large |TMD| and |aRM| increased the differences in TLE between each n; however, the difference in 3D {sup MRA}TLEs was, at most, 0.6 mm. Thus, the authors conclude that it is acceptable to continue fiducial marker-based radiotherapy as long as |TMD| is maintained at ≤58.7 mm for a 3D |aRM| ≥ 10 mm.

60 APPLIED LIFE SCIENCES↗

Detector for measuring the π + → e + v branching fraction

The PIENU experiment at TRIUMF is aimed at a measurement of the branching ratio R e/u = Γ((π + → e + v e ) + (π + → e + v e γ))/Γ((π + → μ + v μ ) + (π + → μ + v μ γ)) with precision < 0.1%. Incident pions, delivered at the rate of 60 kHz with momentum 75 MeV/c, were degraded and stopped in a plastic scintillator target. Pions and their decay product positrons were detected with plastic scintillators and tracked with multiwire proportional chambers and silicon strip detectors. The energies of the positrons were measured in a spectrometer consisting of a large NaI(Tℓ) crystal surrounded by an array of pure CsI crystals. This paper provides a description of the PIENU experimental apparatus and its performance in pursuit of R e/u

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

BCS (CSP Beam Characterization System) [SWR-23-13]

The Beam Characterization System (BCS) is an image-processing tool for estimating heliostat tracking errors. A large mirror, or heliostat, reflects the sun onto a distant target. A carefully calibrated camera then takes an image of this target to capture the shape of the reflected beam. The software kit hosts a series of scripts to identify key features and run analysis on the captured images.

Kesseli, Devon↗

The high-foot implosion campaign on the National Ignition Facility

If you could identify only one key skill that a primary or secondary designer should possess, it would be the ability to design an implosion that works reliably and as advertised. Being able to harness an implosion is a key skill because of what an implosion does – an implosion is a “pressure amplifier” that takes absorbed energy and turns that energy, with significant energy loss, into pressure. The pressure generated in implosions is used to compress materials to high densities in the primary designers case, and high densities and temperatures in the secondary designers case. While primary designers and their simulation tools can be tested against experiments at scale fielded at high-explosive facilities around the NNSA complex, secondary designers are much more limited in the experimental facilities that can access relevant conditions (facilities such as Omega at the Laboratory for Laser Energetics, the Z-machine at Sandia National Lab in Albuquerque and the National Ignition Facility at Livermore are more-or-less it). Ignition conditions are the highest-pressure and therefore hardest conditions to access with facility levels of energy, but the struggle to obtain ignition has been an illuminating test of the stockpile stewardship model. If you thought the criteria for ignition is when the fusion energy output from an inertially confined fusion (ICF) implosion exceeds the energy delivered to the target, you’d be wrong. While the above definition is used for milestone tracking purposes, the actually definition of ignition that has been used in fusion research since 1957 is when the power produced by the fusing region exceeds the rate at which energy is lost from the fusing region due to x-ray radiation processes and heat conduction processes. This simple statement about fusion power and rates of energy loss lead to a quantitative criterion for ignition that is known as the “Lawson Criteria.”

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Development of selenium imaging detectors toward a definitive search for neutrinoless ββ decay

Imaging sensors made from an ionization target layer of amorphous selenium (aSe) coupled to a silicon complementary metal-oxide-semiconductor (CMOS) active pixel array for charge readout are a promising technology for neutrino physics. The high spatial resolution in a solid-state target provides unparalleled rejection of backgrounds from natural radioactivity in the search for the neutrinoless ββ decay of 82 Se. With this grant, we experimentally determined two crucial factors necessary for the realization of this novel technology: i) the intrinsic energy response of aSe to ionizing electrons, and ii) the feasibility to couple a target layer of aSe to a CMOS active pixel sensor to image electron tracks.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Status of the Jefferson Lab Eta Factory (JEF) experiment

The Jefferson Lab Eta Factory (JEF) experiment is an experiment running in Hall D at Jefferson Lab that focuses on studying the decays of the ¿ meson. These decays provide a rich laboratory for searching for new charge conjugation violating / parity conserving (CVPC) processes, looking for hints of Beyond Standard Model physics, and probing higher order terms in Chiral Perturbation Theory. The flagship channel is the rare decay ¿ ¿ p0¿¿, the measurement of which required an upgrade to the existing equipment in Hall D. The experiment uses the GlueX detector, a fixed-target large acceptance spectrometer based on a solenoid magnet containing drift chambers for tracking charged particles and a lead-scintillator barrel calorimeter in the central region and an array of 4 × 4 × 45 cm3 lead glass blocks in the forward region for detecting neutral particles. During the last two years the inner 80×80 cm2 region of the forward calorimeter has been replaced by an array of 2 × 2 × 20 cm3 lead tungstate crystals, which provide factors of two improvement in energy and position resolution. The first round of data taking with this configuration took place this year. A first look at the data will be presented.

Taylor, Simon [Thomas Jefferson National Accelerat↗

Thorium-uranium fission radiography

Results are described for studies designed to develop routine methods for in-situ measurement of the abundance of Th and U on a microscale in heterogeneous samples, especially rocks, using the secondary high-energy neutron flux developed when the 650 MeV proton beam of an accelerator is stopped in a 42 x 42 cm diam Cu cylinder. Irradiations were performed at three different locations in a rabbit tube in the beam stop area, and thick metal foils of Bi, Th, and natural U as well as polished silicate glasses of known U and Th contents were used as targets and were placed in contact with mica which served as a fission track detector. In many cases both bare and Cd-covered detectors were exposed. The exposed mica samples were etched in 48% HF and the fission tracks counted by conventional transmitted light microscopy. Relative fission cross sections are examined, along with absolute Th track production rates, interaction tracks, and a comparison of measured and calculated fission rates. The practicality of fast neutron radiography revealed by experiments to data is discussed primarily for Th/U measurements, and mixtures of other fissionable nuclei are briefly considered.

Haines, E. L.↗

Performance analysis of pulse Doppler digital radars with application to the Shuttle Ku-band system

A pulse Doppler digital radar is one of the primary components of the Ku-band integrated radar and communication equipment on the Space Shuttle. The performance of the Ku-band rendezvous radar to be used on the Space Shuttle is analyzed in four parts. First an overall functional block diagram description is presented to illustrate the signal processing in the detection and the tracking modes. The detection capabilities and limitations of the radar are investigated taking all of the system losses into account. A new unified analysis of digital radar tracking loops is developed which takes into consideration the effects of a scintillating target and receiver front end noise. The behavior of the radar is discussed in the presence of thermal noise, amplitude scintillation, and target glint.

Alem, W. K.↗

Design of a laser system for instantaneous location of a longwall shearer

Calculations and measurements for the design of a laser system for instantaneous location of a longwall shearer were made. The designs determine shearer location to approximately one foot. The roll, pitch, and yaw angles of the shearer track are determined to approximately two degrees. The first technique uses the water target system. A single silicon sensor system and three gallium arsenide laser beams are used in this technique. The second technique is based on an arrangement similar to that employed in aircraft omnidirectional position finding. The angle between two points is determined by combining information in an onmidirectional flash with a scanned, narrow beam beacon. It is concluded that this approach maximizes the signal levels.

Stein, R.↗

A portable real-time data processing system for standard meteorological radiosondes

The UMET-1 is a microprocessor-based portable system for automatic real-time processing of flight data transmitted from the standard RAWINSONDE upper atmosphere meteorological balloonsonde. The first 'target system' is described which was designed to receive data from a mobile tracking and telemetry receiving station (TRADAT), as the balloonsonde ascends to apogee. After balloon-burst, the UMET-1 produces user-ready hardcopy.

Staffanson, F. L.↗

Langley Research Center Photogrammetric Measurements of Solar Array Dynamics: Preliminary Results

The NASA Langley Research Center participated in the Solar Array Experiment with two primary objectives: (1) to study the structural and control dynamics of a new class of large, lightweight, low-frequency space structures, and (2) to develop technology for remote video measurement of structural motions. The shuttle orbiter's closed circuit television (CCTV) system was used to provide recorded video images of the solar array from four locations in the payload bay, two on the forward bulkhead and two on the aft bulkhead. White reflective targets were placed on the array to provide discrete points at which to track array motion. A dynamic test consisted of a quiescent period in which orbiter operations were inhibited and crew motion restricted, an excitation period, and a free decay period. The orbiter was placed in free drift while in a gravity gradient orientation and dynamics tests were timed to occur at orbital noon so that the Sun would illuminate one side of the array and Earth albedo the other. The CCTV system was turned on during the quiescent period, approximately 3 minutes prior to excitation. Video from all four CCTV cameras was recorded continuously through the excitation and free-decay periods for a total test record of 8 to 10 minutes.

Brumfield, M. L.↗

Network Queueing System (NQS)

Program provides batch and device queueing facilities for various computers networked in UNIX environment. Allows network manager to allocate and track resources across network without requiring user to specifically log in on remote target machines.

Kingsbury, B.↗

An Investigation of the Effects of the Time Lag Due to Long Transmission Distances upon Remote Control: Tracking Experiments - Phase 1

A series of pursuit tracking tasks were performed incorporating a transport lag in the control loop. The target was a mixture of four sine waves, the fastest having a frequency of 16 cycles per minute at full speed. An attempt was made to design the experiments so that they would provide data applicable to remote control of a ground vehicle over long transmission distances. Three programs were run. In each the time lag was placed between the control and the display. In the first program a velocity control was used and the operator was told that his knob controlled a vehicle, the problem represented a road 9 and he was to drive his vehicle along the road 9 using the delayed vehicle position as feedback for whatever means he desired. The objective was not to match the display traces. In the second program a velocity control was used, and the operator was told that the problem trace represented a road and the delayed trace represented a vehicle and he was to keep them together. The objective was to match display traces. The third program was identical with the first, except that an acceleration control was used rather than a velocity control. Target speeds used were full speed, 1/2 speed, 1/4 speed, 1/8 speed, and 1/16 speed. Time lags were 1/4 second, l/2 second, 1 second, 1-1/2 second, 2 second, 3 second, and 6 seconds. The experimental results are presented in the last section of this report.

Adams, James L.↗

Time-to-Passage Judgments under Violations of Various Constancy Assumptions

Time-to-passage (TTP) derivations typically assume constant translational velocities and consistent object orientation. In our first study, we examined the impact of acceleration, and observer roll and heading (relative to track vector) on TTP judgments. Judgments reflected an insensitivity to acceleration; roll did not affect performance, but the decoupling of observer heading and track vector did. Our second study examined the effect of multi-axis target rotation on TTP and time-to-contact judgments.

Kaiser, Mary K.↗

NASA’s Mid-Atlantic Communities and Areas at Intensive Risk Demonstration: Translating Compounding Hazards to Societal Risk

Remote sensing provides a unique perspective on our dynamic planet, tracking changes and revealing the course of complex interactions. Long term monitoring and targeted observation combine with modeling and mapping to provide increased awareness of hydro-meteorological and geological hazards. Disasters often follow hazards and the goal of NASA’s Disasters Program is to look at the earth as a highly coupled system to reduce risk and enable resilience. Remote sensing and geospatial science are used as tools to help answer critical questions that inform decisions. Data is not the same as information, nor does understanding of processes necessarily translate into decision support for disaster preparedness, response and recovery. Accordingly, NASA is engaging the scientific and decision-support communities to apply remote sensing, modeling, and related applications in Communities and Areas at Intensive Risk (CAIR). In 2017, NASA’s Applied Sciences Disasters Program hosted a regional workshop to explore these issues with particular focus on coastal Virginia and North Carolina. The workshop brought together partners in academia, emergency management, and scientists from NASA and partnering federal agencies to explore capabilities among the team that could improve understanding of the physical processes related to these hazards, their potential impact to changing communities, and to identify methodologies for supporting emergency response and risk mitigation. The resulting initiative, the mid-Atlantic CAIR project, demonstrates the ability to integrate satellite derived earth observations and physical models into actionable, trusted knowledge. Severe storms and associated storm surge, sea level rise, and land subsidence coupled with increasing populations and densely populated, aging critical infrastructure often leave coastal regions and their communities extremely vulnerable. The integration of observations and models allow for a comprehensive understanding of the compounding risk experienced in coastal regions and enables individuals in all positions make risk-informed decisions. This initiative uses a representative storm surge case as a baseline to produce flood inundation maps. These maps predict building level impacts at current day and for sea level rise (SLR) and subsidence scenarios of the future in order to inform critical decisions at both the tactical and strategic levels. To accomplish this analysis, the mid-Atlantic CAIR project brings together Federal research activities with academia to examine coastal hazards in multiple ways: 1) reanalysis of impacts from 2011 Hurricane Irene, using numerical weather modeling in combination with coastal surge and hydrodynamic, urban inundation modeling to evaluate combined impact scenarios considering SLR and subsidence, 2) remote sensing of flood extent from available optical imagery, 3) adding value to remotely sensed flood maps through depth predictions, and 4) examining coastal subsidence as measured through time-series analysis of synthetic aperture radar observations. Efforts and results are published via ArcGIS story maps to communicate neighborhoods and infrastructure most vulnerable to changing conditions. Story map features enable time-aware flood mapping using hydrodynamic models, photographic comparison of flooding following Hurricane Irene, as well as visualization of heightened risk in the future due to SLR and land subsidence.

Rogers, Laura↗