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At least 901 records · Page 50

SU-C-9A-03: Simultaneous Deconvolution and Segmentation for PET Tumor Delineation Using a Variational Method

Purpose: To implement a new method that integrates deconvolution with segmentation under the variational framework for PET tumor delineation. Methods: Deconvolution and segmentation are both challenging problems in image processing. The partial volume effect (PVE) makes tumor boundaries in PET image blurred which affects the accuracy of tumor segmentation. Deconvolution aims to obtain a PVE-free image, which can help to improve the segmentation accuracy. Conversely, a correct localization of the object boundaries is helpful to estimate the blur kernel, and thus assist in the deconvolution. In this study, we proposed to solve the two problems simultaneously using a variational method so that they can benefit each other. The energy functional consists of a fidelity term and a regularization term, and the blur kernel was limited to be the isotropic Gaussian kernel. We minimized the energy functional by solving the associated Euler-Lagrange equations and taking the derivative with respect to the parameters of the kernel function. An alternate minimization method was used to iterate between segmentation, deconvolution and blur-kernel recovery. The performance of the proposed method was tested on clinic PET images of patients with non-Hodgkin's lymphoma, and compared with seven other segmentation methods using the dice similarity index (DSI) and volume error (VE). Results: Among all segmentation methods, the proposed one (DSI=0.81, VE=0.05) has the highest accuracy, followed by the active contours without edges (DSI=0.81, VE=0.25), while other methods including the Graph Cut and the Mumford-Shah (MS) method have lower accuracy. A visual inspection shows that the proposed method localizes the real tumor contour very well. Conclusion: The result showed that deconvolution and segmentation can contribute to each other. The proposed variational method solve the two problems simultaneously, and leads to a high performance for tumor segmentation in PET. This work was supported in part by National Natural Science Foundation of China (NNSFC), under Grant Nos. 60971112 and 61375018, and Fundamental Research Funds for the Central Universities, under Grant No. 2012QN086. Wei Lu was supported in part by the National Institutes of Health (NIH) Grant No. R01 CA172638.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

MO-FG-202-04: Gantry-Resolved Linac QA for VMAT: A Comprehensive and Efficient System Using An Electronic Portal Imaging Device

Purpose: To automate gantry-resolved linear accelerator (linac) quality assurance (QA) for volumetric modulated arc therapy (VMAT) using an electronic portal imaging device (EPID). Methods: A QA system for VMAT was developed that uses an EPID, frame-grabber assembly and in-house developed image processing software. The system relies solely on the analysis of EPID image frames acquired without the presence of a phantom. Images were acquired at 8.41 frames per second using a frame grabber and ancillary acquisition computer. Each image frame was tagged with a gantry angle from the linac’s on-board gantry angle encoder. Arc-dynamic QA plans were designed to assess the performance of each individual linac component during VMAT. By analysing each image frame acquired during the QA deliveries the following eight machine performance characteristics were measured as a function of gantry angle: MLC positional accuracy, MLC speed constancy, MLC acceleration constancy, MLC-gantry synchronisation, beam profile constancy, dose rate constancy, gantry speed constancy, dose-gantry angle synchronisation and mechanical sag. All tests were performed on a Varian iX linear accelerator equipped with a 120 leaf Millennium MLC and an aS1000 EPID (Varian Medical Systems, Palo Alto, CA, USA). Results: Machine performance parameters were measured as a function of gantry angle using EPID imaging and compared to machine log files and the treatment plan. Data acquisition is currently underway at 3 centres, incorporating 7 treatment units, at 2 weekly measurement intervals. Conclusion: The proposed system can be applied for streamlined linac QA and commissioning for VMAT. The set of test plans developed can be used to assess the performance of each individual components of the treatment machine during VMAT deliveries as a function of gantry angle. The methodology does not require the setup of any additional phantom or measurement equipment and the analysis is fully automated to allow for regular routine testing.

60 APPLIED LIFE SCIENCES↗

NASA spinoffs to bioengineering and medicine

Through the active transfer of technology, the National Aeronautics and Space Administration (NASA) Technology Utilization (TU) Program assists private companies, associations, and government agencies to make effective use of NASA's technological resources to improve U.S. economic competitiveness and to provide societal benefit. Aerospace technology from areas such as digital image processing, space medicine and biology, microelectronics, optics and electrooptics, and ultrasonic imaging have found many secondary applications in medicine. Examples of technology spinoffs are briefly discussed to illustrate the benefits realized through adaptation of aerospace technology to solve health care problems. Successful implementation of new technologies increasingly requires the collaboration of industry, universities, and government, and the TU Program serves as the liaison to establish such collaborations with NASA. NASA technology is an important resource to support the development of new medical products and techniques that will further advance the quality of health care available in the U.S. and worldwide.

Biomedical Engineering/instrumentation/trends↗

Processing of Mars Exploration Rover Imagery for Science and Operations Planning

The twin Mars Exploration Rovers (MER) delivered an unprecedented array of image sensors to the Mars surface. These cameras were essential for operations, science, and public engagement. The Multimission Image Processing Laboratory (MIPL) at the Jet Propulsion Laboratory was responsible for the first-order processing of all of the images returned by these cameras. This processing included reconstruction of the original images, systematic and ad hoc generation of a wide variety of products derived from those images, and delivery of the data to a variety of customers, within tight time constraints. A combination of automated and manual processes was developed to meet these requirements, with significant inheritance from prior missions. This paper describes the image products generated by MIPL for MER and the processes used to produce and deliver them.

Instruments↗

In Situ Height and Width Estimation of Sorghum Plants from 2.5d Infrared Images

Plant phenotyping, or the measurement of plant traits such as stem width and plant height, is a critical step in the development and evaluation of higher yield biofuel crops. Phenotyping allows biologists to quantitatively estimate the biomass of plant varieties and therefore their potential for biofuel production. Manual phenotyping is costly, time-consuming, and errorprone, requiring a person to walk through the fields measuring individual plants with a tape measure and notebook. In this work we describe an alternative system consisting of an autonomous robot equipped with two infrared cameras that travels through fields, collecting 2.5D image data of sorghum plants. We develop novel image processing based algorithms to estimate plant height and stem width from the image data. Our proposed method has the advantage of working in situ using images of plants from only one side. This allows phenotypic data to be collected nondestructively throughout the growing cycle, providing biologists with valuable information on crop growth patterns. Our approach first estimates plant heights and stem widths from individual frames. It then uses tracking algorithms to refine these estimates across frames and avoid double counting the same plant in multiple frames. The result is a histogram of stem widths and plant heights for each plot of a particular genetically engineered sorghum variety. In-field testing and comparison with human collected ground truth data demonstrates that our system achieves 13% average absolute error for stem width estimation and 15% average absolute error for plant height estimation.

09 BIOMASS FUELS↗

Optical Navigation Preparations for New Horizons Pluto Flyby

The New Horizons spacecraft will encounter Pluto and its satellites in July 2015. As was the case for the Voyager encounters with Jupiter, Saturn, Uranus and Neptune, mission success will depend heavily on accurate spacecraft navigation, and accurate navigation will be impossible without the use of pictures of the Pluto system taken by the onboard cameras. We describe the preparations made by the New Horizons optical navigators: picture planning, image processing algorithms, software development and testing, and results from in-flight imaging.

image processing↗

Validation of a DIXON-based fat quantification technique for the measurement of visceral fat using a CT-based reference standard

Purpose: The purpose of the study is to determine whether a novel semi-automated DIXON-based fat quantification algorithm can reliably quantify visceral fat using a CT-based reference standard. Methods: This was an IRB-approved retrospective cohort study of 27 subjects who underwent abdominopelvic CT within 7 days of proton density fat fraction (PDFF) mapping on a 1.5T MRI. Cross-sectional visceral fat area per slice (cm{sup 2}) was measured in blinded fashion in each modality at intervertebral disc levels from T12 to L4. CT estimates were obtained using a previously published semi-automated computational image processing system that sums pixels with attenuation − 205 to − 51 HU. MR estimates were obtained using two novel semi-automated DIXON-based fat quantification algorithms that measure visceral fat area by spatially regularizing non-uniform fat-only signal intensity or de-speckling PDFF 2D images and summing pixels with PDFF ≥ 50%. Pearson’s correlations and Bland–Altman analyses were performed. Results: Visceral fat area per slice ranged from 9.2 to 429.8 cm{sup 2} for MR and from 1.6 to 405.5 cm{sup 2} for CT. There was a strong correlation between CT and MR methods in measured visceral fat area across all studied vertebral body levels (r = 0.97; n = 101 observations); the least (r = 0.93) correlation was at T12. Bland–Altman analysis revealed a bias of 31.7 cm{sup 2} (95% CI [− 27.1]–90.4 cm{sup 2}), indicating modestly higher visceral fat assessed by MR. Conclusion: MR- and CT-based visceral fat quantification are highly correlated and have good cross-modality reliability, indicating that visceral fat quantification by either method can yield a stable and reliable biomarker.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Phase Shift Interferometer and Growth Set Up to Step Pattern Formation During Growth From Solutions. Influence of the Oscillatory solution Flow on Stability

We have assembled an experimental setup based on Michelson interferometry with the growing crystal surface as one of the reflective surfaces. The crystallization part of the device allows optical monitoring of a face of a crystal growing at temperature stable within 0.05 C in a flow of solution of controlled direction and speed. The reference arm of the interferometer contains a liquid crystal element that allows controlled shifts of the phase of the interferograms. We employ an image-processing algorithm, which combines five images with a pi/2 phase difference between each pair of images. The images are transferred to a computer by a camera capable of capturing 60 frames per second. The device allows data collection on surface morphology and kinetics during the face layers growth over a relatively large area (approximately 4 sq. mm) in situ and in real time during growth. The estimated depth resolution of the phase shifting interferometry is approximately 50 Angstroms. The data will be analyzed in order to reveal and monitor step bunching during the growth process. The crystal chosen as a model for study in this work is KH2PO4 (KDP). This optically non-linear material is widely used in frequency doubling applications. There have been a number of studies of the kinetics of KDP crystallization that can serve as a benchmark for our investigations. However, so far, systematic quantitative characteristics of step interaction and bunching are missing. We intend to present our first quantitative results on the onset, initial stages and development of instabilities in moving step trains on vicinal crystal surfaces at varying supersaturation, flow rate, and flow direction. Behavior of a vicinal face growing from solution flowing normal to the steps and periodically changing its direction in time was considered theoretically. It was found that this oscillating flow reduces both stabilization and destabilization effects resulted from the unidirectional solution flow directed up the step stream and down the step stream. This reduction of stabilization and destabilization comes from effective mixing which entangles the phase shifts between the spatially periodic interface perturbation and the concentration wave induced by this perturbation. Numerical results and simplified mixing criterion will be discussed.

Chernov, Alex A.↗

Evaluation of an experimental system for spaceborne processing of multispectral image data

An experimental data processing system has been developed to demonstrate the feasibility of processing high speed, multispectral image data on board the spacecraft. The design incorporates real-time processing with adaptable operation in an expandable architecture. The experimental hardware is coupled to test support and computing equipment to provide a laboratory tool for evaluating and demonstrating each of the processing functions as well as the overall system operation. An evaluation of the high speed processor was conducted to ensure that the desired system throughput was achieved without sacrificing processing accuracy. A description of the system is presented along with the results of the test and evaluation activity.

Meredith, B. D.↗

Aerosol Plume Detection Algorithm Based on Image Segmentation of Scanning Atmospheric Lidar Data

An image-processing algorithm has been developed to identify aerosol plumes in scanning lidar backscatter data. The images in this case consist of lidar data in a polar coordinate system. Each full lidar scan is taken as a fixed image in time, and sequences of such scans are considered functions of time. The data are analyzed in both the original backscatter polar coordinate system and a lagged coordinate system. The lagged coordinate system is a scatterplot of two datasets, such as subregions taken from the same lidar scan (spatial delay), or two sequential scans in time (time delay). The lagged coordinate system processing allows for finding and classifying clusters of data. The classification step is important in determining which clusters are valid aerosol plumes and which are from artifacts such as noise, hard targets, or background fields. These cluster classification techniques have skill since both local and global properties are used. Furthermore, more information is available since both the original data and the lag data are used. Performance statistics are presented for a limited set of data processed by the algorithm, where results from the algorithm were compared to subjective truth data identified by a human.

97 MATHEMATICS AND COMPUTING↗

Effects of Convective Transport of Solute and Impurities on Defect-Causing Kinetics Instabilities

For in-situ studies of the formation and evolution of step patterns during the growth of protein crystals, we have designed and assembled an experimental setup based on Michelson interferometry with the surface of the growing protein crystal as one of the reflective surfaces. The crystallization part of the device allows optical monitoring of a face of a crystal growing at temperature stable within 0.05 C in a developed solution flow of controlled direction and speed. The reference arm of the interferometer contains a liquid-crystal element that allows controlled shifts of the phase of the interferograms. We employ an image processing algorithm which combines five images with a pi/2 phase difference between each pair of images. The images are transferred to a computer by a camera capable of capturing 6-8 frames per second. The device allows data collection data regarding growth over a relatively large area (approximately .3 sq. mm) in-situ and in real time during growth. The estimated dept resolution of the phase shifting interferometry is about 100 A. The lateral resolution, depending on the zoom ratio, varies between 0.3 and 0.6 micrometers. We have now collected quantitative results on the onset, initial stages and development of instabilities in moving step trains on vicinal crystal surfaces at varying supersaturation, position on the facet, crystal size and temperature with the proteins ferritin, apoferritin and thaumatin. Comparisons with theory, especially with the AFM results on the molecular level processes, see below, allow tests of the rational for the effects of convective flows and, as a particular case, the lack thereof, on step bunching.

Vekilov, Peter G.↗

High-Multiplicity Muon Airshower Analysis at NOvA Far Detector

We process and analyze muon airshower data from the NOvA far detector using various image processing algorithms, such as Fast Fourier Transformation, and Hough line transformation. From the processed event images, we calculate multiple parameters for our study. We are looking for physics features, including East-West Asymmetry, anisotropies in right ascension, and seasonal variation. Additionally, we have developed an algorithm to count the multiplicity of muons in the airshower events using the single muon data.

Lima, Aklima Khanam [Syracuse U.]↗

Advanced data mining in field ion microscopy

Field ion microscopy (FIM) allows to image individual surface atoms by exploiting the effect of an intense electric field. Widespread use of atomic resolution imaging by FIM has been hampered by a lack of efficient image processing/data extraction tools. Recent advances in imaging and data mining techniques have renewed the interest in using FIM in conjunction with automated detection of atoms and lattice defects for materials characterization. After a brief overview of existing routines, we review the use of machine learning (ML) approaches for data extraction with the aim to catalyze new data-driven insights into high electrical field physics. Apart from exploring various supervised and unsupervised ML algorithms in this context, we also employ advanced image processing routines for data extraction from large sets of FIM images. The outcomes and limitations of such routines are discussed, and we conclude with the possible application of energy minimization schemes to the extracted point clouds as a way of improving the spatial resolution of FIM.

36 MATERIALS SCIENCE↗

MO-FG-303-04: A Smartphone Application for Automated Mechanical Quality Assurance of Medical Accelerators

Purpose: The mechanical quality assurance (QA) of medical accelerators consists of a time consuming series of procedures. Since most of the procedures are done manually – e.g., checking gantry rotation angle with the naked eye using a level attached to the gantry –, it is considered to be a process with high potential for human errors. To remove the possibilities of human errors and reduce the procedure duration, we developed a smartphone application for automated mechanical QA. Methods: The preparation for the automated process was done by attaching a smartphone to the gantry facing upward. For the assessments of gantry and collimator angle indications, motion sensors (gyroscope, accelerator, and magnetic field sensor) embedded in the smartphone were used. For the assessments of jaw position indicator, cross-hair centering, and optical distance indicator (ODI), an optical-image processing module using a picture taken by the high-resolution camera embedded in the smartphone was implemented. The application was developed with the Android software development kit (SDK) and OpenCV library. Results: The system accuracies in terms of angle detection error and length detection error were < 0.1° and < 1 mm, respectively. The mean absolute error for gantry and collimator rotation angles were 0.03° and 0.041°, respectively. The mean absolute error for the measured light field size was 0.067 cm. Conclusion: The automated system we developed can be used for the mechanical QA of medical accelerators with proven accuracy. For more convenient use of this application, the wireless communication module is under development. This system has a strong potential for the automation of the other QA procedures such as light/radiation field coincidence and couch translation/rotations.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

DENNIS: a design and analysis tool for dynamic material x-ray diffraction experiments

We present DENNIS (Diffraction Experiment desigN and aNalysiS): a graphical software tool useful for the design and analysis of dynamic x-ray diffraction experiments, such as those performed on the Z Pulsed Power Facility, Thor Pulsed Power Generator, and Dynamic Compression Sector (DCS) of the Advanced Photon Source. DENNIS provides rapid powder and single-crystal diffraction pattern predictions and powder diffraction pattern image integration in three-dimensional geometries. Additional features include crystallographic information file reading, image processing, and synthetic diffraction pattern image generation. We overview the software's capabilities, detail the prediction and integration methodologies, and provide example implementations on Z and DCS experiments.

47 OTHER INSTRUMENTATION↗

LLM integration into EPICS

The utilization of large language models (LLMs) such as ChatGPT has seen a remarkable increase in various fields over the past few years. These models have demonstrated their versatility and capability in understanding and generating human-like text, making them invaluable tools in numerous applications. In this project, we explore the integration of a LLM into the Experimental Physics and Industrial Control System (EPICS). The primary focus of this integration is to employ the LLM for advanced image processing and spatial analysis on images obtained from the beamlines. By leveraging the capabilities of the LLM, we aim to enhance the accuracy and efficiency of image interpretation, enabling more precise data analysis and decision-making within the EPICS framework. This integration not only showcases the potential of LLMs in scientific and industrial applications but also sets the stage for future advancements in automated control systems.

Adams, Ethan↗

Cloud elevations in near real time

The paper shows how cloud elevations can be obtained from geosynchronous satellites within 15 min of an event and to an accuracy of less than 250 m. After careful consideration of pertinent factors, it is decided that a dual satellite system in parallel geosynchronous orbits would be the most feasible configuration for stereographic imaging of cloud systems. The discussion covers tracking accuracy, choice of imaging systems, data transmission and processing, image correlation, and proposed cloud heighting system. The described partially man-interactive system is substantially within the present state of the art and could be the basis for an interim system for cloud height determination.

Shull, C. W.↗

Observation of the Earth by radar

Techniques and applications of radar observation from Earth satellites are discussed. Images processing and analysis of these images are discussed. Also discussed is radar imaging from aircraft. Uses of this data include ocean wave analysis, surface water evaluation, and topographic analysis.

Elachi, C.↗