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Characterization of polymer networks presents unique challenges due to the insolubility of the materials, but this also enables characterization by new techniques that take advantage of the bulk network structure.
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Interdisciplinary environmental and sustainability (IES) programs are different from other fields because they focus on a complex integration of humanities, social, and natural sciences concepts centered on the interactions of coupled human and natural systems. The interdisciplinary nature of IES programs does not lend itself to traditional discipline-specific concept inventory frameworks for critically evaluating preconceptions and learning. We discuss the results of the first phase of a research project to develop a next generation concept inventory for evaluating interdisciplinary concepts important for introductory IES courses. Using the Food-Energy-Water (FEW) Nexus (the intersections/interdependencies of food, energy, and water sectors) as our focus, we conducted a content analysis of eight representative college-level introductory environmental course syllabi and course materials (e.g., textbooks, journal articles, print media) to identify common interdisciplinary FEW Nexus concepts taught in introductory IES courses. Results demonstrate that all IES introductory course materials reference the FEW Nexus. Food, energy, and/or water resources as individual elements of the FEW Nexus are frequently described, but connections between these resource systems are included less often. Biology, energy systems, waste and pollution in the natural environment, agriculture, earth sciences and geology, climate change, behavioral social sciences, and economics concepts are most associated with FEW concepts, hinting at commonalities across IES topics that anchor systems thinking. Despite differences in IES programs, there appears to be some alignment between core concepts being taught at the FEW Nexus in introductory courses.
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The Protein Data Bank (PDB) was established as the first open-access digital data resource in biology and medicine in 1971 with seven X-ray crystal structures of proteins. Today, the PDB houses >210 000 experimentally determined, atomic level, 3D structures of proteins and nucleic acids as well as their complexes with one another and small molecules ( e.g. approved drugs, enzyme cofactors). These data provide insights into fundamental biology, biomedicine, bioenergy and biotechnology. They proved particularly important for understanding the SARS-CoV-2 global pandemic. The US-funded Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) and other members of the Worldwide Protein Data Bank (wwPDB) partnership jointly manage the PDB archive and support >60 000 `data depositors' (structural biologists) around the world. wwPDB ensures the quality and integrity of the data in the ever-expanding PDB archive and supports global open access without limitations on data usage. The RCSB PDB research-focused web portal at https://www.rcsb.org/ (RCSB.org) supports millions of users worldwide, representing a broad range of expertise and interests. In addition to retrieving 3D structure data, PDB `data consumers' access comparative data and external annotations, such as information about disease-causing point mutations and genetic variations. RCSB.org also provides access to >1 000 000 computed structure models (CSMs) generated using artificial intelligence/machine-learning methods. To avoid doubt, the provenance and reliability of experimentally determined PDB structures and CSMs are identified. Related training materials are available to support users in their RCSB.org explorations.
To combat climate change, the United States joined 193 Parties in committing to the Paris Agreement, which aims to limit global warming to 2 degrees C or less, and decarbonizing transportation will be a key requirement for achieving this goal. School buses (SBs) are a common form of student transport in the U.S. with nearly all SBs today powered by fossil fuels (primarily diesel). As a result, SBs have historically been a concerning source of both greenhouse gas (GHG) emissions and local air pollutants with negative health impacts for students and others living nearby. Electric SBs (ESBs) are a promising emerging technology for decarbonizing student transport, however, ESB adoption in the U.S. remains at an early stage (approximate 1.1%) with many outstanding uncertainties. This study aims to elucidate several of these by taking inventory of the total SB stock within U.S. states and studying real-world SB operating profiles to infer potential battery range requirements, daily charging opportunities, and charging infrastructure requirements for ESBs. In addition, we observe the geographic trends of early-stage ESB adoption, which can be used to better understand early adopter patterns and train vehicle technology adoption models.
This special issue celebrates the scientific legacy of Dr. Malcolm J. Andrews, former Editor of the ASME Journal of Fluids Engineering (2010–2018). Malcolm devoted his career to the development and applications of computational, experimental, and analytical tools to investigate and solve diverse, complex fluid dynamics, and heat transfer problems. Malcolm’s most notable research accomplishments include: (i) contributions to innovative experiments, simulations, and theory to understand buoyancydriven turbulent mixing due to Rayleigh–Taylor instability; (ii) development of the multiphase particle-in-cell method for understanding fragmentation in spray jets, coal-water slurry, and other dense particulate flows; (iii) mixing in nano- and biomaterials in applications ranging from protein glues to carbon nanotube composites; (iv) determining dispersion in proteins to improve therapeutic drug delivery via micro-encapsulation; (v) innovative methods for storing information using nanopinned dipole magnetic vortices in superconducting materials; and (vi) modeling and design modifications for shell-and-tube heat exchangers, as well as heat transfer in rotating systems such as turbine blades. The results of his research have been published in a long series of trend-setting journal and conference papers, book chapters, and patents.
The reflectance spectra of solid and liquids can be complicated since they depend not only on absorption, but also on the refraction, reflection, and scattering of light, all of which are wavelength dependent. The physical form and morphological effects associated with solid and liquid samples are thus known to affect their reflectance spectra in a non-linear fashion, particularly in the infrared. Measuring the optical constants n(?) and k(?) represents an alternative approach, allowing one to model these many effects and thus requiring fewer laboratory measurements. In this paper an overview is presented of the protocols used to measure the n/k optical constants, particularly for liquids. For the liquids, a multiple path length measurements approach is employed, and in this paper we demonstrate the method to determine the complex optical constants n(?) and k(?) of squalene. The resultant calculated spectra of 1 µm and 100 µm thick layers of squalene on an aluminum substrate as derived from the experimental n(?) and k(?) values are shown to demonstrate such effects. The public availability of the n(?)/k(?) data as well as solids hemispherical reflectance data are also discussed.
This presentation will focus on the present role of ultrasound medical physics in clinical practices. The first part of the presentation will provide an overview of ultrasound QC methodologies and testing procedures. A brief review of ultrasound phantoms utilized in these testing procedures will be presented. The second part of the presentation will summarize ultrasound imaging technical standards and professional guidelines by American College of Radiology (ACR), American Institute of Ultrasound in Medicine (AIUM), American Association of Physicists in Medicine (AAPM) and International Electrotechnical Commission (IEC). The current accreditation requirements by ACR and AIUM for ultrasound practices will be described and the practical aspects of implementing QC programs to be compliant with these requirements will be discussed. Learning Objectives: Achieve familiarity with common ultrasound QC test methods and ultrasound phantoms. Understand the coverage of the existing testing standards and professional guidelines on diagnostic ultrasound imaging. Learn what a medical physicist needs to know about ultrasound program accreditation and be able to implement ultrasound QC programs accordingly.
The world faces two seemingly unrelated challenges—a shortfall in the STEM workforce and increasing antibiotic resistance among bacterial pathogens. We address these two challenges with Tiny Earth, an undergraduate research course that excites students about science and creates a pipeline for antibiotic discovery.
The 2013 International Conference on Intelligent Biology and Medicine (ICIBM 2013) was held on August 11-13, 2013 in Nashville, Tennessee, USA. The conference included six scientific sessions, two tutorial sessions, one workshop, two poster sessions, and four keynote presentations that covered cutting-edge research topics in bioinformatics, systems biology, computational medicine, and intelligent computing. Here, we present a summary of the conference and an editorial report of the supplements to BMC Genomics and BMC Systems Biology that include 19 research papers selected from ICIBM 2013.
The Office of Radiological Security (ORS) within the U.S. DOE’s National Nuclear Security Administration (NNSA) is charged to “work with government, law enforcement, and businesses across the globe to protect radioactive sources used for medical, research, and commercial purposes; remove and dispose of disused radioactive sources; and reduce the global reliance on high activity radioactive sources through the promotion of viable non-radioisotopic alternative technologies.” In this effort, the NNSA/ORS, along with the Office of Defense Nuclear Nonproliferation R&D, has been working with government and private entities that utilize gamma-ray irradiators in areas that include blood irradiation, radiotherapy, biology research, well logging, and radiation processing to consider alternative technologies that do not depend upon radioactive materials. In the medical device industry, nearly 50% of products are sterilized with ethylene oxide, 40.5% with cobalt-60 gamma-rays, 4.5% with electron-beam (e-beam), and <1% with X-ray.(1,2) The cobalt-60 irradiation facilities use an estimated 150 MCi of isotope to sterilize approximately 200 million cubic feet of product annually.(3) Due to growing safety regulations governing cobalt-60 use, continued advancements in e-beam and X-ray accelerator technology, and the greater irradiation durations and costs for cobalt-60 irradiation compared to e-beam and X-ray, switching to these non-radionuclide modalities is increasingly economically competitive. However, this breakdown of 40.5% cobalt-60 and 5.5% accelerator for product sterilization illustrates the difficulty that market forces and industry players have had in overcoming barriers in transitioning to non-nuclide alternatives. Besides those associated with construction of new e-beam and X-ray facilities, significant financial and regulatory obstacles are also associated with the irradiation and comprehensive testing of product constituent polymers and elastomers. The standards associated with product material performance testing are the Association for the Advancement of Medical Instrumentation (AAMI) Technical Information Report 17 (TIR 17), and its referenced American Society for Testing and Materials (ASTM) polymer testing standards. In the study now underway, and the subject of this article, the NNSA/ORS provided R&D funding to the Pacific Northwest National Laboratory (PNNL) in partnership with university researchers, leading medical product manufacturers, accelerator manufacturers, and contract sterilizers. The resulting Team Nablo (in memory of Sam Nablo) includes individuals representing PNNL, Becton Dickinson (BD), Johnson & Johnson, Stryker, Texas A&M University (TAMU), Steri-Tek, Mevex, Ion Beam Applications (IBA), and Sterigenics. The goals of this study are to 1) Identify specific polymer and/or elastomer-based medical products that are currently sterilized with gamma-rays, and for which there are data gaps and would be of greatest industry impact, 2) Work with relevant ASTM subcommittees for guidance and for potential standard revision, 3) Work with an appropriate Food & Drug Administration (FDA) office for potential collaboration on a guidance document for device manufacturers, 4) Measure the physical effects that product materials exhibit when they are given sterilization-level radiation doses from cobalt-60, e-beam or X-ray, and determine whether these effects would preclude the use of e-beam or X-ray for sterilization, 5) Communicate the resulting scientific datasets and findings via industry conferences, peer-reviewed journals, and relevant trade magazines, and 6) Post the resulting datasets on a publicly accessible website, which can be built on in future years. The end objective is to identify technical barriers preventing the adoption of X-ray and e-beam technologies, and share the results to encourage X-ray and e-beam adoption where feasible.